Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effect of Aromatherapy and Apipuncture on Malassezia-related Otitis Externa in Dogs

개 말라세지아성 외이염에 대한 아로마치료와 약침의 치료 효과

  • Shin, Jin-Cheol (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Sang-Hun (Hanaro Animal Clinics) ;
  • Park, Hyung-Jin (College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung-Won (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (College of Veterinary Medicine, Chungnam National University)
  • Accepted : 2012.12.18
  • Published : 2012.12.31
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Abstract

Aromatherapy and apipuncture was evaluated for its efficacy on canine Malassezia-related otitis externa. Ten dogs with Malassezia-related otitis externa were used in the present study. The control group was treated with ketoconazole, and the experimental group was treated with aromatherapy (topical aroma-oil drop) and apipuncture (injection-acupuncture of apitoxin). Clinical scores of the control group after 2-week treatment (p < 0.01) revealed a significant decrease compared with scores of pre-treatment. Experimental group scores after 2-week treatment revealed a significant decrease compared with scores of pre-treatment (p < 0.05). In the control group, ALT levels were significantly increased in the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), compared with the pretreatment levels. The experimental group ALT levels did not significantly change after 1-week and the 2-week treatments, compared with pre-treatment. ALT levels of the experimental group after the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), was significantly lower than those of the control group. In conclusion, a combination therapy of apipuncture and topical aroma-oil drop is not hepatotoxic and similar to the effect of ketoconazole treatment for Malassezia-related otitis externa in dogs.

말라세지아성 외이염에 대한 아로마치료법 (아로마오일)과 약침치료법 (아피톡신)을 적용하여 임상증상 개선효과를 알아보기 위해 본 연구를 실시하였다. 실험군 5두는 아로마치료와 약침을 실시하였고 대조군 5두는 케토코나졸을 적용하였다. 임상증상은 대조군과 실험군에서 치료 전에 비해 각각 치료 후 2주 후에 유의성 있는 개선효과를 나타내었다 (p < 0.01, p < 0.05). ALT 수치는 대조군에서 치료 전에 비해 치료 후 1주, 2주 후에 각각 유의성 있는 증가소견을 나타내었다 (p < 0.05, p < 0.01). 실험군의 ALT 수치의 변화는 대조군에 비해 치료 1주 후, 2주 후에 각각 유의성 있는 감소소견을 나타내었다 (p < 0.05, p < 0.01). 결론적으로 말라세지아성 외이염에 대한 아로마치료법(아로마 오일)과 약침치료법은 효과가 있으며 대조군에 비해 간독성은 적은 것으로 나타났다.

Keywords

References

  1. Bell KL. Aromatherapy for dogs. In: Holistic aromatherapy for animals, Forres: Findhorn Press. 2002: 145-159.
  2. Cafarchia C, Gallo SS, Capelli S, Otranto D. Occurrence and population size of Malassezia spp. in the external ear canal of dogs and cats both healthy and with otitis. Mycopathologia 2005; 160:143-149. https://doi.org/10.1007/s11046-005-0151-x
  3. Chon SK, Park YJ, Kim HE, Kim NS. Prevalence of Malassezia pachydermatis in canine otitis externa in Chonbuk. J Vet Clin 2006; 23:1-5.
  4. Chryssanthou E, Broberger U, Petrini B. Malassezia pachydermatis fungaemia in a neonatal intensive care unit. Acta Paediatr 2001; 90: 323-327. https://doi.org/10.1111/j.1651-2227.2001.tb00312.x
  5. Cole LK, Luu DH. Rajala-Schultz PJ, Meadows C, Torres AH. In vitro activity of an ear rinse containing tromethamine, EDTA, benzyl alcohol and 0.1% ketoconazole on Malassezia organisms from dogs with otitis externa. Vet Dermatol 2007;18:115-119. https://doi.org/10.1111/j.1365-3164.2007.00583.x
  6. Danny W, William H, Craig E. Disease of otitis externa. In: Muller and Kirk's Small animal dermatology. Philadelphia: Saunders. 1995: 927-943,
  7. Fan YM, Huang WM, Li SF, Wu GF, Lai K, Chen RY. Granulomatous skin infection caused by Malassezia pachydermatis in a dog owner. Arch Dermatol 2006; 142: 1181-1184. https://doi.org/10.1001/archderm.142.9.1181
  8. Ginel PJ, Lucena R, Rodriguez JC, Ortega JA. Semiquantitative cytological evaluation of normal and pathological samples from the external ear canal of dogs and cats. Vet Dermatol 2002; 13: 151-156. https://doi.org/10.1046/j.1365-3164.2002.00288.x
  9. Girao MD, Prado MR, Brilhante RS, Cordeiro RA, Monteiro AJ, Sidrim JJ, Rocha MF. Malassezia pachydermatis isolated from normal and diseased external ear canals in dogs: a comparative analysis. Vet J 2006; 172; 544-548. https://doi.org/10.1016/j.tvjl.2005.07.004
  10. Gotthelf LN. Perpetuating factors and treatment of otitis externa. In: Small animal ear diseases: an illustrated guide, St. Louis: Elsevier. 2005: 173-201.
  11. Gueho E, Simmons RB, Pruitt WR, Meyer SA, Ahearn DG. Association of Malassezia pachydermatis with systemic infections of humans. J Clin Microbiol 1987; 25: 1789-1790.
  12. Kim MH. The main component of bee venom. In: Bee venom therapy and bee acupuncture therapy, Seoul: Korean Education and Planning Co. 1992: 67-132.
  13. Larocco M, Dorenbaum A, Robinson A, Pickering LK. Recovery of Malassezia pachydermatis from eight infants in a neonatal intensive care nursery: clinical and laboratory features. Pediatr Infect Dis J 1988; 7: 398-401. https://doi.org/10.1097/00006454-198806000-00006
  14. Lefebvre SL, Waltner-Toews D, Peregrine AS, Reid-Smith R, Hodge L, Arroyo LG, Weese JS. Prevalence of zoonotic agents in dogs visiting hospitalized people in Ontario: implications for infection control. J Hosp Infect 2006; 62: 458-466. https://doi.org/10.1016/j.jhin.2005.09.025
  15. Marshall MJ, Harris AM, Horne JE. The bacteriological and clinical assessment of a new preparation of the treatment of otitis externa in dogs and cats. J Small Anim Pract 1974;15: 401-410. https://doi.org/10.1111/j.1748-5827.1974.tb06514.x
  16. Masuda A, Sukegawa T, Mizumoto N, Tani H, Miyamoto T, Sasai K, Baba E. Study of lipid in the ear canal in canine otitis externa with Malassezia pachydermatis. J Vet Med Sci 2000; 62: 1177-1182. https://doi.org/10.1292/jvms.62.1177
  17. Masuda A, Sukegawa T, Tani H, Miyamoto T, Sasai K, Morikawa Y, Baba E. Attachment of Malassezia pachydermatis to the ear dermal cells in canine otitis externa. J Vet Med Sci 2001; 63: 667-669. https://doi.org/10.1292/jvms.63.667
  18. Morgan RV. Disease of external ear and pinna. In: Handbook of small animal practice, St. Louis: Saunders Elsevier. 2008: 1045-1050.
  19. Morris DO. Malassezia dermatitis and otitis. Vet Clin North Am Small Anim Pract 1999; 29: 1303-1310. https://doi.org/10.1016/S0195-5616(99)50128-9
  20. Morris DO. Malassezia pachydermatis carriage in dog owners. Emerg Infect Dis 2005; 11: 83-88. https://doi.org/10.3201/eid1101.040882
  21. Nakano Y, Matsuo S, Tani H, Sasai K, Baba E. Therapeutic effects of beta-thujaplicin eardrops on canine Malasseziarelated otitis externa. J Vet Med Sci 2006; 68: 373-374. https://doi.org/10.1292/jvms.68.373
  22. Plumb DC. Plumb's veterinary drug handbook, 6th ed, Ames: Blackwell Publishing. 2008: 695-700.
  23. Scheon AM, Wynn SG. Aromatherapy. In: Complementary and alternative veterinary medicine, St. Louis: Mosby. 1998:561-578.