• Journal of the Korean Operations Research and Management Science Society
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• v.21 no.2
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• pp.35-47
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• 1996

The tolerance approach to the sensitivity analysis in linear programming considers simultaneous and independent variations in the coefficients of the objective function or of the right-hand side terms and gives a region in which the coefficients and terms can be changed and still keeps the current optimal basis B for the original problem as an optimal basis for the perturbed problem. In this paper we describe a procedure that expands the region S obtained by the tolerance approach into a larger region R, so that more variations in the objective function coefficients or the right-hand side terms are permissible.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2001.05a
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• pp.47-51
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• 2001

According as the controlled plants become more complex and large-scaled, the development of more intelligent control schemes is required in the control field. A fuzzy logic control (FLC) is one of proper schemes for this tendency. Recently, fuzzy control has been applied successfully to many industrial applications due to a number of advantages. But it still has some disadvantages. The conventional FLC has many tuning parameters: membership functions, scaling factors, and so forth. In order to improve this problem, a single-input fuzzy logic control (SFIC) which greatly simplifies the design process of the conventional FLC was proposed. Many research has also been proposed to develop the stability analysis of the FLC. In this paper we analyze the absolute stability of the SFLC. We first expand a nonlinear controlled plant into a Taylor series about a nominal operating point. And a fuzzy control system is transformed into a Lure system with nonlinearities. We also prove that the closed-loop system with the SFLC satisfies the sector condition globally.

• Journal of the Korean Society for Precision Engineering
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• v.11 no.4
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• pp.126-137
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• 1994

Performance management of computer networks is intended to improve a given network performance in order for more efficient information exchange between subsystems of an integrated large-scale system. Importance of perfomance management is growing as many functions of the large- scale system depend on the quality of communication services provided by the network. The role of performance management is to manipulate the adjustable protocol parameters on line so that the network can adapt itself to a dynamic environment. This can be divided into two subtasks : performance evaluation to find how changes in protocol parameters affect the network performance and decision making to determine the magnitude and direction of parameter adjustment. This paper is the first part of the two papers focusing on conceptual design, development, and evaluation of performance management for token bus networks. This paper specifically deals with the task of performance evaluation which utilizes the principle of perturbation analysis of discrete event dynamic systems. The developed algorithm can estimate the network performance under a perturbed protocol parameter setting from observations of the network operations under a nominal parameter setting.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.300-306
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• 2004

This paper is concerned with the application of perturbation method to the dynamic analysis of free-free beam. In general, the rigid-body motions and elastic vibrations are analyzed separately. However, the rigid-body motions cause vibrations and elastic vibrations also affect rigid-body motions in turn, which indicates that the rigid-body motions and elastic vibrations are coupled in nature. The resulting equations of motion are hybrid and nonlinear. We can discretize the equations of motion by means of admissible functions but still we have to cope with nonlinear equations. In this paper, we propose the use of .perturbation method to the coupled equations of motion. The resulting equations consist of zero-order equations of motion which depict the rigid-body motions and first-order equations of motion which depict the perturbed rigid-body motions and elastic vibrations. Numerical results show the efficacy of the proposed method.

• Journal of the Earthquake Engineering Society of Korea
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• v.6 no.6
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• pp.55-64
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• 2002

For nonlinear analysis of sloshing of fluid in rectangular tanks, a new method using the perturbation approach is presented. The results by presented method show good agreement with results in previous study. The importance of nonlinear sloshing analysis is demonstrated by comparing nonlinear behaviors of sloshing in broad and tall tanks with different site conditions. In general, the results by nonlinear analysis are greater than those by linear analysis. Specially, the nonlinear behavior is significant in softer soil site and broad tank. Therefore, nonlinear behavior analysis has to be considered in the design of large liquid storage tanks.

• Structural Engineering and Mechanics
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• v.16 no.3
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• pp.327-340
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• 2003

Variations in system parameters due to uncertainties of parameters may result in system performance deterioration and create system internal stability problems. Uncertainties in structural modeling of structures are often considered to ensure that the control system is robust with respect to response errors. So the uncertain concept plays an important role in the analysis and design of the engineering structures. In this paper, the active control of the intelligent structures with the uncertainties is studied and a new method for analyzing the robustness of systems with the uncertainties is presented. Firstly, the system with uncertain parameters is considered as the perturbation of the system with deterministic parameters. Secondly, the feedback control law is designed on the basis of deterministic system. Thirdly, perturbation analysis and robustness analysis of intelligent structures with uncertainties are discussed when the feedback control law is applied to the original system and perturbed system. Combining the convex model of uncertainties with the finite element method, the analysis theory of the robustness of intelligent structures with the uncertainties can be developed. The description and computation of the robustness of intelligent structures with uncertain parameters is obtained. Finally, a numerical example of the application of the present method is given to show the validity of the method.

• Proceedings of the KSME Conference
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• 2001.06a
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• pp.854-859
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• 2001

An eigenvalue analysis of a tunable micro-mechanical actuator is presented. The actuator is modeled as a continuum structure. The eigenvalue modified by the tuning voltage is computed through the linearization of the relation between the electrostatic force and the displacement at the equilibrium. A staggered algorithm is employed to perform the coupled analysis of the electrostatic and elastic fields. The stiffness matrix of the actuator is modified at this equilibrium state. The displacement field is perturbed using an eigenmode profile of the actuator. The configuration change of the actuator due to perturbation modifies the electrostatic field and thus the electrostatic force. The equivalent stiffness matrix corresponding to the perturbation and the change in the electrostatic force is then added to stiffness matrix in order to explain natural frequency shifting. The numerical examples are presented and compared with the experiments in the literatures.

• Molecules and Cells
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• v.42 no.8
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• pp.579-588
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• 2019

Gene set enrichment analysis (GSEA) is a popular tool to identify underlying biological processes in clinical samples using their gene expression phenotypes. GSEA measures the enrichment of annotated gene sets that represent biological processes for differentially expressed genes (DEGs) in clinical samples. GSEA may be suboptimal for functional gene sets; however, because DEGs from the expression dataset may not be functional genes per se but dysregulated genes perturbed by bona fide functional genes. To overcome this shortcoming, we developed network-based GSEA (NGSEA), which measures the enrichment score of functional gene sets using the expression difference of not only individual genes but also their neighbors in the functional network. We found that NGSEA outperformed GSEA in identifying pathway gene sets for matched gene expression phenotypes. We also observed that NGSEA substantially improved the ability to retrieve known anti-cancer drugs from patient-derived gene expression data using drug-target gene sets compared with another method, Connectivity Map. We also repurposed FDA-approved drugs using NGSEA and experimentally validated budesonide as a chemical with anti-cancer effects for colorectal cancer. We, therefore, expect that NGSEA will facilitate both pathway interpretation of gene expression phenotypes and anti-cancer drug repositioning. NGSEA is freely available at www.inetbio.org/ngsea.

• Journal of the Korean Magnetic Resonance Society
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• v.15 no.1
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• pp.54-68
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• 2011

$^1H$ nuclear magnetic resonance (NMR) spectroscopy of biological samples has been proven to be an effective and nondestructive approach to probe drug toxicity within an organism. In this study, ketoprofen toxicity was investigated using $^1H$-NMR spectroscopy coupled with multivariate statistical analysis. Histopathologic test of ketoprofen-induced acute gastrointestinal damage in rats demonstrated a significant dose-dependent effect. Furthermore, principal component analysis (PCA) derived from $^1H$-NMR spectra of urinary samples showed clear separation between the vehicle-treated control and ketoprofen-treated groups. Moreover, PCA derived from endogenous metabolite concentrations through targeted profiling revealed a dose-dependent metabolic shift between the vehicle-treated control, low-dose ketoprofen-treated (10 mg/kg body weight), and high-dose ketoprofen-treated (50 mg/kg) groups coinciding with their gastric damage scores after ketoprofen administration. The resultant metabolic profiles demonstrated that the ketoprofen-induced gastric damage exhibited energy metabolism perturbations that increased urinary levels of citrate, cis-aconitate, succinate, and phosphocreatine. In addition, ketoprofen administration induced an enhancement of xenobiotic activity in fatty oxidation, which caused increase levels of N-isovalerylglycine, adipate, phenylacetylglycine, dimethylamine, betaine, hippurate, 3-indoxylsulfate, N,N-dimethylglycine, trimethyl-N-oxide, and glycine. These findings demonstrate that $^1H$-NMR-based urinary metabolic profiling can be used for noninvasive and rapid way to diagnose adverse drug effects and is suitable for explaining the possible biological pathways perturbed by nonsteroidal anti-inflammatory drug toxicity.

• The KSFM Journal of Fluid Machinery
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• v.15 no.5
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• pp.48-53
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• 2012

This paper presents a systematic procedure for three-dimensional noise analysis of an axial-flow fan by using computational aero-acoustics based on Ffowcs Williams-Hawkings equation. Flow-fields of a basic fan model are simulated by solving three-dimensional, unsteady, Reynolds-averaged Navier-Stokes equations using the commercial code ANSYS CFX 11.0. Starting with steady flow results, unsteady flow analysis is performed to extract the fluctuating pressures in the time domain at specified local points on the blade surface of the axial flow fan. The perturbed density wave by rotating blades reaches at the observer position, which is simulated by an in-house noise prediction software based on Ffowcs Williams-Hawkings equation. The detailed far-field noise signatures from the axial-flow fan are analyzed in terms of source types, field characteristics, and interpolation schemes.