• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1566-1571
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• 2008

Bone is a dynamic tissue that is constantly resorbed by osteoclasts and then replaced by osteoblasts. Osteoclasts, multinucleated cells of monocyte/macrophage lineage, are responsible for bone disorders, including osteoporosis and rheumatoid arthritis. In this study, we examined the effect of the curcumin on osteoclast survival and bone resorption. We found that curcumin significantly inhibited RANKL-mediated osteoclast survival. DAPI stainingrevealed that curcumin induced the apoptotic features of osteoclasts. Although curcumin did not suppress the phosphorylation of Akt and ERK in osteoclasts treated with RANKL, curcumin induced the cleavage of pro-caspase-9 and -3 its active forms. Also, curcumin inhibited the formation of actin rings of osteoclasts. RANKL-mediated bone resorption was inhibited by the addition of curcumin. Together with the results of this study, these findings suggest that the curcumin inhibited the survival of osteoclasts by activating caspase-9 and -3 and suppressed the bone resorptive activity. Thus, curcumin may be developed as antiresorptive drugs for the treatment of bone-related disorders.

• Korean Journal of Materials Research
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• v.10 no.9
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• pp.629-635
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• 2000

The texture evolution during isothermal forging and subsequent heat treatment in Ti-48.5at%Al-0.6at%Mo alloy was investigated. Especially, in the present study, research interest was focused on the interrelation between lamellar volume fraction and textures varied with the change of heat-treated time and temperature. It was found that texture components having ND┴{302) and TD$\perp${100} with minor TD$\perp${111} were developed by isothermal forging. In addition, when the followed heat-treatment time and temperature increased from $1330^{\circ}C$/10h to $1350^{\circ}C$/20h respectively, both the lamellar volume fraction and the intensity of textures mentioned above also gradually increased. However, the tensile elongation at room temperature decreased oppositely, as the lamellar volume fraction increased. These results suggested that tensile properties of $\gamma$-TiAl with the nearly lamellar microstructure at room temperature were affected more strongly by the microstructural features such as lamellar volume fraction rather than by textures.

• Korean Journal of Microbiology
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• v.49 no.1
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• pp.83-89
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• 2013

A bacterium, isolated from a vegetable field in a plastic film house and named strain CY6 was capable of biodegrading chlorpyrifos (CP). Based on the phenotypic features and the phylogenetic similarity of 16S rRNA gene sequences, strain CY6 was identified as a Naxibacter sp.. CP was utilized as the sole source of carbon and phosphorus by Naxibacter sp. CY6. We examined the role of this Naxibacter sp. in the degradation of other OP insecticides under liquid cultures. Parathion, methyl parathion, diazinon, cadusafos, and ethoprop could also be degraded by Naxibacter sp. CY6 when they are provided as the sole sources of carbon and phosphorus. Additionally, Naxibacter sp. CY6 ($10^8$ CFU/g) added to soil with CP (100 mg/kg) resulted in a higher degradation rate of approximately 90% than the rate obtained from uninoculated soils. These results highlight the potential of this bacterium to be used in the cleanup of contaminated pesticide soil.

• Food Science and Preservation
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• v.15 no.6
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• pp.847-851
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• 2008

The handling and processing of agricultural products in Korea is done manually. Small plastic boxes, nets, and corrugated cardboard boxes are used as containers during harvesting, sorting and other product handling operations. However, these practices are labor-intensive, time-consuming, require various kinds of packing materials, and are expensive because of high operating costs. To overcome these problems, the use of pallet bins with pre-cooling and storage features for handling and processing bulk farm products was investigated. The airflow resistances through bulk potato, onion and mandarin stocks were measured, and the pallet bins and a pressure pre-cooling device were manufactured. The opening ratio, bed depth and airflow rate through bulk potato, onion and mandarin in the pallet bin were defined with regression equations. The cooling rates of bulk potato, onion and mandarin were 0.8C/h ($21.7{\rightarrow}0C$, 14.5 h), 0.4C/h ($15.4{\rightarrow}.0C$, 32.2 h) and 0.7C/h ($13.7{\rightarrow}C$, 18.8 h), respectively, with the pressure pre-cooling system. Temperature deviances for storage of bulk potato, onion and mandarin were 0.12C, 0.12C and 0.17C, respectively.

• Journal of the Korea Organic Resources Recycling Association
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• v.18 no.3
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• pp.77-86
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• 2010

In this study, the model of the indirect wind suction waste sorting machine for characteristics of the screening of waste was studied using computational fluid dynamics and the drag coefficient for the model and the suction wind speed were obtained. The wind separator are developing by installing a cyclone air outlet to the suction blower impeller waste is selective in a way that does not pass the features and characteristics of the inlet pipe of the pressure loss and separation efficiency can have a significant impact on. Using Wind separator for selection of waste in the waste prior research on the aerodynamic properties are essential. For plastic cases, it is reasonable to take the drag coefficient between 0.8 and 1.0, and for cans, compression depending on whether the cans, the drag coefficient is in the range from 0.2 to 0.7. The separation efficiency of waste as change suction speed was the highest efficiency when the suction speed was 25~26 m/s. Shape of the inlet, depending on how the transfer pipe of the duct pressure loss occurs because the inlet velocity changes through the appropriate design standards to allow for continued research is needed.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.4
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• pp.323-330
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• 2009

The objective of this research was to develop a practical integrated approach using extracted features from electrical resistance measurements and coupled electromechanical models of damage, for in-situ damage detection and sensing in carbon fiber reinforced plastic(CFRP) composites. To achieve this objective, we introduced specific known damage (in terms of type, size, and location) into CFRP laminates and established quantitative relationships with the electrical resistance measurements. For processing of numerous measurement data, an autonomous data acquisition system was devised. We also established a specimen preparation procedure and a method for electrode setup. Coupon and panel CFRP laminate specimens with several known damage were tested. Coupon specimens with various sizes of artificial delaminations obtained by inserting Teflon film were manufactured and the resistance was measured. The measurement results showed that increase of delamination size led to increase of resistance implying that it is possible to sense the existence and size of delamination. A quasi-isotropic panel was manufactured and electrical resistance was measured. Then three different sizes of holes were drilled at a chosen location. The panel was prepared using the established procedures with six electrode connections on each side making a total of twenty-four electrodes. Vertical, horizontal, and diagonal pairs of electrodes were chosen and the resistance was measured. The measurement results showed the possibility of the established measurement system for an in-situ damage detection method for CFRP composite structures.

• Journal of the Korean Society of Costume
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• v.6
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• pp.7-26
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• 1982

Investigation for industrial revolution has been recognized as an important issue of historical science, since industrial revolution itself was a historical moment in modern economic society and in the forming of modern capitalistic culture. If clothing culture had been developed in close relation to social culture. industrial revolution which gave a base for modern capitalistic culture, would be a birth of modern clothing as well as a moment for modernization of western clothing. As it takes for granted that industrial revolution, historical phenomenon is a developmental base of modern clothing culture. This study tried to enlighten the origin of modern clothing culture phenomenon with investigation of industrial revolution as a historical moment in modern clothing culture through documental study. Historian's point of view and method of studying are important when we investigate the clothing phenomenon. Although culture phenomenon of industrial revolution has been evaluated usually through socialogical aspect, studying for clothing culture phenomenon must be carried out on aethetical as well as well as sociological aspect, on account of dualism of clothing, as it is social and artistic nature. In 19th century, there were technical improvement, changing patterns of production, changing social relation and beginning of mass culture. At the same time clothing culture phenomenon was changed in relation to modern capitalistic society. The findings of the study could be summarized as follows. 1. Technical improvement in textile industry and fitting process brought about mechanization of clothing industry. 2. Appearance of popular clothing culture made it easy to spread to various classes of society. 3. Development of transportation system and communication channel made it internationalization of western clothing. 4. Recognition of importance in functional style of clothing. 5. The pursuit of modern aesthetics made rapid changing mode of clothing. Above distinctive features of modern clothing culture were derived from by-product of machinary culture, mass culture, internationalism, rapidly changing mode of various culture during industrial revolution. Industrial revolution was a change of the material world as well as in industry owing to machine advent, then the culture part that displayed directly these changes was the plastic arts of living that mould the material. The problem of clothing construction caused by industrial revolution was solved by pursuing the functional aesthetics. Clothing phenomenon as a process of value transfer participates mass culture in closs relation to general change of various culture caused by industrial revolution. Therefore western clothing gained the qualities of modern culture, condensed as function, and popularity in the process of modernization.

• Journal of Bio-Environment Control
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• v.23 no.2
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• pp.95-108
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• 2014

The objective of this study is to develop the plastic greenhouse models which are structurally safe under the weather condition of Seongju and have the dimensions suitable for oriental melon cultivation as well. To grasp the structural features of greenhouses in Seongju, the field survey was conducted on 406 farmhouses which included 2,068 greenhouses. The field survey showed that the roof shape of arch type accounted for the highest rate, but recently even span or peach type became more popular and the width and height of greenhouse tended to increase as the period of use was short. The relationship of the width, ridge height and eaves height were established based on field survey data. Using climate data of Gumi adjacent to Seongju, the regressions were determined for the design wind speed and design snow depth depending on recurrence period. To design the greenhouse models against weather disasters in Seongju, the optimal design loads are 23.7 cm of snow depth and $33.8m{\cdot}s^1$ of wind speed. As the design results, four models of single-span greenhouse, two models of double-span greenhouses including extension were developed.

• Journal of Life Science
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• v.34 no.7
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• pp.520-530
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• 2024

Tumor suppressor genes (TSGs) play a crucial role in maintaining cellular homeostasis. When the function of these genes is lost, it can lead to cellular plasticity that drives the development of various cancers, including small-cell lung cancer (SCLC), which is known for its aggressive nature. SCLC is primarily driven by numerous loss-of-function mutations in TSGs, often involving genes that encode epigenetic regulators. These mutations pose a significant therapeutic challenge as they are not directly targetable. However, understanding the molecular changes resulting from these mutations might provide insights for developing tumor intervention strategies. We propose that despite the heterogeneous genomic landscape of SCLC, the effects of mutations in patient tumors converge on a few critical pathways that drive malignancy. Specifically, alterations in epigenetic regulators lead to transcriptional dysregulation, pushing mutant cells toward a highly plastic state that makes them immune evasive and highly metastatic. This review will highlight studies showing how an imbalance of epigenetic regulators with opposing functions leads to the loss of immune recognition markers, effectively hiding tumor cells from the immune system. Additionally, we will discuss the role of epigenetic regulators in maintaining neuroendocrine features and how aberrant transcriptional control promotes epithelial-to-mesenchymal transition during tumor development. Although these pathways seem distinct, we emphasize that they often share common molecular drivers and mediators. Understanding the connection among frequently altered epigenetic regulators will provide valuable insights into the molecular mechanisms underlying SCLC development, potentially revealing preventive and therapeutic vulnerabilities for SCLC and other cancers with similar mutations.

• Journal of the Korean Society of Costume
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• v.22
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• pp.263-276
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• 1994

The achievement of notable social reoforms attained during the period of 19th and 20th centuries needlessly speaking remodelded the social environmental into several different patterns such as :1) high industrialization 2) propensity to consume 3) up graded overall social stands. Accordingly the industrial world of the but-tons too established the mess production syhstem by breaking from convention of hand-craft work of 17th century. The raw materials used in the production line on buttons during the 20th century are almost all-kind of materials one can possibly named including cheap plastic which enabled production lines to produce cheaper but higher productivities of the buttons being produced, The design (incused design) used in the 19-20h centuries are : men landscape, sports features, birds, livestocks, bugs, or geomatric features, tec, 1, The classification o f the buttons by materials Techniques shapes colors marking (Incused design) used in the productionof buttons in the England United States of America Laska Italy france Denmark Japan and India are categolizzed as : natural raw materials and syntetical resines. 1) Of the natural raw materials used are : Matal Enamel Iodine Agate, Coral, Green jade(Jasper) Granite, Wood, Ivory, Horn and bone etc. 2) The sythetical resin used in the button in-dustries are : Artificial jewell glass Acrylic material Styroform Celluloid and Nylon etc. 2. The thecnique quoted in producing buttons are hand craft work inlay work precision casting press mosic dye etching, processing, engraving and embossed carving etc. 3. The major designs used in the buttons in -dustries are : Round shape however elliptical column angular and edge shape often used. 4. The colors used are : The multi-colors were highly used than mono-colored materials such as : Adjoining Color and Contrast Color. The highest consideration to be considered in choosing the colors for the buttons are harmonization and matching factor with the garment or dresses to be wore. 5. The major design(incused design) on the buttons are embodiment and the design were also used in order of abstractive-combination abstractive with has offers much surprising. The button industries during the 19th and 20th centuries were not only the determination factors those can judge the value of self-pride of Nation and which were far beyond the in-dustrial arts in those days but also highly refelected and influenced by cultural sense ideology and self-pride of the Nation of those period. The followings are details of the role of the buttons categolized in the order of functional ornamental and symbolical aspects : 1. The functional role : The functional role of the buttons were simply designed for dress how-ever the buttons beyond from this role of function now a days. 2. The ornamental role : The ornamental role of he button beyond from this role of the button were effectuated by : 1) shape materials colors 2) technique locations size and design (incused design) 3) The ramaterials used for buttons shall not be over looked because it is highly depends on the taste sense and combination of harmony with the garment to be wore. 4) The color of the buttons are made well contrasted with the color of garments just as in the case of other artistical area such as matchs with the color of garment of contrast with brigtness of colors contrasted as complementary color and so and so. 5) The technique being adoped are: precision casting press handcraft inlay work etching mosic etc,. Since the buttons are no longer a simple catching devise used to fasten together the different part of the dress but now it has formed own and occupied the independent role in the garment or dresses location can be de-termined and varying depending on the ideas of designers. The size of the buttons has no specific limits, However the variation has widely dependined on the entire circumperence rhythm contrast harmonization of the garments. 3. The symbolical role : Since the button is no longer a just a simple devise for catching and fastening device used fastening together the different part of the garments but now were built a independent area as major part of the Garment and well reflected all kinds of occupations political background cultural as-pect etc. on the buttons. The design of buttons in the western circles are more simplified but they are polished looks and their techniques of manufacturing are comination of both machanis and handcraft. The colors used in the buttons are pretty well harmonized with garment(dress). Almost all kind of materials can be used in the but-tons however materials used in the buttons are : Bone of livestocks ivory, turtle shell are no longer used because the prevention of cruely of animal. On the contraly the level of buttons indus-try of Korea is far to reach and catch up with the level of western circles. It is highly suggested therefore the but-tons industrial field of Republic of Korea shall place and encouragement in producing beter industrial environment of the buttons based on the traditional and cultural aspect of republic of Korea to produce both manufacturing of qulified and best designed and colored buttons.