• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권6호
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• pp.535-538
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• 2011

Malignant otitis externa (MOE) originates as inflammation of the epidermis in the external auditory canal, and spreads to the surrounding structures and neck, leading to abscess formation. MOE is associated with an immunosuppressive condition and diabetes. Patients with MOE suffer from otalgia, otorrhea and hearing loss. According to the literature, surgery to the temporomandibular joint is controversial as the treatment of choice.

• 대한수의학회지
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• 제61권2호
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• pp.16.1-16.6
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• 2021

Pseudomonas aeruginosa is one of the most common pathogenic species associated with canine otitis externa (OE). Their resilience is achieved by forming a biofilm, which allows these bacteria to evade even the harshest of treatments. This study evaluated the in vitro synergistic efficacy of N-acetylcysteine (NAC) with different antimicrobial agents against P. aeruginosa isolated from dogs with OE to develop an effective treatment against P. aeruginosa. The antimicrobial activity was evaluated by the minimum inhibitory concentration test using the microdilution method. The efficacy of antibiofilm formation was evaluated using a crystal violet stain method. The treatment solutions included NAC alone, and in synergy with enrofloxacin, polymyxin B, and gentamicin. NAC alone exhibited antimicrobial and antibiofilm abilities. On the other hand, the combination of NAC and the antibiotics did not show any significant synergistic effects against P. aeruginosa.

• 한국임상수의학회지
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• 제34권1호
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• pp.23-26
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• 2017

Otitis externa (OE) is an inflammatory disease of the externa auditory meatus that occurs commonly in dogs. Antimicrobial susceptibility tests should be performed in case of chronic OE for successful treatment. In this study, identification and antimicrobial susceptibility test of bacteria isolated from dogs with chronic OE was performed. From 60 dogs with chronic OE, 60 bacterial species were identified. The most frequently identified species were Staphylococcus spp. (51%), followed by Pseudomonas spp. (15%) and Enterococcus spp. (14%). A single bacterial infection and multiple bacterial infections were observed in 67.5% and 32.5%, respectively. Staphylococcus spp. was susceptible to imipenum. Pseudomonas spp. was found to be susceptible to amikacin, cefepime, imipenum and piperacillin-tazobactam. Enterococcus spp. was susceptible to ampicillin-sulbactam, imipenum and piperacillin-tazobactam. Imipenum was highly susceptible antibiotic against both Gram-positive and negative bacteria whereas aztreonam and vancomycin were highly resistant. These results could suggest the optimal choice of antimicrobial agents for canine OE treatment.

• 한국임상수의학회지
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• 제26권3호
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• pp.303-305
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• 2009

A 7-month-old, female miniature pig was presented with excessive cerumen and pruritus. Greasy brown cerumen in both exteranal ear canal and sporadic head shaking were observed in the physical examination. Numerous budding yeasts in the cerumen were examined on microscopic examination. For species identification, PCR-RFLP using incubated colony on modified Dixon's medium was performed and finally, causative yeast was identified as M. furfur.

• Journal of Veterinary Science
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• 제21권1호
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• pp.11.1-11.7
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• 2020

The increase in canine skin and soft tissue infections, such as pyoderma and otitis, caused by Staphylococcus schleiferi strains, is of significant zoonotic concern. In this study, we report the first complete genome sequence for a methicillin-resistant clinical isolate of S. schleiferi (MRSS) designated as SS4, obtained from a dog with otitis externa, in Korea. The genome of SS4 strain was of 2,539,409 bp and presented high G+C content ratio (35.90%) with no plasmid. Comparative analysis of SS4 genome revealed that it is closely related to 2142-05 and 5909-02 strains isolated from the canine skin infections in the USA.

• 대한수의학회지
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• 제61권4호
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• pp.37.1-37.6
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• 2021

This study evaluated the efficacy of a new, single-dose otic solution combining florfenicol, terbinafine, and mometasone furoate for the treatment of canine otitis externa (OE) in vitro and in vivo. Forty-one client-owned dogs with OE were included in the study and divided into a treatment group that received the test solution and a negative control group that received a normal saline solution. On day 0, the dogs were treated either with the test or the control solution and evaluated over 30 days. Clinical efficacy was evaluated by clinical signs and cytological organism counts. In vitro antimicrobial susceptibility was evaluated by the minimum inhibitory concentration (MIC). After treatment with the test solution, clinical signs continuously decreased and cytological scores were significantly reduced. The results of MIC testing showed that the test solution was potent against the common pathogenic causes of canine OE. In this study, the most common causative pathogens were Staphylococcus pseudintermedius, Pseudomonas spp. and Malassezia pachydermatis. No issues related to safety were identified. Based on these results, this new ototopical drug can be used as first line treatment for canine OE.

• 한국임상수의학회지
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• 제19권3호
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• pp.353-356
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• 2002

A 9-year-old male Yorkshire terrior with recurrent chronic otitis externa and otitis interna was referred to the Veterinary Medical Teaching Hospital of Seoul National University. Radiographic findings indicated mineralization around the right ear canal. A tan nodular mats, 1 cm in diameter. was noted near the tympanum after total ear canal ablation. Cytologically. the imprint smear of the cut surface of the mass produced clusters of cells with abundant and weakly basophilic cytoplasm, one small round nucleus and one or two nucleoli, mixed with both degenerate and non degenerate neutrophils. The location of the nuclei was eccentric, and some cells contained somewhat coarse black granules in their cytoplasms, on which the mass was diagnoted as ceruminous gland adenoma or hyperplasia associated with inflammation. Histopathologic examination of the tumor was compatible with a diagnosit of ceruminous gland adenoma. The patient is responding well to sugery and antimicrobial treatment.

• 한국임상수의학회지
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• 제29권6호
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• pp.470-473
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• 2012

말라세지아성 외이염에 대한 아로마치료법 (아로마오일)과 약침치료법 (아피톡신)을 적용하여 임상증상 개선효과를 알아보기 위해 본 연구를 실시하였다. 실험군 5두는 아로마치료와 약침을 실시하였고 대조군 5두는 케토코나졸을 적용하였다. 임상증상은 대조군과 실험군에서 치료 전에 비해 각각 치료 후 2주 후에 유의성 있는 개선효과를 나타내었다 (p < 0.01, p < 0.05). ALT 수치는 대조군에서 치료 전에 비해 치료 후 1주, 2주 후에 각각 유의성 있는 증가소견을 나타내었다 (p < 0.05, p < 0.01). 실험군의 ALT 수치의 변화는 대조군에 비해 치료 1주 후, 2주 후에 각각 유의성 있는 감소소견을 나타내었다 (p < 0.05, p < 0.01). 결론적으로 말라세지아성 외이염에 대한 아로마치료법(아로마 오일)과 약침치료법은 효과가 있으며 대조군에 비해 간독성은 적은 것으로 나타났다.

• 한국임상수의학회지
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• 제30권3호
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• pp.172-177
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• 2013

본 연구는 개 외이염에 대한 enrofloxacin-silver sulfadiazine (Baytril$^{(R)}$ otic, Bayer, USA)의 치료효과를 평가하는 것이다. 24두의 외이염 이환견을 대상으로 처치군에는 바이트릴 오틱을, 대조군에는 증류수를 이도내 7일간 국소투약한 후 7일후에 임상증상, 미생물 및 효모균수를 통해 효과를 비교하였다. 또한 외이염에서 분리된 세균 및 효모균에 대한 바이트릴 오틱의 최소억제농도를 산출하였다. 주요 분리균으로는 Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Proteus spp and Malassezia pachydermatis.이었다. 임상증상의 경감은 81%, 미생물수는 87% 감소하였다. 바이트릴 오틱은 분리된 균에 대한 살균효과가 충분하였고 국소투약에 대한 부작용은 관찰되지 않았다. 따라서 바이트릴 오틱은 개의 외이염 감염에 대한 효과적이며 안전한 제제로 판단된다.

• 한국임상수의학회지
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• 제38권3호
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• pp.159-162
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• 2021

A 5-year-old, intact male, poodle dog with right external auditory canal obstruction and subaural mass was presented. Physical examination revealed that right external auditory canal opening was absent and right head tilt was identified. Aspiration in right subaural mass revealed a small amount of dark brown exudate. Streptococcus canis and Staphylococcus spp. were identified on the microbial culture. Radiography of the skull was revealed absence of air-filled ear canal at the right external ear canal (EEC) level. Computed tomography (CT) revealed well capsulated, hypoattenuated mass in the right EEC region. On the contrast enhanced CT images, rim enhancement around the mass and ear canal obstruction were identified. Fluid attenuated material filled with right bulla. Mild thickening of the right tympanic bulla wall with mild lytic lesion of the ventral wall were found. Based on the images findings, the case was tentatively diagnosed as right external auditory canal atresia with otitis media. Total ear canal ablation and lateral bulla osteotomy was performed. The entire ear canal was removed, numerous hair in the canal and the thickening wall were founded. Right ear canal was sent for histopathological evaluation and found to otitis externa. The patient was followed up for two weeks and there were no complications. This report described the CT diagnosis of right EEC atresia with otitis media rarely reported in small breed dogs.