• Nutrition Research and Practice
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• 제17권2호
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• pp.192-205
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• 2023

BACKGROUND/OBJECTIVES: It is known that the renin-angiotensin system (RAS) in the brain could regulate cognitive functions as well as blood pressure. Inhibition of RAS for the improvement of cognitive function may be a new strategy, but studies so far have mostly reported on the effects of RAS inhibition by drugs, and there is no research on cognitive improvement through RAS inhibition of food ingredients. Therefore, this study investigated the effect of curcumin on blood pressure and cognitive function and its related mechanism in spontaneously hypertensive rat/Izm (SHR/Izm). MATERIALS/METHODS: Six-week-old SHR/Izm rats were divided into 5 groups: control group (CON), scopolamine group (SCO, drug for inducing cognitive deficits), positive control (SCO and tacrine [TAC]), curcumin 100 group (CUR100, SCO + Cur 100 mg/kg), and curcumin 200 group (CUR200, SCO + Cur 200 mg/kg). Changes in blood pressure, RAS, cholinergic system, and cognitive function were compared before and after cognitive impairment. RESULTS: The SCO group showed increased blood pressure and significantly reduced cognitive function based on the y-maze and passive avoidance test. Curcumin treatments significantly improved blood pressure and cognitive function compared with the SCO group. In both the CUR100 and CUR200 groups, the mRNA expressions of angiotensin-converting enzyme (ACE) and angiotensin II receptor type1 (AT1), as well as the concentrations of angiotensin II (Ang II) in brain tissue were significantly decreased. The mRNA expression of the muscarinic acetylcholine receptors (mAChRs) and acetylcholine (ACh) content was significantly increased, compared with the SCO group. CONCLUSIONS: The administration of curcumin improved blood pressure and cognitive function in SCO-induced hypertensive mice, indicating that the cholinergic system was improved by suppressing RAS and AT1 receptor expression and increasing the mAChR expression.

• Nuclear Engineering and Technology
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• 제54권11호
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• pp.4329-4337
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• 2022

Jet impinging device is designed for decay heat removal on horizontal fuel rods in a low temperature heating reactor. An experimental system with a fuel rod simulator is established and experiments are performed to evaluate water film covering capacity, within 0.0287-0.0444 kg/ms mass flow rate, 0-164.1 kW/m² heating flux and 13.8-91.4℃ feeding water temperature. An effective method to obtain the film coverage rate by infrared equipment is proposed. Water film flowing patterns are recoded and the film coverage rates at different circumference angles are measured. It is found the film coverage rate decreases with heating flux during single-phase convection, while increases after onset of nucleate boiling. Besides, film coverage rate is found affected by Marangoni effect and film accelerating effect, and surface wetting is significantly facilitated by bubble behavior. Based on the observed phenomenon and physical mechanism, dry-out depth and initial dry-out rate are proposed to evaluate film covering potential on a heating surface. A model to predict film coverage rate is proposed based on the data. The findings would have reliable guide and important implications for further evaluation and design of decay heat removal system of new reactors, and could be helpful for passive containment cooling research.

• 한국지반공학회논문집
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• 제22권12호
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• pp.45-55
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• 2006

본 논문에서는 우리나라 태안지역에서 총 30회 수행한 암반앵커 현장시험의 결과를 나타내었다. 대상암반은 편마암으로써 풍화가 심한 것부터 신선한 암에 이르기까지 다양하며, 시험앵커의 깊이는 $1{\sim}4m$로 설치하였다. 앵커는 SD4O-D51mm를 사용함으로써 다른 파괴가 일어나기 전에 암반파괴가 먼저 일어나도록 유도하여 암반의 인발지지력을 파악하고자 하였다. 많은 시험에서 파괴는 극한하중까지 이르는 것을 관찰할 수 있었으며, 암반파괴형상은 암반이 들어올려지면서 방사상으로 균열이 발달하는 형상을 나타내었다. 시험결과, 암반앵커의 인발지지력은 암반의 종류, 암질, 앵커의 정착깊이, 앵커텐던의 인장강도 등에 영향을 받는 것으로 나타났다. 본 시험을 통해 암반앵커시스템의 인발지지력을 지배하는 주요파라메터들을 도출하고 이에 대해 논하였다.

• 한국지반공학회논문집
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• 제25권10호
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• pp.5-15
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• 2009

본 논문에서는 옥천 및 창녕지역에서 총 24회 수행한 암반앵커 현장인발시험의 결과를 나타내었다. 시험앵커의 정착깊이는 1~6m로 서로다른 암반내에 설치하였다. 앵커의 대부분은 고강도 이형철근인 SD40-D51mm를 사용함으로써 다른 파괴가 일어나기 전에 암반파괴가 먼저 일어나도록 유도하여 암반의 인발저항력을 파악하고자 하였으며, 일부에서는 SD40-D32mm앵커를 설치하여 앵커의 파괴도 아울러 살펴보았다. 많은 시험에서 파괴는 항복에 이르는 극한하중까지 관찰할 수 있었으며, 암반파괴형상은 암반이 들어올려지면서 방사상으로 균열이 발달하는 형태를 나타내었다. 또한 시멘트그라우트와 텐던사이의 부착강도를 평가하고자 방식쉬이스가 설치된 앵커에 대해 실내실험을 실시하였다. 실험결과 텐던-그라우트 사이의 부착강도는 그라우트 일축압축강도의 18~25%로 나타났으며, 방식쉬이스에 의한 부착력 감소는 무시할 수 있을 정도로 작게 나타났다.

• Structural Engineering and Mechanics
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• 제86권6호
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• pp.739-750
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• 2023

This study examines the two-level behavior of the toggle brace damper within a steel frame having a yielding pipe damper and rotational friction damper. The proposed system has two kinds of fuse for energy dissipation in two stages. In this mechanism, rotational friction damper rather than hinged connection is used in toggle brace system, connected to a pipe damper with a limited gap. In order to create a gap, bolted connection with the slotted hole is used, such that first a specific movement of the rotational friction damper solely is engaged but with an increase in movement, the yielding damper is also involved. The performance of the system is such that at the beginning of loading the rotational friction damper, as the first fuse, absorbs energy and with increasing the input load and further movement of the frame, yielding damper as the second fuse, along with rotational friction damper would dissipate the input energy. The models created by ABAQUS are subjected to cyclic and seismic loading. Considering the results obtained, the flexibility of the hybrid two-level system is more comparable to the conventional toggle brace damper. Moreover, this system sustains longer lateral displacements. The energy dissipation of these two systems is modeled in multi-story frames in SAP2000 software and their performance is analyzed using time-history analysis. According to the results, permanent relocations of the roof in the two-level system, in comparison with toggle brace damper system in 2, 5, and 8-story building frames, in average, decrease by 15, 55, and 37% respectively. This amount in a 5-story building frame under the earthquakes with one-third scale decreases by 64%.

• 한국심리학회지 : 문화 및 사회문제
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• 제9권spc호
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• pp.1-14
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• 2003

이 글은 특집호에 게재된 사고에 있어서 심리학적 의미에 관한 여덟 편의 논문을 안내하기 위하여 쓴 것이다. 우리의 기억을 잠시만 거슬러 가도 수많은 대형참사를 떠올릴 수 있을 정도이고 우리 스스로 우리나라를 사고공화국으로 낙인찍기에 이르렀다. 산업재해, 직업성 요통, 교통사고 등 모든 사고의 원인으로 심리적 요인과 한국의 문화적 특성이 발견되었다. 사고의 원인에 대한 심리적 요인과 문화적 요인을 고려하여 사고에 대한 예방대책을 강구하여야 될 것이다. 사고에 대하여 연구하고 관리하는 일원화된 국가단위의 항구적인 기구와 제도가 필요하다. 심리학자들이 사고의 원인과 예방대책에 대하여 더 많은 관심을 가지고 사고현장에서 깊이 있는 연구를 하여야 할 때이다. 이 글을 마칠 즈음인 2003년 2월 18일 대구 지하철에서 발생한 화재 참사를 계기로 이 땅에서 더 이상 이런 엄청난 사고가 발생하지 않도록 지속적이고도 치밀한 대책을 국가적 차원에서 수립하여 실행하기 바란다.

• 융합보안논문지
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• 제24권2호
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• pp.55-61
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• 2024

IoT 기술 발전으로 스마트 헬스케어나 스마트 의료서비스도 급격히 발전하고 있다. 이 서비스에 필요한 웨어러블 디바이스는 스마트 밴드 등의 형태로 센서, 컨트롤러로 사용되고 있다. 웨어러블 디바이스는 가능한 장시간 사용을 위해 매우 간결한 SW 로직으로 구현할 뿐만 아니라, 편의성 증진을 위해 무선 통신 프로토콜을 사용한다. 그러나 이 웨어러블 디바이스는 경량성을 추구하고 있어, 다른 정보서비스에 사용되는 단말보다 보안에 취약하다. 본 연구에서는 웨어러블 서비스의 기술적인 운영 환경을 분석, 웨어러블 디바이스에 대한 인증 정보 재사용 공격, BIAS 공격, 배터리 소진 공격, 펌웨어 공격을 식별하고, 각 보안 위협의 메커니즘을 분석하고 공격 효과를 조사하였다. 또 본 연구에서는 식별한 보안 위협에 대한 대응 방안을 제시하였다. 웨어러블 서비스를 개발할 때 본 연구에서 제안한 대응 방안을 고려한다면, 더 안전한 서비스를 구축할 수 있을 것으로 기대된다.

• Journal of Trauma and Injury
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• 제19권2호
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• pp.126-134
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• 2006

Purpose: The aim of this study was to determine the kinematical characteristics of the pendular and the translational movements of each cervical vertebra at flexion and extension for understanding the mechanism of injury to the cervical spine. Methods: Twenty volunteers, young men (24~37 years), with clinically and radiographically normal cervical spines were studied. We induced two directional passive movements and then took X-ray pictures. The range of pendular movement could be measured by measuring the variation of the distance between the center point of two contiguous cervical vertebrae, and the range of translational movement could be measured by measuring the variation of the shortest distance between the center point of a vertebra and an imaginary line connecting the center points of two lower contiguous cervical vertebrae. The measurements were done by using a picture archiving and communicating system (PACS). Results: The total length of all cervical vertebrae in the neutral position was, on average, 133.66 mm, but in both flexion and extension, the lengths were widened to 134.83 mm and 134.79 mm, respectively. The directions of both the pendular and the translational movements changed at the $2^{nd}$ cervical vertebra, and the ranges of both movements were significantly larger from the $5^{th}$ cervical vertebra to the $7^{th}$ cervical vertebra for flexion and combined flexion and extension motion (p<0.05). Conclusion: The kinematical characteristics for flexion and extension motions were variable at each level of cervical vertebrae. The $1^{st}$ and the $2^{nd}$ cervical vertebrae and from the $5^{th}$ to the $7^{th}$ cervical vertebrae were the main areas of cervical spinal injury. This shows, according to "Hook's law," that the tissues supporting this area could be weak, and that this area is sensitive to injury.

• Advances in Traditional Medicine
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• 제9권2호
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• pp.115-127
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• 2009

Samsoeum (SSE) is used in traditional oriental medicine for various medicinal purposes. However, the exact mechanism that accounts for the anti-allergy and anti-inflammatory effects of the SSE is still not fully understood. The aim of the present study is to elucidate whether and how SSE modulates the allergic reactions in vivo, and inflammatory reaction in vitro. In this study, we showed that SSE significantly decreased compound 48/80-induced systemic anaphylaxis, ear-swelling response, histamine release from preparation of rat peritoneal mast cells and anti-dinitropheny IgE-induced passive cutaneous reaction. Also, SSE inhibited the expression of inflammatory cytokine and cyclooxygenase-2 in PMA plus A23187-stimulated human mast cells (HMC-1). In addition, we showed that anti-inflammatory mechanism of SSE is through suppression of nuclear factor-${\kappa}B$ activation and $I{\kappa}B-{\alpha}$ phosphorylation/degradation in HMC-1. These results provided new insight into the pharmacological actions of SSE as a potential molecule for therapy of inflammatory allergic diseases.

• The Korean Journal of Physiology
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• 제7권1호
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• pp.23-31
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• 1973

Numerous factors concern with the absorption of substances through the membrane of the gastrointestinal tract. To simplify the experimental condition, present work has been restricted to observe the disappearance rate of substance from the intestinal loop which was made in the jejunum, 70 cm apart from the pylorus of the adult rabbit. The purpose of the study is to clarify the absorption of urea through the jejunal wall is solely attributable to the concentration difference between the luminal fluid and plasma, and to observe the effect of adding red pepper upon the rate of absorption. The rabbits were anesthetized with nembutal, 35mg/kg I.V. Jejunal loop was made by ligating at 2 spots, 70 cm and 80cm apart from the pylorus. After rinsing with normal saline solution through the polyethylene tubing inserted from the end of the loop, 8 ml of test solution was placed through the same tubing. The test solution contained 200 mg% of urea and 150mg% of polyethylene glycol(M.W. 4,000) in normal saline solution. Right after placing the test solution the first specimen was taken through the tubing, and successive samplings were performed at 5, 10, 20, and 30 minutes. Logarithm of the difference of urea concentration between the luminal fluid and plasma was plotted against time elapsed after the onset of the experiment. If straight line is revealed, it would verify the nature of transport mechanism as diffusion, obeying the Fick's principle. The concentration of polyethylene glycol (PEG) was also measured in order to examine the change in the volume. PEG was used as the marker substance because it is not absorbable in the intestinal tract. Consequently the concentration of PEG relates inversely to the volume of the loop. Instantaneous concentration of urea in the loop times the volume will give the amount of urea remaining in the luminal fluid. The change in the amount of any substance is directly relate to the volume of the compartment and differs from the change in the concentration which is independent of the volume. After completion of the experiment without red pepper, it was added in the test solution and was centrifuged after thorough mixing. Supernatant of the mixture was placed in the loop and similar sampling were performed with the same time intervals that of previous run in order to observe the effects of the red pepper on the passive transport of the water soluble small substance, urea. The results obtained were as follows: 1. Logarithm of the concentration difference of urea between the luminal fluid and plasma was diminished exponentially as time elapsed. The decay constant in the experiment without red pepper was 0.0563/min. By adding red pepper in the test solution as much as the concentration rose to 4,000 mg% and 8,000 mg%, the decay constants were lowered to 0.0493/min and to 0.0506/min, respectively. The time interval by which the concentration difference dropped to one half of the initial value was prolonged. Without red pepper the half concentration time was 13.30 minutes, and by adding extract of red pepper, 15.31 minutes and 15.71 minutes were revealed. 2. The profile of the diminishing rate of tile amount of urea was quite different from that of the concentration because of the change in the volume of the loop during the observed period. 3. By adding the extract of red pepper, it slowed down the rate of absorption of urea in the intestinal loop, suggesting an increase in the diffusional barrier. 4. Larger dosage of red pepper brought an increase in the secretion of intestinal fluid with concomitant expansion of the luminal volume, and the retardation of the absorption of urea was noticed. This effect was largely dependent on the sensitivity of the individual animal to the red pepper, extract. The amount of urea remained after 10 minutes interval was 55.5% of the initial amount in the experiment without red pepper. On the other hand it was not consistent after administration of red pepper, showing 50.6% and 66.5% of the initial figures by adding 400 mg and 800 mg of red pepper in the test solution, respectively. It was postulated that symptom of diarrhea often encountered by taking a hot (red pepper) food might be attributable to the increase of secretion and the retardation of absorption in the intestinal tract.