• 한국임상약학회지
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• 제6권2호
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• pp.24-27
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• 1996

In order to determine whether there was a clinically sufficient amount of drug remaining in used fentanyl patches, quantitative analysis of two different types of patches, each containing 2.5 mg (n=36) and 5 mg (n=20) was performed. After being used for approximately 72 hours by patients with cancer, each patch was put in the plastic bag and stored at $4^{\circ}C$ until analysis. Fentanyl remaining in patches was extracted with 50 ml methanol, diluted with water, and counted twice in a $\gamma-Counter$ (expressed as CPM). Patches that originally contained 2.5 mg and 5 mg of fentanyl were shown to have $0.48{\sim}1.86\;mg\;(mean:\;1.03\;mg,\;41.16\%)\;and\;0.37{\sim}3.95\;mg\;(mean:\;2.37\;mg,\;47.33\%)$ after use, respectively. A wide interpatient variability was observed in the rate of fentanyl release from patches although the application period was standardized to 72 hours. Since a significant amount of drug remained in the discarded patches, it is highly recommended that patients dispose used ones under supervision to prevent abuse or misuse of the narcotic drug.

• 대한임상독성학회지
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• 제5권1호
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• pp.53-56
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• 2007

Nicotine poisoning arising from the use of nicotine patches is rare. However, because nicotine patches are classified as an OTC drug, the risk of misuse or abuse is increasing. Nicotine poisoning using nicotine patches shows an unusual clinical presentation compared to that from oral ingestion of multiple doses of nicotine. We present a case of misused nicotine patches that cause a nicotine poisoning. A thirty-nine year-old healthy man visited the ER with complaints of an intermittent cramping abdominal pain with nausea and vomiting. Upon physical examination, there were no specific findings except increased bowel sounds, and the patient's initial laboratory findings were also unremarkable except for an increased bilirubin level. CT revealed a mild degree of fatty liver. The patient's symptoms did not improve any further with conservative management. During his ED stay, we meticulously took his history again, and we discovered that he had used nicotine patches for three days, six days before admission, and had misused the nicotine patches as NSAID patches. The patient's diagnosis of nicotine poisoning was confirmed by a urine cotinine level ten times the normal value. After a 12-hour stay in the ED, his symptoms disappeared without any specific management.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2003년도 추계학술대회논문집
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• pp.333-337
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• 2003

The use of reactive shearing structural intensity to place small patches of constrained layer damping material in order to achieve the largest reduction in the radiated sound power of Air-conditioner outdoor unit is described. The normal surface velocity of each panel was measured using a laser doppler vibrometer. Experimental results indicated that patches of constrained layer damping material placed over areas of high reactive structural intensity reduced the radiated sound power significantly more than patches of the same area placed over areas of low reactive structural intensity

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.375-377
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• 2003

In this study, we employ the control patches, which have been created in previous photogrammetric projects, serving for the candidates of the control points that are likely to be found in the newly taken photos by utilizing image matching technique. Among others, the successful implementation of the above idea lies in the underlying factors: (1). Predicting the control patches and projecting them onto new photos; (2). Alignment of control patches with respect to the new photos; (3). Generating the equivalent ground elements of control patches versus the new photos for the purpose of correlation; (4). Developing effective matching methods and matching strategy; (5). Refining the exterior orientation parameters. What may show significance in this work comparing to traditional aerial-triangulation chain is that whenever at least three matched control patches succeed in a single photo, it follows that single photo orientation is applicable. The experiments suggest the potential efficiency of automatic control point measurement from control patch database and photo orientation by the proposed workflow.

• 천문학회지
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• 제28권1호
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• pp.89-95
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• 1995

We examined a total of 166 images of $3.5{\mu}m\;H_3^+$ emission in the auroral regions of Jupiter observed with the Protocam on IRTF in 1991 and 1992, and found that 30 images contain a clearly isolated small emission patch in the vicinity of the northern auroral regions. Two different time sequences of the images show the small patches at the dusk limb in the range of System III longitudes from $270^{\circ}\;through\;0^{\circ}\;to\;90^{circ}$. The small patches in one sequence of the images, which were taken at 10 phase between $240^{\circ}\;and\;260^{\circ}$, may be related to the 10 flux tube, similarly suggested by Connerney et al. (1993). However, the small patches in the other sequence are separated from Io as much as $80^{\circ}$ in longitude. The positions of the small patches in both sequences are deviated equatorward from the 10 footprint oval by $5^{\circ}-8^{\circ}$ latitude in the longitudinal range of $270^{\circ}-360^{\circ}$. A significant modification is required in current Jovian magnetic field models near the Jupiter's surface if the small patches are produced at the foot of the 10 flux tube.

• Journal of Pharmaceutical Investigation
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• 제34권3호
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• pp.193-199
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• 2004

The decreasing effect of wrinkle on the pressure sensitive adhesive hydrogel patches containing ulmi cortex extract and sorbitol as the drug for anti-wrinkle were investigated. In this study, hydrogels were prepared by the crosslinking reaction of acrylic polymers and aluminum ions produced by L(+)-tartaric acid hydrolysis of the dihydroxy aluminum aminoacetates. The inhibition concentration of ulmi cortex extract on the collagenase exhibited at 0.01%. Furthermore, the moisturizing effect of hydrogel patches formulated with sorbitol was higher than that without it. In vivo animal test in hairless mouse showed that the ulmi cortex-loaded hydrogel patches had about 31.2% of anti-wrinkle effect compared to blank (before attaching the patches). Human test showed that only 33% of subjects showed the decreasing of wrinkle during 8 weeks. In conclusion, the model pressure sensitive adhesive hydrogel patches in this study would be pharmaceutically applicable for the wrinkle treatment on the facial skin.

• 약학회지
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• 제45권5호
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• pp.506-512
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• 2001

Ketoprofen (KP) was formulated as a transdermal patch using the percutaneous penetration enhancers sorbitan monmmleate(SMO), polyvinylpyrrolidone(PVP). The control patch without penetration enhancers showed a KP flux of 8.9$\pm$0.75$\mu\textrm{g}$/$\textrm{cm}^2$/h The flux was increased in proportion to the concentration of SMO added. Furthermore, lag times were decreased upon addition of SMO. Conversely; the skin flux of KP was decreased in proportion to the concentration of PVP added. Pharmacokinetic parameters including $C_{max}$, $T_{max}$, and AUC were increased when SMO was added. However, $C_{mas}$ significantly decreased by the addition of PVP. $T_{max}$ was not significantly different in 2%, 4%, and 8% PVP patches. Patches containing 4% PVP showed the highest AUC value (19.158$\mu\textrm{g}$.h/ml). We found that the effectiveness of the two percutaneous penetration enhancers for topical KP patches was similar, with the addition of appropriate amounts of HPC modifying both skin flux and lag time of KP in the patches. In conclusion, it is possible to manufacture KP patches exhibiting high AUC, high skin flux, and short lag time using percutaneous penetration enhancers of SMO and PVP.

• 한국토양비료학회지
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• 제42권6호
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• pp.447-453
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• 2009

간척지에서 식생의 분포와 토양 염농도 간의 관계를 분석하기 위하여, 간척 후 교란이 없는 대호 간척지의 식생보전지구에서 본 연구를 수행하였다. 출현 식물 종을 분류하고, 집락 유형별로 토양 염농도를 측정하여 비교하였고, 식생도를 작성하였다. 대호 간척지의 식물 종은 주기적인 침수가 이루어지는 갯벌 및 초기 간척지에 비해 매우 다양하였다. 출현한 식물 집락은 단일 종으로 이루어진 순수 집락과 여러 종의 혼합으로 이루어진 혼생 집락으로 구분되었다. 식물 집락별 출현지의 토양 염농도에 근거할 때 퉁퉁마디, 해홍나물 및 나문재의 단일 집락은 토양 염농도가 31.05 dS/m 정도인 곳에, 이들의 혼생 집락은 42.75 dS/m에 출현하여 내염성이 강하였고, 사데풀, 갯개미취, 새섬매자기 등의 단일집락은 11.73 dS/m 인 곳에, 이들의 혼생집락은 9.43 dS/m 정도인 곳에 출현하여 저염생식물군의 특성을 보였고, 띠, 레드클로버, 억새, 강아지풀 및 잠자리피의 단일집락은 2.42 dS/m 정도인 곳에 분포하여 내염성이 약한 중성식물군의 특성을 보였다. 이와 같이 식물 집락의 분포는 토양 염농도의 영향을 받고 있어, 간척지 토양의 염농도는 식물 집락 분포의 제한요소로 작용함을 보였다. 이 결과는 토양 염농도에 따라 다르게 나타나는 식물 종과 식물 집락의 분포 양상이 간척지 토양의 탈염화 지표로 유용함을 시사하고 있다.

• Animal cells and systems
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• 제5권4호
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• pp.319-325
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• 2001

Transport of colored papers and decomposition of leaf litter of Quercus mongolica, Acer pseudo-sieboldianum, and Kalopanax pictus were investigated on three patches differentiated by aspect and understory in a temperate hardwood forest. Two patches are represented by dwarf bamboo (Patch SS) and herbaceous plants (Patch S), respectively, Iying on a south-west-facing slope. The other patch (Patch N) is located on a northeastfacing slope with herbaceous plants. Colored papers were placed on the patches to understand the pattern of litter movement on the ground. Papers were move dispersed in Patch S than in the other two patches. Some of the colored papers placed in Patch S moved upward. The results suggest that the litter movement is affected by aspect and that the leaf litter is retained by dwarf bamboo in Patch SS. Decay constant of Q. mongolica was significantly (p＜0.05) lower than those of K. pictus and A. pseudo-sieboldianum. Decay rates of Q. mongolica were significantly different between Patches N and S and between Patches SS and S (p＜0.05). On the other hand, decay rates of the other species were not significantly different among the three patches. The results suggest that aspect and understory exert an influence on redistribution and decomposition of leaf litter and that the effects could be different among the plant species.

• 한국환경복원기술학회지
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• 제13권5호
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• pp.135-145
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• 2010

This study was carried out to investigate the current urban forest network and future plan of forest framework using nearest features program where stepping stones within 5km from the core forest were selected in the program. We found several conclusions as follows: First, we found that cities in inland area including Daegu, Dajeon and Gwangju have quite different types of forest network with comparing to the cities nearby coastline including Busan, Incheon and Ulsan. The cities in inland area have large mountain patch around each city. However they have small and lower number of island forests within their urban area. Otherwise, cities nearby coastline have more forest patches than in the cities in inland area, and Busan and Incheon especially have strong forest network using various size of forest patches. Second, Daegu and Daejeon have much smaller forest patches distributed in each urban area. So additional forest patches should be added to have highly strong forest network within urban area. Third, Ulsan and Gwangju have most stepping-stone forests close to the large mountain patches in suburban area, which are not able to connect to the forest patches in the central area of each city So additional forest patches are needed to be added in the central area of each city for reinforcing the effect of stepping stone in the central area. Though there should be an addition approach except for forest size and its isolation to construct the ecological network in an urban area, this indices can be a good method to check an environmental and ecological status in an urban area.