Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Samsoeum inhibits systemic anaphylaxis and release of histamine, cytokine in vivo and in vitro

  • Kim, Su-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Na-Hyung (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Moon, Phil-Dong (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Myung, Noh-Yil (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Min-Chol (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Lee, Ki-Taek (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Jo, Hyung-Mook (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Kim, Na-Hyun (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Rim, Hong-Kun (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Seo, Min-Jun (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Kim, Jin-Man (College of Oriental Medicine, Wonkwang University) ;
  • Lee, Seung-Eun (College of Oriental Medicine, Wonkwang University) ;
  • An, Nyeon-Hyung (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Lee, Kang-Min (Division of Biological Sciences, College of Natural Science, Chonbuk National University) ;
  • Lee, Si-Hyung (College of Oriental Medicine, Wonkwang University) ;
  • Park, Yun-Jum (Division of Horticulture and Pet Animal-Plang Science, Wonkwang University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University) ;
  • Um, Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hyung-Min (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University)
  • Published : 2009.06.30
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Abstract

Samsoeum (SSE) is used in traditional oriental medicine for various medicinal purposes. However, the exact mechanism that accounts for the anti-allergy and anti-inflammatory effects of the SSE is still not fully understood. The aim of the present study is to elucidate whether and how SSE modulates the allergic reactions in vivo, and inflammatory reaction in vitro. In this study, we showed that SSE significantly decreased compound 48/80-induced systemic anaphylaxis, ear-swelling response, histamine release from preparation of rat peritoneal mast cells and anti-dinitropheny IgE-induced passive cutaneous reaction. Also, SSE inhibited the expression of inflammatory cytokine and cyclooxygenase-2 in PMA plus A23187-stimulated human mast cells (HMC-1). In addition, we showed that anti-inflammatory mechanism of SSE is through suppression of nuclear factor-${\kappa}B$ activation and $I{\kappa}B-{\alpha}$ phosphorylation/degradation in HMC-1. These results provided new insight into the pharmacological actions of SSE as a potential molecule for therapy of inflammatory allergic diseases.

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References

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