• 한국조경학회지
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• 제43권4호
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• pp.98-111
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• 2015

도시개발과 기후변화로 인해 증가하는 도시침수, 지하수 고갈, 하천오염 그리고 도시 열섬 현상 등의 환경문제는 도시 물순환 회복을 통해 경감시킬 수 있다. 효과적인 물순환 회복 계획수립을 위해서는 개별 사업이나 소규모 시설에 대해 물수지 현황과 변화를 면적으로 나타낼 수 있는 지도형태의 분석틀이 필요하다. 이를 위해, 토양-식생 기반의 물수지 모델 BAGLUVA의 구조를 분석하고, BAGLUVA 모델의 수문요소와 입력자료와 관련된 우리나라 관련 연구결과에 대해 조사하였다. BAGLUVA 모델은 기후, 토지이용, 지형, 토양수문 그리고 관개 등의 5가지 부문으로 구성된다. 5가지 구성요소의 상호 연계 구조와 개별 입력데이터 그리고 지형 계수, 최대증발산 비율, 유효근권 등의 개념과 적용 방법을 비교 분석하였다. 그리고, 실제 증발산량-잠재증발산량-강수량 간의 관계를 매개하는 Bagrov 계수의 산정 방식을 나타내었다. 면적단위의 토지이용별 물순환지도(Hydrotope Map)를 통해, 임의의 소규모 지역 물수지 현황을 효과적으로 파악할 수 있다. 그리고, 물순환 보전 및 관리를 위한 분산형 빗물관리, 저영향개발(LID) 시설의 계획 설계 상의 목표량 설정을 공정하고 용이하게 수행할 수 있다. 또한, 수자원 관리를 조경 및 도시계획에 통합시키는 유용한 도구이다.

• Journal of Pharmaceutical Investigation
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• 제34권6호
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• pp.521-527
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• 2004

Cimetidine is a histamine $H_2-receptor$ antagonist, used for the treatment of endoscopically or radiographically comfirmed duodenal ulcer, pathologic GI hypersecretory conditions, and active, benign and gastric ulcer. Simple method for determining cimetidine in human plasma has been developed and validated. The analytical procedure for cimetidine showed a linear relationship in the concentration ranges from $0.05\;to\;5\;{\mu}g/ml$. Coefficient of variance (CV, %) for intraday and interday validation and relative error (RE, %) were less than ${\pm}15%$. Based on this analytical method, the bioequivalence of two cimetidine 400 mg tablets, reference (Tagamet 400 mg) and test drug (Sinil CIMETIDINE 400 mg) was evaluated according to the guidelines set by the Korea Food and Drug Administration (KFDA). Release of cimetidine from the tablets in vitro was tested using KP VIII Apparatus II with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). Twenty-four healthy volunteers, $21.38{\pm}1.86$ years in age and $68.71{\pm}8.68\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was performed. After oral administration of a tablet containing 400 mg of cimetidine, blood samples were taken at predetermined time intervals and concentrations of cimetidine in plasma were determined using HPLC equipped with UV detector. The dissolution profiles of the two tablet formulations were very similar at all dissolution media. In addition, pharmacokinetic parameters such as $AUC_t$ and $C_{max}$ were calculated and ANOVA was employed for the statistical analysis of parameters. The results were revealed that the differences in $AUC_t$ and $C_{max}$ between the two tablets were 4.17 % and 0.97% respectively. At 90% confidence intervals, the differences in these parameters were also within ${\pm}20%$. All of the above mentioned parameters have met the criteria of KFDA guidelines for bioequivalence, indicating that the test drug tablet (Sinil CIMETIDINE tablet) is bioequivalent to Tagamet 400 mg tablet.

• 지질공학
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• 제11권2호
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• pp.163-174
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• 2001

탄성파 굴절법 탐사를 이용한 지반조사시 탐사 결과로부터 표토층 및 풍화대 깊이, 연암 또는 기반암의 심도, 단층 파쇄대나 연약지반의 위치 및 규모, 지질경계 등을 파악, 지하 속도분포를 도출함으로서 Rippability 등 지반 공학적 특성의 정량적 평가가 가능하다. 이를 위하여는 양질의 자료 취득은 물론 조사 목적과 탐사심도에 맞는 측선길이 및 배치, 수진점과 진원점 감격 및 배치, 지형기복 여부 등 현장조사 파라미터의 설정이 중요하다. 택지개발 지역의 절토 사면부에서는 수진점 간격을 3∼5m 정도가 적합하며 측선의 배열은 주측선과 주요 지점에서 이에 사교하는 부측선 배치가 필요하다. 굴절법 토모그라피 해석기법의 적용시, 조사장비의 가용 채널 수에 1/4 이상의 진원점으로부터 자료를 취득해야 지하구조 해석시 지형의 영향에 의한 왜곡현상을 감소시킬 수 있다. 편마암 지대인 절토사면부에서 시추자료와 비교하여 탄성파 속도 토모그램에 의한 지반분류는 토사 700 m/s 이하, 풍화암 700∼1,200m/s, 연암 1,200∼1,800m/s 이고 굴삭난이도(리퍼빌리티)는 리핑암 700∼1,200m/s, 발파암 1,800m/s 이상으로 나타났다.

• 한국항해항만학회지
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• 제44권3호
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• pp.158-165
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• 2020

해상등부표는 선박 통항의 안전을 위해 필요한 시설로 파손 및 유실되는 경우 예상치 못한 예산 지출뿐 아니라 등부표 운용이 불가능해짐에 따라 선박 통항 안전에도 큰 영향을 미칠 수 있다. 본 연구에서는 해역의 교통흐름을 반영할 수 있는 해상교통평가지표를 적용하여 등부표 접촉사고의 위험성을 평가하고자 한다. 이를 위하여 평가대상 해역을 등부표 설치기수가 많고 등부표 접촉사고가 많이 발생하는 부산항 제5항로로 설정하고, 대상해역의 등부표 접촉사고 현황을 조사했다. 그리고 해상교통평가지표로 사용될 수 있는 해상위험평가도구인 IALA Waterway Risk Assessment Programme(IWRAP MkII)와 Potential Assessment of Risk Model(PARK Model)를 활용하여 등부표 접촉사고 발생의 위험성을 평가했다. 그 결과, 마산항 입출항 선박과 부산항신항 입출항 선박으로 교통흐름이 복잡한 경계해역 인근에 위치한 등부표와 항로를 따르지 않는 선박들이 항로를 가로지르는 운항패턴을 보이는 가덕수도 입구 인근에 위치한 등부표, 부산항신항 내항항로의 방파제 인근에 위치한 등부표가 접촉사고 위험성이 큰 것으로 평가되었다. 본 연구는 등부표 사고 위험성을 평가할 수 있는 통합 모델을 만드는 기초 자료로 활용될 수 있으며, 추후에 다양한 해역의 접촉사고 위험성을 평가하고, 미래교통량을 추정·적용하여 등부표 신설 시 안전한 등부표 설치 위치를 선정할 수 있을 것이다.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.112-121
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• 2017

Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts for >50% of reported DILI cases but little is known for the cause of individual variations in the severity. Intrinsic genetic variation is considered a key element but the identity of the genes was not well-established. Here, pre-biopsy method and microarray technique was applied to uncover the key genes for APAP-induced liver injury in mice, and a cause and effect experiment employing quantitative real-time PCR was conducted to confirm the correlation between the uncovered genes and APAP-induced hepatotoxicity. We identified the innately and differentially expressed genes of mice susceptible to APAP-induced hepatotoxicity in the pre-biopsied liver tissue before APAP treatment through microarray analysis of the global gene expression profiles (Affymetrix $GeneChip^{(R)}$ Mouse Gene 1.0 ST for 28,853 genes). Expression of 16 genes including Gdap10, Lpl, Gabra3 and Ccrn4l were significantly different (t-test: FDR <10%) more than 1.5 fold in the susceptible animals than resistant. To confirm the association with the susceptibility to APAP-induced hepatotoxicity, another set of animals were measured for the expression level of selected 4 genes (higher two and lower two genes) in the liver pre-biopsy and their sensitivity to APAP-induced hepatotoxicity was evaluated by post hoc. Notably, the expressions of Gabra3 and Lpl were significantly correlated with the severity of liver injury (p<0.05) demonstrating that these genes may be linked to the susceptibility to APAP-induced hepatotoxicity.

• 한국토양비료학회지
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• 제44권5호
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• pp.944-958
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• 2011

Soil hydraulic properties such as hydraulic conductivity or water retention which are costly to measure can be indirectly generated by soil pedotransfer function (PTF) using easily obtainable soil data. The field soil structure description which is routinely recorded could also be used in PTF as an input to reduce the uncertainty. The purposes of this study were to use qualitative morphological soil structure descriptions and soil structural index into PTF and to evaluate their contribution in the prediction of soil hydraulic properties. We transformed categorical morphological descriptions of soil structure into quantitative values using categorical principal component analysis (CATPCA). This approach was tested with a large data set from the US National Pedon Characterization database with the aid of a categorical regression tree analysis. Six different PTFs were used to predict the saturated hydraulic conductivity and those results were averaged to quantify the uncertainty. Quantified morphological description was successively used in multiple linear regression approach to predict the averaged ensemble saturated conductivity. The selected stepwise regression model with only the transformed morphological variables and structural index as predictors predicted the $K_{sat}$ with $r^2$ = 0.48 (p = 0.018), indicating the feasibility of CATPCA approach. In a regression tree analysis, soil structure index and soil texture turned out to be important factors in the prediction of the hydraulic properties. Among structural descriptions size class turned out to be an important grouping parameter in the regression tree. Bulk density, clay content, W33 and structural index explained clusters selected by a two step clustering technique, implying the morphologically described soil structural features are closely related to soil physical as well as hydraulic properties. Although this study provided relatively new method which related soil structure description to soil structure index, the same approach should be tested using a datasets containing the actual measurement of hydraulic properties. More insight on the predictive power of soil structure index to estimate hydraulic properties would be achieved by considering measured the saturated hydraulic conductivity and the soil water retention.

• PNF and Movement
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• 제13권4호
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• pp.181-188
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• 2015

Purpose: This study aimed to examine the effects of proprioceptive neuromuscular facilitation (PNF) lower extremity patterns combined with elastic bands applied to stroke patients diagnosed with hemiplegia through self-training using the non-paralyzed side approach and the paralyzed side approach, and to investigate the differences in the effects. Methods: Nine chronic stroke patients who were being treated not more than twice a week at H, K, R, and C hospitals located in Gangwon-do, performed self-training for 16 minutes, two times per day for four weeks between August and October 2015. The subjects' balance ability was measured using the Tetrax stability index, the weight distribution index, the Berg Balance Scale (BBS), and the Timed Up and Go (TUG) test before the experiment and four weeks later. Among the statistical methods, paired t-tests were conducted for intra-group comparison of the measurements taken before and after the experiment, and independent t-tests were conducted for inter-group comparison of the ex post facto values. The statistical significance level was set to 0.05. Results: When the lower extremity patterns were applied to the non-paralyzed side group and the paralyzed side group, significant intra-group differences were observed for the Tetrax stability index, the weight distribution index, the Berg Balance Scale (BBS), and Timed Up and Go (TUG) tests (p<0.05); however, the inter-group comparisons showed no significant differences. Conclusion: The non-paralyzed side approach was found to be easy for patients to participate in and it also affected the patients' paralyzed side. Although the paralyzed side approach produced good exercise effects in a short period of time, it could result in adverse effects, such as a decrease in motivation and self-confidence. Therefore, these approaches are considered to be more effective when they are selectively applied depending on the purpose of the intervention and the degree of a patients' participation.

• 한국식품과학회지
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• 제53권6호
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• pp.739-748
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• 2021

본 연구에서는 가공용 쌀 이용성 향상을 위한 쌀 가공 제품개발과 쌀 생면 제조 기술 확보를 위해 반응표면분석법을 이용하여 글루텐 프리 쌀 우동의 주원료인 쌀가루, 변성전분(아세틸아디핀산이전분), 트레할로스의 함량에 따른 글루텐 프리 쌀 우동의 품질에 미치는 영향을 분석하고 제조 배합비를 Box-Behnken법을 이용하여 최적화하였다. 반응모형에서 쌀가루 함량이 높을수록 수분흡수율, 부피, 황색도, 탄성, 검성, 씹힘성, 응집성이 증가하였으며 변성전분의 함량이 적을수록 황색도, 탄성이 높았다. 수분함량, 명도, 황색도는 linear 모델로 결정되었으며 p-value는 <0.0001, 0.0113, 0.0214로 유의적 차이를 보였다. 글루텐 프리 쌀 우동 주원료의 배합비는 트레할로스의 첨가 없이 쌀가루 60 g, 변성전분 18.81 g 사용하는 것이 바람직한 것으로 나타났다. 반응표면 분석법을 통한 최적 배합비에 따라 글루텐 프리 쌀 우동을 제조한 결과 백색도는 73.09, 수분 흡수율은 59.73%, 부피 32.61 mL, 탁도 0.44, 조리손실율 5.74%, 용출고형분 함량은 1.86%였다. 이 연구 결과는 글루텐 프리 쌀 우동 제조에 기초자료로 제공되어 향후 제품 개발에 도움이 될 것으로 여겨진다.

• 대한방사선기술학회지:방사선기술과학
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• 제44권5호
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• pp.443-449
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• 2021

In this study, the purpose is to present the foot inclination angle for realizing an image similar to that of the existing examination method and to present the clinical usefulness of the new examination method through comparison between the existing examination method and the newly designed standing foot oblique projection. A foot phantom was used, and the magnification of the image according to the angle was quantitatively evaluated by attaching a nut to the position of the cuboid of the phantom. The internal oblique image acquired using a 30° wedge was set as the standard image. And that image was compared with the images acquired by changing the angle of the foot from 20° to 65° at intervals of 5°. Image evaluation was performed by 3 radiological technologists, and qualitative evaluation using a Likert 5-point scale for evaluation items of true oblique view and quantitative evaluation of the value obtained by measuring the diameter of a nut in each image were performed as image evaluation. For data analysis, reliability analysis between the measure and comparative analysis of the average value for each angle were performed. The qualitative evaluation score for each image was 4.5 to 5 points for most questions in the case of the standard image. And 4 points or less for most questions in the images with a foot angle of 45° or less, and an evaluation score close to the standard image was obtained in the image of 50° or more. And in the quantitative evaluation, the diameter of the nut was measured to be 9.28~9.56 mm. The qualitative evaluation showed a reliability of 0.95~1.0 and the quantitative evaluation was 0.62. As a result of comparing and analyzing the average of the quantitative and qualitative average values for each angle image, the group with the average value most similar to the standard image was images obtained at 55° and 60°, and in the post-analysis, the images of both groups were the same group as the standard image(p<0.01). As a result of this study, it was found that the angle of inclination of the foot for realizing the image most similar to the existing image in the standing foot oblique projection is 55°~60°. In addition, if this test method is applied to the clinic, it is believed that it will help prevent safety accidents such as falls during the test and improve test efficiency by minimizing the movement of patients for the test.

• 한국항해항만학회지
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• 제45권6호
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• pp.276-283
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• 2021

해운업은 선박투자에 대규모의 자본이 소요되는 한편 시장의 변동성이 극심하기 때문에 투자자금의 조달구조는 기업의 안정성과 직결된다. 지금까지의 해운업 자본구조 연구는 주로 재무제표를 기반으로 자본구조의 결정요인을 도출하는 형태로 진행되었지만 이 연구에서는 접근을 달리하여 과거의 선박가격, 이자율 그리고 부채비중의 변화가 실제 어느 정도의 현금손익으로 이어졌는지 역사적 시뮬레이션을 통해 파악하였다. 연구 결과 현금손익이 0이 되는 손익분기점이 파나막스선은 부채비중 64.38%(부채비율 180.74%), 케이프선은 73.04%(부채비율 270.92%)인 것으로 나타났는데 이는 케이프선에서 추가적인 부채 활용이 가능함을 의미한다. 또한 'Super Boom' 이전과 이후로 구분하여 분석한 결과 선종별로 다른 패턴이 형성되었다. 이를 통해 선종 즉, 영업영역별로 다른 레버리지의 관리가 필요하며 시황 국면에 따라서도 탄력적인 관리가 필요하다는 시사점을 찾을 수 있었다. 이 연구는 해운기업의 입장에서는 기업의 장기적인 안정성을 확보하는 자금조달 구조파악 측면에서, 그리고 해운과 선박금융 정책을 입안하는 정책당국의 입장에서는 해운산업의 건전성을 견인하는 측면에서 실무적인 기여를 할 것으로 기대된다.