A STUDY ON BIOLOGICAL MARKERS FOR THE ASSESSMENT OF GENOTOXICITY AND OXIDATIVE DAMAGE IN CHROMIUM EXPOSED WORKERS.

  • Maeng, Seung-Hee (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Hiroshi Kasai (Department of Environmental Oncology, Institute of Industrial Ecological Science, School of Medicine, University of Occupation and Environmental Healt) ;
  • Yu, Il-Je (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Lee, Byung-Moo (Division of Toxicology, college of pharmacy, Sungkyunkwan Univ) ;
  • Lee, Jong-Yoon (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Lee, Kwon-Seob (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Chung, Ho-Keun (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Chung, Hai-Won (School of Public Health, Seoul National University)
  • Published : 2001.10.01

Abstract

According to the epidemiological studies in chromium workers, hexavalent chromium is associated with the risk of lung cancer. Genotoxicity such as chromosome aberration, and cellular oxidative damages by reactive oxygen species produced by hexavalent chromium exposure may play an important role in the carcinogenesis process. We investigated the availabilities of several kinds of biological markers to assess the genotoxicity and oxidative damages from chromium exposure in Korean chromium plating workers.(omitted)

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