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http://dx.doi.org/10.5012/jkcs.2011.55.1.070

DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives  

Mansouri-Torshizi, Hassan (Department of Chemistry, University of Sistan and Baluchestan)
Saeidifar, Maryam (Department of Chemistry, University of Sistan and Baluchestan)
Ghasemi, Zahra Yekke (Department of Chemistry, University of Sistan and Baluchestan)
Khastan, Mahmood (Department of Chemistry, University of Sistan and Baluchestan)
Divsalar, Adeleh (Department of Biological Sciences Tarbiat Moallem University)
Saboury, Ali Akbar (Institute of Biochemistry and Biophysics, University of Tehran)
Publication Information
Journal of the Korean Chemical Society / v.55, no.1, 2011 , pp. 70-80 More about this Journal
Abstract
Two new palladium (II) complexes, [Pd (phen)(pip-dtc)]$NO_3$ and [Pd(phen)(mor-dtc)]$NO_3$, (where phen is 1,10-Phenantroline, pip-dtc is piperidinedithiocarbamate anion and mor-dtc is morpholinedithiocarbamate anion) have been synthesized and characterized by elemental analysis, spectroscopic studies (FT-IR, $^1H$ NMR, UV-Vis) and conductance measurement. In these complexes, the dithiocarbamate ligands coordinate with Pd (II) center as bidentate with two sulfur atoms. These two complexes have been tested against chronic myelogenous leukemia cell line, K562. They show $IC_{50}$ values less than cisplatin and thus the mode of binding of the complexes to calf thymus DNA (CT-DNA) were investigated by ultraviolet difference and fluorescence spectroscopy. They can denature DNA, exhibit cooperative binding and intercalate into DNA. Several binding and thermodynamic parameters are also described.
Keywords
DNA binding; Pd(II) complex; piperidinedithiocarbamate; morpholinedithiocarbamate; cytotoxicity;
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