Journal of Pharmaceutical Investigation
- Volume 30 Issue 1
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- Pages.21-26
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- 2000
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Comparative Bioavailability of Ipriflavone by Pharmaceutical Preparation Types
제제헝태에 따른 이프리플라본의 생체이용률 비교
- Jeong, Je-Kyo (Department of Polymer Science and Technology, Chonbuk National University) ;
- Khang, Gil-Son (Department of Polymer Science and Technology, Chonbuk National University) ;
- Rhee, John M. (Department of Polymer Science and Technology, Chonbuk National University) ;
- Shin, Ho-Chul (Pharmacokinetics & Toxicokinetics Laboratory, Korea Research Institute of Chemical Technology) ;
- Lee, Hai-Bang (Biomaterials Laboratory, Korea Research Institute of Chemical Technology)
- 정제교 (전북대학교 고분자공학과) ;
- 강길선 (전북대학교 고분자공학과) ;
- 이종문 (전북대학교 고분자공학과) ;
- 신호철 (한국화학연구소 약물독성동태팀) ;
- 이해방 (한국화학연구소 생체의료고분자팀)
- Published : 2000.03.20
Abstract
Bioavailability of ipriflavone (3-phenyl-7-isopropoxy-4H-I-benzopyran-4-one, IP), an antiosteoporotic drug with poor water-solubility, was studied for various types of pharmaceutical preparation in SD rats. The IP preparation types included (1) intact IP, (2) freezer milled IP (FIP), (3) freezer milled IP physically mixed with freezer milled poly-N-vinylpyrrolidone (PVP) (FIP+FPVP) and (4) spray-dried IP with PVP (SIP). Upon oral administration, SIP showed significantly higher absorption and elimination half-lives and the lag time