• Journal of Korean Society of Rural Planning
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• v.10 no.1 s.22
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• pp.9-17
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• 2004

For the problems in executing rural development, recent recognitions are that discovery, preservation, and utilization of area-unique resource are unsatisfactory, that participation of local residents was neglected, and that approach to gradual refurbishment of houses and common space of town in consideration of existing spatial pattern of the town was not adequate. Especially, neglect for exact investigation, analysis and evaluation on rural local resources is bringing about social problems such as mass production of uniform rural area and loss of local identity. In this study, rural resources were listed and resource evaluation items was designed in order to establish development direction of rural village. According to these results, for the efficient and reasonable drive of the resource evaluation system, following items are required; A premise of local development by participation of local people, Development of diversely appliable resource evaluation clauses, Establishment of development type in connection with resource evaluation clauses, Systematic management of local resource through spreading DB resource. This research was loused on unearthing direction development of rural village and theme. However, what should be reconsidered through continuous study is that resource evaluation clauses are somewhat general and not concretely illustrated. Therefore establishment of characterized development is expected through clarifying local identity and presenting direction of local development, with the importance of resource and systematic analysis in planning on rural village in the future.

• Journal of the Korea Society of Computer and Information
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• v.22 no.10
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• pp.109-119
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• 2017

In recent through development of IOT owing to that mass stream data is being generated in variety of application complex event processing technology is being watched with keen interest as a technology to analyze this kind of real-time continuous data. However, the existing study related with complex event processing only comes to an end at simple event processing based on low-level event or comes to an end at service defect discovery with providing limited operator and so on. Accordingly, there would be limitation to provide useful analysis information. In this paper in consideration of complex event along with aspect-oriented programming an extended complex event model is provided, which is possible to provide more valuable and useful information. Specifically, we extend the model to support hierarchical event structures and let the model recognize point-cuts of aspect-oriented programming as events. We provide the event operators designed to specify the events on instances and handle temporal relations of the instances. It is presented that syntax and semantics of constructs in our event processing language including various and progressive event operators, complex event pattern, etc. In addition, an event context mechanism is proposed to analyze more delicate events. Finally, through application studies application possibility of this study would be shown and merits of this event model would be present through comparison with other event model.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.36.1-36.1
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• 2011

It is generally believed that eruptive phenomena in the solar atmosphere such as solar flares and coronal mass ejections (CMEs) occur in the solar active regions with complex magnetic structures. Magnetic helicity has been recognized as a useful parameter to measure the complexity such as twists, kinks, and inter-linkages of magnetic field lines. The objective of this study is to understand a long-term (a few days) variation of magnetic helicity in active regions and its relationship with the energy buildup and instability leading to flares and CMEs. Statistical studies of flare productivity and magnetic helicity injection in about 400 active regions were carried out. The temporal variation of magnetic helicity injected through the photosphere of active regions was also examined related to 46 CMEs. The main findings in this study are as follows: (1) the study of magnetic helicity for active regions producing major flares and CMEs indicates that there is always a significant helicity injection through the active-region photosphere over a long period of 0.5 - a few days before the flares and CMEs; (2) for the 30 CMEs under investigation, it is found that there is a fairly good correlation (linear correlation coefficient of 0.71) between the average helicity injection in the CME-productive active regions and the CME speed. Beside the scientific contribution, a major impact of this study is the observational discovery of a characteristic variation pattern of magnetic helicity injection in flare/CME-productive active regions which can be used for the improvement of solar eruption forecasting.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2007.11a
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• pp.19-27
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• 2007

An important potential of metabolomics-based approach is the possibility to develop fingerprints of diseases or cellular responses to classes of compounds with known common biological effect. Such fingerprints have the potential to allow classification of disease states or compounds, to provide mechanistic information on cellular perturbations and pathways and to identify biomarkers specific for disease severity and drug efficacy. Metabolic profiles of biological fluids contain a vast array of endogenous metabolites. Changes in those profiles resulting from perturbations of the system can be observed using analytical techniques, such as NMR and MS. $^1H$ NMR was used to generate a molecular fingerprint of serum or urinary sample, and then pattern recognition technique was applied to identity molecular signatures associated with the specific diseases or drug efficiency. Several metabolites that differentiate disease samples from the control were thoroughly characterized by NMR spectroscopy. We investigated the metabolic changes in human normal and clinical samples using $^1H$ NMR. Spectral data were applied to targeted profiling and spectral binning method, and then multivariate statistical data analysis (MVDA) was used to examine in detail the modulation of small molecule candidate biomarkers. We show that targeted profiling produces robust models, generates accurate metabolite concentration data, and provides data that can be used to help understand metabolic differences between healthy and disease population. Such metabolic signatures could provide diagnostic markers for a disease state or biomarkers for drug response phenotypes.

• Parasites, Hosts and Diseases
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• v.54 no.5
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• pp.617-623
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• 2016

An excavation of the Vesakoyakha II-IV and Nyamboyto I burial grounds was conducted during the 2014 field season, and soil samples from intact burials dating from the 19th and 20th centuries, respectively, were analyzed to determine interactions between parasites and host/vectors. Considering the discovery of Diphyllobothrium sp. and Taenia sp. eggs in soil samples from the pelvic region, diphyllobothriasis was the most frequent helminthic infection among the Taz Nenets. The Nyamboyto Nenets mainly consumed uncooked fish, while the Vesakoyakha Nenets had a bigger variety in food choices, including reindeer meat. Nenets children were given raw fish from early childhood. The paleoparasitological results corroborate rare ethnographic records about the consumption of uncooked reindeer cerebrum which led to beef tapeworm helminthiases. This is the first parasitological report of helminthic diseases among the Taz Nenets, and, as such, it provides insight into their subsistence activities and food patterns and broadens our understanding of their health condition.

• Journal of Preventive Medicine and Public Health
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• v.40 no.2
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• pp.185-190
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• 2007

Objectives : Since the first human infection from avian influenza was reported in Hong Kong in 1997, many Asian countries have confirmed outbreaks of highly pathogenic H5N1 avian influenza viruses. In addition to Asian countries, the EU authorities also held an urgent meeting in February 2006 at which it was agreed that Europe could also become the next target for H5N1 avian influenza in the near future. In this paper, we provide the general and applicable information on the avian influenza in the bioinformatics field to assist future studies in preventive medicine. Methods : We introduced some up-to-date analytical tools in bioinformatics research, and discussed the current trends of avian influenza outbreaks. Among the bioinformatics methods, we focused our interests on two topics: pattern analysis using the secondary database of avian influenza, and structural analysis using the molecular dynamics simulations in vaccine design. Results : Use of the public genome databases available in the bioinformatics field enabled intensive analysis of the genetic patterns. Moreover, molecular dynamic simulations have also undergone remarkable development on the basis of the high performance supercomputing infrastructure these days. Conclusions : The bioinformatics techniques we introduced in this study may be useful in preventive medicine, especially in vaccine and drug discovery.

• Journal of Information Processing Systems
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• v.13 no.5
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• pp.1158-1167
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• 2017

Many real-world applications information are organized and represented with graph structure which is often used for representing various ubiquitous networks, such as World Wide Web, social networks, and protein-protein interactive networks. In particular, similarity evaluation between graphs is a challenging issue in many fields such as graph searching, pattern discovery, neuroscience, chemical compounds exploration and so forth. There exist some algorithms which are based on vertices or edges properties, are proposed for addressing this issue. However, these algorithms do not take both vertices and edges similarities into account. Towards this end, this paper pioneers a novel approach for similarity evaluation between graphs based on formal concept analysis. The feature of this approach is able to characterize the relationships between nodes and further reveal the similarity between graphs. Therefore, the highlight of our approach is to take vertices and edges into account simultaneously. The proposed algorithm is evaluated using a case study for validating the effectiveness of the proposed approach on detecting and measuring the similarity between graphs.

• Genomics & Informatics
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• v.20 no.2
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• pp.24.1-24.8
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• 2022

Hypomyelinating leukodystrophy type 2 (HLD2), is an inherited genetic disease of the central nervous system caused by recessive mutations in the gap junction protein gamma 2 (GJC2/GJA12). HLD2 is characterized by nystagmus, developmental delay, motor impairments, ataxia, severe speech problem, and hypomyelination in the brain. The GJC2 sequence encodes connexin 47 protein (Cx47). Connexins are a group of membrane proteins that oligomerize to construct gap junctions protein. In the present study, a novel missense mutation gene c.760G>A (p.Val254Met) was identified in a patient with HLD2 by performing whole exome sequencing. Following the discovery of the new mutation in the proband, we used Sanger sequencing to analyze his affected sibling and parents. Sanger sequencing verified homozygosity of the mutation in the proband and his affected sibling. The autosomal recessive inheritance pattern was confirmed since Sanger sequencing revealed both healthy parents were heterozygous for the mutation. PolyPhen2, SIFT, PROVEAN, and CADD were used to evaluate the function prediction scores of detected mutations. Cx47 is essential for oligodendrocyte function, including adequate myelination and myelin maintenance in humans. Novel mutation p.Val254Met is located in the second extracellular domain of Cx47, both extracellular loops are highly conserved and probably induce intramolecular disulfide interactions. This novel mutation in the Cx47 gene causes oligodendrocyte dysfunction and HLD2 disorder.

• International Journal of Advanced Culture Technology
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• v.10 no.4
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• pp.460-469
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• 2022

Increasing interest in the metaverse world these days, interest in realistic content such as 3D displays is growing. In particular, hologram images seen in movies provide viewers with an immersive display that cannot be seen in conventional 2D images. Since the first discovery of holography by Dennis Gabor in 1948, this technology has developed rapidly. Spatially, this beginning of technology like Optical hologram called analog hologram and Digital hologram such as computer-generated hologram (CGH). In analog and digital holograms, a recording angle and a recording wavelength are having important role when reproducing and display hologram. In the hologram, diffraction of light causes by unexpected formed by the synthesis from interference with object and reference light. When recording, the incident light information and mismatched reproduction light reconstruct the hologram in an undesirable direction. Reproduction light that is out of sync with incident light information with initial condition of recording will cause reconstructed image in an undesirable direction. Therefore, we analyze the holographic interference pattern generated by hologram recording in volume holograms using photopolymer and analyze the characteristics that vary depending on the angle of the reproduced light. This is expected to be used as a basic research on various holographic application that may cause as holograms are applied to industries in the future.

• Genomics & Informatics
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• v.21 no.2
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• pp.21.1-21.14
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• 2023

Fusobacterium nucleatum is a gram-negative bacteria associated with diverse infections like appendicitis and colorectal cancer. It mainly attacks the epithelial cells in the oral cavity and throat of the infected individual. It has a single circular genome of 2.7 Mb. Many proteins in F. nucleatum genome are listed as "Uncharacterized." Annotation of these proteins is crucial for obtaining new facts about the pathogen and deciphering the gene regulation, functions, and pathways along with discovery of novel target proteins. In the light of new genomic information, an armoury of bioinformatic tools were used for predicting the physicochemical parameters, domain and motif search, pattern search, and localization of the uncharacterized proteins. The programs such as receiver operating characteristics determine the efficacy of the databases that have been employed for prediction of different parameters at 83.6%. Functions were successfully assigned to 46 uncharacterized proteins which included enzymes, transporter proteins, membrane proteins, binding proteins, etc. Apart from the function prediction, the proteins were also subjected to string analysis to reveal the interacting partners. The annotated proteins were also put through homology-based structure prediction and modeling using Swiss PDB and Phyre2 servers. Two probable virulent factors were also identified which could be investigated further for potential drug-related studies. The assigning of functions to uncharacterized proteins has shown that some of these proteins are important for cell survival inside the host and can act as effective drug targets.