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Effects of Pear Phenolic Compound on Blood Pressure, Plasma Renin, ANP and Cardiac Hypertophy in Hypertensive RAT Induced by 2K1C  

Na Chang Su (Department of Oriental Medicine Dongshin University)
Yun Dae Hwan (Department of Oriental Medicine Dongshin University)
Choi Dong Hee (Department of Oriental Medicine Dongshin University)
Kim Jeong sang (Department of Oriental Medicine Dongshin University)
Jo Chun Hwa (Department of Medicine Chonbuk National University)
Eun Jong Bang (Department of food science and technology Chonnam National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 363-367 More about this Journal
Abstract
Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoaction, diabetes in oriental medicine. In this study, it was investigated that pear phenolic compound effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide(ANP) in plasma, Cardiac hypertrophy. The experiments were performed on Sprague Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5mg/Kg(PPC-A) 10mg/Kg(PPC-B) 15mg/Kg(PPC-c) and control group. Pear phenolic compound solution were supplied with them for 3weeks, a day's interval. The results are that The blood pressure was significantly decreased at 15days in PPC-A group than control group. The plasma ANP was increased in PPC-A and PPC-C group, and cardiac hypertrophy was significantly decrease in PPC-C group compared with control group.
Keywords
Pear phenolic compound; Blood pressure; Plasma renin; ANP; Cardiac hypertophy; 2K1C;
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