• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.4
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• pp.353-359
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• 1999

Purpose : A new method of lateral cephalometric analysis for midface, focusing on zygomatic bone, was created in this study, and measured in Korean adults. The purposes of this study are understanding about new approach for midfacial depression, especially zygomatic bone, and using to make adequate diagnosis and treatment plan. Materials and methods : In this study, esthetic Korean adults, 25 males and 25 females who were between $0^{\circ}$ and $4^{\circ}$ in ${\angle}ANB$, and between 62% and 70% in P/A facial height ratio, and had normal overbite and overjet, were used. Orbitale(Or) and Soft tissue orbitale(Or') were used for indicators of anteroposterior position of zygomatic area. And, mean value and standard deviation of linear and angular measurements, and ratio about each linear measurements, were obtained. then, standard deviation diagram - wiggle diagram - was made for visualization of results. Results : Mean values, standard deviations and ranges of 19 measurements were obtained, and among them, 5 linear measurements that had large standard deviation were excluded and the others were used for making standard deviation diagram. In standard deviation diagram, the following results were obtained. 1. If the measurements are located on more left side of mean-value-vertical -line, the potential of midfacial hypoplasia are stronger, especially zygomatic area. 2. If the measurements are located on more right side of mean-value-vertical-line, the potential of midfacial hypoplasia are decreased. Conclusion : This study presented a new method of lateral cephalometric analysis focusing on zygomatic bone in Korean adults. We expect that the results of this study can be used as parameter when clinicians make decisions about diagnosis and treatment plan for rehabilitation of esthetics and function. But, it is necessary to prove its usefulness, and to further evaluate the results.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.16 no.1
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• pp.105-111
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• 2003

Wheel for passenger car support the car weight with tires, and they transmit rolling and braking power into the ground. Whittling away at wheel weight is more effective to boost fuel economy than lighting vehicle body structure. A shape of hole in disk is optimized for minimizing the weight of steel wheel. Pro/ENGINEER program is used for formulating the design model, and ANSYS package is selected for analyzing the design model. It has difficulties to interface these commercial software directly. For Combining both programs, response surface methodology is applied to construct approximation functions for maximum stresses and maximum displacements are obtained by full factorial design of five levels. This steel wheel is modeled in 14-inch diameter of rim, and wide parameter of hole in disk is only selected as design variable for reducing the weight of steel whee. PLBA(Pshenichny-Lim-Belegundu-Arora) algorithm, which used the second-order information in the direction finding problem and uses the active set strategy, is used for solving optimization problems.

• Journal of the Earthquake Engineering Society of Korea
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• v.11 no.6
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• pp.33-39
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• 2007

The seismic source parameters of the Uljin earthquake on 29 May 2004, including focal depth, focal mechanism, magnitude, and moment tensor elements for source characteristics, are analysed using moment tensor seismic source inversion. The Green‘s function for 3 crust models representing the southern Korean Peninsula are used. Also 3 kinds of epicenters are used to find optimum solution for seismic source parameters. Results show that seismic source parameters have a little dependency of azimuthal distribution and epicentral distances of seismic stations. Final results show that the event, considering 6 moment tensor elements, is caused by the typical reverse fault with nearly NS strike. The focal mechanism implies that the tectonic force around epicenter area currently has compressive environment, with nearly EW principal axis. The focal depth is estimated to be about 12km. The resultant focal mechanism show fairly good agreement to those of other studies. However, focal depth is much different from that of other studies.

• Journal of Haehwa Medicine
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• v.12 no.1
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• pp.1-9
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• 2003

This experimental study was carried out to evaluate the effects of Kimchi intake of Acanthopanacis cortex extract (APCE) supplementation on cytokine-induction and immune response in mice. To study in experiments using male Balb/c mice fed Kimchi and Kimchi of APCE supplementation (addition of 2% of total Kimchi weight) containing fed experimental diet during 2 weeks. Experimental mice were fed control diet or diet containing freeze-dried Kimchi at the level of 5%(w/w) or 5% freeze-dried Kimchi with 2% APCE supplementation. The main ingredient of Kimchi was Korean cabbage and fermentation was carried out at $4^{\circ}C$ for three weeks. Freeze-dried 2% APCE supplementation was added to Kimchi at the begining of fermentation. In order to investigate the effect of Kimchi intake of APCE supplementation (5%Kimchi-2%APCE), the following was performed; body weight, food intake, hematological parameter, serum level of mouse interleukin-4 (mlL-4) and mouse interferon-$\gamma$ (mIFN-$\gamma$ ), and, the percentage of CD3+/CD4+, CD3+/CD8+, B220+ in splenic cells. The results of final body weight, and food diet intake of two Kimchi groups were lower than those of the control group (not supplemented experimental diet). The hematology change obtained from the level of WBC (white blood cell) and platelet were not affected by feeding different dietary regiments, but the level of RBC (red blood cells) HB (hemoglobin), and spleen weight of two Kimchi groups were increased significantly than those of the control group. The serum level of IL-4 and IFN-$\gamma$ of two Kimchi groups were increased significantly than those of the control group, also enhanced the percentages of the CD3+/CD4+ and CD3+/CD8+ by 5% freeze-dried Kimchi, and 5%Kimchi-2%APCE group were 43.9 and 65.2%, and 96.0 and 208% than those of the control group, respectively. From these results, it can be concluded that Kimchi itself has an immuno-stimulatory effect and Kimchi contaning 2% APCE supplementation has the more pronounced effect in vivo system.

• Advances in environmental research
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• v.5 no.3
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• pp.153-167
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• 2016

We applied multilayer perceptron (MLP) and radial basis function (RBF) neural network in upstream and downstream water quality stations of the Karaj Reservoir in Iran. For both neural networks, inputs were pH, turbidity, temperature, chlorophyll-a, biochemical oxygen demand (BOD) and nitrate, and the output was dissolved oxygen (DO). We used an MLP neural network with two hidden layers, for upstream station 15 and 33 neurons in the first and second layers respectively, and for the downstream station, 16 and 21 neurons in the first and second hidden layer were used which had minimum amount of errors. For learning process 6-fold cross validation were applied to avoid over fitting. The best results acquired from RBF model, in which the mean bias error (MBE) and root mean squared error (RMSE) were 0.063 and 0.10 for the upstream station. The MBE and RSME were 0.0126 and 0.099 for the downstream station. The coefficient of determination ($R^2$) between the observed data and the predicted data for upstream and downstream stations in the MLP was 0.801 and 0.904, respectively, and in the RBF network were 0.962 and 0.97, respectively. The MLP neural network had acceptable results; however, the results of RBF network were more accurate. A sensitivity analysis for the MLP neural network indicated that temperature was the first parameter, pH the second and nitrate was the last factor affecting the prediction of DO concentrations. The results proved the workability and accuracy of the RBF model in the prediction of the DO.

• Clinical and Experimental Reproductive Medicine
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• v.15 no.2
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• pp.149-155
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• 1988

To increase fertilization rate in vitro, separation of viable spermatozoa from the seminal plasma and its other components may be a useful procedure. Ejaculates from healthy men, whose semen analysis findings were normal in 19, and abnormal in 10, were filtered using the glass-wool filtration technique to yield a concentrated, viable sperm samples for IVF, and the usefulness and safety of this method were evaluated. The recovery rate of motile sperm in abnormal groups was 46.2% and 54.5% in normal group. The % motility was increased significantly compared with original sample after filtration, and the grade motility was improved, too. The sperm population with normal morphology was also increased significantly in both group. Using transmission electron microscopy, the ultrastructural integrity of acrosomal segment was examined in order to evaluate the potentially hazardous effect of glass-wool filtration to sperm head, however, sperm population with normal ultrastructure was increased compared with that of original ejaculate after separation. The filtered sperm was then processed for IVF, as the fertilizing capacity is the ultimate parameter of the sperm function. In abnormal group, the fertilization rate(41.5 %) and the ET rate per stimulated cycle were much lower than that of mormal group(69.6%). However, the cleavage rate and the number of embryos transfered per ET cycle were comparable with those of nomal group. The results suggest that the glass-wool filtration of sperm, particularly in oligo-asthenozoospsrmia, may be useful and safe method in the preparation of sperm for IVF.

• YAKHAK HOEJI
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• v.39 no.6
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• pp.636-644
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• 1995

Comparison of bioavailabflity (BA) of three brands of ranitidine (RT) tablets has been studied m rats. The purpose of this study was to characterize the pharniacolunetics of RT tablets in the rat and to coinpare phannacolunetic parameters of three brands of RT tablets. In addition, it was investigated whether plasma RT concentrations m humans can be predicted from pharmacokinetic parameters obtained in rats. RT was administered intravenously in dose of RT.HCI 10mg/kg and orally in dose of RT.HCI 50mg/kg as solution or crushed sample of thablets. Plasma RT concentrations were determned by HPLC. Plasma RT concentrations as a function of time were fitted to two compartment model. Plasma RT concentrations declined with a terminal half life ($t_{{1}/2{\betha}}$) of 40.9 min. The plasma RT concentration-time curve showed two peak plasma concentrations following an oral administration of solution or crushed sample in rats like humans. No significant difference among pharmacokinetic parameters was observed except $T_{max2}$ (p<0.05). The BA for crushed sample A, B and C were found to be 54.6 40.7 and 40.0%, respectively. Equivalence of $C_{max1}$ and $T_{max2}$ were guaranteed in this study. However, it was concluded that three brands of RT tablets are bioequivalent, taking the following characteristics of RT into consideration;(1) rapid onset of the effect is not required, (2) $C_{max1}$ and $T_{max2}$ do not seem to influence the effectiveness of the drug during a long-term treatment by the usual administration of twice a day. Results from this study were combined with plarmacokinetic data for RT in dogs and humans to develop a basis for interspecies scale-up of the disposition characteristics of the drug. there were similarities in the general disposition of the drug. Allometric relationships were sought between pharmacokinetic parameters nd species body weight. Significant interspecies correlations were found for total body clearance($Cl_{t}$) and steady state volume of distribution ($Bd_{ss}$). Thus, plasma RT concentrations in humans can be predicted from pharmacokinetic parameters obtained in rats.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.39 no.2
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• pp.116-127
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• 2002

A new approach to improve the speaker adaptation algorithm by means of the variable number of observation density functions for CDHMM speech recognizer has been proposed. The proposed method uses the observation density function with more than one mixture in each state to represent speech characteristics in detail. The number of mixtures in each state is determined by the number of frames and the determinant of the variance, respectively. The each MAP Parameter is extracted in every mixture determined by these two methods. In addition, the state segmentation method requiring speaker adaptation can segment the adapting speech more Precisely by using speaker-independent model trained from sufficient database as a priori knowledge. And the state duration distribution is used lot adapting the speech duration information owing to speaker's utterance habit and speed. The recognition rate of the proposed methods are significantly higher than that of the conventional method using one mixture in each state.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.37 no.3
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• pp.1-8
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• 2000

This paper presents a simulation model of the Quadrature detector to demodulate FSK signal, which is widely used in wireless paging system for its simple hardware implementation and economics of It fabrication. Quadrature detecter has nonlinear phase characteristic for changes linear changes of input signal frequency. So until now Quadrature detector system analysis remained a difficult problem and performance analysis has not been carried out adequately On these backgrounds, this paper presents the FSK signal demodulation process using Quadrature detector and optimal performance derived from digital simulation technique. First, PSN(Phase Shift Network) which is composed of analog RLC tank circuit is transformed into its equivalent digital transfer function using First-order-hold theorem. Though the demodulated outputs of the Quadrature detector for 4FSK are 4-level signals, only 2 comparators are used and it is shown that optimal performance can be obtained by choosing operation parameter Q value and threshold level decision which are proposed herein.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2002.04a
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• pp.123-130
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• 2002

A general formulation for shape design sensitivity analysis over three dimensional beam structure is developed based on a variational formulation of the beam in linear elasticity. Sensitivity formula is derived based on variational equations in cartesian coordinates using the material derivative concept and adjoint variable method for the displacement and Von-Mises stress functionals. Shape variation is considered for the beam shape in general 3-dimensional direction as well as for the orientation angle of the beam cross section. In the sensitivity expression, the end points evaluation at each beam segment is added to the integral formula, which are summed over the entire structure. The sensitivity formula can be evaluated with generality and ease even by employing piecewise linear design velocity field despite the bending model is fourth order differential equation. For the numerical implementation, commercial software ANSYS is used as analysis tool for the primal and adjoint analysis. Once the design variable set is defined using ANSYS language, shape and orientation variation vector at each node is generated by making finite difference to the shape with respect to each design parameter, and is used for the computation of sensitivity formula. Several numerical examples are taken to show the advantage of the method, in which the accuracy of the sensitivity is evaluated. The results are found excellent even by employing a simple linear function for the design velocity evaluation. Shape optimization is carried out for the geometric design of an archgrid and tilted bridge, which is to minimize maximum stress over the structure while maintaining constant weight. In conclusion, the proposed formulation is a useful and easy tool in finding optimum shape in a variety of the spatial frame structures.