• 동의생리병리학회지
• /
• 제18권2호
• /
• pp.507-516
• /
• 2004

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the commom disease in public health service. Although a variety of oriental presciptions in study POD(Polygala tenuifolia extracted from dichlorometan) have been traditionally utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet fully elucidated. It has been widely believed that AP peptide divided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that CT105, carboxy terminal 105 aminoacids peptide fragment of APP, may be an important factor causing neurotoxicity in AD. SK-N-SH cells expressed with CT105 exhibited remarkable apoptotic cell damage. Based on morphological observations by phase contrast microscope and NO formation in the culture media, the CT105-induced cell death was significantly inhibited by POD. In addition, AD is one of brain degeneration disease. So We studied on herbal medicine that have a relation of brain degeneration. From old times, In Oriental Medicine, PO water extract has been used for disease in relation to brain degeneration. We were examined by ROS formation, neurite outgrowth assay and DPPH scravage assay. Additionally, we investigated the association between the CT105 and neurite degeneration caused by CT105-induced apoptotic response in neurone cells. We studied on the regeneratory and inhibitory effects of anti-Alzheimer disease in pCT105-induced neuroblastoma cell lines by POD. Findings from our experiments have shown that POD inhibits the synthesis or activities of CT105, which has neurotoxityies and apoptotic activities in cell line. In addition, treatment of POD(>50 ㎍/㎖ for 12 hours) partially prevented CT(105)-induced cytotoxicity in SK-N-SH cell lines, and were inhibited by the treatment with its. POD(>50 ㎍/㎖ for 12 hours) repaired CT105-induced neurite outgrowth when SK-N-SH cell lines was transfected with CT105. As the result of this study, In POD group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuroblastoma cells by CT105 expression is promoted. Decrease of memory induced by injection of scopolamin into rat was also attenuted by POD, based on passive avoidance test. Taken together, POD exhibited inhibition of CT105-induced apoptotic cell death. POD was found to reduce the activity of AchE and induced about the CA1 in rat hippocampus. Base on these findings, POD may be beneficial for the treatment of AD.

• 한국측량학회지
• /
• 제33권5호
• /
• pp.373-383
• /
• 2015

공간정보는 국토의 효율적 관리와 재해·재난·환경·시설물·기업마케팅·문화재 관리 등 사회전반에 걸쳐 활용되고 있으며, 향후 더 많은 수요가 예상되고 있다. 이에 중앙정부, 지방자치단체, 공공기관 등에서는 데이터 품질이 확보된 정확한 정보를 기반으로 국가공간정보시스템(국토교통부 국토정보정책관실에서 관리하는 15개의 공간정보 관련 시스템) 체계를 구축해야하며, 이를 통해 정책결정이나 민원지원에서 공간정보의 활용과 편의를 도모할 수 있다. 그러나, 현재 국가공간정보시스템은 개별 업무처리 위주로 시스템을 구축하고, 분산된 연계 채널로 인해 데이터 중복구축과 품질 저하라는 문제가 발생하여 공간정보의 공개·개방이 소극적으로 이루어지고 있는 상황이다. 본 연구에서는 국가공간정보시스템의 데이터 흐름에 가치사슬 모형을 적용하여 ‘생산·구축’, ‘통합·공유’, ‘응용·융복합’, ‘공개·개방’ 이라는 4단계의 공간정보 데이터 흐름 기준을 도출하였으며, 이를 기반으로 15개의 국가공간정보시스템에 대한 현황분석을 통해 시사점을 도출하고 국가공간정보시스템 개편 추진 방향을 제시하였다. 향후 국가공간 정보시스템의 개편 모델과 순환체계를 통해 최신성·일관성·정확성·연계성이 확보된 공간정보서비스를 제공하여 수요자의 요구를 만족시키고 공공활용 및 민간개방 활성화를 기대한다.

• 한국콘텐츠학회논문지
• /
• 제17권1호
• /
• pp.183-192
• /
• 2017

본 연구는 흡연자와 비흡연자 모두를 위해 담배 연기로 인한 피해를 최소화하고 사용자에게 편안함을 줄 수 있는 흡연 부스를 디자인하기 위함이다. 연구방법으로 첫째, 흡연부스에 대한 의식조사, 둘째 제품 디자인에 대한 선호도조사, 셋째 감성어휘에 의한 흡연부스 감성평가 조사를 하였다. 흡연부스에 대한 의식조사결과, 대부분 모든 사람들이 터미널, 역에 흡연부스가 필요하다고 하였다. 디자인 선호도에 조사결과로 첫째, 외부 흡연자를 위한 디자인부스는 딱딱하고 투박한 이미지 보다는 멀리서도 알기 쉽고 거부감이 들지 않는 형태의 디자인으로 제작되어져야 한다. 둘째, 원색 계열의 색상보다는 화이트와 파스텔 톤의 난색계열 및 밝은 색상을 적용하여 디자인한다. 셋째, 흡연부스이므로 내부 순환 필터 문제가 잘 관리 될 수 있도록 한다. 감성어휘에 의한 감성평가결과 자극물에 대하여 4가지 차원으로 구분하여 인지하고 있었다. 각 인자의 함축 언어로 1인자에 대한 대표 이미지 언어는 '기능적 감정' 2인자의 대표 이미지 언어는 '심리적감정' 3인자의 대표 이미지 언어는 '색상감정' 4인자의 대표 이미지 언어는 '형태감정'으로 정의하였다. 흡연자와 비 흡연자 양쪽 모두를 위해 담배연기로 인한 피해를 최소화 시킬 수 있어야 하며 혼자만의 휴식을 취할 수 있는 사용자 중심의 서비스 디자인이 필요하다.

• 기본간호학회지
• /
• 제4권1호
• /
• pp.43-60
• /
• 1997

This study was to identify the nursing intervention method in finding out the incidence, risk factor, prevention and treatment of bed sore cilents who received regional home care nursing services. The eleven home care nurse practitioners took the survey on 97 patients who received home care nursing service from Seoul City Nurses Association for one month from September 26 to October 26 1996. A modified version of Braden's bed sore assessment tool for bed sore risks and a tool for assessment of bed sore stage and measurement bed sore sizes by Bergstrom, Braden, Laguzza and Holman(1987) were as research tools for this study and a questionnare with 40 questions and 12 items on nursing activities was used to find out the prevention and treatment of bed sores. Also, two open ended questions were used on current approaches and efforts of the treatment being applied to clients. The finding of the study were summarized as following : 1. The rate of bed sore occurrence was 47.4% 2. The areas of bed sore occurrence were hip(28.9%), sacrum(18.6%), great trochanter(14.4%) and the average number of sore spots were 2.26 3. Two groups-one with bed sores and the other without-were studied to determine prediction factors for bed sore risks. Sensory function, humidity, level of activity, mobility, nutrition, skin friction and chapping and body temperature turned out to be statistically significant factors for bed sores. Also the age of clients turned out to be a individual characteristic variable significantly affecting the rate of bed sore occurrences. 4. The education for clients and family on systematic skin assessment and bed sores and practice of active/passive R.O.M. are mainly used as nursing activities for bed sore care. 5. The treatment method varied by stages of bed sores. Sometimes folk remedies like applying the powders of dried elm tree roots to sores were used. Good nutrition, frequent position change and skin care turned to be the most effective means to fast recovery of sores.

• 대한간호학회지
• /
• 제5권1호
• /
• pp.17-30
• /
• 1975

The concept and definition of nursing and her role have been changing in accordance with the socio-cultural factors of the initial society. At present, nursing is conceptualized as a health care profession assisting man to restore, maintain and promote health by providing knowledge, wilt strength and resources through various processes of interaction. Man′s behavior, of individual and group activities for health inclusive, is driven by the initial man′s value orientation. The purpose of this study is to investigate the value orientation regarding health of rural health center milieu in order to give data for; 1. the planning for the delivery of community nursing service, 2. the health education plan at all level of nursing care activities, and 3. the planning of curriculum for nursing education. A hundred opinion leaders among the labor population residing in rural areas (P-group), hundred and six professional nurses at rural health centers (N-group) were indirectly interviewed through questionaries. And ninety five of N-group were interviewed likewise of their perceptions of P-group (NP-group) from July 15, to October 15, 1974. The result is as follows: 1. Maintenance of health is revealed to be the most valued component for man′s happiness in all the three groups. (P-group: 7.30 S. D.=1.31), (N-group :7.84 S. D. =49), and (NP-group : 5.93 S. D. =2.28) 2. The average value score of the maintenance of health revealed significant difference by P〈.001 level between each of the three groups. (Between N-group and P-group : T= -4.07 P and NP ; T=-6.93, N and NP: T=-9.35) 3. Basic health maintenance activities necessary for maintenance and promotion of personal health were moderately valued by all the three groups, P-group ; 3.74 (S. D. =.43) , N-group: 3.52 (S. D. =.34), NP-group: 3.07 (S. D. :.55) Among the 8 categories of basic health maintenance activities, "food intake" was highly valued by P-group (mean value score; 4.00 S. D=.51) , "exercise and rest" and "personal cleanliness" was highly valued by both P-group (4.02, 4.08) and N-group (4.08, 4.22). 4. The mean value score of basic health maintenance activities revealed significant difference by P〈.001 level between each of the three groups (between P-group and N-group: T=-4, 07, N-and NP: T=-6.93, P and NP T=-9.35) 5. Among the 30 questionaries, dynamic activities for health maintenance were more valued in comparison to passive activities in an tile three groups. 6. In N-group, correlation between the value of basic health maintenance activities and the personal health status personal revealed moderate significance. Correlation between the value of basic health maintenance activities and the age revealed low significance. 7. In group, correlation between the value of basic health maintenance activities and; perception of personal health status revealed non significance, between the age and sex revealed low sign affiance, and between the educational status revealed moderate significance. Recommendations are as follows ; 1. The efforts towards alteration of value orientation concerning health in general in community nursing practice de focussed be that of family Planning. 2. In order to prepare professional nurses competent in understanding individual and group, social science and behavioral science be strength ended in planning nursing curriculum. 3. Milieu of nursing experience during nursing education be Planned to begin at simple nursing problem and move towards complex, f. e. home care towards health crisis situation in order to achieve dynamic role mastery.

• 한국사회복지학
• /
• 제54권
• /
• pp.35-64
• /
• 2003

본 연구에서는 우리나라에서 지역기반으로 정신장애인 직업재활서비스를 제공하는 기관을 조합하여 규정하고, 이들간의 연계경험과 연계실태 및 연계에 영향을 미치는 요인을 분석하였다. 연구방법은 질적조사와 양적조사를 병행하여 실시하는 삼각측정방식(triangulation)으로 진행되었다. 근거이론에 바탕을 둔 Strauss & Cobin의 절차에 따라 한 지역을 선정하여 담당자들의 연계경험을 분석하였으며, 설문조사를 통해 122개 기관의 연계실태와 연계시도요인, 연계강좌요인을 분석하였다. 조사결과, 연계경험은 '다른 기관에 관심돌리기', 즉 '협력추구'과정을 도출되었으며, 협력추구유형으로는 '주도형 협조형 권위형 반응형'으로 분류되었다. 연계실태는 전반적으로 Tobin(1986)의 연계긴밀도 5단계에 따라 정신장애인 직업재활수행기관들은 3단계 조정(Coordination)이 필요한 시기로 나타났으며, 정신보건기관과 전통적 재활기관사이에는 '협조(Cooperation)'가 정신보건기관간, 전통적 재활기관간에는'조정'이 더 필요한 것으로 나타났다. '연계시도'와 '연계강좌'에 영향을 미치는 요인에 대한 구성을 개인요인과 조직요인으로 구분하여 로지스틱 회귀분석과 중다귀회귀분석을 실시하였다. 그 결과, 개인의 '정신장애인 이해를 위한 교육연수경청'이 있을 경우, 조직의 '자원의존도'가 높을수록 연계시도를 할 확률이 증가하는 것으로 나타났다. 또한 개인의 '현 근무지 근무기간'이 길수록, '관련기관 사업인지도'가 높을수록, '정신장애인 이해를 위안 교육연수경험'이 있을 경우, 조직에 '직업재활전담인력'이 있을 경우 연계가 강화되는 것으로 분석되었다. 본 연구는 이러한 실증적 분석을 통하여 정신장애인 직업재활수행기관간 연계강화방안을 논의하였다.

• 시큐리티연구
• /
• 제1호
• /
• pp.283-319
• /
• 1997

Our society witnesses the rapid progress in the areas of politics, economy, society and culture in the process of national modernization since 1960s, which in turn as a reverse function gets to contract a societic pathology, totally lowering the security level of citizens' lives owing to various violent crimes like hostage commotions and murders with rifles and deadly weapons. what is the main reason for that? That may be partly because the chief police force concentrates on the current situation resulting in the vacuum of the public peace. However, the main reason is that the police fall short of man-power and equipments even if the whole police power were put to use in preventing and quelling the crimes. That is true not only of Korea but also of the advanced countries like the U.S.A., England and Japan. We realize that these advanced countries have higher level of security in every individual's life and property than Korea because their progress of the private guard systems can fill in a vacuum of the shortage of the police power, Therefore, we should without delay internationalize our private guard systems expecting the widely opening of the guard service markets in the age of Uruguay Round. To do this, we need to change our ideas for fostering the policy of the private guard from passive defense ideas into positive aggressive ones. Our police should urgently set up a plan to pursue the orientation of vision that we should dispatch our private guards overseas before foreign guards rush into our markets. Accordingly it goes without saying that the private guard group should distinguish their services from the public services initiating their own theory and strategy of private guard services and also readjust themselves between the public duties and the private services with the study of minimizing the reverse function of the private guard systems. The history criminal justice has always shown that the criminal system progressed at the initiative of the civil factor in case its demand and supply do not make both ends meet. Nevertheless, in the process the power of the government never weakens, rather it is built up in general. In conclusion, the necessity of the build-up of the private guard services must duly be acknowledged by the police as well as by the business which has its unique sphere within the criminal justice instead of as the suplemtary services of the simple the police power on the long-term basis. The purpose of the private guard services can be largely classified into the two categories; first it means the function to prevent the crimes against the citizens and secondly to enhance the national interest as an increasing mammoth business with a worldly competition capacity. The police has an absolute responsibility that they should protect the modem public in general from feeling the crisis of the personal threat, tension, anxiety and nervousness. In short, if we develop the complete private guard system to guarantee the societic atmosphere for all citizens, keep the public peace, and protect all citizens' lives and properties, we will sure enjoy a beautiful land, a wholesome society and a happy life in goodharmony of law and order.

• 한국콘텐츠학회논문지
• /
• 제11권3호
• /
• pp.230-240
• /
• 2011

갤러리는 미술작품을 소통을 목적으로 생산 공급자인 작가와 중개자인 기획자, 경영자 그리고 수요자인 소장자, 대중의 만남을 이루고 소통의 장을 제공하는 공간으로써의 기능을 제공하고 있다. 이러한 역할을 수행하고 있는 갤러리에 대한 대전지역의 현황을 원도심을 중심으로 한 현황분석과 그들의 기능적 역할을 심층면접 및 3차에 걸친 델파이 방법을 통해 분석하였다. 대전지역의 원도심에서 운영되고 있는 갤러리들은 열악한 환경 속에서도 그들의 사명감과 자부심으로 지역의 젊은 작가와 미술트랜드를 형성해 나가고 있다. 델파이 조사의 결과 갤러리의 역할은 지역작가 발굴과 미술 트렌드와 패러다임에 대한 제공 및 사회적, 문화적 책임을 수행하는 문화공간으로 인식하고 있다. 갤러리 측면에서 작품의 선정요인으로는 작품성, 시장성 및 갤러리와의 조화를 중요한 요인으로 인식하고 있으며, 작가의 측면에서는 갤러리의 전문성, 갤러리의 인지도 및 작품 판매 능력을 중요한 능력으로 인식하고 있다. 따라서 이제 갤러리들도 수동적이고 1차원적인 기능에만 머물 것이 아니라 다양한 문화 체험의 공간으로써, 문화 서비스 공간으로써의 기능을 고려해야 해야 할 것이다.

• 시큐리티연구
• /
• 제32호
• /
• pp.205-225
• /
• 2012

본 연구는 시설보안 운영수준을 평가하여 시설보안 향상방안을 제시하는 것을 목적으로 한다. 연구목적을 위하여 보안업무가 이루어지는 특정시설을 대상으로 설문조사를 실시하였으며, 그 결과는 다음과 같다. 첫째, 보안인력은 시설보안업무의 기본이 되는 중요한 요소인데, 조사대상 시설에 보안인력이 배치되어 있지만 시설의 특성에 맞게 보안인력을 적절히 운영하지 못하는 것으로 나타났다. 둘째, 보안인력의 직무교육 훈련 수준은 비교적 적절한 것으로 나타났는데, 이는 근무교대방식과 시설에 상주하는 임직원에 대한 서비스마인드 수준, 보안인력의 근무의지 수준이 적절하게 나타난 것과 관련이 있는 것으로 볼 수 있다. 셋째, 보안상황실 운영이 잘 이루어지고 있지만 통제구역 설정과 출입자 통제 수준, 물품에 대한 통제 및 검색 수준, 차량통제 수준이 낮게 나타났다. 넷째, 보안업무를 위해 참고할 수 있는 보안업무매뉴얼의 활용수준은 보안계획서의 활용수준과 사고예방 및 대응매뉴얼의 활용 수준보다 높은 것으로 나타났다. 시설보안을 향상시키기 위해 조사결과에서 수준이 낮게 평가된 보안인력 운영과 출입통제, 물품검색, 차량통제 및 주차관리, 화재 및 각종 안전사고에 대비한 조치 등에 관한 내용을 활용도가 높게 나타난 보안업무매뉴얼에 세부적으로 명시하여 수준이 높게 나타난 교육 훈련 수준을 활용할 수 있다.

• 한국산업보건학회지
• /
• 제26권1호
• /
• pp.38-47
• /
• 2016

Objectives: The objective of this study was to determine the exposure levels of forklift operators to diesel engine exhaust(DEE) using black carbon(BC), elemental carbon(EC), and nitrogen dioxide($NO_2$) as indicators. Methods: A total of eight forklift operators in six collection companies were assessed over a period of two months from July to September 2015. BC was measured using a real-time monitor and respirable EC samples were analyzed using the NIOSH method 5040. $NO_2$ samples were collected using a passive badge-type sampler. Results: The geometric mean of BC, EC and $NO_2$ were $3.1-19.1{\mu}g/m^3$, $2.1-23.8{\mu}g/m^3$, and 12.5-166.6 ppb at all companies. When forklifts were operating both outside and inside, BC concentrations increased 2.0-5.6 times. The highest increase was observed when forklifts were operating indoors. The increase in BC concentrations varied by company(company A: 2.0 times, B: 3.2 times, C: 5.6 times, D: 2.1 times, E: 5.1 times, F: 2.6 times). The geometric mean of BC, EC, and $NO_2$ for the forklift operators was $9.6{\mu}g/m^3$, $7.9{\mu}g/m^3$, and 48.9 ppb, respectively. The geometric mean of BC, EC, and $NO_2$ for manufacturing workers was $9.3{\mu}g/m^3$, $0.9{\mu}g/m^3$, and 85.2 ppb, respectively. The mean BC and EC exposure levels for the forklift operators were slightly higher than those for manufacturing workers, but $NO_2$ levels for manufacturing workers were higher than those for the forklift operators(p>0.05). Multiple regression analysis revealed that diesel exhaust emissions standard, forklift weight and forklift manufacturer were the most influential factors in determining worker exposure. Conclusions: In the DEE work environment, workers who perform tasks within the workplace as well as inside forklifts as operators are likely to be exposed to a lack of ventilation. Further study of forklift operators' exposure to DEE indicators should be conducted to include a wider range of occupational and environmental situations, such as collection procedures, seasonal situations, types of fuel used, and number of forklifts.