• Title/Summary/Keyword: pcaA and pcaB

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Plasma Vascular Endothelial Growth Factors A and C in Patients undergoing Prostatic Biopsy and TURP for Suspected Prostatic Neoplasia

  • Singh, A.N.;Gautam, Kirti A.;Dalela, D.;Sankhwar, S.N.;Natu, S.M.;Sankhwar, P.L.;Srivastava, A.N.
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.2053-2058
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    • 2013
  • Background: Formation of new blood vessels is necessary for the development and spread of neoplasms more than 1 mm3 in volume, angiogenesis being responsible for formation of new from pre-existing blood vessels. Vascular endothelial growth factor (VEGF) is pivotal and the best studied angiogenic factor in all human cancers. Therefore we designed this study to investigate the role of VEGF-A and VEGF-C in prostate cancer in comparison with BPH controls in a north Indian population. Methods: In this case-control study a total of 100 subjects were included on the basis of confirmed histopathological reports, out of which 50 were prostate cancer patients and the other 50 were BPH patients with PSA levels >2 ng/ml and abnormal digital rectal examination (DRE) findings during September 2009 to August 2011 from the Department of Urology, KGMU, Lucknow, India. Plasma levels of VEGF were determined using quantitative immunoassay (ELISA-enzyme linked immunosorbent assay). Statistical analysis was carried out using SPSS 15.0 version. Results: The mean age of prostate cancer ($67.6{\pm}5.72$) patients was significantly higher (p=0.005) than BPH ($63.6{\pm}7.92$) patients. Expression of VEGF-A was not significantly higher in disease stage C1 than D1 or D2 and A or B (p=0.13) while the level of VEGF-A was significantly higher (p=0.04) in prostate cancer as compared to BPH subjects (PCa=13.0 pg/ml, BPH=6.8 pg/ml). Levels of VEGF-C were similar in both groups (PCa=832.6 pg/ml, BPH=823.7 pg/ml). In ROC curve, the area under curve (AUC) was 0.70 (95%CI: 0.60-0.80) and the cut-off value for which a higher proportion of patients was correctly classified (20%) was 26.0 pg/mL. Conclusion: Although VEGF-A is increased in cancer prostate patients a statistically significant correlation could not be established in this study. VEGF-C was not found to be a useful biomarker.

Case Study on Treaty-Based Investor-State Arbitration and Environmental Litigations with Specific Reference to Chevron/Ecuador Litigation (환경 소송과 국제투자중재 - 쉐브론 사건을 중심으로)

  • Kang, Pyoung-Keun
    • Journal of Arbitration Studies
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    • v.25 no.4
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    • pp.3-23
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    • 2015
  • The Chevron saga including Chevron/TexPet v. Ecuador, PCA Case No. 34877(hereinafter referred to as "Chevron I") and Chevron/TexPet v. Ecuador, PCA Case No. 2009-23(hereinafter referred to as "Chevron II") started out of domestic litigations between TexPet and Ecuador in the early 1990s. In Chevron I, the Tribunal decided that Article 2(7) of the U.S.-Ecuador BIT on effective means of provision was breached because of undue delays in the seven legal proceedings TexPet had brought against Ecuador in respect to contractual obligations. In Chevron II, it was contended that through the actions and inactions of the judiciary and the executive, Ecuador breached her several obligations under the BIT. Ecuador objected to the jurisdiction of the Tribunal because TexPet's investment was terminated in 1992, and because Chevron is not a party to the 1995 Settlement Agreement and 1998 Final Release. In its Interim Award on Jurisdiction and Admissibility, the Tribunal applied a prima facie standard to the facts alleged by the Claimants but denied by the Respondent, and decided that questions in respect of the Respondent's jurisdictional objections should be joined to the merits under Article 21(4) of the UNCITRAL Arbitration Rules. In the merits phase of Chevron II, the Tribunal divided the merits of the Parties' dispute into two parts, entitled "Track 1" and "Track 2". In its Partial Award on Track 1, the Tribunal decided that Chevron is a "Releasee" under the 1995 Settlement Agreement. In a decision on "Track 1B", the Tribunal decided that the Lago Agrio complaint cannot be read as pleading "exclusively" or "only" diffuse claims, and that, to this extent, the Claimants' reliance on the 1995 Settlement Agreement as a complete bar to the Lago Agrio complaint must fail, as a matter of Ecuadorian law. The Tribunal maintained the position that the Parties' disputes on both merit and jurisdiction should be reserved for Track 2. It remains to be seen how the Tribunal addresses the Claimants' allegations of multiple denials of justice under international law against the judgments of the Respondent's Courts, together with the Respondent's jurisdictional objections in Track 2 of the arbitration.

Analysis of Characteristics and Test of Combining Ability in Leaf Mustard Allies (갓의 국내 수집종 및 도입종의 형질분석 및 $F_{1}$ 조합능 검정)

  • Park, Han-Ju;Lee, In-Ho;Park, Jong-In;Yang, Seung-Yul;Nou, Ill-Sup
    • Korean Journal of Plant Resources
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    • v.20 no.4
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    • pp.298-303
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    • 2007
  • To examine taxonomic relationships among 24 leaf mustard allies (Brassica juncea) derived from domestic collections and introduced species, principal component analysis (PCA) and cluster analysis on 16 morphological characters were carried out. Of 16 characters, total fresh weight, total dry weight, shoot fresh weight and leaf length were useful characters for the understanding of taxonomic relationships among them. Cluster analysis using scores of the principal components indicated that 24 leaf mustards could be grouped into domestic collections and introduced species at 1.0 of average distance in UPGMA. Moreover, in experiment of $F_{1}$ recombination test, heterosis appeared greatly in Sanchiohbachirimen takana A ${\times}$ Akaohba takana, Goheung namyang ${\times}$ Sanchiohbachirimen takana B, and Goheung namyang ${\times}$ Akaohba takana cross combinations. Sanchiohbachirimen takana A and Akaohba takana have a high parent combining ability for breeding cultivars using cytoplasmic male sterility.

Tracking and Face Recognition of Multiple People Based on GMM, LKT and PCA

  • Lee, Won-Oh;Park, Young-Ho;Lee, Eui-Chul;Lee, Hee-Kyung;Park, Kang-Ryoung
    • Journal of Korea Multimedia Society
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    • v.15 no.4
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    • pp.449-471
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    • 2012
  • In intelligent surveillance systems, it is required to robustly track multiple people. Most of the previous studies adopted a Gaussian mixture model (GMM) for discriminating the object from the background. However, it has a weakness that its performance is affected by illumination variations and shadow regions can be merged with the object. And when two foreground objects overlap, the GMM method cannot correctly discriminate the occluded regions. To overcome these problems, we propose a new method of tracking and identifying multiple people. The proposed research is novel in the following three ways compared to previous research: First, the illuminative variations and shadow regions are reduced by an illumination normalization based on the median and inverse filtering of the L*a*b* image. Second, the multiple occluded and overlapped people are tracked by combining the GMM in the still image and the Lucas-Kanade-Tomasi (LKT) method in successive images. Third, with the proposed human tracking and the existing face detection & recognition methods, the tracked multiple people are successfully identified. The experimental results show that the proposed method could track and recognize multiple people with accuracy.

Functional Haplotypes and Evolutionary Analyses of SBE1 in Collected Rice Germplasm

  • Thant Zin Maung;Yong-Jin Park
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2022.10a
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    • pp.216-216
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    • 2022
  • The starch-branching enzymes (BEs) are responsible for synthesizing the amylopectin, which plays an important role in determining the structural and physical properties of starch granules. BE has two differently functioning isoforms (BEI and BEIIa/b) based on their difference in the chain-length pattern by the degree of polymerization (DP), which mainly contributes to the amylopectin chain length distribution in starch biosynthesis. In this study, we investigated functional haplotypes and evolutionary analyses of SBE1 in 374 rice accessions (320 Korean bred and 54 wild). The analyses were performed based on the classified subpopulations. Haplotype analysis generates a total of 8 haplotypes, of which only four haplotypes were functional carrying four functional SNPs in four different exons of SBE1 on chromosome 6. Nucleotide diversity analysis showed a highest pi-value in aromatic group (0.0029), while the lowest diversity value was in temperate japonica (0.0002), indicating the signal of this gene evolution origin. Different directional selections could be estimated by negative Tajima's D value of temperate japonica (-1.1285) and positive Tajima's D value of tropical japonica (0.9456), where the selective sweeps were undergone by both positive purifying and balancing selections. Phylogenetic analysis indicates a closer relationship of the wild with most of the cultivated subgroups indicating a common ancestor for SBE1 gene. FST-values indicate distant genetic relationships of temperate japonica from all other classified groups. PCA and population structure analysis show an admixed structure of wild and cultivated subpopulations in some proportions.

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Delayed use of Operating Rooms in a University Hospital (한 대학병원의 수술실 이용 지연요인과 개선방안에 관한 연구)

  • Kim, Kyung-Ae;Yu, Seung-Hum;Kim, In-Sook;Sohn, Tae-Yong;Park, Eun-Cheol
    • Korea Journal of Hospital Management
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    • v.7 no.3
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    • pp.44-62
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    • 2002
  • Advanced surgical technology demands more precise, meticulous, and time-consuming procedures. In addition, the patient's preference of tertiary health providers makes over crowding of the University Hospitals. Therefore, it has been necessary to maximize utilization of the operating room of such hospitals to accommodate these requirements. This study, targeting 1,302 surgical cases performed in 22 operating rooms at a university hospital in Seoul from October 8 to November 1, 2001, analyzed reasons for delay, and factors that caused delayed use of operating rooms. This study also assessed that the rate of operating room use would increase if the sources for possible reform were improved. 1. Among total of 1,302 cases of surgery, the incidence of surgeries in which there were no time delays and no factors for delay were discovered is 71.4% or 930 cases: the incidence in which surgeries were delayed was 28.6% or 372 cases. 2. As results of logistic regression for delay, procedures involving women were delayed 1.4 times more frequently than those of men. Compared to Department A, Department B was 1.8 times more likely to be delayed, and Department H was 0.4 times less likely to be delayed. Regional anesthesia was 2.4 times more likely to be delayed than general anesthesia, and surgeries that PCA was applied were 0.6 times less likely to be delayed than those when it was not. Surgeries performed on the Thursday were 1.7 times more likely to be delayed than those performed on the Monday. Compared to surgeries performed between 07:00-07:59, those performed between 08:00-08:29 were 4.3 times higher. 3. The reasons for delay were related to surgeon, surgical department, patient, anesthesia, administrative system, sick ward, and support services. Among these, 5,755 minutes for 276 delayed cases could be resolved easily, and resolving delays of 3,320 minutes for 131 cases would be more difficult. Among the causes for delay that could be improved, delays due to patient's transfer and surgeon's factor were the most common, 21.6% and 17.4% respectively. 4. If resolvable delays are improved, pre-anesthesia room is administered, and regional anesthesia and PCA are done ahead of time, use of emergency operating rooms will increase, we can increase overall utilization by 4.09%, we will save 744 minutes a day, we can reduce the time the operation room is used after 4 PM by 35%, and we can resolve the operation cancellations due to insufficient operating rooms. For the increase in the use of operating rooms, we need to maximally decrease the delays that could be improved, by allocating block time based on used totals hours of elective cases, giving accurate information on surgery schedule, voluntary cooperation by staff participating in surgeries in reducing delay time, and the hospital management's will to improve delay.

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Atmospheric Concentrations of PAHs in the Vapor and Particulate Phases in Chongju

  • Park, Seung-Shik;Kim, Young-J.;Kang, Chang-H.;Cho, Sung-Yong;Kim, Tae-Young;Kim, Seung-Jai
    • Journal of Korean Society for Atmospheric Environment
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    • v.22 no.E2
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    • pp.57-68
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    • 2006
  • Four intensive seasonal sampling campaigns between October 1998 and October 1999 were undertaken at an urban site of Chongju, in which polyurethane foam (PUF) sampler was used to collect particulate- and vapor-phase polycyclic aromatic hydrocarbons (PAHs). The contribution to total (particulate+vapor) PAH concentration by the vapor phase component exceeded the particulate phase contribution by factor of ${\sim}2.6$. Summed concentrations of phenanthrene (30.9%), pyrene (16.6%), naphthalene (11.3%) and fluoranthene (11.0%) account for significant amounts of the vapor-phase, while chrysene (12.5%), benzo[b]fluoranthene (11.6%), indeno[123-cd]pyrene (9.9%), benzo[ghi]perylene (9.5%), benzo[k]fluoranthene (9.4%), pyrene (8.9%), and benzo[a]pyrene (8.3%) are found to be the most common PAH compounds in the particulate phase. The results from application of principal component analysis to particulate-phase PAH data demonstrate that a combination of PAH and $PM_{2.5}$ inorganic data is a more powerful tracer of emission sources than PAH species data alone. Particulate-phase PAH species were found to be associated predominantly with emissions from diesel engine vehicles and incineration.

Effects of Adding Green Grape Juice on Quality Characteristics of Konjak Jelly (청포도 즙의 첨가가 곤약젤리의 품질특성에 미치는 영향)

  • Jeon, Jae-Eun;Lee, In-Seon
    • Journal of the Korean Society of Food Culture
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    • v.34 no.5
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    • pp.629-636
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    • 2019
  • This study examined the quality characteristics of jelly prepared with green grape juice (GJ). The pH, $^{\circ}Brix$ value, color, texture, and sensory evaluation of the jelly were measured. The pH of the jelly significantly decreased with increasing amount of GJ over the range of 3.25-5.27. The $^{\circ}Brix$ value of the jelly showed a significantly higher result as the amount of GJ increased (p<0.001). Lightness (L) and redness (a) decreased with increasing amount of GJ, and yellowness (b) increased. In the texture measurement, the GJ-100 sample group with a high substitute rate of GJ showed high hardness, gumminess, and chewiness (p<0.001). The results of principal component analysis (PCA) showed that the sample groups with high GJ content were classified as having relatively strong yellowness, sweet aroma, metallic aroma, grassy aroma, sweetness, sourness, green grape skin taste, and astringency. In the acceptance test, the GJ-50 sample group was evaluated to be high in flavor (p<0.001) and overall acceptance (p<0.01). However, sample groups consisting of 50% or more GJ were evaluated to be significantly strong in terms of astringency. Therefore, further study needs to be conducted about improving astringency in the future.

Changes of Physical Characteristics of Chubu Perilla Leaves(Penilla Frutescens var. Japonica HARA)during Different Storage Conditions (저장조건에 따른 추부 깻잎의 물리적 특성 분석)

  • Hur, Sang-Sun
    • Journal of the Korean Applied Science and Technology
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    • v.34 no.2
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    • pp.410-417
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    • 2017
  • The physical properties of perilla leaves cultivated in Geumsan province were analyzed according storage conditions. The a/b values of perilla leaves increased with increasing storage period. Electronic nose composed of 12 different metal oxide sensors was used to differentiate flavors of perilla leaves. Sensitivities(delta $R_{gas}/R_{air}$) of sensors from electronic nose were obtained by principal compound analysis(PCA). Proportion of the first principal component was 93.07% at $25^{\circ}C$ and 97.81% at $4^{\circ}C$, respectively. In our result, flavor patterns of perilla leaves can be differentiated according to the storage temperature.

Design of Two-Dimensional Robust Face Recognition System Realized with the Aid of Facial Symmetry with Illumination Variation (얼굴의 대칭성을 이용하여 조명 변화에 강인한 2차원 얼굴 인식 시스템 설계)

  • Kim, Jong-Bum;Oh, Sung-Kwun
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.64 no.7
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    • pp.1104-1113
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    • 2015
  • In this paper, we propose Two-Dimensional Robust Face Recognition System Realized with the Aid of Facial Symmetry with Illumination Variation. Preprocessing process is carried out to obtain mirror image which means new image rearranged by using difference between light and shade of right and left face based on a vertical axis of original face image. After image preprocessing, high dimensional image data is transformed to low-dimensional feature data through 2-directional and 2-dimensional Principal Component Analysis (2D)2PCA, which is one of dimensional reduction techniques. Polynomial-based Radial Basis Function Neural Network pattern classifier is used for face recognition. While FCM clustering is applied in the hidden layer, connection weights are defined as a linear polynomial function. In addition, the coefficients of linear function are learned through Weighted Least Square Estimation(WLSE). The Structural as well as parametric factors of the proposed classifier are optimized by using Particle Swarm Optimization(PSO). In the experiment, Yale B data is employed in order to confirm the advantage of the proposed methodology designed in the diverse illumination variation