Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Clinical-pathologic profile of head and neck rhabdomyosarcoma in children: a systematic review

  • Ludimila Lemes Moura (Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo) ;
  • Beatriz Della Terra Mouco Garrido (Department of Pediatric Dentistry, Orthodontics, and Public Health, Bauru School of Dentistry, University of Sao Paulo) ;
  • Nelson Leonel Del Hierro Polanco (Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo) ;
  • Mattheus Augusto Siscotto Tobias (Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo) ;
  • Viviane da Silva Siqueira (Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo) ;
  • Cassia Maria Fischer Rubira (Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo) ;
  • Paulo Sergio da Silva Santos (Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo)
  • Received : 2022.09.28
  • Accepted : 2022.11.15
  • Published : 2023.04.30
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Abstract

This systematic review aimed to analyze the clinicopathological profile and relevant prognostic factors of head and neck rhabdomyosarcoma in pediatric patients. The search was carried out in the electronic search portals PubMed, Lilacs, Embase, Scopus, and Web of Science. The search yielded studies that were then analyzed regarding study topic, data extraction, and risk of bias using the STROBE (Strengthening the Reporting of Observational Studies) guidelines. Finally, three studies were included for qualitative analysis. Most of the cases involved embryonic and alveolar rhabdomyosarcoma. Expression of MYOD1 was highly correlated with diagnosis of spindle cell/sclerosing rhabdomyosarcoma, which appears to have a poor prognosis in children. Furthermore, tumor size <5 cm and absence of metastasis accompanied by complete resection and administration of adjuvant therapies such as chemotherapy and radiotherapy favored a better prognosis.

Keywords

Acknowledgement

This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) - Finance Code 001.

References

  1. Zhang Y, Zhang WL, Huang DS, Wang YZ, Hu HM, Mei YY, et al. Prognostic factors in children with head and neck rhabdomyosarcoma: a 12-year retrospective study. Brain Behav 2020;10:e01697. https://doi.org/10.1002/brb3.1697 
  2. Zhang WL, Zhang Y, Huang DS, Guo F, Han T, Hong L, Hu HM, Zhi T. Clinical character of pediatric head and neck rhabdomysarcomas: a 7-year retrospective study. Asian Pac J Cancer Prev. 2013;14(7):4089-93. https://doi.org/10.7314/apjcp.2013.14.7.4089 
  3. Yasui N, Yoshida A, Kawamoto H, Yonemori K, Hosono A, Kawai A. Clinicopathologic analysis of spindle cell/sclerosing rhabdomyosarcoma. Pediatr Blood Cancer 2015;62:1011-6. https://doi.org/10.1002/pbc.25367 
  4. Rekhi B, Gupta C, Chinnaswamy G, Qureshi S, Vora T, Khanna N, et al. Clinicopathologic features of 300 rhabdomyosarcomas with emphasis upon differential expression of skeletal muscle specific markers in the various subtypes: a single institutional experience. Ann Diagn Pathol 2018;36:50-60. https://doi.org/10.1016/j.anndiagpath.2018.07.002 
  5. Zhu J, Zhang J, Tang G, Hu S, Zhou G, Liu Y, et al. Computed tomography and magnetic resonance imaging observations of rhabdomyosarcoma in the head and neck. Oncol Lett 2014;8:155-60. https://doi.org/10.3892/ol.2014.2094 
  6. Schmidt D, Reimann O, Treuner J, Harms D. Cellular differentiation and prognosis in embryonal rhabdomyosarcoma. A report from the Cooperative Soft Tissue Sarcoma Study 1981 (CWS 81). Virchows Arch A Pathol Anat Histopathol 1986;409:183-94. https://doi.org/10.1007/bf00708327 
  7. Healy GB, Jaffe N, Cassady JR. Rhabdomyosarcoma of the head and neck: diagnosis and management. Head Neck Surg 1979;1:334-9. https://doi.org/10.1002/hed.2890010406 
  8. Feldman BA. Rhabdomyosarcoma of the head and neck. Laryngoscope 1982;92:424-40. https://doi.org/10.1288/00005537-198204000-00013 
  9. Lyos AT, Goepfert H, Luna MA, Jaffe N, Malpica A. Soft tissue sarcoma of the head and neck in children and adolescents. Cancer 1996;77:193-200. https://doi.org/10.1002/(sici)1097-0142(19960101)77:1%3C193::aid-cncr31%3E3.0.co;2-z 
  10. Meza JL, Anderson J, Pappo AS, Meyer WH; Children's Oncology Group. Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: the Children's Oncology Group. J Clin Oncol 2006;24:3844-51. https://doi.org/10.1200/jco.2005.05.3801 
  11. Dillon P, Maurer H, Jenkins J, Krummel T, Parham D, Webber B, et al. A prospective study of nonrhabdomyosarcoma soft tissue sarcomas in the pediatric age group. J Pediatr Surg 1992;27:241-4; discussion 244-5. https://doi.org/10.1016/0022-3468(92)90320-7 
  12. Radzikowska J, Kukwa W, Kukwa A, Czarnecka AM, Kawecki M, Lian F, et al. Management of pediatric head and neck rhabdomyosarcoma: a case-series of 36 patients. Oncol Lett 2016;12:3555-62. https://doi.org/10.3892/ol.2016.5072 
  13. Haussler SM, Stromberger C, Olze H, Seifert G, Knopke S, Bottcher A. Head and neck rhabdomyosarcoma in children: a 20-year retrospective study at a tertiary referral center. J Cancer Res Clin Oncol 2018;144:371-9. https://doi.org/10.1007/s00432-017-2544-x 
  14. Agaram NP, Chen CL, Zhang L, LaQuaglia MP, Wexler L, Antonescu CR. Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis. Genes Chromosomes Cancer 2014;53:779-87. https://doi.org/10.1002/gcc.22187 
  15. Agaram NP, LaQuaglia MP, Alaggio R, Zhang L, Fujisawa Y, Ladanyi M, et al. MYOD1-mutant spindle cell and sclerosing rhabdomyosarcoma: an aggressive subtype irrespective of age. A reappraisal for molecular classification and risk stratification. Mod Pathol 2019;32:27-36. https://doi.org/10.1038/s41379-018-0120-9 
  16. Badr MA, Al-Tonbary YA, Mansour AK, Hassan TH, Beshir MR, Darwish A, et al. Epidemiological characteristics and survival studies of rhabdomyosarcoma in East Egypt: a five-year multicenter study. ISRN Oncol 2012;2012:674523. https://doi.org/10.5402/2012/674523