• 한국해양학회지
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• 제28권4호
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• pp.281-291
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• 1993

대한 해협 및 황해의 해수수송량 변화와 수입자의 라그랑지안(Lagrangian) 이동경 로의 추적을 통하여 실제의 해저지형을 고려한 시간의존적 간략화된 2차원적 수치모델 의 계산을 수행하였다. 이 일련의 수치실험에서 에디에 의한 쿠로시오 해류의 지류들 은 대륙붕의 해류순환을 조율할 수 있을 정도의 충분한 강도를 지니고 있음을 보여준 다. 대륙붕 지역에서의 이러한 해수유입은 바람, 조류 및 부력 등과 같이 해수운동에 영향을 미치는 중요한 영향력들 중의 하나로 사료된다. 대륙붕사면의 해수수송량 변화 는 쿠로시오 지류, 특히 큐슈섬의 남서지역에서의 수송량 변화가 대한해협 및 황해 남부지역의 수송량과 밀접한 관련이 있음을 보여준다. 모델에 의한 수입자의 궤적은 WOCE/TOGA 계획의 일환으로 얻어진 인공위성추적 표류부의(drifter) 의 궤적과 잘 일 치하고 있으나 그 이동 시간이 현재의 모델에서는 다소 더 걸리고 있는 점이 다르다.

• Journal of Pharmaceutical Investigation
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• 제30권1호
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• pp.21-26
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• 2000

Bioavailability of ipriflavone (3-phenyl-7-isopropoxy-4H-I-benzopyran-4-one, IP), an antiosteoporotic drug with poor water-solubility, was studied for various types of pharmaceutical preparation in SD rats. The IP preparation types included (1) intact IP, (2) freezer milled IP (FIP), (3) freezer milled IP physically mixed with freezer milled poly-N-vinylpyrrolidone (PVP) (FIP+FPVP) and (4) spray-dried IP with PVP (SIP). Upon oral administration, SIP showed significantly higher absorption and elimination half-lives and the lag time $(t_{lag})$ than those of FIP+FPVP (approximately 2-fold). These results may be due to a sustained releasing effect of IP in the gastrointestinal tract by spray-drying with PVP. The $C_{max}$ of SIP was about 2 and 10 times higher than those of FIP+FPVP and FIP, respectively. The AUC of SIP was about 6 times higher than that of FIP+FPVP and 60 times that of FIP. Scanning electron microscopy (SEM) showed that SIP consisted of the finest particle size and minimal aggregation than other IP preparations. It is concluded that the IP formula prepared by the spray-drying method with PVP is the most effective approach to the improvement of bioavailability of IP.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.151-160
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• 1990

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

• Journal of Pharmaceutical Investigation
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• 제37권6호
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• pp.339-347
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• 2007

SMEDDS is mixture of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle agitation and digestive motility that would be encountered in the gastro-intestinal(GI) tract. The main purpose of this work is to prepare self-microemulsifying drug delivery system(SMEDDS) for oral bioavailability enhancement of a poorly water soluble drug, atorvastatin calcium. Solubility of atorvastatin calcium was determined in various vehicles. Pseudo-ternary phase diagrams were constructed to identity the efficient self-emulsification region and particle size distributions of the resultant micro emulsions were determined using a laser diffraction sizer. Optimized formulations for in vitro dissolution and bioavailability assessment were $Capryol^{(R)}$ 90(50%), Tetraglycol(16%), and $Cremophor^{(R)}$ EL(32%). The release rate of atorvastatin from SMEDDS was significantly higher than the conventional tablet ($Lipitor^{(R)}$), 2-fold. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as atorvastatin calcium by the oral route.

• Journal of Animal Science and Technology
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• 제63권5호
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• pp.1182-1193
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• 2021

The aims of this study were to develop a milk protein-based probiotic delivery system using a modified rennet-induced gelation method and to determine how the skim milk powder concentration level and pH, which can affect the rennet-induced intra- and inter-molecular association of milk proteins, affect the physicochemical properties of the probiotic delivery systems, such as the particle size, size distribution, encapsulation efficiency, and viability of probiotics in simulated gastrointestinal tract. To prepare a milk protein-based delivery system, skim milk powder was used as a source of milk proteins with various concentration levels from 3 to 10% (w/w) and rennet was added to skim milk solutions followed by adjustment of pH from 5.4 or 6.2. Lactobacillus rhamnosus GG was used as a probiotic culture. In confocal laser scanning microscopic images, globular particles with a size ranging from 10 ㎛ to 20 ㎛ were observed, indicating that milk protein-based probiotic delivery systems were successfully created. When the skim milk powder concentration was increased from 3 to 10% (w/w), the size of the delivery system was significantly (p < 0.05) increased from 27.5 to 44.4 ㎛, while a significant (p < 0.05) increase in size from 26.3 to 34.5 ㎛ was observed as the pH was increased from 5.4 to 6.4. An increase in skim milk powder concentration level and a decrease in pH led to a significant (p < 0.05) increase in the encapsulation efficiency of probiotics. The viability of probiotics in a simulated stomach condition was increased when probiotics were encapsulated in milk protein-based delivery systems. An increase in the skim milk powder concentration and a decrease in pH resulted in an increase in the viability of probiotics in simulated stomach conditions. It was concluded that the protein content by modulating skim milk powder concentration level and pH were the key manufacturing variables affecting the physicochemical properties of milk protein-based probiotic delivery systems.

• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.267-275
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• 2002

A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was thε mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). Thε efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet $(Mevacor^{\circledR},\;20\;mg/tab)$ by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The arεa under the serum concentration-time curve from time zero to the last measured time in serum, $AUC_{0{\rightarrow}24h}$, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.

• 생명과학회지
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• 제30권2호
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• pp.191-201
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• 2020

사회의 급속한 발전과 함께 수반되는 환경오염이 인간의 건강을 위협하는 커다란 위험인자로 인식되기 시작하면서 공기오염을 억제하기 위한 노력과 공기오염에 의해 유발되는 여러 질환을 억제 및 치료하기 위한 연구개발이 급속히 증가하고 있다. 인간 건강에 나쁜 영향을 주는 공기오염의 주된 원인중의 하나인 미세먼지는 (particulate matter, PM) 크기에 따라 일반미세먼지와(PM₁₀) 초미세먼지(PM_2.5)로 나누어 질 수 있으며, 호흡기, 소화기, 및 피부에 흡수 및 부착되어 이상 면역반응을 유발하여 만성호흡기질환, 당뇨병 및 면역질환등을 촉진하는 것으로 알려져 있다. 그동안 인류의 건강을 위해 미세먼지의 발생을 억제하기 위한 범 국가적 노력과 함께 미세먼지의 유해성을 증명하기 위한 많은 연구가 진행되어 왔다. 본 총설에서는 여러 인체질환에 있어서 미세먼지가 미치는 유해성을 중심으로 소개하고 미세먼지의 생물학적 위험성을 평가하는 세포 및 동물실험법에 대해 요약하였다.

• 대한원격탐사학회지
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• 제38권6_1호
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• pp.1191-1205
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• 2022

복잡하고 광범위한 원인을 가진 대기오염물질 중 particulate matter (PM)은 입자의 크기에 따라 분류된다. 그 중 PM_2.5는 그 크기가 매우 작아 사람이 흡입하면 인간의 호흡기나 심혈관에 질병을 유발할 수 있다. 이러한 위험에 대비하기 위해서는 국가 중심의 관리와 사전에 예방할 수 있는 모니터링 및 예측이 중요하다. 본 연구는 고농도 미세먼지의 발생이 잦은 서울시의 PM_2.5를 local data assimilation and prediction system (LDAPS) 기상 관련 인자 15가지와 aerosol optical depth (AOD), 화학인자 4가지를 독립변수로 하여 앙상블 모델 두 가지 random forest (RF)와 extreme gradient boosting (XGB)로 예측하고자 하였다. 예측에 사용된 두 모델의 성능 평가와 인자 중요도 평가를 수행하였으며, 계절별 모델 분석도 수행하였다. 예측 정확도 결과, RF가 R² = 0.85, XGB가 R² = 0.91의 높은 예측 정확도를 보이며 XGB가 RF보다 PM_2.5 예측에 적합한 모델임을 확인하였다. 계절별 모델 분석 결과, 봄에 농도가 높은 관측 값과 비교하여 예측 수행이 잘 되었다고 할 수 있다. 본 연구는 다양한 인자를 이용하여 서울시의 PM_2.5를 예측하였고, 좋은 성능을 보이는 앙상블 기반의 PM_2.5 예측 모델을 구축하였다.