• Journal of the Korean housing association
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• v.21 no.6
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• pp.143-154
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• 2010

The purpose of this study is to propose a new development method for urban residential area, considering the urban site and development conditions rather than just meeting the development limit and regulations. Gwangju Metropolitan city is investigated as a case city and the new method verifies a decision process of pertinent development types and housing forms in urban blocks. The consequences of this study are summarized as follows. The process of a new development method consists of four steps; First, current conditions of the residential area of Gwangju are analysed in order to find out the site characteristics and housing development situations. And the theoretical research is made to set up the development goals and objectives, regarding current trends and future paradigms of residential development. Next, the suitable development sites are selected, and their site characteristics and relevant development types for the future are compared and matched with a close analysis. Finally some pertinent housing forms for each development site are suggested, which fit well in terms of urban context and are appropriate for building up sustainable city in the future.

• Child Health Nursing Research
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• v.15 no.1
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• pp.42-52
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• 2009

Child is a being and provides the genetic continuity of parents and society, and therefore the fitness of these children for survival, growth and development towards reproduction, is of significance to parents and society. The aim of health care for high-risk children is not only to minimize or eliminate health problems, but also to optimize their fitness. Considering that the health care of children is influenced by available resources of parents and society, and sociocultural values and paradigms in a given environment of evolutionary adaptedness (EEA), child health care professionals need to understand factors affecting the optimal fitness of children with risks. This paper introduces a new integrated theory for health care in high-risk children, entitled, Health for Optimal Fitness of High-Risk Children. Five main components were identified with associate concepts or midrange theories affecting heath for optimal fitness of high-risk children; EEA, optimal fitness, health problems, investment resources, and anthropological values. It may provide an integrated perspective on health of high-risk children in both the proximately biomedical approach and ultimately evolutionary approach as optimizing their fitness. Further study is needed to develop substantial statements between components with existential examples.

• Journal of the Korean Data and Information Science Society
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• v.20 no.6
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• pp.1009-1014
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• 2009

The Internet has changed the daily lives of human being in Korea and elsewhere in the world. It has changed the paradigms of traditional commercial activities and created immense opportunities for new business models. Recently, there has been much attention to the internet shopping mall as a means of commercial transaction. To make internet shopping mall competitive, effective customer satisfaction service should be provided and it is necessary to dynamic analysis method for customers' purchasing pattern. In this paper we apply the sequential analysis to comparison of two kinds of sales through the analysis of customers' purchasing pattern.

• BMB Reports
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• v.48 no.3
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• pp.147-152
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• 2015

Small interfering RNA (siRNA) functions through pairing with specific mRNA sequences and results in the mRNA's degradation. It is a potential therapeutic approach for many diseases caused by altered gene expression. The delivery of siRNA is still a major problem due to its rapid degradation in the circulation. Various strategies have been proposed to help with the cellular uptake of siRNA and short or small hairpin RNA (shRNA). Here, we reviewed recently published data regarding local applications of siRNA. Compared with systemic delivery methods, local delivery of siRNA/shRNA has many advantages, such as targeting the specific tissues or organs, mimicking a gene knockout effect, or developing certain diseases models. The eye, brain, and tumor tissues are 'hot' target tissues/organs for local siRNA delivery. The siRNA can be delivered locally, in naked form, with chemical modifications, or in formulations with viral or non-viral vectors, such as liposomes and nanoparticles. This review provides a comprehensive overview of RNAi local administration and potential future applications in clinical treatment.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.261-269
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• 2008

This experiment was performed to investigate the anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen (CFAZ), by using the experimental paradigms of anxiety, and compared with those of a known anxiolytic, diazepam. CFAZ (8.0 mg/kg, p.o.) increased the percentage of time spent on the open arms and the number of open arms entries in the elevated plus-maze test, increased the number of head dips in the hole-board test, and increased the percentage of center zone ambulatory time in the open-field box. However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, $GABA_A$ receptors $\gamma$-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by $GABA_A$ receptors.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2001.05b
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• pp.4-16
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• 2001

Sperm competent for fertilization can become capacitated, bind to the zona pellucida (ZP)of an egg in a specific manner, and complete acrosomal exocytosis. Failure to carry out these functions results in infertility. Although the interactions between the ZP and the plasma membrane overlying the sperm acrosome have been considered important for sperm-egg recognition and signalling recent results have prompted a reassessment of current paradigms concerning these interactions. In this review, we're going to discuss about the roles of the acrosomal matrix, the particulate component of the acrosomal contents, in fertilization. The general hypothesis is that acrosomal exocytosis leads to the exposure of acrosomal matrix proteins that become de facto extracellula matrix(ECM) on the surface of the sperm head, and that the dynamic interactions of this newly-exposed sperm ECM with the egg ECM (the ZP) govern sperm-egg recognition and sperm penetration of the ZP. Informations from these experiments may provide new ways to address the poor ZP binding of sperm from some human infertility patients and may offer new avenues for contraception through the disruption of purposeful sperm-ZP binding.

• Korean Institute of Interior Design Journal
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• v.13 no.2
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• pp.56-63
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• 2004

Harmony between men and their surroundings has been one of the most profound motives in space and object design for a long time. It is often expressed in design as the concept of 'organic'. Nowdays the term of organic is expanding its meaning in the contemporary sense of organicism. Nature, human 'beings, and digital technology are the key issues in future design paradigms. Karim Rashid is one of the most futuristic and vendible designer and his works show these issues. His designs flow organically and he uses materials that allow his forms to flow like the body, echoing life forms. it's very sensual, very tactile. In his work, a new concept of organic design is expressed in the organic unity of experience. He tries to contribute objects to our physical landscape that inspires, engages, and encourage positive experiences. Also, Technology is at constant play in his design process. With the latest three dimensional design software it is much easier to design and model sophisticated and complex shape and forms. Digital technology affects not only his design processes but also cultural views. New technologies and social shifts are changing our understanding of interior space.

• Journal of Korea Multimedia Society
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• v.2 no.2
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• pp.129-136
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• 1999

A linear feature often provide sufficient information for image understanding and coding. An objective of the research reported in this paper is to develop and analyze the reliable methods of extracting lines in gray scale images. The Hough Transform is known as one of the optimal paradigms to detect or identify the linear features by transforming edges in images into peaks in parameter space. The scheme proposed here uses the fuzzy gradient direction model and weights the gradient magnitudes for deciding the voting values to be accumulated in parameter space. This leads to significant computational savings by restricting the transform to within some support region of the observed gradient direction which can be considered as a fuzzy variable and produces robust results.

• Journal of Korean Library and Information Science Society
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• v.46 no.3
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• pp.255-275
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• 2015

The purpose of this study is to develop an approach to teaching qualitative research methods (TQRM) for Library and Information Science. To draw trend of TQRM, 76 course syllabi collected in the research oriented universities' master and doctoral programs, were analyzed using content analysis. The study proposes both common topics and essential strategies for TQRM in terms of the paradigm of qualitative research, research design, wide range of approaches to QR, diversity of collecting and analyzing data, writing, and evaluation criteria. It is very important to identify qualitative stance and to understand paradigms and philosophical and theoretical frameworks of QR for conducting QR reiteratively, creatively, reflectively.

• Korean Institute of Interior Design Journal
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• no.10
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• pp.34-49
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• 1997

Architectual environment in this study means a language and meaning complex which makes communication between human beings and environment possible. The purpose of this study is to propose a semiotic approach to analyze and examine meaning, as a semiotic system, and its effects, focusing on the generative meaning in the relationship between human beings and environment. For this purpose, it examines the academic status of modern semiotics in postmodernism and the possibility of its being metalanguatge for a study of a variety of cultural phenomena and desigv. It also provides two viewpoints as propositions for its analysis: it explains the necessity of environmental-discoursive attitude and social-semiotic viewpoint which understands environment as social-cultural reflectors. Finally, it provides framework and all the interpretative procedures for analysis of environmental meanings on the basis of the approach of semiotics of space. By applying the methods proposed this study to the case studies, it also proves validity of this approach and the potentialities of the application of semiotics. This study emphasizes not only denotative configuration of the architectural environment but also its connotative meanings. It maintains that designers, architects, and theorists should realize correctly today's changed value system and social and aesthetic paradigms. It also stresses the necessity of development of the new architectural language and meaning system.