• Archives of Pharmacal Research
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• v.28 no.5
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• pp.598-603
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• 2005

The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appen dicitis patients. Gentamicin was administered intravenously over 0.5 h every 8 h. Three specimens were collected at 48 h after the first dose from all patients at the following times, just before regularly scheduled infusion, at 0.5 h and 2 h after the end of 0.5 h infusion. Serum gentamicin levels were analyzed by fluorescence polarization immunoassay technique with TDxFLx. The standard deviation (SD) of the assay over its working range had been determined at the serum gentamicin concentrations of 0, 2, 4, 8, 12, and 16 ${\mu}g$/mL in quadruplicate. The polynominal equation of gentamicin assay error was found to be SD (${\mu}g$/mL) = 0.0246-(0.0495C)+ (0.00203C$^2$). There were differences in the influence of weight with gentamicin assay error on pharmacokinetic parameters of gentamicin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynominal equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result would be improved dosage regimens and better, safer care of patients receiving gentamicin.

• Physical Therapy Korea
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• v.4 no.2
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• pp.1-9
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• 1997

Skeletal muscle fatigue is often associated with diminished athletic performance and inability to maintain an expected force output as a function of time. The purpose of this study was to compare the effect of duration of exercise on skeletal muscle fatigue between Weight Lifters(WL) and Non-Weight Lifters(NWL). There were twelve normal healthy adult volunteers, ranging in age from 18 to 35 years. The group consisted of six NWL and six WL. Randomized cross-over design was set up and work-rest cycle was 8 minutes work and 1 minute rest based on 15% MVC. Muscle fatigue was measured by the amount of force produced by the wrist flexor muscle and EMG amplitude over time. Repeated measures ANOVAs($2{\times}4$) were used to determine two types of subjects(WL, NWL) during four different duration of exercises(16, 32, 48, 64 minutes). The force decreased over time in NWL and WL, but there was no significant difference(F=2.83, p>0.05). However, the EMG amplitude increased in WL(0.8200) and NWL(0.6348). The WL exhibited an increase in EMG at the end of the period, especially at 48 minutes of exercises than did the NWL(F=9.58, p<.05). This suggests the WL were able to adjust to prolonged effort with adaptations in neural effect over time, resulting in higher EMG amplitude. That is, WL may be able to learn to recruit more motor units with training. It is important to the degree of neuromuscular fatigue and the time needed for recovery may differ considerably between WL and NWL, there is a need to plan proper strength training or rehabilitation protocols to match with the requirements in different characteristics of groups.

• Journal of Acupuncture Research
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• v.32 no.4
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• pp.77-89
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• 2015

Objectives : To evaluate the safety of multiple-dose intramuscular Shinbaro Pharmacopuncture in male and female Sprague-Dawley(SD) rats over a period of 4 weeks(12 sessions). Methods : In order to test the safety of multiple-dose intramuscular Shinbaro Pharmacopuncture we used 40 healthy male and female 6-week old SD rats(male weight 171.79~196.37 g, female weight 127.93~146.43 g). Shinbaro Pharmacopuncture was administered intramuscularly to male and female SD rats at doses of 4.6 (low dose group, n=10), 9.2 (moderate dose group, n=10), and 18.5 mg/kg(high dose group, n=10), respectively. General symptoms, body weight changes, blood tests, biochemical testing, necropsy, organ weight and histopathogical findings were examined over a 4-week period. Results : 1. No mortalities or adverse effects were caused by the investigational substance were observed during the study period. 2. There was no significant difference in body weight caused by the the investigational substance across all groups. 3. No significant between-group difference was found to be caused by the investigational substance in blood tests and biochemical testing. 4. No abnormalities were detected by a necropsy examination with the unaided eye at the macro level after treatment with the investigational substance. 5. Difference in organ weight between groups caused by the investigational substance was not found. 6. All groups did not exhibit pathological findings caused by the investigational substance in histopathogical examination. Conclusions : According to these results, Shinbaro Pharmacopuncture has no systemic or organ toxicity with multiple-dose intramuscular administrations in male and female SD rats over a 4-week period (12 sessions). These results imply that no adverse effects are observed at a level (NOAEL) of Shinbaro Pharmacopuncture of 18.5 mg/kg.

• Bulletin of the Korean Mathematical Society
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• v.55 no.3
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• pp.717-734
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• 2018

By choosing defining set properly, several classes of linear codes with a few weights over the finite field ${\mathbb{F}}_p$ are constructed for an odd prime p, and the complete weight enumerators of these classes of codes are determined.

• Journal of the Korean Mathematical Society
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• v.58 no.1
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• pp.219-236
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• 2021

Let �� be a weighted projective line defined over the algebraic closure $k={\bar{\mathbb{F}}}_q$ of the finite field ��q and σ be a weight permutation of ��. By folding the category coh-�� of coherent sheaves on �� in terms of the Frobenius twist functor induced by σ, we obtain an ��q-category, denoted by coh-(��, σ; q). We then prove that coh-(��, σ; q) is derived equivalent to the valued canonical algebra associated with (��, σ).

• Korean Journal of Mathematics
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• v.18 no.1
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• pp.63-77
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• 2010

Infinite finite range inequalities relate the norm of a weighted polynomial over ${\mathbb{R}}$ to its norm over a finite interval. In this paper we extend such inequalities to generalized polynomials with the weight $W(x)={\prod}^{m}_{k=1}{\mid}x-x_k{\mid}^{{\gamma}_k}{\cdot}{\exp}(-{\mid}x{\mid}^{\alpha})$.

• Journal of applied mathematics & informatics
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• v.5 no.1
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• pp.99-110
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• 1998

In this paper we study cyclic codes in $Z_m$. i.e., ideals in $Z_mG$, G afinite abelian group and we give a classification of such codes. We also sgtudy the minimum Hamming distance and the generalized Hamming weight of BCH codes over $Z_m$.

• Korean Journal of Applied Biomechanics
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• v.25 no.2
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• pp.191-198
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• 2015

Objective : The purpose of this study was to conduct biomechanical analysis of varying backpack loads on the lower limb movements during downhill walking over $-20^{\circ}$ ramp. Method : Thirteen male university students (age: $23.5{\pm}2.1yrs$, height: $175.7{\pm}4.6cm$, weight: $651.9{\pm}55.5N$) who have no musculoskeletal disorder were recruited as the subjects. Each subject walked over $20^{\circ}$ ramp with four different backpack weights (0%, 10%, 20% and 30% of body weight) in random order at a speed of $1.0{\pm}0.1m/s$. Five digital camcorders and two force plates were used to obtain 3-d data and kinetics of the lower extremity. For each trial being analyzed, five critical instants were identified from the video recordings. Ground reaction force, loading rate, decay rate, and resultant joint moment of the ankle and the knee were determined by the inverse dynamics analysis. For each dependent variable, one-way ANOVA with repeated measures was used to determine whether there were significant differences among four different backpack weight conditions (p<.05). When a significant difference was found, post hoc analyses were performed using the contrast procedure. Results : The results of this study showed that the medio-lateral GRFs at RHC in 20% and 30% body weight were significantly greater than the corresponding value in 0% of body weight. A consistent increase in the vertical GRFs as backpack loads increased was observed. The valgus joint movement of the knee at RTO in 30% body weight was significantly greater than the corresponding values in 0% and 10% body weight. The increased valgus moment of 30% body weight observed in this phase was associated with decelerating and stabilizing effects on the knee joint. The results also showed that the extension and valgus joint moments of the knee were systematically affected by the backpack load during downhill walking. Conclusion : Since downhill walking while carrying heavy external loads in a backpack may lead to excessive knee joint moment, damage can occur to the joint structures such as joint capsule and ligaments. Therefore, excessive repetitions of downhill walking should be avoided if the lower extremity is subjected to abnormally high levels of load over an extended period of time.

• Proceedings of the Korean Geotechical Society Conference
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• 2003.03a
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• pp.767-772
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• 2003

The clay which transported into a pond under the high water content condition have no effective stress which develop from the starting point of sedimentation and self-weight consolidation. Since sedimentation and self-weight consolidation dependent on self-weight of solids is made progress over a long time, to accelerating it have many advantages in the economic view In this paper, sand spreading method which is one of sedimentation and self-weight consolidation acceleration method is studied through a series of experiments considering the mixing ratio of sand and clay. The test results show that the mixing ratio of clay and sand of 1:0.2 is the biggest rate of consolidation and the pouring at the end point of sedimentation considerably effects on consolidation rate.

• International Journal of Contents
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• v.9 no.4
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• pp.67-71
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• 2013

This study examined the effects of biofeedback postural control training on the weight distribution rate and functional ability of subjects with stroke. A total of 30 stroke patients were enrolled in this study. Subjects were divided into a biofeedback postural training group (experimental group, n=15) and a dynamic balance training group (control group, n=15). Experimental subjects received biofeedback postural training and control subjects received dynamic balance training for 30 minutes per day, 5 times per week over a 6 week period. Weight distribution rate and functional ability were measured to identify the effect of the biofeedback postural training. Significant difference in weight distribution rate was observed in the experimental group, compared with the control group (p=0.05), and a significant difference in functional ability. The results of this study provide evidence in support of incorporating a biofeedback postural training for the improvement of weight distribution rate and functional ability of stroke patients.