• 동의생리병리학회지
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• 제17권2호
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• pp.363-367
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• 2003

Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoaction, diabetes in oriental medicine. In this study, it was investigated that pear phenolic compound effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide(ANP) in plasma, Cardiac hypertrophy. The experiments were performed on Sprague Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5mg/Kg(PPC-A) 10mg/Kg(PPC-B) 15mg/Kg(PPC-c) and control group. Pear phenolic compound solution were supplied with them for 3weeks, a day's interval. The results are that The blood pressure was significantly decreased at 15days in PPC-A group than control group. The plasma ANP was increased in PPC-A and PPC-C group, and cardiac hypertrophy was significantly decrease in PPC-C group compared with control group.

• 한국유기농업학회지
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• 제22권4호
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• pp.825-839
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• 2014

Antioxidant activity is important for reducing oxidative stress that causes various metabolic disorders. Metabolic disorders are highly related to loss of productivity in livestock. Therefore, development of effective antioxidant compounds originating from plants is important for organic agriculture. Phenolic compounds in edible plants are regarded as major components relevant to antioxidant activity. The present study investigated the changes in antioxidant activity and phenolic compound profiles of Aronia (Aronia meloncarpa) by fermentation using different strains of Leuconostoc mesenteroides. A total of 5 strains of L. mesenteroides were used as starter cultures and their ${\beta}$-glucosidase activities were measured. A total of 6 experiment runs were prepared, one for control (uninoculated) and the others (inoculated) for treatments. For biological activity, antioxidant and antibacterial activities were measured. For phenolic compound profiling, TLC and HPLC analysis were performed. The strains of KACC12313 and KACC12315 showed greater enzyme activity than others. Treatment with KCCM35046 showed strong and broad antibacterial activity against to Listeria monocytogenes. Treatments with KCCM35046 and KACC12315 showed the highest total polyphenol content. The highest antioxidant activity was found in KACC12315 treatment. No remarkable alteration was found in thin layer chromatography (TLC) analysis. In phenolic compound profiling analysis, KCCM35046 showed notable alteration in compound area ratio compared to others and also showed the highest caffeic acid content. In chlorogenic acid, treatments with KCCM35046 and KACC12315 showed great content than others. Treatment with KACC12315 showed the greatest content of trans-ferulic acid. As a result of relative performance indexing analysis, L. mesenteroides KCCM35046 and KACC12315 were selected as the best strain for the fermentation of Aronia.

• 한국토양비료학회지
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• 제32권4호
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• pp.440-445
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• 1999

메밀의 지방산 및 페놀화합물 생합성과 tyrosinase 저해 활성에 대한 몇가지 비료의 영향을 조사한 결과 다음과 같다. 메밀 식물체중의 지방산 함량은 곡류중의 지방산 함량 보다 작으며 메밀 식물체와 곡류중의 지방산은 포화지방산과 불포화지방산으로 구성되어 있으며 불포화지방산이 포화지방산보다 많은 것으로 나타났다. 메밀중의 페놀화합물은 $682.6{\sim}1822.0mg\;kg^{-1}$이며 석회 시용구의 메밀중 페놀화합물이 $1822.0mg\;kg^{-1}$로 다른 비료 시용구보다 높았다. 한편 석회가 시용된 메밀 곡류중의 sediment c의 tyrosinase 저해활성은 92.8%로 같은 처리내의 sediment c의 compound A, B, C 보다 높았다. 그러나 붕사가 처리된 메밀 곡류중의 compound C의 tyrosinase의 저해활성은 80.9%로 같은 처리구 내의 sediment나 다른 compound보다 높은 것으로 나타났다.

• Natural Product Sciences
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• 제27권3호
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• pp.169-171
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• 2021

A new phenolic compound and three known flavonoids isolated from the MeOH extracts of Lespedeza tomentosa. Based on spectral data, the isolated compounds were identified as methyl 4,5-dihydroxy-3-methoxy-2-(3-methylbut-2-en-1-yl)benzoate (1), 1-methoxylespeflorin G₁₁ (2), farrerol (3) and 1-methoxylespeflorin I₂ (4). Methyl 4,5-dihydroxy-3-methoxy-2-(3-methylbut-2-en-1-yl)benzoate (1) is newly isolated from plant source.

• 대한의생명과학회지
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• 제26권4호
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• pp.319-326
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• 2020

This study was conducted to develop a new functional material by optimizing the conditions for high concentrations of chlorogenic acid and eleutheroside E in Acanthopanax koreanum stem. The total phenolic compound content was the highest in the 20 hours sonication Acanthopanax koreanum stem extract (UAK-20). In addition, eleutheroside E, a typical functional ingredient of Cortex Acanthopanacis, in the 20 hours treated Acanthopanax koreanum stem extract showed the highest content at 1.646%. However, another functional ingredient, chlorogenic acid, showed the highest content of 2.625% in 1 hour treated Acanthopanax koreanum stem extract. Therefore, it is considered that the optimal conditions for high concentrations of total phenolic compound and eleutheroside E are 20 hours sonication Acanthopanax koreanum stem extract.

• 한국식품영양학회지
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• 제36권6호
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• pp.572-580
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• 2023

Hypertension is characterized by excessive renin-angiotensin system activity, leading to blood vessel constriction. Several synthetic compounds have been developed to inhibit renin and angiotensin-converting enzyme (ACE). These drugs often have adverse side effects, driving the exploration of plant protein-derived peptides as alternative or supplementary treatments. This study assessed the phenolic compound and amino acid content and the antioxidant and antihypertensive activity of 5 South Korean staple crops. Sorghum had the highest phenolic compound content and exhibited the highest antioxidant activity. Millet grains, particularly finger millet (38.86%), showed higher antihypertensive activity than red beans (14.42%) and sorghum (17.16%). Finger millet was found to contain a large proportion of branched-chain, aromatic, and sulfur-containing amino acids, which are associated with ACE inhibition. In particular, cysteine content was positively correlated with ACE inhibition in the crops tested (r=0.696, p<0.01). This study confirmed that the amino acid composition was more correlated with the antihypertensive activity of grains than the phenolic compound content. Finger millet mainly contained amino acids, which have higher ACE inhibitory activity, resulting in the strongest antihypertensive activity. These findings underscore the antihypertensive potential of select crops as plant-based food ingredients, offering insight into their biological functions.

• 한국미생물·생명공학회지
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• 제32권3호
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• pp.286-289
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• 2004

Transglycosylation from sucrose to phenolic compounds by the recombinant sucrose phosphorylase from Bifidobacterium longum was studied. HPLC analysis revealed that the enzyme transferred glucosyl residue of sucrose to 1,2-dihydroxybenzene, 1,4-dihydroxybenzene, 1,2,3-trihydroxybenzene, and 2-hydroxybenzyl alcohol. The enzyme could transfer the glucosyl moiety of sucrose to phenolic compounds which have phenolic OH or alcoholic (hydroxymethyl) OH group.

• 한국식품영양과학회지
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• 제28권5호
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• pp.1087-1091
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• 1999

Microwave extraction system equipped with closed vessels, which is known to rapidly extract target compounds from natural products, was applied to monitor the changes in phenolic compounds, browning color intensity and electron donating ability by using response surface methodology(RSM). Maximum content of phenolic compound was 21.65mg/100ml in 67.88% of ethanol concentration, 145oC of extraction temperature, and 6.24min of extraction time. The phenolic compounds in extracts are dependent on the increase of the extraction temperature and the ethanol concentration. Browning color intensity, which was maximized in 67.21%, 147oC, and 6.02min, was proportional to the increase of the extraction temperature. Maximum value of electron donating ability was 24.50units in 54.33%, 147oC, and 6.11 min. The electron donating ability of extracts was dependent on the increase of extraction temperature and maximized in the range from 50 to 65% of ethanol concentration.

• Journal of Ginseng Research
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• 제22권2호
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• pp.91-95
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• 1998

The distribution of phenolic components of Korean ginseng (Panax ginseng KG) and American ginseng (Panax quinquefolium, AG) were compared by thin-layer chromatography (TLC). Silica gel TLC gave 3~4 spots, while $NH_2$ HPTLC 5~6 spots, which were colored by both $FeCl_3$/$K_3Fe(CN)_6$ and Folin-Ciocalteu. The distribution of phenolic components was quite different between KG and AG. Especially, a polyphenol (m.w. 578), which had been isolated from KG by the author, was not found in AG. This result suggests that the polyphenol could be used as an index compound for the differentiation of KG from AG.

• 대한의생명과학회지
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• 제10권3호
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• pp.263-268
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• 2004

This study was carried out to evaluate the cytotoxic effect of phenolic compound on normal NIH 3T3 fibrolasts. The colorimetric assay for phenol compound, syringic acid was performed by MTT assay or XTT assay. MTT or XTT assays are known as a very sensitive method in measuring the cytotoxic effect of chemical agents in vitro. In the present study, syringic acid on normal Nlli 3T3 fibroblasts did not show any cytotoxicity for MTT assay or XTT assay compared with control after cells were treated with various concentrations of syringic acid for 48 hours. MTT/sub 50/ and XTT/sub 50/ were 3,340.9 μM and 2,462.4 μM of syringic acid, respectively. From the above the results, it is suggested that phenolic compound of syringic acid did not have any cytotoxicity on normal NIH 3T3 fibroblasts.