• Journal of The Korean Society of Clinical Toxicology
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• v.11 no.1
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• pp.49-52
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• 2013

Fentanyl, a synthetic, highly selective opioid ${\mu}$-receptor agonist, is 50 to 100 times more potent than morphine. The low molecular weight, high potency, great transdermal permeation rate and lipid solubility of fentanyl make it very suitable for transdermal administration. Durogesic is a novel matrix transdermal system providing continuous systemic delivery of fentanyl. In recently, there are many reports that misused or overused fentanyl transdermal patches result in severe intoxication of fentanyl. We present a case of fentanyl toxicity with misused durogesic transdermal patch and discuss the safe and appropriate application of the patches. In conclusion, fentanyl patches should be used in opioid tolerant patients and prescribed at the lowest possible dose and titrated upward as needed. All patients and their caregivers should be educated safe application of fentanyl patches and advised to avoid exposing the patches application site to direct external heat sources, such as heating pads, or electric blankets, heat lamps, sauna, hot tubs, and others. In addition, concomittant medications that affect fentanyl's metabolism should be avoided.

• Korean Journal of Organic Agriculture
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• v.30 no.1
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• pp.89-101
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• 2022

This study was conducted to examine decay incidence of citrus fruit treated with antifungal patches during short-term storage using 10 kg paper boxes at room temperature. It was investigated for 15 days in 'Iwasaki' and for 30 days in 'Miyagawa' treated with 200 mg/kg and 500 mg/kg patches of hexanal, carvacrol, and cinnamaldehyde alone or mixed. When it was treated with 200 mg/kg in 'Iwasaki, The decay rate of fruit was at 1.0% in carvacrol alone. In 'Miyagawa', The decay rate of fruit showed lower at cinnamaldehyde and hexanal+cinnamaldehyde mixture of 500 mg/kg than others. And also hexanal+cinnamaldehyde mixture of 200 mg/kg was twice lower than others. In conclusion, the mixed antifungal patches was more effective in reducing citrus fruit decay in citrus fruits than alone at room temperature.

• Journal of Korean Society of Forest Science
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• v.89 no.5
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• pp.645-654
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• 2000

The aim of this study was to described the genetic structure of Eleutherococcus senticosus in Korea. We investigated 10 patches, which are eight Korean patches and two foreign patches come from Russia and China growing at Korean habitat, using ISSR(inter-simple sequence repeats) markers. In ISSR PCR, the overall percentage of polymorphic ISSR amplicons was 76% and the mean number of amplicons per ISSR primer was 11.5, which were higher than the RAPD results for the some cultivars collected in Korea(Kim et al., 1998) ; 57% and 5.7, respectively. So ISSR markers provide more powerful tool than RAPD markers for the investigation of genetic variation in E. senticosus. There are relatively high genetic variation among patches as 62.8%, but low variation within eight Korean patches. Such pattern of genetic variation, which is not ordinary in other tree species, may be result from the narrow and limited habitats and the asexual reproduction of this species at the natural stands in Korea. Although the small sample size in this study seemed to be resulted in the high genetic variation among patches, the overall genetic interpretation of this study might not be much affected on the basis of the characteristics of the distribution and the reproduction system of E. senticosus. Analysis of genetic distance between all pairs of the patches did not reveal any trends with regard to geographic distance, which was confirmed by the results obtained from AMOVA(analysis of molecular variance) and PCA(principal component analysis). These results suggest that, in addition to the preservation of the natural stands, the conservation of larger number of patches with small number of individuals per patch is more effective for the ex situ conservation and for maintaining the genetic diversity of E. senticosus in Korea than smaller patches with large number of individuals.

• ETRI Journal
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• v.31 no.5
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• pp.554-564
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• 2009

In information security and network management, attacks based on vulnerabilities have grown in importance. Malicious attackers break into hosts using a variety of techniques. The most common method is to exploit known vulnerabilities. Although patches have long been available for vulnerabilities, system administrators have generally been reluctant to patch their hosts immediately because they perceive the patches to be annoying and complex. To solve these problems, we propose a security vulnerability evaluation and patch framework called PKG-VUL, which evaluates the software installed on hosts to decide whether the hosts are vulnerable and then applies patches to vulnerable hosts. All these operations are accomplished by the widely used simple network management protocol (SNMP). Therefore, system administrators can easily manage their vulnerable hosts through PKG-VUL included in the SNMP-based network management systems as a module. The evaluation results demonstrate the applicability of PKG-VUL and its performance in terms of devised criteria.

• Biomolecules & Therapeutics
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• v.5 no.3
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• pp.260-264
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• 1997

The bioequivalence of two nicotine patches was evaluated in 16 normal male volunteers (age 21 ~ 27 yrs) following single transdermal application. Test product was "Nicostop patch" made by Sam Yang Co. and reference product was "Nicotinell TTS patch" made by Korean Searle Ciba-Geigy Co. After nicotine patches were applied onto the inside of the forearm, blood was taken at predetermined time intervals and the nicotine concentration in plasma was determined with a sensitive GC method using NPD detector. AUC and Cm\ulcorner were calculated and statistically analyzed for the bioequivalence of the two products. The results showed that the differences in AUC and $C_{msx}$between two products were 5.47% and 2.70%, respectively. The powers (1-$\beta$) for AUC and $C_{max}$. were >90% and 88.76%, respectively. Detectable differences($\Delta$) and confidence intervals were all less than 20%. All of these parameters met the criteria of KFDA for bioequivalence, indicating that "Nicostop patch" is bioequivalent to "Nicotinell TTS patch" . . .

• Structural Engineering and Mechanics
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• v.52 no.6
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• pp.1209-1224
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• 2014

In Current paper, the voltages of patches optimization are carried out for minimizing the power consumption of piezoelectric patches and maximum vertical displacement of symmetrically FML panels using the modified multi-objective Elitist-Artificial Bee Colony (E-ABC) algorithm. The voltages of patches, panel length/width ratios, ply angles, thickness of metal sheets and edge conditions are chosen as design variables. The classical laminated plate theory (CLPT) is considered to model the transient response of the panel, and numerical results are obtained by the finite element method. The performance of the E-ABC is also compared with the PSO algorithm and shows the good efficiency of the E-ABC algorithm. To check the validity, the transient responses of isotropic and orthotropic panels are compared with those available in the literature and show a good agreement.

• Journal of Institute of Control, Robotics and Systems
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• v.15 no.4
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• pp.445-450
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• 2009

This paper presents a new mobile robot localization method for indoor robot navigation. The method uses hexagon distributed color-coded patches on the ceiling and a camera is installed on the robot facing the ceiling to recognize these patches. The proposed "cell-coded map", with the use of only seven different kinds of color-coded landmarks distributed in hexagonal way, helps reduce the complexity of the landmark structure and the error of landmark recognition. This technique is applicable for navigation in an unlimited size of indoor space. The structure of the landmarks and the recognition method are introduced. And 2 rigid rules are also used to ensure the correctness of the recognition. Experimental results prove that the method is useful.

• Smart Structures and Systems
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• v.17 no.5
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• pp.725-742
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• 2016

This paper is focused on stiffness ratio effect and a new method to specify the best pattern of piezoelectric patches placement around a hole in a plate under tension to reduce the stress concentration factor. To investigate the stiffness ratio effect, some different values greater and less than unity are considered. Then a python code is developed by using particle swarm optimization algorithm to specify the best locations of piezoelectric actuators around the hole for each stiffness ratio. The results show that, there is a line called "reference line" for each plate with a hole under tension, which can guide the location of actuator patches in plate to have the maximum stress concentration reduction. The reference line also specifies that actuators should be located horizontally or vertically. This reference line is located at an angle of about 65 degrees from the stress line in plate. Finally two experimental tests for two different locations of the patches with various voltages are carried out for validation of the results.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2002.11a
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• pp.293-296
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• 2002

In this paper, we proposed a beam tilting microstrip patch array antenna for the reception of satellite signals by using low cost copper etched polyester films and foams. The configuration and coupling mechanism of the proposed antenna are similar to the dipole Yagi-Uda antenna. It is composed of 3 layers of polyester films and three layers of foam. In order to prevent unwanted radiation and coupling loss by microstrip feeding networks and parasitic patches, a stacked layer with rectangular slots above the driver patch array is inserted. The 16${\times}$8 element microstrip Patch way antenna is Presented by experimental results. Its beam patterns are affected by many parameters such as sizes of the patches, gap between the patches. characteristics of the substrates, feeding method, etc. Owing to its complexities of various design parameters, both simulation and experiment were performed. The fabricated antenna received DBS signal from KOREASAT 3 by doing nothing but adjusting azimuth direction.

• International Journal of CAD/CAM
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• v.6 no.1
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• pp.149-156
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• 2006

This paper presents a novel approach for constructing a piecewise triangular cubic polynomial surface with $C^1$ continuity around a common corner vertex. A $C^1$ continuity condition between two cubic triangular patches is first derived using mixed directional derivatives. An approach for constructing a surface with $C^1$ continuity around a corner is then developed. Our approach is easy and fast with the virtue of cubic reproduction, local shape controllability, $C^2$ continuous at the corner vertex. Some experimental results are presented to show the applicability and flexibility of the approach.