• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6549-6556
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• 2013

Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression and relapse, and thus represent a critical target for therapeutic intervention. Hence, it is extremely urgent to explore new therapeutic strategies directly targeting LSCs for acute myelogenous leukemia (AML) therapy. We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML $CD34^+CD38^-$ cell proliferation in vitro culture in a dose-dependent manner while sparing normal hematopoietic stem and progenitor cells at physiologically achievable concentrations. Furthermore, ASP exerted cytotoxic effects on AML K562 cells, especially LSC-enriched $CD34^+CD38^-$ cells. Colony formation assays further showed that ASP significantly suppressed the formation of colonies derived from AML $CD34^+CD38^-$ cells but not those from normal $CD34^+CD38^-$ cells. Examination of the underlying mechanisms revealed that ASP induced $CD34^+CD38^-$ cell senescence, which was strongly associated with a series of characteristic events, including up-regulation of p53, p16, p21, and Rb genes and changes of related cell cycle regulation proteins P16, P21, cyclin E and CDK4, telomere end attrition as well as repression of telomerase activity. On the basis of these findings, we propose that ASP represents a potentially important agent for leukemia stem cell-targeted therapy.

• Journal of Korean Public Health Nursing
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• v.34 no.1
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• pp.22-34
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• 2020

Purpose: This study aimed to identify the effects of adolescent sexual media literacy and sexual permissiveness on gender sensitivity and to provide evidences useful in developing a sex education program that would promote gender sensitivity among adolescents. Methods: Data were derived from 250 adolescents' responses to questionnaires. Collected data were analyzed using ANOVA, Pearson's correlation coefficient, and multiple regression. Results: Gender sensitivity according to gender was significantly different (t=-6.54, p=0.001). Gender sensitivity was positively correlated with sexual media literacy (r=0.36, p<0.001), and negatively correlated with sexual permissiveness (r=.22, p<.001). Sexual media literacy was negatively correlated with sexual permissiveness (r=-0.39, p<0.001). The variables affecting the participants' gender sensitivity on media literacy were gender (β=0.33, p<0.001) and sexual depiction scene (β=0.24, p<0.001). Conclusion: Gender and sexual media literacy influenced participants' gender sensitivity. Therefore, when developing a school-based sex education program, sexual media literacy should be included as a key concept; moreover, gender-specific programs need to be developed. Furthermore, teaching methods should enhance media literacy related to sexual depiction scenes and promote safe and healthy sexual permissiveness.

• Honam Mathematical Journal
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• v.34 no.4
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• pp.483-494
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• 2012

The set of all polynomial permutations of $\mathbb{Z}_{p^r}$ forms a group. We investigate the structure of the group and some related groups, and completely determine the structure of the group of all polynomial permutations of $\mathbb{Z}_{p^2}$.

• Journal of the korean academy of Pediatric Dentistry
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• v.37 no.4
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• pp.453-460
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• 2010

This study was one of the caries pattern studies. The purpose was to investigate the degree of intraoral symmetry of dental caries in the primary dentition. The dmfs data from children aged 36 to 71 months were analyzed. Pearson correlation coefficients between right teeth and left teeth were from 0.558 (upper canines) to 0.847 (upper central incisors) and 0.905 in total (P<0.01). Differences between right teeth and left teeth were mostly not significant (P>0.05). Pearson correlation coefficients between upper teeth and lower teeth were from 0.150 (right lateral incisors) to 0.506 (right first molars) and 0.680 in total (P<0.01). Differences between upper teeth and lower teeth were mostly significant (P<0.05). Percentages of bilateral caries experience cases per cases having caries experience were from 34.0% (upper canines) to 80.1% (upper central incisors), and from 53.9% (distal) to 84.9% (mesial) in upper central incisors, from 34.1% (mesial) to 45.0% (occlusal) in upper first molars, from 20.7% (distal) to 48.0% (occlusal) in upper second molars, from 34.4% (buccal) to 58.1% (occlusal) in lower first molars, and from 29.7% (distal) to 61.4% (occlusal) in lower second molars, respectively.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.8
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• pp.1206-1211
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• 2006

The effects of taurine supplementation on growth performance, serum and liver concentrations of lipid, fatty acid composition and lipid peroxidation in the livers of broilers under chronic heat exposure conditions were investigated. The chicks with a similar body weight were equally assigned to one of three controlled-environment chambers. The brolier chicks, which were kept at $34^{\circ}C$ were fed either with a control diet or the control diet supplemented with 0.8% taurine, whereas broiler chicks kept at $22^{\circ}C$ were fed a control diet. Both of the BW and BW gains of broilers maintained at a temperature of $34^{\circ}C$ were significantly lower than those of the control group, which was maintained at a temperature of $22^{\circ}C$ (p<0.05). However, taurine addition in the diet of birds submitted to heat stress siginficantly improved BW gain (p<0.05). The feed intake of chicks declined with increases in temperature. The relative liver and gall bladder weights of chicks fed the control diet and maintained at $34^{\circ}C$ were significantly lower than those measured in the control birds (p<0.05). However, dietary taurine was found to compensate for these reductions in liver and gall bladder weights. Relative weights of abdominal fat did not differ significantly among the three groups. Serum triglyceride concentrations were significantly lower in the chicks fed the control diet and maintained at $34^{\circ}C$ compare to those measured in the chicks fed the control diet at $22^{\circ}C$ (p<0.05). Heat stress resulted in a significant reduction in total lipid and triglyceride levels, but also increased the levels of total cholesterol in the liver (p<0.05). However, dietary taurine supplementation under the heat stress condition resulted in the recovery, to control levels, of serum triglyceride concentrations, as well as the amounts of total lipids, triglycerides, and cholesterol in the liver. The livers of chicks fed on taurine diets at $34^{\circ}C$ showed significantly higher proportions of C14:0, C16:1, C18:1, C18:2, and 20:3, and lower C18:0 and C20:4 proportions than those of chicks fed on control diets at the same temperature (p<0.05). The total levels of saturated fatty acids decreased, but monounsaturated fatty acids and unsaturated fatty acid levels increased in chicks fed the taurine diet, as compared to chicks fed the control diet at $34^{\circ}C$ (p<0.05). Peroxidizability indices were significantly lower in the heat-exposed chicks fed the taurine diet than in the non-taurine heat-exposed groups (p<0.05). In conclusion, dietary taurine results in an increase in the growth performances of chicks under heat stress conditions via improvements in lipid absorption and metabolism, as well as an induced reduction in lipid peroxidation.

• Journal of Genetic Medicine
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• v.14 no.1
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• pp.34-37
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• 2017

5p deletion syndrome, also known as Cri-du-Chat syndrome, is a chromosomal abnormality caused by a deletion in the short arm of chromosome 5. Clinical features of 5p deletion syndrome are difficult to identify prenatally by ultrasound examination, thus most cases of 5p deletion syndrome have been diagnosed postnatally. Here, we report eight cases of 5p deletion syndrome diagnosed prenatally, but were unable to find common prenatal ultrasound findings among these cases. However, we found that several cases of 5p deletion syndrome were confirmed prenatally when karyotyping was performed on the basis of abnormal findings in a prenatal ultrasound scan. Hence, it is necessary to carefully perform prenatal ultrasonography for detection of rarer chromosomal abnormalities as well as common aneuploidy.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.2
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• pp.245-253
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• 2003

The degree of conversion of cross-linked polymer has great importance in determining the physical and mechanical properties, and biocompatibility. Therefore, this study examined the comparison of light-cured composite resin polymerization of various light-curing systems composed of plasma arc, halogen, LED curing units and pluse-delay curing with FTIR. From this experiment, The following results were obtained : 1. From FTIR, the degree of conversion(DC) of composite resin was 34.52-49.31%, DC of composite resin used in Flipo was $39.36{\pm}1.22%$, CrediII $45.64{\pm}1.34%$, XL3000 $43.48{\pm}1.34%$, VIP(mode 4) $44.31{\pm}0.72%$, LUXOMAX $49.31{\pm}2.37%$, Elipar Freelight $44.51{\pm}0.62%$ and $34.52{\pm}0.85%$ in pulse-delay curing. 2. The degree of conversion of composite resin in each light-curing unit was highest DC of the LUXOMAX system, lowest DC of the pulse-delay curing. 3. Compared with other curing system, Flipo, LUXOMAX, and pulse-delay curing were significant difference(p<0.05). 4. In same curing method group, the differences of each light-curing unit were no significace in halogen(conventional) curing method(p>0.05), but significance in plasma arc curing and LED curing method(p<0.05).

• Journal of Korean Academy of Nursing
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• v.34 no.2
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• pp.270-277
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• 2004

Purpose: The purpose of this study was to investigate the relationship between decision-making factors(theoretical knowledge, expertise, empowerment, intuition) and participation in proportion to nurses's clinical experience. Method: Data was collected by quota sampling from July 10, 2001 to August 22, 2001 from 132 clinical nurses who work for 3 General hospitals. Data was analyzed using SPSSWIN 10.0 with crosstab, ANOVA, and stepwise multiple regression. Result: Expertise(F=34.347, p=.000), empowerment(F=29.316, p=.000), and participation(F=3.276, p=.041) were significantly different among 3 clinical experience groups. Clinical experience correlated with expertise(r=.551, p=.000) and empowerment(r=.492, p=.000), and Decision-making participation also correlated with expertise(r=.351, p=.000) and empowerment(r=.265, p=.002). Decision-making participation is effected by theoretical knowledge(under 3.00yr clinical experience), expertise(3.01-5.00yr), and empowerment(above 5.01yr). Conclusion: These findings indicate that factors(theoretical knowledge, expertise, or empowerment) on decision-making participation varies as nurses's clinical experience differs. Therefore, decision-making needs bilateral agreement between staff nurses and nurse managers rather than the responsibility of one.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.6099-6104
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• 2015

Background: Previous studies investigating the association between miR-34b/c rs4938723 polymorphism and cancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR- 34b/c rs4938723 polymorphism and digestive cancer risk. Materials and Methods: Literature database including PubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerning the association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk. Results: A total of 6 studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysis suggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model, homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CC vs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs TT/TC: OR=0.68, 95%CI=0.58-0.80, p-value=0.000). Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger's funnel plot and Egger's test did not show significant publication bias. Conclusions: The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.

• Tuberculosis and Respiratory Diseases
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• v.48 no.5
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• pp.773-780
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• 2000

Background : pH measurement is an important test in assessing the etiology of pleurisy and in identifying complicated parapneumonic effusion. Although the blood gas analyzer is the gold standard method' for pleural pH measurement, pH meter & pH strip methods are also used for this purpose interchangably. However, the correlation among the pH data measured by the three different methods needs to be evaluated. In this study, we measured the pH of pleural fluid with the three different methods respectively and evaluated the correlation among the measured data. Methods : From August 1999 to March 2000, we measured the pleural fluid pH in 34 clinical samples with three methods-blood gas analyzer, pH meter, and pH strip. In the blood gas analyzer and pH meter methods, the temperature of pleural fluid was maintained around $0^{\circ}C$ in air-tight condition before analysis and measurement was performed within 30 minutes after collection. As for the pH strip method, the pleural fluid pH was checked in the ward immediately after tapping and in the clinical laboratory of our hospital. This part is unclear. Results : The causes of pleural effusion were tuberculosis pleurisy in 16 cases, malignant pleural effusion 5 cases, parapneumonic effusion 9 cases, empyema 3 cases, and congestive heart failure 1 case. The pH of pleural fluid (mean$\pm$SD) was 7.34$\pm$0.12 with blood gas analyser, 7.52$\pm$0.25 with pH meter, 7.37$\pm$0.16 with pH strip of immediate measurement and 6.93$\pm$0.201 with pH strip of delayed measurement. The pH measured by delayed pH strip measurement was lower than those of other methods (p<0.05). The correlation of the results between the blood gas analyzer and pH meter(p=0.002, r=0.518) and the blood gas analyzer and pH strip of immediate measurement(p<0.001, r=0.607). Conclusion : In the determination of pH of pleural fluid, pH strip method could be a simple and reliable method under immediate measurement conditions after pleural fluid tapping.