• Biomolecules & Therapeutics
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• v.20 no.3
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• pp.256-267
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• 2012

Tamoxifen is a central component of the treatment of estrogen receptor (ER)-positive breast cancer as a partial agonist of ER. It has been clinically used for the last 30 years and is currently available as a chemopreventive agent in women with high risk for breast cancer. The most challenging issue with tamoxifen use is the development of resistance in an initially responsive breast tumor. This review summarizes the roles of ER as the therapeutic target of tamoxifen in cancer treatment, clinical values and issues of tamoxifen use, and molecular mechanisms of tamoxifen resistance. Emerging knowledge on the molecular mechanisms of tamoxifen resistance will provide insight into the design of regimens to overcome tamoxifen resistance and discovery of novel therapeutic agents with a decreased chance of developing resistance as well as establishing more efficient treatment strategies.

• Corrosion Science and Technology
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• v.4 no.6
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• pp.236-241
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• 2005

Hydrogen induced cracking (HIC) is one of the hydrogen degradation phenomena of linepipe steels caused by $H_2S$ gas in the crude oil or natural gas. However, NACE TM0284-96 standard HIC test method is hard to satisfy the steel requirements for sour service application since it uses more severe environmental conditions than actual conditions. Therefore, in order to use steels effectively, it is required to evaluate HIC resistance of steels in the practical range of environmental severity. In this study, HIC resistance of two high strength low alloy (HSLA) steels being used as line pipe steels was evaluated in various test solutions with different $H_2S$ pressures and pH values. The results showed that the key parameter affecting crack area ratio (CAR) is $H_2S$ partial pressure of test solution when the pH value of test solution is not over 4. Hydrogen diffusivity was not a constant value, but it was rather affected by the hydrogen ion concentration (pH value) in the solution.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.129-136
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• 2005

The deterministic analysis method has generally used to evaluate the slope stability and it evaluates the slope stability with decision value that is a representative value of design variables. However, one of disadvantages in the deterministic approach is there is not able to consider the uncertainty of soil strength properties, even though it is the biggest influential parameter of the slope stability. On the other hand, the limit state design(LSD) can take a consideration of uncertainties and computes both the reliability index and the probability of failure. LSD method is capable of overcoming the disadvantages of deterministic method and evaluating the slope stability more reliably. In this study, both the mean value and standard deviation of the internal land's representative soil strength properties applied to process the LSD method. The major purpose of this study is to gauge the general applicability of the limit state design in soil slope and to weigh the comparative validity of the proposed partial safety factor. In order to reach the aim of this study, the partial safety factor and resistance factor which totally satisfied the slope's overall safety factor were calculated by the load and resistance safety factor design (LRFD).

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.11
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• pp.73-82
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• 2011

The solid insulation system of stator windings in high voltage rotational machines is usually aging in accordance with long time operation. The partial discharge test have been known to check whether insulation deterioration exist or not, and the PD test can effectively diagnose a solid insulation condition regardless of during operation(on-line) or not(off-line). The on-line PD measurement have proven to be a successful technique in monitoring stator insulation condition nowadays. This paper describes the characteristics of comparing the on-line PD measurement data using PDMS-HG(Partial Discharge Monitoring System for Hydro-electric Generator) installed in field with the off-line diagnosis measurement data(insulation resistance, winding resistance, PI, ${\Delta}tan{\delta}$ and PD) on hydro generator(13[kV]) stator windings. These results make good use of managing rotational machines through evaluating the solid insulation condition of stator windings.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.7 no.4
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• pp.1-12
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• 1987

The Advanced First Order Second Moment(AFOSM) method is commonly used to determine partial safety factors in the development of probability based LRFD code. However, design format using load and resistance factors based on this method may result in different reliability levels from specified ones. Reliability-Conditioned(RC) method recently proposed by Ayyub et al. gives partial safety factors which do not affect the target reliability level as specified. However, this method has some numerical difficulties and the procedure is not consistent. The proposed RC/AFOSM combined method has not only numerical consistency, but also results in almost constant partial safety factors with respect to various design conditions, and the resulting reliability levels are very close to specified ones.

• Journal of Ocean Engineering and Technology
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• v.9 no.1
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• pp.111-119
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• 1995

The elastic-plastic fracture toughness($J_{IC}$) and fracture resistance (J-R curve) of SA508-3 alloy steel used for nuclear reactor pressure vessel are investigated by using CT-type specimens. Fracture toughness tests are conducted by unloading compliance method and multiple specimen method at room temperature, -2$0^{\circ}C$ and 20$0^{\circ}C$. The apparent negative crack growth phenomenon which usually arises in partial unloading compliance test is well known. The negative crack growth phenomenon in determining J sub(IC) or J-R cure from partial unloading compliance experiments may be eliminated by the offset technique. In this study, the evaluation of $J_{IC}$ multiple specimen method recommended by the JSME gives the most reliable results by using half-size CT(similar-type) specimens.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.35 no.1
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• pp.17-25
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• 1986

Discussions on this paper are related to the effects of organic materials to treeing phenomena of low density polyethylene. As additives, 11 kinds of organic compounds are selected by considering the respective features such as melting point, boiling point, electron affinity as well as molecular structure, and then the specimens of low density polyethylene are prepared by blending with 10wt% of the selected additives. For the comparison of effectiveness of treeing resistance and interpretation of the mechanism of compounds as treeing retardants, several investigations such as the tree acceleration test, the prestressed test and the measurement of internally occurred partial discharge are carried out. As the results, meta-Cresol is regard as the most effective retardant among those, and it is supposed that this aromatic compound to be comprised of radical having large electron affinity has strong capability to accept energetic electron to prevent or delay the growth of discharge streamer. Furthermore, by activating partial discharge at the wall of tree pit through the function of trapped electron at this material, the gas pressure in the pit is increased up to prevent the growth of streamer.

• Steel and Composite Structures
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• v.19 no.6
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• pp.1381-1402
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• 2015

The application of composite steel-concrete slabs with profiled steel sheeting has increased, due to the various advantages in relation to reinforced concrete slabs such as, the reduced thickness, the reduced amount of lost formwork needed, as well as the speed of execution. The loss of longitudinal shear resistance is, generally, the governing design mode for simply supported spans of common lengths. For common distributed loadings, the composite behaviour is influenced by the partial shear connection between the concrete and the steel sheeting. The present research work is intended to contribute to improving the ultimate limit state behaviour of composite slabs using end anchorage. Eurocode 4, Part 1.1 (EN 1994-1-1) provides an analytical methodology for predicting the increase of longitudinal resistance, achieved by using shear studs welded through the steel sheeting as the end anchorage mechanism. The code does not supply an analytical methodology for other kinds of end anchorage so, additional tests or studies are needed to prove the effectiveness of these types of anchorage. The influence of end anchorage mechanisms provided by transverse rebars at the ends of simply supported composite slabs is analysed in this paper. Two experimental programmes were carried out, the first to determine the resistance provided by the new end anchorage mechanism and the second to analyse its influence on the behaviour of simply supported composite slabs.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.288-288
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• 2012

In this study, we investigated that the resistance switching characteristics of W-doped NbOx films with increasing W doping concentration. The W-doped NbOx based ReRAM devices with a TiN/W-doped NbOx/Pt/Ti/SiO2 were fabricated on Si substrates. The 50 nm thick W-doped NbOx films were deposited by reactive dc magnetron co-sputtering at $400^{\circ}C$ and oxygen partial pressure of 35%. Micro-structure of W-doped NbOx films and atomic concentration were investigated by XRD, TEM and XPS, respectively. The W-doped NbOx films showed set/reset resistance switching behavior at various W doping concentrations. The process voltage of set/reset is decreased and whereas the initial current level is increased with increasing W doping concentration in NbOx films. The change of resistance switching behavior depending on doping concentration was discussed in terms of concentration of metallic tungsten of oxygen of W-doped NbOx.

• The Korean Journal of Health Service Management
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• v.6 no.2
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• pp.71-80
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• 2012

The purposes of this study were to effect the upper extremities strength and ADL with upper extremities in frail elders. This study comparison upper extremities strength to pre-exercise and post-exercise and ADL with upper extremities. 30 elders who was in C silver hospital in Busan after resistance exercise during 12 weeks using elastic band, It was confirmed that improvement upper extremities strength and ADL with upper extremities after resistance exercise. As a result of study about effect of elastic band based resistance exercise on ADL of frail elders, it seems to have good effect on over all items(eating, dressing, bathing, make-up, go to a rest room). Therefore, it is necessary to find method about rehabilitation exercise for frail or partial disability elders.