• Archives of Pharmacal Research
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• 제28권5호
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• pp.598-603
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• 2005

The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appen dicitis patients. Gentamicin was administered intravenously over 0.5 h every 8 h. Three specimens were collected at 48 h after the first dose from all patients at the following times, just before regularly scheduled infusion, at 0.5 h and 2 h after the end of 0.5 h infusion. Serum gentamicin levels were analyzed by fluorescence polarization immunoassay technique with TDxFLx. The standard deviation (SD) of the assay over its working range had been determined at the serum gentamicin concentrations of 0, 2, 4, 8, 12, and 16 ${\mu}g$/mL in quadruplicate. The polynominal equation of gentamicin assay error was found to be SD (${\mu}g$/mL) = 0.0246-(0.0495C)+ (0.00203C$^2$). There were differences in the influence of weight with gentamicin assay error on pharmacokinetic parameters of gentamicin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynominal equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result would be improved dosage regimens and better, safer care of patients receiving gentamicin.

• 한국통신학회논문지
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• 제16권6호
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• pp.545-555
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• 1991

본 논문에서는 단층 퍼센트론 모델의 학습기능과 신경회로망 형성메모리의 오류정정 능력이 서로 보완적으로 결합된 새로운 적응 패턴인식 시스템의 광학적구현을 실현하였다. 여기서, 단층 퍼센트론 모델은 2차원 LCTV 공간 광변조기를 이용하여 편광인코딩방법과 비전형 양자화 방법으로 구현하였으며, Hopfield 연장메모리는 2차원 모델로 황장하고multifocus holoens를 이용하여 광학적으로 구현하였다. 아리비아 숫자 짝.홀수 판별에 고나한 광학적 실험 결과, 오류 및 부분 입력에 대한 정확한 패턴 분류가 됨을 확인함으로서, 본 논문에서 제시한 새로운 적응 광 패턴인식 시스템이 실제로 영상처리, 패턴인식 등의 분야에서 그 응용 가능성을 제시하였다.

• Bulletin of the Korean Chemical Society
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• 제31권4호
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• pp.999-1003
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• 2010

Raman spectra of a single layer graphene sheet placed in different gold substrates were obtained and are discussed in the context of surface enhanced Raman scattering (SERS). The gold substrates were composed of a combination of a thermally deposited gold film and a close-packed gold nanosphere layer. The SERS effects were negligible when the excitation wavelength was 514 nm, while the Raman signals were enhanced 3-to 50-fold when the excitation wavelength was 633 nm. The large SERS enhancement accompanied a spectral distortion with appearance of several unidentifiable peaks, as well as enhancement of a broadened D peak. These phenomena are interpreted as the local field enhancement in the nanostructure of the gold substrates. The difference in the enhancement factors among the various gold substrates is explained with a model in which the spatial distribution and polarization of the local field and the orientation of the inserted graphene sheet are considered important.

• 천문학회지
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• 제32권1호
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• pp.65-73
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• 1999

In this study we present a new improved nonlinear calibration method for vector magnetograms made by the Solar Flare Telescope of BOAO. To identify Fe I 6302.5 line, we have scanned monochromatic images of the line integrated over filter passband, changing the location of the central transmission wavelength of a Lyot filter. Then we obtained a filter-convolved line profile, which is in good agreement with spectral atlas data provided by the Sacramento Peak Solar Observatory. The line profile has been used to derive calibration coefficients of longitudinal and transverse fields, employing the conventional line slope method under the weak field approximation. Our improved nonlinear calibration method has also been used to calculate theoretical Stokes polarization signals with various angles of inclination of magnetic fields. For its numerical test, we have compared input magnetic fields with the calibrated ones, which have been derived from the new improved non-linear method and the conventional method respectively. The numerical test shows that the calibrated fields obtained from the improved method are consistent with the input fields, but not with those from the conventional method. Finally, we applied our new improved method to a dipole model which characterizes a typical field configuration of a single, round sunspot. It is noted that the conventional method remarkably underestimates the transverse field component near the inner penumbra.

• 한국정보통신학회논문지
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• 제5권4호
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• pp.807-811
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• 2001

파수 원형 섹터 마이크로스트립 안테나를 제안하였다 그리고 이것을 사용하여 5.6 GHz 에서 송신과 5.5 GHz 에서 수신 동작을 하는 트랜시버를 제작하였다. 트랜시버의 송수신 주파수 분리에 제안된 안테나의 좋은 격리도 특성을 이용하였다. 제안한 이중 주파수 안테나의 동작 주파수 및 편파 특성을 공진기 모델을 사용하여 계산하였으며, 안테나의 S 파라미터 및 복사패턴을 측정하였다. 전력증폭기 및 저잡음 증폭기를 설계하여 안테나와 집적하여, 송신 및 수신 이득이 각각 약 13dB 및 약 8dB가 되는 트랜시버를 제작하였다.

• 대한금속재료학회지
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• 제48권8호
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• pp.724-729
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• 2010

The effect of potassium permanganate ($KMnO_4$) in an electrolyte on the corrosion performance of magnesium alloy coated by micro-arc oxidation (MAO) has been investigated in this study. For this purpose, MAO coating was carried out on the present sample under AC condition in an alkaline silicate electrolyte with and without $KMnO_4$. Irrespective of the addition of $KMnO_4$, it was found from structural observation that the ceramic coating layers consisted of inner and outer layers. In the sample processed in the electrolyte with $KMnO_4$, the outer layer became dense and even contained a number of $Mn_2O_3$ atoms, resulting in high corrosion resistance. Based on the results of a potentiodynamic polarization test, it was confirmed that the coating layer formed in the electrolyte with $KMnO_4$exhibited better corrosion resistance than that without $KMnO_4$. The high corrosion resistance of the MAO-treated magnesium alloy was explained in relation to the equivalent circuit model.

• 약학회지
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• 제57권1호
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• pp.32-36
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• 2013

The purpose of this study was to determine the influence of assay error for improved pharmacokinetic modeling and simulation of vancomycin on the Bayesian and nonlinear least squares regression analysis in 24 Korean gastric cancer patients. Vancomycin 1.0 g was administered intravenously over 1 hr every 12 hr. Three specimens were collected at 72 hr after the first dose from all patients at the following times, at 0.5 hr before regularly scheduled infusion, at 0.5 hr and 2 hr after the end of 1 hr infusion. Serum vancomycin levels were analyzed by fluorescence polarization immunoassay technique with TDX-FLX. The standard deviation (SD) of the assay over its working range had been determined at the serum vancomycin concentrations of 0, 20, 40, 60, 80 and $120{\mu}g/ml$ in quadruplicate. The polynomial equation of vancomycin assay error was found to be SD $({\mu}g/ml)=0.0224+0.0540C+0.00173C^2$ ($R^2=0.935$). There were differences in the influence of weight with vancomycin assay error on pharmacokinetic parameters of vancomycin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynomial equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result suggests the improvement of dosage regimens for the better and safer care of patients receiving vancomycin.

• Journal of Electrochemical Science and Technology
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• 제9권4호
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• pp.260-275
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• 2018

The corrosion inhibition of cast iron in 1 M HCl by Phenanthroline (Phen) was investigated using potentiodynamic polarization (PDP) curves, electrochemical impedance spectroscopy (EIS), surface analysis and theoretical calculations. It is found that Phen exhibits high inhibition activity towards the corrosive action of HCl and its adsorption obeys the Langmuir adsorption isotherm model. The results showed that inhibition efficiency increases with Phen concentration up to a maximum value of 96% at 1.4 mM, and decreases slightly with the increase in temperature. The free adsorption energy value indicates that Phen adsorbs on cast iron surface in 1 M HCl via a simultaneous physisorption and chemisorption mechanism. Scanning electron microscopy (SEM) micrographs, atomic force microscopy (AFM) and FTIR analysis confirmed the formation of a protective film on cast iron surface, resulting in the improvement of its corrosion resistance in the studied aggressive solution. Quantum chemical calculations at the DFT level were achieved to correlate electronic structure parameters of Phen molecules with their adsorption mode.

• Asia-Pacific Journal of Atmospheric Sciences
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• 제54권4호
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• pp.527-544
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• 2018

This paper presents a nighttime sea fog detection algorithm incorporating unsupervised learning technique. The algorithm is based on data sets that combine brightness temperatures from the $3.7{\mu}m$ and $10.8{\mu}m$ channels of the meteorological imager (MI) onboard the Communication, Ocean and Meteorological Satellite (COMS), with sea surface temperature from the Operational Sea Surface Temperature and Sea Ice Analysis (OSTIA). Previous algorithms generally employed threshold values including the brightness temperature difference between the near infrared and infrared. The threshold values were previously determined from climatological analysis or model simulation. Although this method using predetermined thresholds is very simple and effective in detecting low cloud, it has difficulty in distinguishing fog from stratus because they share similar characteristics of particle size and altitude. In order to improve this, the unsupervised learning approach, which allows a more effective interpretation from the insufficient information, has been utilized. The unsupervised learning method employed in this paper is the expectation-maximization (EM) algorithm that is widely used in incomplete data problems. It identifies distinguishing features of the data by organizing and optimizing the data. This allows for the application of optimal threshold values for fog detection by considering the characteristics of a specific domain. The algorithm has been evaluated using the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) vertical profile products, which showed promising results within a local domain with probability of detection (POD) of 0.753 and critical success index (CSI) of 0.477, respectively.

• 한국재료학회지
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• 제32권7호
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• pp.313-319
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• 2022

Double-layer capacitors (DLCs) are developed with high surface electrodes to achieve a high capacitance value. In the present work, the initial bulk concentration of 1 mol/m³ and 3 mol /m³ are selected to show the consequential effects on the performance of a double-layer capacitor. A 1D model of COMSOL Multiphysics has been developed to analyze the electric field and potential in cell voltage, the electric displacement field and polarization induced by the field, and energy density in a double-layer structure. The electrostatics and the electric circuit modes in COMSOL are used to simulate the electrochemical processes in the double-layer structure. The analytical analysis of a double-layer capacitor with different initial bulk concentrations is investigated by using Poisson-Nernst-Plank equations. From the simulation results, the differential capacitance changes as a function of compact layer thickness and initial bulk concentration. The energy density varies with the differential capacitance and voltage window. The values of energy density are dominated by the interaction of ions in the solution and electrode surface.