• Title/Summary/Keyword: pip

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DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives (디티오카르바메이트 유도체의 새로운 1,10-페난트롤린 팔라디움(II) 착물의 DNA 결합 성질 및 세포독성에 관한 연구)

  • Mansouri-Torshizi, Hassan;Saeidifar, Maryam;Ghasemi, Zahra Yekke;Khastan, Mahmood;Divsalar, Adeleh;Saboury, Ali Akbar
    • Journal of the Korean Chemical Society
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    • v.55 no.1
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    • pp.70-80
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    • 2011
  • Two new palladium (II) complexes, [Pd (phen)(pip-dtc)]$NO_3$ and [Pd(phen)(mor-dtc)]$NO_3$, (where phen is 1,10-Phenantroline, pip-dtc is piperidinedithiocarbamate anion and mor-dtc is morpholinedithiocarbamate anion) have been synthesized and characterized by elemental analysis, spectroscopic studies (FT-IR, $^1H$ NMR, UV-Vis) and conductance measurement. In these complexes, the dithiocarbamate ligands coordinate with Pd (II) center as bidentate with two sulfur atoms. These two complexes have been tested against chronic myelogenous leukemia cell line, K562. They show $IC_{50}$ values less than cisplatin and thus the mode of binding of the complexes to calf thymus DNA (CT-DNA) were investigated by ultraviolet difference and fluorescence spectroscopy. They can denature DNA, exhibit cooperative binding and intercalate into DNA. Several binding and thermodynamic parameters are also described.

Design of MTP memory IP using vertical PIP capacitor (Vertical PIP 커패시터를 이용한 MTP 메모리 IP 설계)

  • Kim, Young-Hee;Cha, Jae-Han;Jin, Hongzhou;Lee, Do-Gyu;Ha, Pan-Bong;Park, Mu-Hun
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.13 no.1
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    • pp.48-57
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    • 2020
  • MCU used in applications such as wireless chargers and USB type-C require MTP memory with a small cell size and a small additional process mask. Conventional double poly EEPROM cells are small in size, but additional processing masks of about 3 to 5 sheets are required, and FN tunneling type single poly EEPROM cells have a large cell size. In this paper, a 110nm MTP cell using a vertical PIP capacitor is proposed. The erase operation of the proposed MTP cell uses FN tunneling between FG and EG, and the program operation uses CHEI injection method, which reduces the MTP cell size to 1.09㎛2 by sharing the PW of the MTP cell array. Meanwhile, MTP memory IP required for applications such as USB type-C needs to operate over a wide voltage range of 2.5V to 5.5V. However, the pumping current of the VPP charge pump is the lowest when the VCC voltage is the minimum 2.5V, while the ripple voltage is large when the VCC voltage is 5.5V. Therefore, in this paper, the VPP ripple voltage is reduced to within 0.19V through SPICE simulation because the pumping current is suppressed to 474.6㎂ even when VCC is increased by controlling the number of charge pumps turned on by using the VCC detector circuit.

Protein Interaction Possibility Ranking Method based on Domain Combination (도메인 조합 기반 단백질 상호작용 가능성 순위 부여 기법)

  • Han Dong-Soo;Kim Hong-Song;Jong Woo-Hyuk;Lee Sung-Doke
    • Journal of KIISE:Computing Practices and Letters
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    • v.11 no.5
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    • pp.427-435
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    • 2005
  • With the accumulation of protein and its related data on the Internet, many domain based computational techniques to predict protein interactions have been developed. However, most of the techniques still have many limitations to be used in real fields. They usually suffer from a low accuracy problem in prediction and do not provide any interaction possibility ranking method for multiple protein pairs. In this paper, we reevaluate a domain combination based protein interaction prediction method and develop an interaction possibility ranking method for multiple protein pairs. Probability equations are devised and proposed in the framework of domain combination based protein interaction prediction method. Using the ranking method, one can discern which protein pair is more probable to interact with each other than other protein pairs in multiple protein pairs. In the validation of the ranking method, we revealed that there exist some correlations between the interacting probability and the precision of the prediction in case of the protein pair group having the matching PIP(Primary Interaction Probability) values in the interacting or non interacting PIP distributions.

A Case Study on the Domestic Business Processes Analysis for RosettaNet Application (로제타넷 표준 적용을 위한 국내 프로세스 사례분석)

  • 김선호;최혁승;김영상
    • Proceedings of the CALSEC Conference
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    • 2003.09a
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    • pp.97-102
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    • 2003
  • 본 논문에서는 로제타넷의 글로벌 표준을 국내 기업에 적용하기 위하여 업무 프로세스를 조사 및 분석하였다. 여기서는 우선, 국내외에서 적용된 로제타넷 구현 사례를 조사하였다. 그리고, 국내 기업 중 로제타넷을 적용하려고 하는 기업을 대상으로 하여 업무 프로세스를 분석하여 로제타넷 PIP의 적용 가능성을 판단하였다.

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Kernel Thread Scheduling in Real-Time Linux for Wearable Computers

  • Kang, Dong-Wook;Lee, Woo-Joong;Park, Chan-Ik
    • ETRI Journal
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    • v.29 no.3
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    • pp.270-280
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    • 2007
  • In Linux, real-time tasks are supported by separating real-time task priorities from non-real-time task priorities. However, this separation of priority ranges may not be effective when real-time tasks make the system calls that are taken care of by the kernel threads. Thus, Linux is considered a soft real-time system. Moreover, kernel threads are configured to have static priorities for throughputs. The static assignment of priorities to kernel threads causes trouble for real-time tasks when real-time tasks require kernel threads to be invoked to handle the system calls because kernel threads do not discriminate between real-time and non-real-time tasks. We present a dynamic kernel thread scheduling mechanism with weighted average priority inheritance protocol (PIP), a variation of the PIP. The scheduling algorithm assigns proper priorities to kernel threads at runtime by monitoring the activities of user-level real-time tasks. Experimental results show that the algorithms can greatly improve the unexpected execution latency of real-time tasks.

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Identification of a host range determinant from Ralstonia solancearum race 3

  • Yeonhwa Jeong;Lee, Seungdon;Ingyu Hwang
    • Proceedings of the Korean Society of Plant Pathology Conference
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    • 2003.10a
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    • pp.71.2-71
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    • 2003
  • Ralstonia solancearum infects many solanaceous plants, however race 3 infects only potato and tomato weakly. To identify genes responsible for race specificity of R. solanacearum, we mobilized genomic library of LSD2029 (race 3) into LSD341 (race 1) and inoculated 1,000 transconjugants into hot pepper. One transconjugant that did not induce wilt symptom in hot pepper was isolated. We found that a cosmid clone, pRSl, conferred avirulence to LSD341. By deletion and mutational analyses of pRSl, we found the 0.9-kb PstI/Hindlll fragment carries avirulence functions. We sequenced the fragment and identified one possible open reading frame, a rsal gene, possibly encoding 110 amino acids. The rsal was preceded with a plant-inducible promoter (PIP) box, indicating that the gene might be regulated by HrpB. Interestingly, the promoter region of the rsal homolog in the strain GM11000 (race 1) did not have the PIP box. Rsal did not show any significant homologies with proteins in the database, indicating th e protein is different from the previously reported avirulence proteins. When we mutated the rsal gene by marker-exchange in LSD2029, the mutant was less virulent in potato.

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A study on the fabrication of polymer-coated SAW sensors and their sensing properties for some toxic chemical compounds (SAW 센서의 제작 및 독성화학물질 감도특성 연구)

  • Lim, Y.R.;Park, B.H.;Choi, S.K.;Song, K.D;Lee, D.D.
    • Journal of Sensor Science and Technology
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    • v.17 no.2
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    • pp.143-146
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    • 2008
  • Polymer-coated film SAW sensors have been fabricated and their sensing properties for toxic chemicals have been extensively investigated. Four types of the toxic chemical compounds of hydrogen cyanide(AC), carbonyl dichloride(CG), pinacolyl methylfluorophosphonate(GD), 2,2'-dichlorodiethylthio ether(HD) were used as target gases. SAW sensors using five different kinds of polymers were used to detect toxic chemicals and their gas sensing characteristics were investigated. The polymers used as the sensing materials were polyisobutylene(PIB), polyepichlorohydrin(PECH), polydimethylsiloxane(PDMS), polybutadiene(PBD) and polyisoprene(PIP). The recommendable mixing ratio of PIB, PECH, PDMS, PBD and PIP to solvents were 1:30, 1:40, 1:10, 1:30 and 1:30, respectively. The sensing characteristics of the SAW sensors were measured by using E-5061A network analyzer.