Browse > Article
http://dx.doi.org/10.14579/MEMBRANE_JOURNAL.2014.24.4.268

Preparation of Phenoxy-Methylamino Cosubstituted Polyphosphazene Diagnostic Membranes for Blood Glucose Measurements  

Kwon, Suk-Ky (Department of Biological and Chemical Engineering, Hongik University)
Publication Information
Membrane Journal / v.24, no.4, 2014 , pp. 268-275 More about this Journal
Abstract
The water-insoluble poly(phenoxy-methylamino)phosphazene has been synthesized and investigated as the new type of diagnostic membrane for the measurements of blood glucose level. Final absorbances at 680 nm through activated polyphosphazene membranes were measured at various concentration of glucose in blood. The end-point results of varing absorbance values according to time (K/S) were used to obtain glucose concentration. The effects of substitution rates with hydrophilic methylamino groups and hydrophobic phenoxy groups on the measurements of glucose concentration were studied. Dose-response slope (DRS) values between glucose concentration and K/S values increased as the hydrophilic substitution rates increased. However, in less than 5% of the hydrophilic substitution rates, DRS values are too low, and in more than 25% of the hydrophilic substitution rates, because DRS increased rapidly, it was difficult to measure exact concentration level of glucose.
Keywords
phenoxy-methylamino phosphazene; membrane; diabetics; glucose; measurements;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 S. Kwon, I. Park, and D. Yoon, "The Preparation of Polyacrylonitrile Diagonostic Membranes for Blood Glucose Measurements (1) : Effects of Temperature and Humidity on the Measurements of Glucose Concentration", Membrane Journal, 17, 4 (2007).
2 S. Kwon and B. Lee, "A Study on the Preparation of Ion-Exchange Membranes with Polyphospha-zenes", J. Ind. Eng. Chem., 9, 3 (1998).
3 J. Kim, "Diabetes : Diagnostics and Control", Ohsung, Seoul (1997).
4 T. Asano and T. Norioka, "Diabetes", Nihon Bungeisha, Tokyo (2000).
5 Home Health Management Research Institute, "Diabetes", Kumyoung, Seoul (1992).
6 K. Huh, "Diabetic Health", D and C Media, Seoul (2006).
7 S. Kim, "Life Guide for Diabetes Control", Hyoseong, Seoul (1993).
8 S. Kwon, "A Study on the Preparation of Polyurethane Diagnostic Membrane for Urine Glucose Test", J. Ind. Eng. Chem., 5, 6 (1994).
9 T. Asano, "Diabetic Food and Life Style", Shufu-To-Seikatsusha Co., Tokyo (2005).
10 S. Kwon, "Studies on the Muti-Layered Gelatin Diagnostic Membranes for Diabetes(2) : Effects of Interferents in Blood on the Diffusion-Controlled Rates of Glucose", Membrane Journal, 9, 4 (1999).
11 S. Kwon, "Effects of Testing and Storage Environments on the Blood Glucose Measurements by Using Phosphazene Diagnostic Membranes", Membrane Journal, 22, 5 (2012).
12 S. Kwon, I. Park, and D. Yoon, "Studies on the Preparation of Polyurethane Diagnostic Membranes for Blood Glucose Measurements (5) : Effects of Temperature and Humidity on the Measurements of Glucose Concentration", Membrane Journal, 17, 1 (2007).
13 S. Kwon, "Studies on the Preparation of Diagnostic Membranes for Blood Glucose Measurements (3) : Effects of Hematocrit on the Measurements of Glucose Concentration", Hongik Industrial Technology, 14 (2004).
14 S. Kwon, "Studies on the Preparation of Diagnostic Membranes for Blood Glucose Measurements (2) : Effects of Temperature on the Measurements of Glucose Concentration", Hongik Industrial Technology, 13 (2003).
15 S. Kwon, "Basic Studies on the Preparation of Diagnostic Membranes by Using Multi-Layered Gelatin Films to Measure Blood Glucose Level of Diabetics", Membrane Journal, 8, 1 (1998).
16 R. P. Back, "Biosensor Technology", Marcel Dekker, New York (1990).
17 R. E. Kesting, "Synthetic Polymeric Membranes", Wiley-Interscience, New York (1985).
18 M. Gordon, "Polymer Membranes", Springer-Verlag, New York (1985).
19 S. Kwon and M. Choi, "The Preparation of Polyacrylonitrile Diagnostic Membranes for Blood Glucose Measurements (2) : Effects of Blood Constituens on the Measurements of Glucose Concentration", Membrane Journal, 18, 4 (2008).
20 S. Kwon, "Studies on the preparation of Diagnostic Membranes fir Blood Glucose Measurements (1) : Model Experiments by Using Microporous Polyurethane Membrane", Hongik Industrial Technology, 12 (2002).
21 H. R. Allcock and S. Kwon, "Covalent Linkages of Proteins to Surface-Modified Poly (organophosphazenes) : Immobilization of Glucose-6-Phosphate Dehydrogenase and Trypsin", Macromolecules, 19, 1502 (1986).   DOI
22 S. Kwon and C. Jun, "Studies on Polyphosphazenes-Bound Wittig Reactions", J. Ind. Eng. Chem., 5, 5 (1994).
23 H. R. Allcock, M. Gebura, S. Kwon, and T. X. Neenan, "Amphiphilic Polyphosphazenes as Membrane Materials : Influence of Side Group on Radiation Crosslinking, Semipermeability, and Surface Morphology", Biomaterials, 9, 500 (1988).   DOI   ScienceOn
24 H. R. Allcock and S. Kwon, "Hydrophilic Polyphosphazenes as Hydrogels : Radiation Crosslinking and Hydrogel Characteristics of Poly[bis(methoxyethoxy)phosphazene]", Biomaterials, 7, 6 (1986).
25 S. Kwon and B. Lee, "A Study on the Preparation of Metal-Ion Separation Membrane with Hydrophilic Polyphosphazene", J. Ind. Eng. Chem., 10, 3 (1999).
26 S. Kwon, "Effects of Interferents in Blood on the Blood Glucose Measurements by Using Polyphosphazene Diagnostic Membranes" Membrane Journal, 23, 4 (2013).
27 S. Kwon, "Studies on the Polyurethane Diagnostic Membrane for Diabetes (2) : Effects of Additives in Membrane Formulations for the Measurement of Urine Glucose", Polymer (Korea), 18, 6 (1994).
28 S. Kwon, "Studies on the Preparation of Diagnostic Membranes for Blood Glucose Measurements (4) : Effects of Additives in Blood on the Measurements of Glucose Concentration", Hongik Industrial Technology, 15 (2005).
29 S. Kwon and J. Yu, "The Preparation of Polyacrylonitrile Diagnostic Membranes for Blood Glucose Measurements (3) : Effects of Storage Environments on the Measurements of Glucose Concentration", Membrane Journal, 19, 3 (2009).
30 S. Kwon, "Preparation of Polyurethane Diagnostic Membranes for Blood Glucose Measurements (6) : Effects of Hematocrit on the Measurements of Glucose Concentration", Membrane Journal, 20, 3 (2010).