• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7975-7979
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• 2015

Purpose: This study aimed to explore the value of IHC4 in predicting pathological response after neoadjuvant chemotherapy in patients with hormonal receptor (HR)-positive breast cancer (BC). Materials and Methods: In this retrospective exploratory study, data for 68 HR-positive BC patients who received neoadjuvant chemotherapy were recorded. IHC4 scores were calculated based on estrogen receptors/progesterone receptors, Ki-67 and HER2 status. Logistic and ordinal regression analyses in addition to likelihood ratio test were used to explore associations of IHC4 scores and other clinico-pathological parameters with pathological complete response (pCR) and pathological stage. Results: Taking the 25th percentile as the cut-off, a lower IHC4 score was associated with an increased probability of pCR (low; 52.9% vs. High; 21.6%, OR=4.1, 95% CI=1.28-13.16, p=0.018) and a lower pathological stage (OR=3.9, 95% CI=1.34-11.33, p=0.012). When the IHC4 score was treated as a continuous variable, a lower score was again associated with an increased probability of pCR (OR=1.010, 95% CI=1.001-1.018, p=0.025) and lower pathological stage (OR=1.009, 95% CI=1.002-1.017, P=0.008). Lower clinical stage was associated with a better pCR rate that was of borderline significance (P=0.056). When clinical stage and IHC4 score were incorporated together in a logistic model, the likelihood ratio test gave a P-value of 0.004 after removal of the IHC4 score and 0.011 after removal of the stage, indicating a more significant predictive value of the IHC4 score for pCR. Conclusions: This study suggests that the IHC4 score can predict pathological response to neoadjuvant chemotherapy in HR-positive BC patients. This finding now needs to be validated in a larger cohort of patients.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6391-6395
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• 2012

Background: Ovarian cancer is ranked as the fifth most common cause of cancer death in women. In Malaysia, it is the fourth most common cancer in females. CA125 has been the tumor marker of choice in ovarian cancer but its diagnostic specificity in early stages is only 50%. Hence, there is a critical need to identify an alternative tumor marker that is capable of detecting detect ovarian cancer at an early stage. HE4 is a new tumor marker proposed for the early diagnosis of ovarian cancer and disease recurrence. Currently, none of the normal ranges of HE4 quoted in the literature are based on data for a multiethnic Asian population. Therefore, the aim of this study was to determine reference intervals for HE4 in an Asian population presenting in University Malaya Medical Centre, a tertiary reference hospital. Materials and Methods: 300 healthy women were recruited comprising 150 premenopausal and 150 postmenopausal women, aged from 20-76 years. All women were subjected to a pelvic ultrasonograph and were confirmed to be free from ovarian pathology on recruitment. Serum HE4 levels were determined by chemiluminescent microparticle immunoassay (CMIA, Abbott Architect). The reference intervals were determined following CLSI guidelines (C28-A2) using a non-parametric method. Results: The upper limits of the $95^{th}$ percentile reference interval (90%CI) for all the women collectively were 64.6 pmol/L, and 58.4 pmol/L for premenopausal) and 69.0 pmol/L for postmenopausal. The concentration of HE4 was noted to increase with age especially in women who were more than 50 years old. We also noted that our proposed reference limit was lower compared to the level given by manufacturer Abbott Architect HE4 kit insert (58.4 vs 70 pmol/L for premenopausal group and 69.0 vs 140 pmol/L in the postmenopausal group). The study also showed a significant difference in HE4 concentrations between ethnic groups (Malays and Indians). The levels of HE4 in Indians appeared higher than in Malays (p<0.05), while no significant differences were noted between the Malays and Chinese ethnic groups. Conclusions: More data are needed to establish a reference interval that will better represent the multiethnic Malaysian population. Probably a larger sampling size of equal representation of the Malay, Chinese, Indians as well as the other native ethnic communities will give us a greater confidence on whether genetics plays a role in reference interval determination.

• 농촌지도와개발
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• 제8권1호
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• pp.25-40
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• 2001

The purposes of the study were to identify satisfaction and achievement of learning by female learner's characteristics, and to suggest measures to improve quality of education in internet education programs. In order to determine the educational effectiveness associated with the characteristics of learners, this study attempted to employ two way approaches by observing the degree of achievement for learning, which represents an instructor-oriented approach, and the degree of satisfaction for education, which represents a learner-oriented approach to enhance the quality of internet education for female learners. As an approach to evaluate the educational effectiveness, the degree of achievement in learning(Tyler's classical approach), and the degree of satisfaction for education (Scriven's consumer-oriented evaluation model) were utilized. A survey form was developed by the researcher after reviewing the various tools originated from Boshier, Cross, Gagne and Choi, and distributed to a panel of judges that examined the content validity of the instrument. The sample for the study consisted of 160 female learners from three universities in Seoul and capital area, and the survey form was used to collect data for this study. The SPSS WIN program was used in analyzing the data and a series of statistical tests were conducted including frequency, percentile, t-test, ANOVA, correlation, multiple regression, and factor analysis. The statistical significance level was 0.05. The following conclusion were drawn from this study of female internet education. First, it was evident that female internet learners tend to utilize information from internet, and this can be interpreted as participants' positive attitude, and voluntary participation. Second, educational facilities and services should be improved in the future, because the level of satisfaction was low in these areas compared to curriculum and educational methodology. Third, the participating factors influenced by the level of satisfaction for education of learner characteristics were the 'formation of inter-personal relationship and willingness to change' and the 'needs for education on internet', thus appeared that both social and educational needs influenced the level of satisfaction for education. Fourth, the degree of achievement in learning was higher in the order of 1) attitude 2) function 3) knowledge, thus, attitude change was the most important in achievement of learning. Fifth, the individual background that influenced the level of achievement in learning were age and educational experience. As for the individual level of achievement for learning, the younger and more educated group were more satisfied.

• 한국의류학회지
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• 제28권11호
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• pp.1426-1437
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• 2004

The study has an objective of providing the basic data for the bodice basic pattern that is highly appropriate after classifying the torso shapes of women in 60s. In order to classify the torso shape, 200 women in 60s that reside in Seoul were investigated for 52 tests. The factor analysis produced total of 6 factors. Factor 1 tended to be posture of upper part of torso and shape of shoulder. Factor 2 was an element of silhouette and Factor 3 was vertical size of lower part of torso and side silhouette. Factor 4 showed to be width and thickness of torso, Factor 5 was shape of neck, and Factor 6 appeared to be sagging of belly and buttocks. Therefore, it can be known that posture, silhouette, shape of neck and shoulder, sagging of belly and buttocks, and etc. are important factors for classification of the torso shape of women in 60s. Through a cluster analysis, each torso shape was classified into 4 types and each type showed information on size, shape, and posture clearly. Type 1 showed percentage of 24.2%, and values of height and weight showed to be average. Also, the body shape hardly had any curve with high shoulder at the Posture of upper body, and they had saggy stomach and buttocks. 43.5% of them were involved in Type 2 and they were short and overweighted. They were comparatively large in width compared to the height with no curves. Type 2 had the largest percentage and this can be said to be the special shape of women in 60s. People of Type 3 were short and overweighted just like Type 2 and all the sizes were similar to those of Type 2 or bigger. The posture is right posture and 21.7％ fall into this type and there is no body curve. This type is the shortest and most overweighted type, and it is a torso shape with right posture just like Type 4. Type 4 is a torso shape with tallest height and least weight. The percentage was the smallest(10.6％) and the width was smaller than any other type but the height was the tallest. The body curve is very clear and they have thin body but big buttocks so it can be said that the people of this type have the best silhouette. Type 2 that had the highest percentile is short and overweighted so it can be said that Type 2 is the representative torso shape of women in 60s.

• Journal of Dairy Science and Biotechnology
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• 제27권1호
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• pp.1-12
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• 2009

In 2008, baby formula containing melamine was found to be responsible for a large outbreak of renal failure in infants in China. A total of 294,000 infants were hospitalized, and at least 6 babies died due to ingestion of the tainted formula. Melamine contains high levels of nitrogen (>60%), which is used as an indicator of protein content. Therefore, high levels of melamine in infant formula were thought to be the result of deliberate contamination m an attempt to increase its apparent protein content. Following inspections by China's national inspection agency, assorted products from at least 22 dairy manufacturers across China were found to have varied levels of melamine (range: 0.096196.61 mg/kg). Melamine co-exposure with cyanuric acid can induce acute melamine-cyanurate crystal nephropathy, which can lead to renal failure at much lower doses than if either compound were ingested alone. However, currently, there are very few data on melamine analogues other than cyanuric acid. At an expert meeting of the WHO and FAO held to review toxicological aspects of melamine and cyanuric acid on December 14, 2008, a new tolerable daily intake (TDI) of melamine was established that could be applied to the entire population, including infants. Therefore, a risk assessment of the various theoretical melamine contamination levels in infant formula and selected representative foods (other than infant formula and sole-source nutrition products) is urgently needed for Korean babies and children up to 7 years of age. Although the undetectable level regulation for infant formula may be low enough to guarantee the safety of babies under the age of 1 year (including premature babies), the melamine standard of 2.5 ppm for foods other than baby formula could be insufficient to protect the 95th percentile population aged 1~2 years because of this demographic's high consumption of milk, yogurt, and soy milk (hazard index = 1.79). Because TDIs are chronic values intended to protect an individual over his/her lifetime, occasional modest ingestion in excess of the TDI is not likely to be a health concern. However, children aged 1~2 years may have renal systems that are comparatively more sensitive to the crystallization of melamine and its analogues. Therefore, governmental jurisdictions may need to practice more prudent management of food items that could raise the melamine exposure for this population.

• 한국식품영양학회지
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• 제26권4호
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• pp.745-752
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• 2013

The purpose of this study was to define a portion size for dishes frequently consumed by Korean adults especially focusing on main dishes like rice, noodles, soups, and stews. From the original 8,019 people who took part in the Korea National Health and Nutrition Examination Survey (KNHANES) 2010, we analyzed the data for 4,556 persons aged 19 to 64 years and selected dish items consumed based on an intake frequency of 30 or more by all participants. The portion size of each dish item was set on the basis of the median amount ($50^{th}$ percentile) in a single intake by a single person. In the rice category, 15 items were selected, of which the most frequently consumed item was steamed rice with a portion size of 250ml. Among noodles and dumplings, the most frequently consumed dish was ramyeon with a portion size of 500ml. As for soups, the portion size was $250m{\ell}$ for kongnamul guk and $300m{\ell}$ for miyeoguk. In stews, the most frequently consumed items were kimchi jjigae followed by doenjang jjigae with a portion size of $200m{\ell}$ and $125m{\ell}$, respectively. In a comparison of portion sizes between the KNHANES 2010 and KNHANES 2005, the portion size of some noodles, soups, and stews tended to decrease from 2005 to 2010. Portion sizes established in this study for dish items consumed regularly by adults may be conveniently and effectively used in dietary planning, in nutritional education programs, and in assessing the dietary intake status of Korean adults.

• 한국ITS학회 논문지
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• 제9권6호
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• pp.43-53
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• 2010

'97년 전국 5개 지방경찰청 32개 지점에 무인과속과속단속시스템의 도입으로 교통사고 발생 건수와 사망자수를 현저하게 감소시키는 효과를 가져와 지속적으로 확대 설치할 예정에 있다. 2010년 7월말 현재 4,495대를 설치 운영하고 있다. 대교, 터널 및 경사구간 등 위험도로구간에서는 치사율이 일반도로부의 3배 이상 높게 나타나 연속적인 속도관리가 필요하다. 그러나 무인과속단속시스템은 한 지점의 속도만으로 과속을 단속하는 시스템으로 단속지점에서만 속도를 줄이는 캥거루 효과가 발생하고 있어 연속적인 속도감소 효과를 기대할 수 없다. 따라서 위와 같은 연속적인 위험이 존재하는 도로구간에서는 교통사고 예방을 위해서는 위험구간의 평균속도로 과속차량을 단속하는 무인구간속도위반단속시스템 도입이 필요하게 되었다. 이에 본 논문에서는 무인구간속도위반단속시스템과 무인과속단속시스템 설치구간에서의 운전자 운행 특성인 캥거루 효과를 분석하고, 또한 제한속도 준수를 위한 두 시스템에 효과성을 검토하기 위하여 데이터를 수집하고 통계적인 분석을 실시하였다. 그 결과 무인구간속도위반단속시스템에서는 캥거루효과가 발생하지 않았고, 무인과속단속시스템에서만 캥거루효과가 발생하였다. 이러한 캥거루효과에 의한 차량 감속은 약 400m 전방에서 감속을 시작하는 것으로 분석되었다. 그리고 무인구간속도위반단속시스템의 평균속도가 무인과속단속시스템 보다 약 35km/h 낮은 것으로 분석되었다. 결론 적으로 무인구간속도위반단속시스템이 캥거루효과도 없을 뿐만 아니라 제한속도 준수에도 효과적인 것으로 검증되었다.

• 한국보육지원학회지
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• 제6권3호
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• pp.1-22
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• 2010

본 연구는 전북 K시에 위치한 초등학교 5-6학년 남녀 아동 588명을 대상으로 아동이 지각한 부모-자녀간 의사소통과 대인관계성향이 아동의 외로움에 미치는 영향을 알아보는데 목적이 있다. 아동용 자기보고 설문지에 의해 자료를 수집하였으며, 부모-자녀간 의사소통척도(PACI), 아동의 대인관계성향 척도, 아동의 외로움 척도가 사용되었다. 연구결과, 아동의 외로움 수준은 대체적으로 낮은 경향을 보였으며 부모와의 의사소통 수준은 약간 개방적인 경향을 보였다. 아동의 대인관계성향은 사교-우호적 성향이 가장 높고 그 다음이 독립-책임감적, 동정-수용적 성향으로 나타나 대체로 긍정적인 경향이 높게 나타났다. 부모-자녀간 의사소통과 아동의 외로움은 부적상관을 나타내었고, 대인관계성향의 하위변인들과도 대부분 서로 밀접한 관련이 있는 것으로 나타났다. 부모-자녀간 의사소통 및 대인관계성향이 아동의 외로움에 미치는 상대적 영향력을 분석한 결과, 부모-자녀간의 의사소통이 폐쇄적일수록, 사교-우호적 성향이 낮을수록 아동의 외로움 수준이 높은 것으로 밝혀졌다. 연구결과에 기초하여 아동이 외로움을 느끼지 않고 건강하게 성장 발달할 수 있도록 도울 수 있는 가정과 사회의 관심과 지원방향에 대해 논의하였다.

• 기본간호학회지
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• 제7권2호
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• pp.256-270
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• 2000

Invasive hemodynamic monitoring has become a valuable assessment parameters in critical care nursing in patients undergoing open heart surgery patients. During cardiac surgery, the Swan Ganz catheter is placed in the pulmonary artery. Critical care nurses routinely obtain cardiac output, cardiac index, and pulmonary arterial pressure in these patients. Traditionally, patients are positioned flat and supine for cardiac output measurement. Numerous studies have dealt with the effects of changing position on the hemodynamic variables. However, there are a few studies dealing with patients who undergo cardiac surgery in Korea. Thus, the purpose of this study was to determine the effects of changing position on cardiac output, PAP, CVP, BP, HR and discomfort in patients after cardiac surgery. A sample of 21 adults who had CABG and/or valve replacement with Swan Ganz catheters in place was studied. The data were collected in the cardiac ICU of a university hospital in Seoul during the period from July 28, 1999 to August 30. 1999. In this study, the independent variable is patient position in the supine, 30 degree, and 45 degree angles. Dependent variables are C.O., C.I., CVP, PAP, MAP, HR and patients' perceived discomforts. Subject discomfort was measured subjectively by visual analogue scale. Other hemodynamic data where collected by the thermodilution method and by direct measurement. The data were analyzed by percentile, t-test, ANOVA, Linear regression analysis using SPSS-/WIN program. The results are as follows : 1) Changes in cardiac output were absent in different angle positions, 0, 30. 45 degrees(F=.070, P=.932). Changes in cardiac index were absent in different angle positions, 0. 30, 45 degrees(P>.05). 2) Changes in central venous pressure were absent in different angle positions, 0, 30, 45 degree(P>.05). 3) PAP had no change in different angle 0, 30, 45 degree positions; systolic PAP(P>.05), diastolic PAP(P>.05). 4) Changes in systolic blood pressure were absent in different angle positions, 0, 30, 45 degree(P>.05). 5) Changes in heart rates were absent in different angle positions, 0, 30, 45 degree(P>.05). 6) Patients' perceived discomfort was absent in different angle positions, 0, 30, 45 degree(p<.05). In conclusion, critical care nurses can measure C.O., C.I., PAP, BP, & CVP in cardiac surgery patients at 30 degree or 45 degree positions. This can improve the patients' comfort.

• 가정간호학회지
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• 제12권1권
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• pp.92-116
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• 2005

Purpose: This study was a predicative survey to provide home care clients with indwelling urinary catheters for furnishing basic educational material to their families by analyzing the family members' knowledge, educational needs and educational experience about indwelling catheter management. Method : The subjects consisted of 108 family members who cared for home care clients with indwelling catheters. Data were collected by home care nurses in nine hospitals in Pusan, who directly interviewed with them through questionnaires from Sep. 6th to 30th in 2004. The questionnaires for data collection were developed through pre-survey and reference review. The collected data was analyzed by using frequency, percentile, mean, variation, t-test, ANOVA on SPSS 10.1 package. Results : There were characters of home care clients with indwelling catheters: women(67.6%) were more than men; the average age of them was $69.60{\pm}14.99$ years old; neurogenic and cerebrovascular diseases(80.0%) were the most common disease group; 81.5% of them were totally dependent on others in terms of level of activity. Home care clients' families had these characters: women(76.9%) were more than men; the average age was $54.5{\pm}13.70$ years old; 46.3% of them were parents or sons or daughters in terms of relation with patient; tl1e average care period was $39.8{pm}34.20$ months. Level of knowledge about indwelling catheter management of the family members were 69.8% and its mean were $20.24{\pm}4.53$. Educational needs were 90.9% and its mean were $14.55{\pm}3.56$. Educational experience were 53.3% and its mean were $8.53{\pm}4.30$. 'Complications in using an indwelling catheter', 'Symptoms to call for a home care nurse' and 'Method to attach an indwelling catheter' were high ranked in both educational needs and educational experience. 'Anatomy of urinary tract', 'Functions of urinary tract' and 'Catheter placement' were low ranked in both educational needs and educational experience Level of knowledge about indwelling catheter management of the families showed a significant difference according to their age(F=5.35, p=0.01). Educational needs showed a significant difference according to care period(F=3.06, p=0.04). Conclusion: the family members' level of knowledge and educational experience about indwelling catheter management and their educational were not sufficient while their educational needs were high. In other words although the family members were acknowledged education needs, but the care for the patients with indwelling catheter weren't performed well because of their lack of related knowledge. Therefore systematic educational programs about indwelling catheter management for home care clients and their families should be made on the base of this study.