• Title/Summary/Keyword: pathology review

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Clinical-pathologic profile of head and neck rhabdomyosarcoma in children: a systematic review

  • Ludimila Lemes Moura;Beatriz Della Terra Mouco Garrido;Nelson Leonel Del Hierro Polanco;Mattheus Augusto Siscotto Tobias;Viviane da Silva Siqueira;Cassia Maria Fischer Rubira;Paulo Sergio da Silva Santos
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.49 no.2
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    • pp.61-67
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    • 2023
  • This systematic review aimed to analyze the clinicopathological profile and relevant prognostic factors of head and neck rhabdomyosarcoma in pediatric patients. The search was carried out in the electronic search portals PubMed, Lilacs, Embase, Scopus, and Web of Science. The search yielded studies that were then analyzed regarding study topic, data extraction, and risk of bias using the STROBE (Strengthening the Reporting of Observational Studies) guidelines. Finally, three studies were included for qualitative analysis. Most of the cases involved embryonic and alveolar rhabdomyosarcoma. Expression of MYOD1 was highly correlated with diagnosis of spindle cell/sclerosing rhabdomyosarcoma, which appears to have a poor prognosis in children. Furthermore, tumor size <5 cm and absence of metastasis accompanied by complete resection and administration of adjuvant therapies such as chemotherapy and radiotherapy favored a better prognosis.

The evaluation of methodological quality of meta-analysis studies in speech language pathology using AMSTAR (AMSTAR에 기반한 국내 언어치료 분야 메타분석 논문의 방법론적 질평가)

  • Han, Minju;Byeon, Haewon
    • Journal of the Korea Convergence Society
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    • v.11 no.2
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    • pp.161-165
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    • 2020
  • Although research using meta-analysis is increasing in the field of rehabilitation science, not all meta-analytical papers are of the same quality. In particular, although meta-analysis is a research method with the highest level of evidence, it may be possible to derive distorted conclusions or alternatives by simply integrating representative values without considering heterogeneity among individual studies. This study analyzed the current status of meta-analysis papers on the subject of language arbitration published in Korea from January 2010 to June 2019, and used A Measurement Tool to Assess the Methodological Quality of Systematic Review (AMSTAR). As a result of evaluating the methodological quality of the final five papers, the average of 7.4 points out of 11 points was found above average. In order to raise the qualitative level of Meta-analysis in speech-language pathology in the future, it is necessary to include verification of publication bias and specification of conflicts of interest.

Fine Needle Aspiration Cytology of Acinic Cell Carcinoma of the Parotid Gland - A Case Report - (이하선의 선방세포암종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Jeon, Seok-Hoon;Paik, Seung-Sam;Lee, Won-Mi;Park, Moon-Hyang;Lee, Jung-Dal
    • The Korean Journal of Cytopathology
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    • v.7 no.2
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    • pp.225-229
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    • 1996
  • We experienced a case of well-differentiated acinic cell carcinoma of the parotid gland in a 65 year-old woman, which was correctly diagnosed preoperatively by fine needle aspiration(FNA) cytology. FNA cytology smears showed clusters or sheets of monomorphic acinic cells having reticulated or finely vacuolated basophilic or acidophilic cytoplasm. The cellular population was homogeneous or slightly polymorphic, having centrally located, round nuclei with finely reticular chromatin and inconspicuous nucleoli. Herein we report this case with its histologic features and review of literatures.

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Regulation of Pathogenesis by Light in Cercospora zeae-maydis: An Updated Perspective

  • Kim, Hun;Ridenour, John B.;Dunkle, Larry D.;Bluhm, Burton H.
    • The Plant Pathology Journal
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    • v.27 no.2
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    • pp.103-109
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    • 2011
  • The fungal genus Cercospora is one of the most ubiquitous groups of plant pathogenic fungi, and gray leaf spot caused by C. zeae-maydis is one of the most widespread and damaging foliar diseases of maize in the world. While light has been implicated as a critical environmental regulator of pathogenesis in C. zeae-maydis, the relationship between light and the development of disease is not fully understood. Recent discoveries have provided new insights into how light influences pathogenesis and morphogenesis in C. zeae-maydis, particularly at the molecular level. This review is focused on integrating old and new information to provide an updated perspective of how light influences pathogenesis, and provides a working model to explain some of the underlying molecular mechanisms. Ultimately, a thorough molecular-level understanding of how light regulates pathogenesis will augment efforts to manage gray leaf spot by improving host resistance and disease management strategies.

Study on Cost-effectiveness Evaluation of Treatment of Korean Medicine after Rotator Cuff Surgery: A Scoping Review (회전근개 수술 후 한의 치료에 대한 비용효과성 평가 연구 : A Scoping Review)

  • Gong, Na-Gyeong;Kim, Nam-Kwen;Kim, Hyun-Min;Lee, Hye-Yoon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.36 no.2
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    • pp.48-53
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    • 2022
  • This scoping review was conducted to identify the trends of cost-effectiveness studies on treatment of Korean medicine after rotator cuff surgery and indicators used in those studies. In researching stage, "patients after rotator cuff surgery", "cost-effectiveness evaluation" and "treatment of Korean medicine" were set as the keywords in "Pubmed", "Google scholar" and Korean databases (RISS, OASIS, KCI). There were no studies containing all three keywords, and after searching separately for "cost-effectiveness evaluation" and "treatment of Korean medicine", each 7 studies were reviewed. The indicators used in the study were identified such as study design, characteristics of subjects, outcome measurement and others. This study identified the need for cost-effectiveness evaluation on the treatment of Korean medicine after rotator cuff surgery. We expect that those indicators will be used to implement other studies afterwards.

Mission and Operation of Institutional Review Board (임상시험심사위원회의 임무와 운영)

  • Kim, Yong-Jin
    • Journal of Yeungnam Medical Science
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    • v.30 no.2
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    • pp.73-78
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    • 2013
  • An institutional review board (IRB) should independently safeguard the right, safety, and well-being of all clinical trial subjects. It should consist of members who are qualified and experienced to review and evaluate the science, medical aspects, and ethics of the proposed trial. They have to pursue continuing efforts to improve the standards of review. The levels of review include the full board review, expedited review, continuing review, or exempt from review, while the levels of decision-making include approval, conditional approval, deferred approval, and disapproval. Investigators must follow the approved protocols and regulations honestly, and it is the IRB's mission to audit clinical trial sites as well.

Cytologic Features of Glassy Cell Carcinoma of the Uterine Cervix - Three Cases Report - (자궁 경부의 유리질 세포 암종의 세포학적 소견 - 3예 보고 -)

  • Jeon, Seok-Hoon;Paik, Seung-Sam;Lee, Won-Mi;Jang, Se-Jin;Park, Yong-Wook;Park, Moon-Hyang;Lee, Jung-Dal
    • The Korean Journal of Cytopathology
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    • v.7 no.2
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    • pp.197-201
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    • 1996
  • Glassy cell carcinoma is an unusual neoplasm of the uterine cervix that accounts for $1{\sim}2%$ of all cervical malignancy. It is a rapidly progressive and biologically aggressive disease with poor response to therapy. This tumor is considered to be a poorly differentiated mixed adenosquamous carcinoma. The cytologic findings are characterized by tumor cells arranged predominantly in syncytial like aggregates and an inflammatory background. The tumor cells have moderate amounts of eosinophilic or amphophilic cytoplasm, which is often finely granular. The nuclei are relatively large and have fine chromatin with prominent eosinophilic nucleoli. Cytologically, glassy cell carcinoma is most likely to be confused with large cell nonkeratinizing squamous cell carcinoma and with atypical reparative cells. Herein, we report three cases of glassy cell carcinoma of the uterine cervix diagnosed by cervicovaginal smear and confirmed by histologic section with review of literatures.

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Cytologic Features of Pseudoangiomatous Stromal Hyperplasia of the Breast - A Case Report with Review of Literature - (유방의 거짓혈관종모양 버팀질증식의 세포소견 - 1예 보고 -)

  • Lee, Jin-Sook;Shin, Dong-Hoon;Park, Do-Youn;Choi, Kyuug-Un;Lee, Chang-Hoon;Sol, Mee-Young;Kim, Jee-Yeon
    • The Korean Journal of Cytopathology
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    • v.16 no.1
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    • pp.25-30
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    • 2005
  • Pseudoangiomatous stromal hyperplasia (PASH) was initially described by Vuitch et al. as a benign breast lesion, consisting of mammary stromal proliferations which simulate vascular lesions, and which might be mistaken for a low-grade angiosarcoma. This condition occasionally presents as a palpable mass in postmenopausal women, but is more frequently encountered as an incidental component in premenopausal women. Clinical, radiological, and fine-needle aspiration (FNA) findings associated with this condition can mimic those observed in conjunction with a phyllodes tumor or a fibroadenoma. The cytological features of PASH are generally nonspecific, and its diagnosis by FNA cytology is fairly difficult. In this study, we report a case on PASH, manifesting as a palpable mass.

Fine Needle Aspiration Cytologic Features of Follicular Lymphoma (여포성 림프종의 세침흡인 세포학적 소견)

  • Chung, Jin-Haeug;Ha, Hwa-Jeong;Park, Sun-Hoo;Koh, Jae-Soo;Kim, Min-Suk;Lee, Seung-Sook;Cho, Kyung-Ja
    • The Korean Journal of Cytopathology
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    • v.13 no.2
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    • pp.60-65
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    • 2002
  • The accuracy of fine needle aspiration cytology (FNAC) for the diagnosis of follicular lymphoma was investigated by a review of 13 FNAC specimens from 10 patients. All patients Included in this study were confirmed by surgical biopsy preceded by FNAC. Three aspirates were unsatisfactory because of scanty cellularity. Among the remaining 10 cases, 5(50%) were diagnosed as lymphoma, 3(30%) as reactive hyperplasia, one (10%) as metastatic small cell carcinoma, and one (10%) as granulomatous inflammation. Cytologic distinction between follicular lymphoma and reactive hyperplasia is very difficult with cytomorphology alone. Compared to reactive hyperplasia, the characteristic cytologic features such as relatively homogeneous cellular constituent, paucity of tingible body macrophages and lymphohistiocytic aggregates, and less mitotic activity in follicular lymphoma are important findings to prevent false negative diagnosis. In addition, lymphoglandular bodies are useful in distinguishing malignant epithelial tumor from lymphoid lesion.