Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Curcumin on Osteoclasts

파골세포에 대한 커큐민의 효과

  • Kim, Jeong-Joong (Departments of Anatomy, College of Medicine, Wonkwang University) ;
  • Kim, Dong-Joo (Departments of Anatomy, College of Medicine, Wonkwang University) ;
  • Lee, Byung-Ki (Departments of Anatomy, College of Medicine, Wonkwang University) ;
  • Kim, Kwang-Jin (Departments of Anatomy, College of Medicine, Wonkwang University) ;
  • Lee, Myeung-Su (Departments of Internal Medicine, College of Medicine, Wonkwang University) ;
  • Lee, Jae-Hoon (Departments of Internal Medicine, College of Medicine, Wonkwang University) ;
  • Kim, Hun-Soo (Departments of Pathology, College of Medicine, Wonkwang University) ;
  • Lee, Chang-Hoon (Departments of Internal Medicine, College of Medicine, Wonkwang University) ;
  • Byun, Seung-Jae (Departments of Neurosurgery, College of Medicine, Wonkwang University) ;
  • Jang, Sung-Jo (Departments of Reconstructive Surgery, College of Medicine, Wonkwang University) ;
  • Song, Jeong-Hoon (Departments of Plastic Surgery, College of Medicine, Wonkwang University) ;
  • Oh, Jae-Min (Departments of Anatomy, College of Medicine, Wonkwang University) ;
  • Lee, Jun-Seok (Departments of Obstetrics and Gynecology, College of Medicine, Wonkwang University) ;
  • Kim, Kwang-Mee (Department of Anatomy, College of Medicine, Wonkwang University) ;
  • Chun, Churl-Hong (Department of Orthopaedic, College of Medicine, Wonkwang University)
  • 김정중 (원광대학교 의과대학 해부학교실) ;
  • 김동주 (원광대학교 의과대학 해부학교실) ;
  • 이병기 (원광대학교 의과대학 해부학교실) ;
  • 김광진 (원광대학교 의과대학 해부학교실) ;
  • 이명수 (원광대학교 의과대학 내과학교실) ;
  • 이재훈 (원광대학교 의과대학 내과학교실) ;
  • 김헌수 (원광대학교 의과대학 해부병리학교실) ;
  • 이창훈 (원광대학교 의과대학 내과학교실) ;
  • 변승재 (원광대학교 의과대학 일반외과학교실) ;
  • 장성조 (원광대학교 의과대학 신경외과학교실) ;
  • 송정훈 (원광대학교 의과대학 성형외과학교실) ;
  • 오재민 (원광대학교 의과대학 해부학교실) ;
  • 이준석 (원광대학교 의과대학 산부인과학교실) ;
  • 김광미 (원광대학교 의과대학 해부학교실) ;
  • 전철홍 (원광대학교 의과대학 정형외과학교실)
  • Published : 2008.12.25
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Abstract

Bone is a dynamic tissue that is constantly resorbed by osteoclasts and then replaced by osteoblasts. Osteoclasts, multinucleated cells of monocyte/macrophage lineage, are responsible for bone disorders, including osteoporosis and rheumatoid arthritis. In this study, we examined the effect of the curcumin on osteoclast survival and bone resorption. We found that curcumin significantly inhibited RANKL-mediated osteoclast survival. DAPI stainingrevealed that curcumin induced the apoptotic features of osteoclasts. Although curcumin did not suppress the phosphorylation of Akt and ERK in osteoclasts treated with RANKL, curcumin induced the cleavage of pro-caspase-9 and -3 its active forms. Also, curcumin inhibited the formation of actin rings of osteoclasts. RANKL-mediated bone resorption was inhibited by the addition of curcumin. Together with the results of this study, these findings suggest that the curcumin inhibited the survival of osteoclasts by activating caspase-9 and -3 and suppressed the bone resorptive activity. Thus, curcumin may be developed as antiresorptive drugs for the treatment of bone-related disorders.

Keywords

References

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