• Asian-Australasian Journal of Animal Sciences
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• v.19 no.12
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• pp.1702-1705
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• 2006

A simulation study was conducted to evaluate a fine-mapping method exploiting population-wide linkage disequilibrium. Data were simulated according to the pedigree structure based on a large paternal half-sib family population with a total of 1,034 or 2,068 progeny. Twenty autosomes of 100 cM were generated with 5 cM or 1 cM marker intervals for all founder individuals in the pedigree, and marker alleles and a number of quantitative trait loci (QTL) explaining a total of 70% phenotypic variance were generated and randomly assigned across the whole chromosomes, assuming linkage equilibrium between the markers. The founder chromosomes were then descended through the pedigree to the current offspring generation, including recombinants that were generated by recombination between adjacent markers. Power to detect QTL was high for the QTL with at least moderate size, which was more pronounced with larger sample size and denser marker map. However, sample size contributed much more significantly to power to detect QTL than map density to the precise estimate of QTL position. No QTL was detected on the test chromosomes in which QTL was not assigned, which did not allow detection of false positive QTL. For the multiple QTL that were closely located, the estimates of the QTL positions were biased, except when the QTL were located on the right marker positions. Our fine mapping simulation results indicate that construction of dense maps and large sample size is needed to increase power to detect QTL and mapping precision for QTL position.

• Human Ecology Research
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• v.56 no.2
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• pp.123-131
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• 2018

This study investigated associations between attachment and friendship. This study also examined the mediating effects of empathy on the association between two variables. Participants consisted of $4^{th}$ to $6^{th}$ grade elementary school children including 173 boys and 141 girls. Two elementary schools were located in Seoul and Bucheon. Children participated in a peer nomination interview. They nominated their three most liked peers. Children's responses to the best friend of the peer nomination identified the children's best friends. A Friendship Quality Scale measured children's positive friendship quality and friendship satisfaction. Children completed the Inventory of the Parent and Peer Attachment Scale that assessed maternal and paternal attachment. In addition, they completed a children's version of the Empathy Quotient that measured empathy. Pearson's correlation and Structural Equation Modeling were used to analyse the data. The results indicated that attachment had a direct influence on friendship network. Children who had the high levels of attachment security had large friendship network. However, attachment did not have a significant effect on friendship quality. Moreover, empathy had mediating effects on the association between attachment and friendship quality as well as the friendship network. The results of this research highlight the importance of attachment and empathy on children's friendship.

• Korean Journal of Child Studies
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• v.15 no.1
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• pp.187-203
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• 1994

This study investigated the relation of androgynous parent's child-rearing practices to children's self-perceived competence by comparison of the effectiveness of androgynous people as parents compared with parents who are other-typed in their sex-role identity. The subjects were 362 third and sixth grade children and their parents selected from two elementary schools in Seoul. The instruments were a children's self-perceived competence scale, a perception of maternal warmth and control scale, a perception of paternal warmth and control scale, parent's self-esteem scale, and parent's sex-role identity scale. Frequencies, percentiles, mean, ${\chi}^2$ test, two way-ANOVA, one way-ANOVA, Cronbach's ${\alpha}$ and $Scheff{\acute{e}}$-test were used for data-analysis. The major findings showed that (1) Androgynous and masculine fathers had higher self-esteem than feminine or undifferentiated fathers. Androgynous, masculine, and feminine mothers had higher self-esteem than undifferentiated mothers. (2) There was no difference in children's perception of parental warmth and control as related to parent's sex-role identity. Androgynyous parents were not more likely to be authoritative parents. (3) Sons of androgynous parents had higher self-perceived competence than those of sex-typed parents, while daughters of sex-typed parents had higher self-perceived competence than those of androgynous parents.

• Molecules and Cells
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• v.20 no.3
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• pp.423-428
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• 2005

Immediately after fertilization, a chromatin remodeling process in the oocyte cytoplasm extracts protamine molecules from the sperm-derived DNA and loads histones onto it. We examined how the histone H3-lysine 9 methylation system is established on the remodeled sperm chromatin in mice. We found that the paternal pronucleus was not stained for dimethylated H3-K9 (H3-$m_2K9$) during pronucleus development, while the maternal genome stained intensively. Such H3-$m_2K9$ asymmetry between the parental pronuclei was independent of $HP1{\beta}$ localization and, much like DNA methylation, was preserved to the two-cell stage when the nucleus appeared to be compartmentalized for H3-$m_2K9$. A conspicuous increase in H3-$m_2K9$ level was observed at the four-cell stage, and then the level was maintained without a visible change up to the blastocyst stage. The behavior of H3-$m_2K9$ was very similar, but not identical, to that of 5-methylcytosine during preimplantation development, suggesting that there is some connection between methylation of histone and of DNA in early mouse development.

• Journal of Genetic Medicine
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• v.15 no.1
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• pp.34-37
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• 2018

A 1q21.1 microdeletion is an extremely rare chromosomal abnormality that results in phenotypic diversity and incomplete penetrance. Patients with a 1q21.1 microdeletion exhibit neurological-psychiatric problems, microcephaly, epilepsy, facial dysmorphism, cataract, and thrombocytopenia absent radius syndrome. We reported a neonate with confirmed intrauterine growth restriction (IUGR), micrognathia, glossoptosis, upper airway obstruction, facial dysmorphism, and eye abnormality at birth as well as developmental delay at the age of 1 year. These clinical manifestations, except for the IUGR and upper airway obstruction, in the neonate indicated a 1q21.1 microdeletion. Here, we report a rare case of a 1q21.1 microdeletion obtained via paternal inheritance in a newborn with upper airway obstruction caused by glossoptosis and tracheal stenosis.

• Fisheries and Aquatic Sciences
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• v.9 no.1
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• pp.44-47
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• 2006

Morphometric characteristics of female red sea bream, Pagrus major (Temminck et Schlegel) and male black sea bream, Acanthopagrus schlegelii (Bleeker) hybrids is described. From the result of our study, the morphometric characters of hybrid may be 7 paternal-like, 2 maternal-like or even out of the range of parental species. The pigmentation of the hybrid is intermediate in some respects and resembles that of the parental species in others. This study of characterization in morphometric traits of the hybrids, red sea bream and black sea bream may be useful for distinguish of each genotype in commercial sea bream aquaculture.

• Korean Journal of Child Studies
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• v.33 no.3
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• pp.45-62
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• 2012

The purpose of this study is to examine the ways in international married couples perceive the lives of their spouses as well as their own, and the ways in which they perceive their relationships with their children. In addition, the study attempts to explore the implicit meanings at work in the lives of international married families. The participants in this study were eight international married couples from rural areas and the data were gathered by means of semi-structured interviews. According to the findings, international married couples perceived their relationships with their children in terms of individual-specific maternal roles versus the Korean culturally-specific paternal roles. Secondly, in terms of their spouse' life, husbands relied more on their wives and had high expectations of them. On the other hand, wives had the tendency to pay more attention and place more hope on their children rather than their husbands. Lastly, regarding their own lives, the findings revealed that wives tended to maintain the hope and desire for a better life, whereas the husbands were unable to adapted to their reality and tended to look back on the past. In addition, the limitations of this study and suggestions for future studies were also discussed.

• Korean Journal of Child Studies
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• v.35 no.2
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• pp.63-84
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• 2014

The purpose of this study was to explore the effects of parental differential treatment and social support perceived by adolescents with siblings with special needs on their self-esteem and internalized problems. The subjects comprised one hundred 12- to 18-year-old adolescents with siblings with special needs. The major results of this study were as follows. First, there were significant differences in adolescents' self-esteem by participation in support programs for siblings of children with special needs. Second, there was no significant effect of parental differential treatment on adolescents' self-esteem. Third, there was a significant effect of social support (family, friends, and teachers) on adolescents' self-esteem. Fourth, there was no effects of paternal differential parenting on adolescents' internalized problems. However, there was a significant effect of differential maternal affection on adolescents' internalized problems. Fifth, there was a significant effect of social support, especially in terms of support provided by friends, on adolescents' internalized problems. In conclusion, social support and differential maternal affection both have an important role in adolescents' self-esteem and internalized problems.

• Journal of Korean Biological Nursing Science
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• v.10 no.1
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• pp.53-61
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• 2008

Purpose: This study was conducted to estimate the prevalence of asthma and its risk factors in childhood asthma. Method: Random samples of 10,236 were selected from 43 kindergarten (1,418) and 57 elementary (8,718) in K city between september and November (2007). 1,079 (kindergarten children) and 7,271 (elementary children) were in the final analysis. The Korean-translated modified version of the questionnaire for the International Study of Asthma and Allergies in Childhood was used in this cross-sectional survey. Parents were surveyed to answer for the questionnaire. Result: The lifetime and 12-month prevalence of wheezing were 11.50%; 11.06% in kindergarten children and 19.24%; 4.80% in elementary children. The lifetime prevalence of asthma diagnosis and the 12-month prevalence of asthma treatment were 11.59%; 4.43% in kindergarten children and 4.43%; 10.78% in elementary children. The 12-month prevalence of night cough and exercise-induced wheezing were 12.90%; 3.33% in kindergarten children and 20.72%; 4.74% in elementary children. Risk factors analysis showed that age, paternal and maternal asthma, allergic disease, carpet use, monthly income, indoor environment were associated with a higher risk of asthma. Conclusion: The study suggests that prevalence of asthma has increased among the community children. These data have been used to manage a possible role of risk factors as predictors of childhood asthma.

• Journal of Korean Academy of Nursing
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• v.40 no.4
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• pp.571-579
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• 2010

Purpose: The purpose of this study was to explore the effects of a taegyo program on parents-fetal attachment and parenthood in first pregnancy couples (mothers and spouses). Methods: The research design was a nonequivalent control group pretest-posttest experiment. Study participants were 52 first pregnancy couples visiting two medium-scale obstetrics and gynecology clinics located in Gwangju. A total of 52 couples were assigned to the experimental group (25 couples) and the control group (27 couples). The experimental couples were provided with a taegyo program for 4 weeks. Data were analyzed by chi square test, t-test, and ANCOVA using the SPSS program. Results: Post-treatment maternal- fetal attachment, paternal-fetal attachment and motherhood significantly increased in the experimental group as compared to the control group, but post-treatment fatherhood, anxiety, blood pressure and pulse of participants in the experimental group showed no significant difference from those in the control group. Conclusion: From these results, it is suggested that the taegyo program has beneficial effects in enhancing parent-fetal attachment and motherhood in first pregnancy couples. Therefore, a taegyo program can be recommended as a nursing intervention program for first pregnancy couples.