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http://dx.doi.org/10.4333/KPS.2004.34.3.193

Anti-wrinkle Effect of Pressure Sensitive Adhesive Hydrogel Patches Containing Ulmi Cortex Extract  

Lee, Tae-Wan (College of Pharmacy, Chungnam National University)
Kim, Sang-Nyun (LG Household & Healthcare)
Jee, Ung-Kil (College of Pharmacy, Chungnam National University)
Hwang, Sung-Joo (College of Pharmacy, Chungnam National University)
Publication Information
Journal of Pharmaceutical Investigation / v.34, no.3, 2004 , pp. 193-199 More about this Journal
Abstract
The decreasing effect of wrinkle on the pressure sensitive adhesive hydrogel patches containing ulmi cortex extract and sorbitol as the drug for anti-wrinkle were investigated. In this study, hydrogels were prepared by the crosslinking reaction of acrylic polymers and aluminum ions produced by L(+)-tartaric acid hydrolysis of the dihydroxy aluminum aminoacetates. The inhibition concentration of ulmi cortex extract on the collagenase exhibited at 0.01%. Furthermore, the moisturizing effect of hydrogel patches formulated with sorbitol was higher than that without it. In vivo animal test in hairless mouse showed that the ulmi cortex-loaded hydrogel patches had about 31.2% of anti-wrinkle effect compared to blank (before attaching the patches). Human test showed that only 33% of subjects showed the decreasing of wrinkle during 8 weeks. In conclusion, the model pressure sensitive adhesive hydrogel patches in this study would be pharmaceutically applicable for the wrinkle treatment on the facial skin.
Keywords
Hydrogel patch; Ulmi cortex extract; Anti-wrinkle; Collagenase; In vivo test; Moisturizing effect;
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