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A STUDY ON BIOLOGICAL MARKERS FOR THE ASSESSMENT OF GENOTOXICITY AND OXIDATIVE DAMAGE IN CHROMIUM EXPOSED WORKERS.

  • Maeng, Seung-Hee;Hiroshi Kasai;Yu, Il-Je;Lee, Byung-Moo;Lee, Jong-Yoon;Lee, Kwon-Seob;Chung, Ho-Keun;Chung, Hai-Won
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.121-122
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    • 2001
  • According to the epidemiological studies in chromium workers, hexavalent chromium is associated with the risk of lung cancer. Genotoxicity such as chromosome aberration, and cellular oxidative damages by reactive oxygen species produced by hexavalent chromium exposure may play an important role in the carcinogenesis process. We investigated the availabilities of several kinds of biological markers to assess the genotoxicity and oxidative damages from chromium exposure in Korean chromium plating workers.(omitted)

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Assessment of Agricultural Environment Using Remote Sensing and GIS

  • Hong Suk Young
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2005.08a
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    • pp.75-87
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    • 2005
  • Remote sensing(RS)- and geographic information system(GIS)-based information management to measure and assess agri-environment schemes, and to quantify and map environment indicators for nature and land use, climate change, air, water and energy balance, waste and material flow is in high demand because it is very helpful in assisting decision making activities of farmers, government, researchers, and consumers. The versatility and ability of RS and GIS containing huge soil database to assess agricultural environment spatially and temporally at various spatial scales were investigated. Spectral and microwave observations were carried out to characterize crop variables and soil properties. Multiple sources RS data from ground sensors, airborne sensors, and also satellite sensors were collected and analyzed to extract features and land cover/use for soils, crops, and vegetation for support precision agriculture, soil/land suitability, soil property estimation, crop growth estimation, runoff potential estimation, irrigated and the estimation of flooded areas in paddy rice fields. RS and GIS play essential roles in a management and monitoring information system. Biosphere-atmosphere interection should also be further studied to improve synergistic modeling for environment and sustainability in agri-environment schemes.

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Lessons from Generic Promotion Policies in Other Countries (주요국의 제네릭 의약품 활성화 정책 고찰과 시사점)

  • Kim, Dong-Sook;Bae, Seungjin;Jang, Sunmee
    • Health Policy and Management
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    • v.23 no.3
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    • pp.210-223
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    • 2013
  • Backgrounds: Escalating pharmaceutical expenditure has threatened the sustainability of National Health Insurance system in Korea. Generic medicines allow patients to access safe, effective, high-quality medicines at low cost, thus insurers could achieve significant financial savings by promotion of generics, if they are priced much lower than the originator. The purpose of this study was to review generic pricing as well as promotion policies in other countries and assess the implication of those policies. Methods: We reviewed the main measures adopted by the developed countries such as Austria, Belgium, Denmark, Finland, France, Germany, Italy, Japan, Netherlands, Norway, Sweden, United Kingdom, especially in countries where governments are the largest third-party payers or insurance finance resource is the national health insurance. Results: The foreign countries's experience with generic medicine policy shows that demand-side policies such as physician budgets, international nonproprietary name prescribing, generics substitution, patients co-payment as well as supply-side policies relating to pricing and reimbursement seems to play a critical role in developing the generic medicines market. Conclusion: Various strategy should be implemented to promote generic drug use.

Review of Interstitial Cystitis and Need for Therapeutic Strategy Using Traditional Korean Medicine (간질성 방광염의 개괄과 한의학적 연구의 필요성)

  • Park, Sang-Woo;Kim, Chul-Jung;Cho, Chung-Sik
    • The Journal of Korean Medicine
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    • v.33 no.3
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    • pp.120-132
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    • 2012
  • Objectives: This study aimed to analyze the current status of treatments and patients with interstitial cystitis, and then map out a strategy for development of generalized-treatments for interstitial cystitis in Traditional Korean Medicine. Methods: We selected research paper from various databases such as PubMed, Google, KStudy, KoreanTK, OIM, and KOMS. Also, to understand current tendencies of medical cost related with interstitial cystitis, we requested Health Insurance Review and Assessment Service clinical data from 2007 to 2011. Results: It was reported that treatment of interstitial cystitis using Traditional Korean Medicine was effective. However, patients of this usually visit a Western medical center rather than seek Traditional Korean Medicine. To take charge of clinical fields related with interstitial cystitis by Traditional Korean Medicine, we need more research and experiments of interstitial cystitis using Traditional Korean Medicine, and we must make a standardized protocol. Conclusions: Various studies related with interstitial cystitis using Traditional Korean Medicine will have to be undertaken. We expect that Traditional Korean Medicine will play a role in treatment of interstitial cystitis.

Footrest design optimization of a small vehicle to improve ANCAP lower leg injury (호주 신차안전도평가의 하부다리 상해치 개선을 위한 경차의 Footrest 형상 최적화)

  • Kim, Joseph;Lee, Mansu;Nam, Joungin;Han, Jaenyung
    • Journal of Auto-vehicle Safety Association
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    • v.7 no.1
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    • pp.27-32
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    • 2015
  • In order to protect occupant during car crash accident, Regulation and NCAP(New Car assessment Program) have been developed among various countries like U.S.A., Europe, Korea and Australia. Especially NCAP scores affect to sales of vehicles. So vehicle makers are trying to get good score in NCAP. Low leg injuries play an important role in Australia and Euro NCAP and these injuries are related with footrest design. Optimization of footrest design in early stage of vehicle development is necessary to obtain better and robust results of low legs during crash tests. In this paper, DFSS method and finite element model were used to optimize the low leg performance in small RHD vehicles. Compared with the lower leg injury of base model, the lower leg injury of proposed model was slightly improved and robustness was enhanced also.

A Study on the Indirect Expropriation in International Investment - Focused on the Requirements of Indirect Expropriation - (국제투자에 있어서 간접수용에 관한 연구 - 간접수용의 요건을 중심으로 -)

  • Kim, Yong-Il;Lee, Ki-Ok;Li, Jing-Hua
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.47
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    • pp.3-24
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    • 2010
  • The contours of the definition of an indirect expropriation are not precisely drawn. In some recent ICSID decision, tribunals have interpreted the concept of indirect expropriation narrowly and have preferred to find a violation of the standard of fair and equitable treatment. Thus, I analyzed the three Requirements of Indirect Expropriation basis of ICSID Cases as below. First, the effect of measure upon the economic benefit value as well as upon the control over the investment will be the key question when it comes to deciding whether an indirect expropriation has taken place. Whenever this effect is substantial and lasts for a significant period of time, it will be assumed prima facie that a taking of the property has occurred. Second, legitimate play a key role in the interpretation of the fair and equitable treatment standard. But they also found entry into the law governing indirect expropriation. Finally, the duration of a government measure affecting the interests of a foreign investor is important for the assessment of whether an expropriation has occurred.

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Developing Traditional Handcraft Villages: The Determinants of Lending Decision from Binh Duong Province's Banks in Vietnam

  • LE, Man Thi;LE, Dong Nguyen Thanh
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.2
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    • pp.151-156
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    • 2020
  • Small and medium enterprises (SMEs) play a very important role in developing countries. In Vietnam, SMEs operating in the field of handicrafts, besides contributing to the economy, also tasked to maintain and develop traditional handicrafts. However, accessing loans from banks of SMEs faces many difficulties. This study explores the determinants of bank lending decision for SMEs, particular, in traditional handicrafts business. Using dataset based on a survey conducted in Binh Duong province, Vietnam, we investigated to what determinant effects for loan approval. The analytical methods used include descriptive statistics for overall assessment, principal component analysis and regression to examine determinants of lending decisions. The results indicate that company's collateral was the most positive determinant to bank lending decision, follow by company's business plan. The role of company's leader is very important for banks considers to approve credit because company's leaders experience and relationship with stakeholders as well as banks have positive relations with bank's lending decision. Agreed with previous studies, the company's financial statement and company's credit history with banks are also significant determinants for lending decision. Whereas, the business environment seam unaffected lending decision as their relations is not significant..

Estimation of mortality coefficients and survivorship curves for minke whales (Balaenoptera acutorostrata) in Korean waters

  • Zhang, Chang-Ik;Song, Kyung-Jun;Na, Jong-Hun
    • Animal cells and systems
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    • v.14 no.4
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    • pp.291-296
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    • 2010
  • Population ecological characteristics of growth and mortality play an important role in understanding the population dynamics of marine mammals. The instantaneous coefficients of natural and bycatch mortality were estimated for minke whales (Balaenoptera acutorostrata) in Korean waters using a population assessment model composed of bycatch and abundance data. The survivorship curve of this population was fitted to the data, and then the curve was revised using age-specific relative bycatchability coefficients ($q_t$). Instantaneous coefficients of natural and bycatch mortality of minke whales were estimated as 0.024/year and 0.076/year, respectively, and from this the survival rate was estimated as 0.905. This estimated survival rate was comparable to other cetaceans in other regions. The $q_t$ for this population ranged from 0.020 to 0.193. The revised survival rates were higher when the $q_t$ was taken into account. The mortality coefficient, survival rate, $q_t$ and survivorship curves had not previously been determined for minke whale in this area. This estimate could serve as fundamental information to assess the status of this population and for conservation and rational management.

A Vtub-Shaped Hazard Rate Function with Applications to System Safety

  • Pham, Hoang
    • International Journal of Reliability and Applications
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    • v.3 no.1
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    • pp.1-16
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    • 2002
  • In reliability engineering, the bathtub-shaped hazard rates play an important role in survival analysis and many other applications as well. For the bathtub-shaped, initially the hazard rate decreases from a relatively high value due to manufacturing defects or infant mortality to a relatively stable middle useful life value and then slowly increases with the onset of old age or wear out. In this paper, we present a new two-parameter lifetime distribution function, called the Loglog distribution, with Vtub-shaped hazard rate function. We illustrate the usefulness of the new Vtub-shaped hazard rate function by evaluating the reliability of several helicopter parts based on the data obtained in the maintenance malfunction information reporting system database collected from October 1995 to September 1999. We develop the S-Plus add-in software tool, called Reliability and Safety Assessment (RSA), to calculate reliability measures include mean time to failure, mean residual function, and confidence Intervals of the two helicopter critical parts. We use the mean squared error to compare relative goodness of fit test of the distribution models include normal, lognormal, and Weibull within the two data sets. This research indicates that the result of the new Vtub-shaped hazard rate function is worth the extra function-complexity for a better relative fit. More application in broader validation of this conclusion is needed using other data sets for reliability modeling in a general industrial setting.

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Examinations on Preservice Elementary Teachers' Science PCK and Perceptions through Mentoring Program (멘토링을 통한 초등 예비교사의 과학 PCK의 특징 및 멘토링에 대한 인식 고찰)

  • Yoon, Ji-Hyun;Lim, Hee-Jun;Park, Ji-Ae;Noh, Tae-Hee
    • Journal of Korean Elementary Science Education
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    • v.31 no.1
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    • pp.99-108
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    • 2012
  • This study investigated the characteristics of preservice elementary teachers' science PCK through a mentoring program. Their perceptions of the mentoring program were also examined. The participants of this study were 33 preservice elementary teachers who prepared science lessons in small groups. A mentoring program was implemented in the processes of science lessons planning and evaluation to support their professional development. The characteristics of the preservice elementary teachers' science PCK exhibited through the mentoring program were as follows: They showed poor understanding of instructional models and logical connections of each instructional step. They also had problem in setting a clear learning goal for their science lessons. This was related with their poor understanding of the curriculum. They seldom considered students' misconceptions, and their perceptions of assessment were quite restricted. The analyses on their perceptions of the mentoring program revealed that the preservice teachers thought it was helpful for their professional development in several aspects. Mentoring could play an important role to examine and improve preservice elementary teachers' science PCK.