• Journal of Korean Neurosurgical Society
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• 제67권2호
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• pp.202-208
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• 2024

Objective : Failed back surgery syndrome (FBSS) is a common long-term complication following spine surgeries characterized by chronic persistent pain; different strategies of management were employed to deal with it. This clinical trial aims to compare the efficacy of Pregabalin and Gabapentin in the management of this condition. Methods : A double-blind, randomized, comparative study (clinical trial registry NCT05324761 on 11th April 2022) with two parallel arms with Pregabalin and Gabapentin were used in arms one and two, respectively. Visual analog scale was used for basal and endpoint assessment of pain. T-test and analysis of covariance were used to deal with different variables. A pairwise test was used to compare pairs of means. Results : Of 66 patients referred to the trial, 64 were eligible, with 60 patients completing the 30 days trial. Both pregabalin and gabapentin effectively reduce pain, with significant p-values of 0.001 for each group. However, the pregabalin group was superior to gabapentin in pain reduction (p=0.001). Gender was an insignificant factor (p=0.574 and p=0.445 for the pregabalin and gabapentin groups, respectively, with a non-significant reduction (p=0.393) for both groups in total. Location of stenosis before surgery and type of surgery performed show non-significant effect on pain reduction for both groups. Conclusion : Both pregabalin and gabapentin effectively and safely relieve neuropathic pain associated with FBSS; pregabalin was significantly more effective irrespective of the patients' gender.

• 한국정보처리학회논문지
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• 제5권10호
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• pp.2725-2736
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• 1998

본 논문은 WRLS-VFF-VT 알고리듬을 이용한 새로운 피치 검색 방법론을 제안하도록 한다. 제안된 알고리듬에서는 VFF(가변 망각 인자)를 사용하여 유성음에서의 주 여기 펄스 시점과 관련된 성문 폐쇄 점을 확인한다. 또한 본 논문은 VFF 기반 알고리듬과 함께 기존의 EGG 와 LP-Error 방법을 이용한 피치 검색 알고리듬에서 가변 한계 값을 이용 수정된 알고리듬을 제안한다. 제안된 알고리듬들은 주기와 주기 근간에서 강인한 피치 측정 능력과 준 주기 및 비 주기성 음성 신호에서도 우수한 피치 검색 기능을 가지고 있음을 알 수 있다. 제안된 알고리듬의 우수성을 입증하기 위해 실제 사람의 자연스러운 음성 및 사람의 비정상 상태 음성에서 준 주기 및 비 주기성 음성 진동 패턴을 확인하고 검출하는 성능 측정을 통하여 표준 SIFT 알고리듬과 비교 평가하였다.

• Journal of Mechanical Science and Technology
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• 제16권2호
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• pp.165-174
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• 2002

In the present study, interfacial cracks between an isotropic and orthotropic material, subjected to static far field tensile loading are analyzed using the technique of photoelasticity. The fracture parameters are extracted from the full-field isochromatic data and the same are compared with that obtained using boundary collocation method. Dynamic photoelasticity combined with high-speed digital photography is employed for capturing the isochromatics in the case of propagating interfacial cracks. The normalized stress intensity factors for static cracks are greate. when ${\alpha}$: 90$^{\circ}$(fibers perpendicular to the interface) than when ${\alpha}$=0$^{\circ}$(fibers parallel to the interface), and those when ${\alpha}$=90$^{\circ}$are similar to ones of isotropic material. The dynamic stress intensity factors for interfacial propagating cracks are greater when ${\alpha}$=0$^{\circ}$ than ${\alpha}$=90$^{\circ}$. For the velocity ranges (0.1 < C/C$\sub$s1/<0.7) observed in this study, the complex dynamic stress intensity factor │K$\sub$D/│increases with crack speed c, however, the rate of increase of │K$\sub$D/│with crack speed is not as drastic as that reported for homogeneous materials.

• 대한토목학회논문집
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• 제36권4호
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• pp.659-665
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• 2016

풋월 비탈면 설계 시 해석시간이 짧고, 간편하여 한계평형법을 주로 이용하였으나, 쟁기형태파괴를 모사하기에는 어려움이 따른다. 따라서, 본 연구에서는 2차원 DEM (Distinct Element Method) 해석프로그램인 UDEC을 이용해 수치해석을 수행하여 풋월 비탈면에서 발생되는 쟁기형태파괴에 미치는 영향인자를 분석하였다. 매개변수분석은 암반절리(층면절리, 공액절리, 비탈면의 하단에 위치한 절리)의 구조 및 암반절리상태 등을 변경하여 수행하였으며, 비탈면의 안전율은 강도감소법(Strength Reduction Method)을 이용하여 산정하였다. 수치해석 결과를 통해 쟁기형태파괴는 공액절리(conjugate joint)의 경사각에 주로 의존하고 있음을 확인할 수 있었으며, 층리의 한계간격 및 슬래브의 한계길이가 공액절리의 경사각에 영향을 받는 것으로 나타났다. 본 연구결과는 비탈면 보강을 포함한 풋월 비탈면의 최적설계 및 시공에 적용될 수 있을 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.807-812
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• 2014

Background: The clinical course of the neoplasm may vary due to both patient and tumor cell characteristics. Aim: The aim of this study was to research the influence of certain clinical and pathological features on the prognosis of early stage breast cancer. Materials and Methods: This study included 117 women that were treated and followed-up in between the years 2001-2011. The demographic, clinical and histopathological features of the cases were reviewed retrospectively. Statistical analysis: In categorical comparisons between groups, cross-tab statistics were provided and significance levels were estimated using chi-square test. Cox regression analysis, Pearson and Spearman correlation tests, and the Kaplan-Meier test were also used. Results: With an average of 35-months follow-up, the mean disease-free survival of patients was 91 months and the mean overall survival time was 132 months. In the whole study group, the disease-free survival rates were 88, 84, 83 and 52%, while the overall survival rates 95, 94, 83, and 83% within the first, third, fifth and tenth years, respectively. The disease-free and overall survival rates were decreased with increasing tumor grades, though this was not statistically significant. The presence of lymphovascular invasion, positive staining with Ki67 and postmenopausal status were associated with shorter disease-free and overall survival times. In multivariate analysis, only age and Her2/neu receptor status influenced the prognosis significantly. Conclusions: In parallel to clinical, histopathological, and immunohistochemical prognostic features in breast cancer, in this study positive Her2/neu receptor status, a previously accepted poor prognostic factor, was found to have positive influence after trastuzumab treatment.

• 대한산업공학회지
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• 제29권2호
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• pp.179-189
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• 2003

Gate poly-silicon critical dimension is a prime characteristic of a metal-oxide-semiconductor field effect transistor. It is important to achieve the uniformity of gate poly-silicon critical dimension in order that a semiconductor device has acceptable electrical test characteristics as well as a semiconductor wafer fabrication process has a competitive net-die-per-wafer yield. However, on gate poly-silicon critical dimension, the complexity associated with a semiconductor wafer fabrication process entails hierarchical variance components according to run-to-run, wafer-to-wafer and even die-to-die production unit changes. Specifically, estimates of the hierarchical variance components are required not only for disclosing dominant sources of the variation but also for testing the wafer-level uniformity. In this paper, two experimental designs, a two-stage nested design and a randomized complete block design are considered in order to estimate the hierarchical variance components. Since gate poly-silicon critical dimensions are collected from fixed die positions within wafers, a factor representing die positions can be regarded as fixed in linear statistical models for the designs. In this context, the two-stage nested design also checks the wafer-level uniformity taking all sampled runs into account. In more detail, using variance estimates derived from randomized complete block designs, Duncan's multiple range test examines the wafer-level uniformity for each run. Consequently, a framework presented in this study could provide guidelines to practitioners on estimating the hierarchical variance components and testing the wafer-level uniformity in parallel for any characteristics concerned in semiconductor wafer fabrication processes. Statistical analysis is illustrated for an experimental dataset from a real pilot semiconductor wafer fabrication process.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4019-4023
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• 2016

Background: Colorectal cancer (CRC) or bowel cancer is one of the most important cancer diseases, needing serious attention. The cell surface receptor gene human epidermal growth factor receptor (EGFR) may have an important role in provoking CRC. In this pharmaceutical era, it is always attempted to identify plant-based drugs for cancer, which will have less side effects for human body, unlike the chemically synthesized marketed drugs having serious side effects. So, in this study the authors tried to assess the activity of two important plant compounds, ferulic acid (FA) and p-coumaric acid (pCA), on CRC. Materials and Methods: FA and pCA were tested for their cytotoxic effects on the human CRC cell line HCT 15 and also checked for the level of gene expression of EGFR by real time PCR analysis. Positive results were confirmed by in silico molecular docking studies using Discovery Studio (DS) 4.0. The drug parallel features of the same compounds were also assessed in silico. Results: Cytotoxicity experiments revealed that both the compounds were efficient in killing CRC cells on a controlled concentration basis. In addition, EGFR expression was down-regulated in the presence of the compounds. Docking studies unveiled that both the compounds were able to inhibit EGFR at its active site. Pharmacokinetic analysis of these compounds opened up their drug like behaviour. Conclusions: The findings of this study emphasize the importance of plant compounds for targeting diseases like CRC.

• 한국치위생학회지
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• 제12권4호
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• pp.685-693
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• 2012

Objectives : This research was conducted to find the subjective symptoms of musculoskeletal system for main jobs and job posture. Methods : A survey was conducted from September 15, 2011 to October 7, 2011 and 357 dental hygienists were responded. The survey was consisted of the working environment and medical equipments, psycho-social characteristics, health habits and education, job posture, subjective symptoms of musculoskeletal system pain, and so on. Results : In the survey on the frequency of job posture of dental hygienists by jobs, said they cast down or tilt their head by 15 degrees or more or twist or bend their back. The result of the analysis on the subjective symptoms of musculoskeletal system by main job showed that they experienced a pain in neck, shoulder, and back, although the order differed. The order of subjective symptoms of musculoskeletal system for casting down or turning head by 15 degrees or more, twisting or bending back, having shoulders not parallel to the ground, sitting at the end of a chair, and supporting the whole body with one leg or pressing on a pedal for treatment was from the shoulders to the neck to the back. The order of subjective symptoms of musculoskeletal system for having arms too far from the body or hunching for treatment and bending wrists inward or outward for treatment was from the shoulders to the back to the neck. Conclusions : Due to the characteristics of the job which requires one to have a proper view of a patient's oral cavity, most of the postures included casting down of head or bending of back. Therefore a development of new postures is needed to replace the existing job postures which pressure the musculoskeletal system. And shift rotation can be used as a preventive measure.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권3호
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• pp.175-180
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• 2004

In this study, three treatment options to replace two posterior missing teeth were investigated using three dimensional finite element analysis: two wide(${\phi}5.0mm$) implants(the experimental model I), two standard(${\phi}3.75mm$) implants(the experimental model II), and three standard(${\phi}3.75mm$) implants(the experimental model III). Two kinds of load case were applied ; 1) perpendicular on occlusal surface(axial load), parallel on occlusal surface(lateral load). 2) perpendicular on occlusal surface(3mm lateral to central point). The results obtained from this study were as follows; value of Von-mises stress (equivalent stress) was smallest in the two wide implant among the three experimental models. It was reported that the diameter is the efficient factor than osseointegrated surface area.

• 보존과학회지
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• 제26권4호
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• pp.385-395
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• 2010

이 연구는 현풍석빙고의 미기후 특성을 분석하여 손상에 영향을 미친 기후인자를 해석하고 보존환경을 평가한 것이다. 석빙고의 내부 구성부재에는 균열, 이격, 탈락, 박락, 백화, 갈색 변색, 흑색 변색 및 생물에 의한 변색이 발생하였으며, 이 중 생물에 의한 변색이 가장 높은 훼손율(24%)을 보였다. 석빙고 내부의 환경은 외부의 기상 변화에 따라 변동하나 변동폭과 일교차가 작고 일정한 온습도를 유지하는 것으로 나타났다. 이는 석빙고 전면의 산사면과 폐쇄된 입구환경이 외기를 차단하여 온습도의 변화를 최소화하였기 때문이다. 석빙고의 단열환경은 수분의 응축과 동결 현상을 방지하여 물리적 손상도를 저감하고 장빙기능을 극대화한 것으로 판단된다. 그러나 99% 이상의 높은 상대습도는 미생물의 생장을 활성화시켜 생물학적인 손상도를 높인 것으로 해석된다.