Improvement of Solubility of Atorvastatin Calcium Using Self-Microemulsion Drug Delivery System(SMEDDS)
![]() |
Lee, Jun-Hee
(BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Choi, Myoung-Kyu (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) Kim, Yun-Tae (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) Kim, Myoung-Jin (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) Oh, Jae-Min (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) Park, Jung-Soo (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) Mo, Jong-Hyun (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) Kim, Moon-Suk (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) Lee, Hai-Bang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) |
1 | P.P Constantinides, Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm. Res., 12, 1561-1572 (1999) DOI |
2 | K.H. Kim, Y.S. Rhee and J.H. Bae, Improvement of dissolution rate of poorly water soluble drug using selfmicroemulsifying drug delivery system. K. Kor. Pharm. Sci., 29(1), 37-45 (1999) |
3 | N.H. Shah, M.T. Carvajal, C.I. Patel, M.H. Infeld and A.W. Malick, Self-emulsifying drug delivery systems with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs, Int. J. Parm., 106, 15-23 (1994) DOI ScienceOn |
4 | J.H. Yang, Y.I. Kim, H.J. Kim and K.H. Chung, Preparation and characterization of microemulsion containing ibuprofen, J. Kor. Pharm. Sci., 45, 634-640 (2001) 과학기술학회마을 |
5 | D. Langevin, Microemulsion-interfacial aspects, Adv. Collid Interface Sci., 34, 583-595 (1991) DOI ScienceOn |
6 | J.H. Choi, J.Y. Kim and Y.S. Ku, Self-emulsifying drug delivery system containing ibuprofen for oral use, J. Kor. Pharm. Sci., 29, 99-103 (1999) |
7 | S.C. Jeong, S.K. Chon, Y.H. Jo, M.S. Kim, B. Lee, H.B. Lee and G. Khang, Osmotic delivery system for nifedipine using cellulose actate/Eudragit blend membrane, I. The effect of bead size and drug solubility, Polymer(Korea), 29(3), 288-293 (2005) |
8 | B.Y. Yoon, B.K. Kang, S.Y. Jeong, Y.W. Lee, S. Lee, S.J. Hwang, S.H. Yuk, G. Khang, H.B. Lee and S.H. Cho, Improvement of bioavailability for lovastatin using selfemulsifying drug delivery system, J. Korean Pharm. Sci., 32(4), 267-274 (2002) 과학기술학회마을 |
9 | Y.H. Kim, Y.W. Lee, M.S. Kim, S.Y. Yang, G. Khang, J.S. Lee and H.B. Lee, Application of poly(vinylalcohol) as drug delivery carrier, Tissue Eng. Regen. Med., 3(2), 96-100 (2006) |
10 | C.W. Pouton, Self-emulsifying drug delivery systems: Assessment of the efficiency of emulsification, Int. J. Pharm., 27, 335-348 (1985) DOI ScienceOn |
11 | B.Y. Yoon, J. Kim, B.K. Kang, S.Y. Jeung, S.H. Yuk, G. Khang, H.B. Lee and S.H Cho, Effects of various types of lipids on miceoencapsulation of SMEDDS, Macromol. Chem. Symp., 15(4), 395-406 (2002) |
12 | S.A. Charman, W.N. Charman, M.C. Rogge, T.D. Wilson, F.J. Duko and C.W. Pouton, Self-emulsifying drug delivery system : Formulation and biophannaceutical evaluation of and investigational lipophilic compound, Pharm. Res., 9, 87-93 (1992) DOI |
13 | W.W. Bullen, R.A. Miller and R.N. Hayes, Development and validation of a high performance liquid chromatography tandem mass spectrometry assay for atorvastatin, ortho-hydroxy atorvastatin, and para-hydroxy atorvastatin in human, dog, and rat plasma, J. Am. Soc. Mass Spectrom., 10, 55-66 (1999) DOI ScienceOn |
14 | B.K. Kang, J.S. Lee, S.K. Chon, S.Y. Jeung, S.H. Yuk, G. Khang, H.B. Lee and S.H. Cho, Development of selfmicroemulsifying drug delivery systems(SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs, Int. J. Pharm., 274, 65-73 (2004) DOI ScienceOn |
15 | A. Romero, F. Cordobes, M.C. Puppo, A. Guerrero and C. Bengoechea, Rheology and droplet size distribution of emulsions stabilized by cryfish four, Food Hydrocolloids, in press (2007) |
16 | G.S. Chae, J.S. Lee, S.H. Kim, S.Y. Jeong, M.S. Kim, S.H. Cho, H.B Lee and G. Khang, Enhancement of the stability of BCNU uisng self-microernulsifying drug delivery system (SMEDDS) and in vitro antitumor activity of self-microemulsified BCNU-loaded PLGA wafer, Int. J. Pharm., 301, 6-14 (2005) DOI ScienceOn |
17 | Y.S. Hwang, K.T. Lee and S.H. Seo, In vitro controlled release of piracetarn with coated ion-exchange resin, J. Korean Pharm. Sci., 29, 105-109 (1999) |
18 | D. Attwood, C. Mallon and C.J. Taylor, A study on factors influencing the droplet size in nonionic oil-in-waer microemulsions, Int. J. Pharm., 88, 417-422 (1992) DOI ScienceOn |
19 | G. Khang, J.C. Yang, J.T. Ko, J.S. Park, M.S. Kim, J.M. Rhee and H.B. Lee, Preparation and characterization of ibuprofen using self-emulsifying drug delivery system in vivo, Key Engineering Materials, 342-343, 541-544 (2007) |
20 | H.S. Kim, S.K. Lee, S.U. Choi, H.S. Park, H.J. Jeon and Y.W. Choi, Improved dissolution characteristics of ibuprofen employing self-microemulsifying drug delivery system and their bioavailability in rats, J. Kor, Pharm. Sci., 32, 27-33 (2002) |
21 | K.S. Park, E.J. Kim, M.S. Kim, S.H. Cho, H.B. Lee and G. Khang, Preparation and release profile of transforming growth factor B1-loaded alginate beads, Biomaterials Research, 8(1), 14-19 (2004) |
22 | Y.S. Ahn, J.H. Song, M.S. Kim, S.H. Cho, J.M. Rhee, H.B. Lee and G. Khang, Preparation and characterization of liquified ibuprofene using self-microemulsion drug delivery system, J. Korean Pharm. Sci., 34(1), 35-41 (2004) |
23 | A.E. Wiacek, Effect of ionic strength on electrokinetic properties of oil/water emulsions with dipalmitoylphosphatidylcholine, Collids and surfaces A, 302, 141-149 (2007) DOI ScienceOn |
24 | B.K. Kang, B.Y. Yoon, K.S. Seo, S.Y. Jeung, H.J. Kil, G. Khang, H.B. Lee, and S.H. Cho, Preparation of solid dosage form containing SMEDDS of simvastatin by microencapsulation, J. Korean Pharm. Sci., 33(2), 121-127(2003) |
25 | S.A. Charman, W.N. Charman, M.C. Rogge, T.D. Wilson, F.H. Dutko and C.W. Pouton, Self-emulsifying drug delivery systems :Formulation and biopharmaceutical evaluation of an investigational lipophilic compound, Pharm. Res., 9, 87-93 (1992) DOI |
26 | N. Neirynck, P.V. Meeren, M. Lukaszewicz-Lausecker, J. Cocquyt, D. Verbeken and K. Dewettinck, Influence of pH and biopolymer ratio on whey protein-pectin interactions in aqueous solutions and in O/W emulsions, Colloids and Surfaces A, 298, 99-107 (2007) DOI ScienceOn |
![]() |