• Radiation Oncology Journal
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• 제33권3호
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• pp.179-187
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• 2015

Purpose: The purpose of this study was to investigate the predictable value of pretreatment $^{18}F$-fluorodeoxyglucose positron emission tomography-computed tomography ($^{18}F$-FDG PET-CT) in radiotherapy (RT) for patients with hepatocellular carcinoma (HCC) or portal vein tumor thrombosis (PVTT). Materials and Methods: We conducted a retrospective analysis of 36 stage I-IV HCC patients treated with RT. $^{18}F$-FDG PET-CT was performed before RT. Treatment target was determined HCC or PVTT lesions by treatment aim. They were irradiated at a median prescription dose of 50 Gy. The response was evaluated within 3 months after completion of RT using the Response Evaluation Criteria in Solid Tumors (RECIST). Response rate, overall survival (OS), and the pattern of failure (POF) were analyzed. Results: The response rate was 61.1%. The statistically significant prognostic factor affecting response in RT field was maximal standardized uptake value (maxSUV) only. The high SUV group (maxSUV ${\geq}5.1$) showed the better radiologic response than the low SUV group (maxSUV < 5.1). The median OS were 996.0 days in definitive group and 144.0 days in palliative group. Factors affecting OS were the %reduction of alpha-fetoprotein (AFP) level in the definitive group and Child-Pugh class in the palliative group. To predict the POF, maxSUV based on the cutoff value of 5.1 was the only significant factor in distant metastasis group. Conclusion: The results of this study suggest that the maxSUV of $^{18}F$-FDG PET-CT may be a prognostic factor for treatment outcome and the POF after RT. A %reduction of AFP level and Child-Pugh class could be used to predict OS in HCC.

• 대한치과교정학회지
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• 제25권1호
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• pp.1-12
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• 1995

본 연구는 초진시의 골격형태로부터 이모장치에 대한 반응성을 예측하는 지표를 구하여 III급부정교합환자의 조기 치료를 결정할 때 고려할 수 있는 기준를 마련하기 위해 시행하였다. 성장기의 골격성 III급 부정교합아동 40명을 연구대상으로 하였으며, 이들을 영구치열완성 이후의 교합의 안정성과 최대성장기 이후의 안모의 개선도를 기준으로하여 양호반응군 25명과 불량반응군 15명으로 나누었다. 초진시 두 군 사이에 현저한 차이를 보이는 주요 골격계측항목을 선택하고, 판별분석을 시행하여 다음의 결과를 얻었다. 1. 치료전 $Bj\ddot{o}rk$ sum, 전후안면고경비율, genial angle, lower genial angle, occlusal plane to SN, occlusal plane to AB plane angle 등의 항목에서 두 군 사이의 유의성이 인정되어 양호반응군이 불량반응군에 비해 치료전에 보다 수평적인 안모형태를 지니고 있었음을 알 수 이었다. 2. $Bj\ddot{o}rk$ sum등 두군사이에 유의한 차이를 보인 각 항목들의 임계값과 판별력을 구하였다. 3. 판별에 기여도가 높은 세 항목 즉, $Bj\ddot{o}rk$ sum, genial angle 그리고 occlusal plane to An plane angle을 이용한 판별식을 구하였으며, 이를 이용할 때 본 연구에 사용된 표본의 $85\%$를 올바르게 판별할 수 있었다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권5호
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• pp.418-425
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• 2006

Purpose: This study was aimed at evaluating the histological changes of new bone and expression of osteopontin (OPN) after mandibular distraction osteogenesis. Materials and Methods: Unilateral mandibular distraction (0.5 mm twice per day for 10 days) was performed in eight adult dogs. Two animals were sacrificed at 7, 14, 28 and 56 days after completion of distraction, respectively. The distracted bones and contralateral non-distracted control bones were harvested and processed for histological and immunohistochemical examinations. Results: The new bone was arranged to tension direction after distraction osteogenesis. 7 days after distraction, numerous osteoblasts lining the immature trabecular bone and fibroblast-like cells in the fibrous intrezone were observed. 14 days after distraction, the new formed trabecular bones were thickened compared with 7 days after distraction. 28 days after distraction, the fibrous interzone was almost filled with newly calcified bone, and it was more hardened at 56 days after distraction. Increased OPN signals detected in the osteoblasts lining the trabecular bone and fibroblast-like cells in the fibrous interzone at 7 and 14 days after distraction. At 28 days after distraction, the OPN was weakly expressed in the osteoblasts, and it was not detected in all cellular components of distracted bone at 56 days later of distraction. Conclusions: After distraction osteogenesis, the distracted zone was completely calcified during the 56 days of consolidation period. In this study, the staining intensity of OPN increased in the osteoblasts and fibroblast-like cells at 7 and 14 days after distraction. The expression pattern of this protein shown here suggested that OPN play an important role in the osteogenesis during the early consolidation period.

• 기술사
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• 제16권1호
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• pp.20-34
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• 1983

A phenomenon in the unplanned urban sprawl of Cheong-ju city has to be rest-rained from disposing and to develop, though progress in urbanization inevitably decreases rural area. So, this thesis aims at reviewing, revising and guiding toward the more effective land use planning practice and zoning mechanism and system of Cheong-ju city. I proposed that land use planning should be had several factors and thereupon that Korean zoning mechanism and system including Building Code should be amended because of inducing human activities in buildings and facilities not to demarcate and plan every one of them. First, the factors of urban planning are a rather diversified approach to it than a unified, supplementation of the applicable difference in time between preparing and appling it, a solid controlling system, a micro and macro planning theory and giving serious consideration for the inertia from the existing land use. Second, the applicable amendments for our zoning mechanism including Eluding Code are as follows; a need of reorganization for Zoning Ordinance appricated to different regulation concerning a scale and peculiarity of a oily, a decision of the different earmarked confinement in area to different zone ana from Zoning Ordinance in City Planning Law, a demarcated facilities and the more detailed land use concerning human activies than the exsisting and entrusting decision on the ways and processes of it to every rural city planning committee, a settlement of zone ana area considering for block-unit and Planned Unit Development(P. U. D.), and a need of security jurisprudence in order to solve the zoning regulation rather in City Planning Law than in Building Code that our zoning regulation and controlling system are depended on. According to these applicable amendments to Cheong-ju city, I proposed the conceptions of Cheong-ju city land use planning are as follows; a reinforcement with one cored pattern of urban land use, a selection of gradual urban sprawl by way of city development and renewal, a strengthening accessibility to the core of the city with Plurizing the system of arterial roads, a choice of priority to conservation at the core of tile city and security of open spaces and parking area at the area of the city, a harmonization between development and conservation at the inner ring area that is situated between the core and periphery reserved area in order to develop in the future, a buffered open space situated at the congested area with heterogenous functions, and a completion of urban open space system. The proposal made here so far is for the hope of the better structure of Cheong-ju city that should be granted to the peculiarity developed with educational, cultural, conservative and self-sufficient city functions.

• 지역연구
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• 제34권3호
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• pp.55-68
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• 2018

본 연구는 대구혁신도시 사례를 중심으로 신시가지형 혁신도시개발에 따른 대도시 인구분포 변화를 분석하는데 목적을 두었다. 이를 위해 2007~2016년 통계청 인구동향조사와 국내인구이동통계 마이크로데이터를 활용하여 대구광역시 및 주변 시군의 인구변화를 자연적 증가와 사회적 증가(인구이동)로 분해하여 동태적으로 분석하였다. 분석 결과, 대구광역시의 인구는 지속적인 감소경향을 보이는 반면, 도시외곽 혁신도시개발지가 위치한 동구는 해당지역으로의 인구유입에 따라 인구성장을 경험하고 있었다. 특히 2014년 이후 동구로의 높은 순 인구이동의 발생은 대구혁신도시 개발의 준공과 공공기관 이전 시기와 일치하는 패턴을 보여주었다. 2007~2016년 사이 동구로 이동 인구의 전출지역을 분석한 결과 수도권으로부터 유입은 전체의 6.9%인 반면 동구 내부이동(34.5%)과 더불어 대구 내 7개 구군(35.8%)과 주변 4개 시군(8.2%)에서 유입된 인구가 큰 비중을 차지하였다. 특히 대구혁신도시가 위치한 동구로의 전입인구는 동구 인접지역인 수성구, 북구, 경산시로부터 유입인구가 많은 것으로 나타나 시가지형 혁신도시개발은 도시의 외연적 확산을 심화시키고 있음을 확인하였다.

• Radiation Oncology Journal
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• 제32권3호
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• pp.138-146
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• 2014

Purpose: This single institutional study is aimed to observe the outcome of patients who received postoperative radiotherapy after radical prostatectomy. Materials and Methods: A total of 59 men with histologically identified prostate adenocarcinoma who had received postoperative radiation after radical prostatectomy from August 2005 to July 2011 in Seoul St. Mary's Hospital of the Catholic University of Korea, was included. They received 45-50 Gy to the pelvis and boost on the prostate bed was given up to total dose of 63-72 Gy (median, 64.8 Gy) in conventional fractionation. The proportion of patients given hormonal therapy and the pattern in which it was given were analyzed. Primary endpoint was biochemical relapse-free survival (bRFS) after radiotherapy completion. Secondary endpoint was overall survival (OS). Biochemical relapse was defined as a prostate-specific antigen level above 0.2 ng/mL. Results: After median follow-up of 53 months (range, 0 to 104 months), the 5-year bRFS of all patients was estimated 80.4%. The 5-year OS was estimated 96.6%. Patients who were given androgen deprivation therapy had a 5-year bRFS of 95.1% while the ones who were not given any had that of 40.0% (p < 0.01). However, the statistical significance in survival difference did not persist in multivariate analysis. The 3-year actuarial grade 3 chronic toxicity was 1.7% and no grade 3 acute toxicity was observed. Conclusion: The biochemical and toxicity outcome of post-radical prostatectomy radiotherapy in our institution is favorable and comparable to those of other studies.

• 대한한의학원전학회지
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• 제24권2호
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• pp.13-22
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• 2011

"Caraka-sa$\d{m}$hit$\bar{a}$ (闍羅迦集)" and "Su$\'{s}$ruta-sa$\d{m}$hit$\bar{a}$(妙聞集)" are the most important medical scriptures in India and are called the three scriptures of Ayuverda including "Astanga-hrdaya-sa$\d{m}$hit$\bar{a}$(八心集)" (which integrates and summarizes internal medicine and surgery.) that is scribed in 8C. Scriptures that have been told today are deemed to be written in 3 ~ 4C. The three scriptures of Ayuverda and "Yellow Emperor's Canon Internal Medicine(黃帝內經)" are very similar in historical position, transmission and separation and addition, pattern and importance of contents, etc, from the aspect of formation and transmission of scriptures when compared with herb medicine. The characteristics that "SuWen(素問)" concentrates on medical theory and "LingShu(靈樞)" focuses on acupuncture therapy are similar with the characteristics that "Caraka-sa$\d{m}$hit$\bar{a}$" values internal medicine and "Su$\'{s}$ruta-sa$\d{m}$hit$\bar{a}$" appreciates surgery. The chapter 8 of "Caraka-sa$\d{m}$hit$\bar{a}$ (闍羅迦集)" is called as 'a volume of completion (or a volume of success)' and describes details of 'pancakarma (which means five representative treatment methods, that is successful regulations of two kinds of basti(灌腸), $\'{s}$irsavirecana(油劑), virecana(下劑), vamana(吐劑). Therefore, the author compares summery of 'internal therapy' of Indian medicine and drug treatment method with Method Of 'Sweat, Vomit And Diarrhea of the representative treatment in herb medicine, based on "RuMenShiQin(儒門事親)" of ZhangZiHe(張子和).

• Asian-Australasian Journal of Animal Sciences
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• 제15권10호
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• pp.1433-1438
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• 2002

The study was carried out to evaluate leucaena seeds as a protein replacement of mustard seed cake (MSC) in the concentrate mixture of growing lambs. Fifteen owing male lambs (Local${\times}$Corridale) with an average body weight of 16.3 kg were allocated into three dietary treatments (T1, T2, and T3) with five animals in each group. Animals were offered dry mixed grass, berseem hay and concentrate mixture to meet their nutrient requirements. In concentrate mixture of T1, (Control) MSC was used as protein source, while in T2 and T3 groups, 25 and 50% of MSC was replaced by leucaena leucocephala seeds. On completion of three months (90 days) of feeding, a digestion cum-metabolism trial was conducted to determine DMI, nutrient utilization, and nitrogen balance. Changes in body weight were recorded at 15 day internals and eating patterns were recorded for 3 consecutive days at the end of the feeding trial. MSC had higher CP contents than leucaena seeds (27.0%). Mimosine contents in leucaena seeds were 1.1 compared to 0.2 and 0.4% in concentrate mixture of T2 and T3 group, respectively. Dry matter intake varied non-significantly ($79.3{\pm}1.2$ to $83.4{\pm}1.3g/kg$ $w^{0.75}$) across the dietary treatments. Digestibility of DM and cell wall polysaccharides (NDF, ADF. Cellulose and hemicellulose) were comparable, however CP digestibility was relatively lower in leucaena luecocephala seeds based groups (T2 $45.5{\pm}1.7$ and T3 $46.7{\pm}3.5$) compared to MSC supplemented group (T1 $47.7{\pm}0.9%$). The growth rate of lambs was non-significantly higher in T1 ($79.2{\pm}5.4$) compared to T2 ($73.8{\pm}8.8$) and T3 ($73.9{\pm}7.0$), respectively. The animals were in positive nitrogen balance and N-balance varied from 1.8 to 2.9 g/d across treatment groups. The eating rate (% of total offered) of concentrate up-to 15 min was relatively higher in T1 (82.4) than T2 (74.2) and T3 (77.8%). However no effect of leucaena seeds was recorded on total DMI of animals. The results of the study revealed that the inclusion of up to 50% leucaena seeds, as protein source in concentrate mixture of lambs had no adverse effect on DMI, nutrient utilization, eating patterns, nitrogen balance and growth performance of lambs.

• 한국산학기술학회논문지
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• 제18권12호
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• pp.150-156
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• 2017

본 연구는 PSC(Post Tensioned Concrete) 교량 및 사장교(Cable Stayed Bridge) 등에 많이 적용되는 강연선의 국부적 손상에 따른 응력 회복길이를 분석하였다. 강연선은 PC 강선(Prestressing Strand)을 여러 줄을 꼬은 강재이며, 재료의 특성상 준공후 지속적으로 손상이 발생하며 부식 등이 주요 손상원인이다. 이에 따른 손상에 따른 성능저하가 발생하지만, 구조적인 특성상 케이블 내부의 손상 정도 및 응력 변화 패턴을 파악하기 어렵다. 교량에 적용된 케이블의 경우 설치 형상에 따라 채수 등에 따라 부식에 취약한 부분이 발생하며, 이로 인해 국부적인 손상이 발생할 수 있다. 본 연구는 교량 Post-Tensioning 또는 케이블 사장재에 주로 적용되는 강연선(7-Wire Strand)의 국부적 손상에 따른 성능저하 경향 및 응력 회복길이를 FEA 해석을 통하여 분석하였다. 향후 본 연구에서 구축하고자 하는 해석모델을 활용하여 PSC 교량 및 사장교 케이블 등의 안전성 평가 및 잔존수명 예측에 활용될 수 있을 것으로 사료된다.

• 대한두경부종양학회지
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• 제15권2호
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• pp.182-188
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• 1999

Purpose: To investigate the treatment results' and patterns of failure according to the pathologic type of the parotid malignancy who were treated with radical sugery and postoperative radiation therapy. Materials and Methods: Fifty-two patients with various type of the parotid malignancy, who were treated with combined radical surgery and post-operative irradiation at Yonsei Cancer Center, between 1981 and 1995, were retrospectively reviewed after completion treatment, all but one patients were follow up with the median follow up period of 49 months. Results: We found that pathologically confirmed neck node metastasis rate was 28.8% all case and level II was most common site. Overall failure rate was 26.9%, local recurrence rate was 13.5%, node failure rate was 7.7%, and distant failure rate was 5.8%. Five-year disease free survival rate was 70.9%, and overall survival rate was 73.8%. Recurrence rate was low in adenoid cystic carcinoma and acinic cell carcinoma. However distant metastasis was very high in undifferentiated carcinoma. Local recurrence was main pattern of failure in mucoepidermoid carcinoma and nodal failure was frequently observed in adenocarcinoma. Conclusion: Individualized treatment plan may be required to improve a treatment outcome by pathologic subtype of the parotid malignancy.