• Membrane Journal
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• v.24 no.4
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• pp.268-275
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• 2014

The water-insoluble poly(phenoxy-methylamino)phosphazene has been synthesized and investigated as the new type of diagnostic membrane for the measurements of blood glucose level. Final absorbances at 680 nm through activated polyphosphazene membranes were measured at various concentration of glucose in blood. The end-point results of varing absorbance values according to time (K/S) were used to obtain glucose concentration. The effects of substitution rates with hydrophilic methylamino groups and hydrophobic phenoxy groups on the measurements of glucose concentration were studied. Dose-response slope (DRS) values between glucose concentration and K/S values increased as the hydrophilic substitution rates increased. However, in less than 5% of the hydrophilic substitution rates, DRS values are too low, and in more than 25% of the hydrophilic substitution rates, because DRS increased rapidly, it was difficult to measure exact concentration level of glucose.

• Membrane Journal
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• v.26 no.3
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• pp.179-186
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• 2016

The new types of phenoxy-methylamino phosphazene diagnostic membranes were prepared to measure blood glucose level of diabetics. Firstly, effects of mesuring environments on the glucose measurements were examined. With activated phosphazene membranes, the end-point results of varing absorbance values according to time (K/S) were measured at 5, 15, 25, 35, $50^{\circ}C$ and also at 20% to 80% of relative humidities (RH). The slope values of K/S and glucose concentration(DRS) were not seriously affected at high measuring temperatures and humidities. Secondly, after prepared membranes were stored at various environments, the effects of storage temperatures and humidities on the glucose measurements were examined. After 8 weeks at $50^{\circ}C$, the storage time and temperatures did not affect on the glucose measurements with the new phosphazene membranes. The stabilities of new phosphazene diagnostic membranes were confirmed even at RH 80%.