• Korean Journal of Biological Psychiatry
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• v.21 no.4
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• pp.168-174
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• 2014

Objectives Sensory gating dysfunctions in patients with schizophrenia and bipolar disorder have been investigated through two similar methods ; P50 suppression and prepulse inhibition paradigms. However, recent studies have demonstrated that the two measures are not correlated but rather constitute as distinct neural processes. Recent studies adopting spectral frequency analysis suggest that P50 suppression reflects the interaction between gamma and other frequency bands. The aim of the present study is to investigate which frequency component shows more significant interaction with gamma band. Methods A total of 108 mood disorder patients and 36 normal subjects were included in the study. The P50 responses to conditioning and test stimuli with an intra-pair interval of 500 msec were measured in the study population. According to P50 ratio (amplitude to the test stimulus/amplitude to the conditioning stimulus), the subjects with P50 ratio less than 0.2 were defined as suppressed group (SG) ; non-suppressed group (NSG) consisted of P50 ratio more than 0.8. Thirty-five and 25 subjects were included in SG and NSG, respectively. Point-to-point correlation coefficients (PPCCs) of both groups were calculated between two time-windows : the first window (S1) was defined as the time-window of one hundred millisecond after the conditioning auditory stimulus and the second window (S2) was defined as the time-window of 100 msec after the test auditory stimulus. Spectral frequency analysis was performed to investigate which frequency band results in the difference of PPCC between SG and NSG. Results Significant reduction of PPCC between S1 and S2 was observed in the SG (Pearson's r = 0.24), compared to PPCC of the NSG (r = 0.58, p < 0.05). In spectral frequency analysis, gamma band showed "phase-reset" and similar responses after the two auditory stimuli in suppressed and non-suppressed group. However in the case of alpha band, comparison showed significantly low PPCC in SG (r = -0.14) compared to NSG (r = 0.36, p < 0.05). This may be reflecting "phase-out" of alpha band against gamma band at approximately 50 msecs after the test stimulus in the SG. Conclusions Our study suggests that normal P50 suppression is caused by phase-out of alpha band against gamma band after the second auditory stimulus. Thus it is demonstrated that normal sensory gating process is constituted with attenuated alpha power, superimposed on consistent gamma response. Implications of preserved gamma and decreased alpha band in sensory gating function are discussed.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.3 s.47
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• pp.345-352
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• 2004

There are two paradigms to explain the atopic dermatitis. The first is outside-inside paradigm and the second is inside-outside paradigm. According to the outside-inside paradigm the best way to treat the atopic dermatitis is recovery of skin barrier function. The barrier function is maintained by the specific structure of stratum corneum, which is constructed from corneocytes and intercellular lipids. In terms of lipid structures of SC in atopic dermatitis and lamellar ichthyosis, they contain more fluid hexagonal gel structures in SC and show deficiencies in free fatty acids, especially long chains and certain ceramides. With this reason, moisturizer which has the lamellar structure and restoring function of intrinsic intercellualr long periodicity phase can maintain and restore the lamellar structure of intercellular lipids in SC. The moisturizers containing ceramide or pseudoceramide also seem to be reasonable therapy for atopic dermatitis and several skin diseases, which interrelated with impaired skin harrier. By the way, according to the inside-outside paradigm, immune response including helper T cells, IgE, eosinophils is related. It is effective treatment of atopic dermititis to restore imbalance between Th1 and Th2 cells. Even though several kinds of immune-suppressor were introduced, these can affect the intrinsic immune function. SPC and S1P, metabolites of ceramide, would be interesting because they have the function of wound healing and immune modulating properties.

• Journal of the Economic Geographical Society of Korea
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• v.11 no.3
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• pp.302-318
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• 2008

As socio-economic paradigms have been moving towards the knowledge-based capitalism from the industrial capitalism, it is obvious that research on industrial agglomeration and regional innovation has been explosively increased. However, there is a contradictory tendency that the terms and concepts, which are related to industrial agglomeration, have became less clear and more fuzzy. In this sense, this paper attempts to tackle and reconsider the concept, typology and theories of agglomeration and (or) cluster in economic geography. The main claims are as follows. Firstly, the terms and concepts related to industrial agglomeration and cluster need to be clear. It seems to be that cluster is received as an umbrella concept of agglomerations all-embracing the varieties of a geographical concentration of industry. However, the authors claim that the cluster concept should be part of the diverse types of industrial agglomeration. Secondly, the tendency of a less clear definition on agglomeration and cluster could make it difficult to identify the types of agglomeration being in the forms of diversity. Such a tendency would result in a misguided understanding and interpretation of a typology of agglomeration. Finally and most importantly, as perspectives or theories that are associated with industrial agglomeration and cluster show increasingly a propensity of convergence, it is problematic that related theories and perspectives lose their own identity and distinctiveness.

• Journal of Korea Technology Innovation Society
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• v.20 no.4
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• pp.1192-1211
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• 2017

Today, innovation is driven by the challenge of existing paradigms and by cooperating with many other fields as well as their own, and thus the importance of open innovation is emphasized. This study analyzed the effect of open innovation on innovation activities and examined the role of organizational innovation in various innovation activities. For the analysis, Korean Innovation Survey (KIS) data from Science and Technology Policy Institute (STEPI) in 2016 was used. A total of 1,453 manufacturing firms were selected as a sample and logistic regression was performed. As a result, R&D cooperation has a positive effect on product innovation as the most representative means to acquire new knowledge and technology, while R&D cooperation has no relation with process innovation. In the case of organizational innovation, it strengthens positive effects of R&D cooperation on both product innovation and process innovation. Organizational change can be explained to play a positive role in new innovation activities, and then firms will need to consider organizational innovation in relation to R&D cooperation. This study is meaningful in that it analyzes the causal relationship and role in relation to various types of innovation, and will contribute to the firms to smoothly perform innovation activities in the future.

• The KIPS Transactions:PartD
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• v.15D no.5
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• pp.705-712
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• 2008

Recently, interests in the notion of PKMS(Process based on Knowledge Management System) utilizing BPMS(Business Process Management System) and KMS(Knowledge Management System) have been significantly increased. Specially, most public organizations require their own effective knowledge management strategies since public business service needs various knowledge types. Based on a comprehensive framework that reflects lifecycle requirements of KMS and BPMS, we propose an PKMS system architecture, which performs step-by-step knowledge-providing strategy in public organization. To propose a PKMS architecture, this paper first investigates inter-relationships between public business and various knowledge types, and classifies knowledge types into three groups and then we suggest knowledge management strategies considering priority order among knowledge groups. Based on the proposed knowledge management, a PKMS system architecture can combine the advantages of the KM and BPM paradigms. This paper presents the PKMS system applied to employment insurance business part in real environment and demonstrated the advantages via inter-relationships between KM and BPM requirements.

• Biomolecules & Therapeutics
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• v.28 no.1
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• pp.83-91
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• 2020

Tryptamines are monoamine alkaloids with hallucinogenic properties and are widely abused worldwide. To hasten the regulations of novel substances and predict their abuse potential, we designed and synthesized four novel synthetic tryptamine analogs: Pyrrolidino tryptamine hydrochloride (PYT HCl), Piperidino tryptamine hydrochloride (PIT HCl), N,N-dibutyl tryptamine hydrochloride (DBT HCl), and 2-Methyl tryptamine hydrochloride (2-MT HCl). Then, we evaluated their rewarding and reinforcing effects using the conditioned place preference (CPP) and self-administration (SA) paradigms. We conducted an open field test (OFT) to determine the effects of the novel compounds on locomotor activity. A head-twitch response (HTR) was also performed to characterize their hallucinogenic properties. Lastly, we examined the effects of the compounds on 5-HTR1a and 5-HTR2a in the prefrontal cortex using a quantitative real-time polymerase chain reaction (qRT-PCR) assay. None of the compounds induced CPP in mice or initiated SA in rats. PYT HCl and PIT HCl reduced the locomotor activity and elevated the 5-HTR1a mRNA levels in mice. Acute and repeated treatment with the novel tryptamines elicited HTR in mice. Furthermore, a drug challenge involving a 7-day abstinence from drug use produced higher HTR than acute and repeated treatments. Both the acute treatment and drug challenge increased the 5-HTR2a mRNA levels. Ketanserin blocked the induced HTR. Taken together, the findings suggest that PYT HCl, PIT HCl, DBT HCl, and 2-MT HCl produce hallucinogenic effects via 5-HTR2a stimulation, but may have low abuse potential.

• KIPS Transactions on Computer and Communication Systems
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• v.3 no.10
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• pp.337-350
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• 2014

Internet-of-Things(IoT) is the computing paradigm converged with different technologies, where diverse devices are connected via the wireless network, acquire environmental information from their equipped sensors, and are actuated. IoT applications provide smart services to users by interacting with multiple devices connected to the network. IoT devices provide the simple set of the information and also offer smart services by collaborating with other devices. That is, IoT applications always interact with IoT devices which are becoming very popular at a fast pace. However, due to this fact, developing IoT application results in unconventional technical challenges which have not been observed in typical software applications. Moreover, since IoT computing has its own characteristics which are distinguished from other former paradigms such as embedded computing and mobile computing, IoT applications also reveal their own technical challenges. Therefore, we analyze technical challenges occurring in developing IoT applications and present effective solutions to overcome the challenges. To verify identified issues and presented solutions, we present the result of performing a case study of developing an IoT application. Through the case study, we verify how the unconventional technical issues are raised in a real domain and analyze effectiveness of applying the solutions to the application.

• Korean Journal of Social Welfare Studies
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• v.48 no.1
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• pp.55-89
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• 2017

This study suggests future directions or approaches as to how we should appraise qualitative studies by reviewing previous studies on this topic written in English and published outside of Korea. This study explored experiences and perspectives of qualitative researchers in Korea by conducting a focus group discussion on this topic. Results of this focus group discussion indicated that qualitative researchers often face manuscript reviewers who are overly biased with quantitative paradigm which result in feeling of frustration. They also shared feeling burdened and confused as reviewers due to their own lack of training and preparedness in reviewing qualitative articles. However, participants also stressed the feeling of gratitude and being rewarded because of the experience of mutual growth and partnership with peer qualitative researchers as they strive towards improving the quality and completion of peer researchers' work. Previous studies on this topic included wide range of issues concerning qualitative research appraisal from reflections on the experiences as submitters and reviewers of qualitative studies to academic conceptual papers that discussed researchers' dilemma on research paradigms and qualitative research appraising methods. This study ends with suggestions for the future directions for qualitative researchers in Korea.

• Journal of the Korea Society of Computer and Information
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• v.25 no.4
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• pp.165-172
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• 2020

In this paper we propose an uses on-device-based edge computing technology and big data analysis methods through the use of on-device-based edge computing technology and analysis of big data, which are distributed computing paradigms that introduce computations and storage devices where necessary to solve problems such as transmission delays that occur when data is transmitted to central centers and processed in current general smart factories. However, even if edge computing-based technology is applied in practice, the increase in devices on the network edge will result in large amounts of data being transferred to the data center, resulting in the network band reaching its limits, which, despite the improvement of network technology, does not guarantee acceptable transfer speeds and response times, which are critical requirements for many applications. It provides the basis for developing into an AI-based facility prediction conservation analysis tool that can apply deep learning suitable for big data in the future by supporting intelligent facility management that can support productivity growth through research that can be applied to the field of facility preservation and smart factory industry with integrated hardware technology that can accommodate these requirements and factory management and control technology.

• Journal of the Korea Convergence Society
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• v.10 no.2
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• pp.133-139
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• 2019

A Convergence Research Study of Southern Fujian Region in China during the Song Dynasty analyzing the Export of Ceramics During the Song Dynasty in China ceramics made in the Southern Fujian (also known as Minnan) region were exported to different countries in Southeast Asia including the Philippines, Thailand and more. They were even exported to Korea, Japan and through trade they traveled as far as Africa. Ceramics was one of the three main sea route export item of China at the time and there were active commercial trading between Korea as well as other countries, enabling ceramics to develop rapidly. The harmonious reciprocal relationship between the geographical, political, cultural, economical characteristics of Southern Fujian enabled a unique type of celadon ware widely recognized to develop. Ceramics of this region is one of a kind in terms of history when we relate it to research on integrating different elements. It suggests a unique convergence of culture when we study its forms and its industrial characteristics. The study attempts to analyze the influence of geography, politics, economy and culture on the different phenomena found in ceramics. Different paradigms associated with changes of environment reflect on continued development in the field of ceramics.