• The Korean Journal of Pain
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• 제19권1호
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• pp.107-110
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• 2006

Tremor is a rhythmic, involuntary and oscillatory movement of body parts, and it is the most common movement disorder. Spasticity is also one of the movement disorders that is commonly accompanied with Complex Regional Pain Syndrome; however, the basic nature of spasticity has not yet been proved. A 25-year-old male patient had two operations and he was being treated because of a back injury that occurred 4 years ago. He suffered from pain, tremor and spasticity on both his lower legs, and his symptoms were diagnosed as failed back surgery syndrome. The tremor and spasticity were aggravated despite of continuous treatments. We then treated him with spinal cord stimulation. His pain, tremor and spasticity disappeared after spinal cord stimulation.

• Applied Biological Chemistry
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• 제48권3호
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• pp.273-279
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• 2005

To develop cosmetics using Jindalae flowers (Rhododendron mucronulatum), the surface tensions of extracts were measured and the properties and stability of cream with extracts were investigated. The surface tension of 0.1% ethanol extract was 30.42 mN/m and that of distilled water was 72.2 mN/m. The surface tension of cream with 0.1% ethanol extract was similar to that of sample cream and the measured pH were weakly alkalic. The surface tension of 1% ethanol extract was the lowest value of 24.98 mN/m, the measured pH of cream with 1% ethanol extract was weakly acidic and the particle size of cream was stable. According to an oscillatory test, linear viscoelastic region was extended by adding of 1% water extract and 1% ethanol extract to cream, indicating that the cream had greater enhanced resistance for preserving inner structure as compared to outside stress.　Besides, as a result of the diminished loss angle of ethanol extract cream, the elasticity of cream was increased more than that of sample cream and cream with 0.1% ethanol extract. In contrast, in the case of the increased loss angle of water extract cream, the viscosity of cream was increased. In conclusion, Rhododendron mucronulatum can be deliberated as a cosmetic material because 0.1% water and ethanol extracts showed efficacious physiological activities and cream with 1% extracts could extend linear viscoelastic region.

• 한국항공우주학회지
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• 제37권1호
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• pp.62-68
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• 2009

하이브리드 로켓 연소에서 발생하는 산화제 난류 유동과 연료의 기화로 인한 분출유동 사이의 상호 간섭은 매우 복잡하고 특별한 유동 간섭을 일으킨다. 이를 연구하기 위하여 연소반응을 제외하고, 산화제의 난류 유동과 연료 벽면에서의 분출 유동을 모사한 채널 유동에 대한 LES 해석을 수행하였다. 고체추진 로켓의 연소 과정에서 관찰되는 현상과 매우 흡사하게 벽면 근처에서 특정주파수로 진동하는 유동 현상이 존재한다는 것을 확인하였고, 산화제와 분출 유동의 간섭에 기인한 유동의 진동현상은 벽면 근처의 매우 얇은 영역에서만 존재하였다. 큰 길이 스케일의 유동현상을 보여주는 압력 섭동장으로부터 채널 내 주유동이 특정 주파수 특성을 갖고 하류로 진행해 가는데, 이는 산화제 유동이 분출유동과 상호작용을 하면서 발생된 전단유동의 특성을 나타낸 것이다. 그러나 하이브리드 로켓 연소실 유동의 진동 특성은 고체 추진 로켓에서 관찰되는 유동 특성과는 달리, 진동의 강도가 벽면에서 온도 구배를 변화시켜 열전달의 향상을 발생시키기에는 충분하지 못한 것으로 보인다. 그러나 벽면 근처에서 특정 주파수 특성을 갖는 유동현상이 존재한다는 사실은 비슷한 크기의 주파수를 갖는 음향 가진과 같은 외부교란이 작용한다면 공진으로 발전할 수 있는 가능성을 의미한다.

• The Korean Journal of Physiology and Pharmacology
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• 제9권2호
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• pp.131-135
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• 2005

Potassium channels in human skin fibroblast have been studied as a possible site of Alzheimer disease pathogenesis. Fibroblasts in Alzheimer disease show alterations in signal transduction pathway such as changes in $Ca^{2+}$ homeostasis and/or $Ca^{2+}-activated$ kinases, phosphatidylinositol cascade, protein kinase C activity, cAMP levels and absence of specific $K^+$ channel. However, little is known so far about electrophysiological and pharmacological characteristics of large-conductance $Ca^{2+}$-activated $K^+$ ($BK_{Ca}$) channel in human fibroblast (CRL-1474). In the present study, we found Iberiotoxin- and TEA-sensitive outward rectifying oscillatory current with whole-cell recordings. Single channel analysis showed large conductance $K^{+}$ channels (106 pS of chord conductance at +40 mV in physiological $K^+$ gradient). The 106 pS channels were activated by membrane potential and $[Ca^{2+}]_i$, consistent with the known properties of $BK_{Ca}$ channels. $BK_{Ca}$ channels in CRL-1474 were positively regulated by adenylate cyclase activator ($10{\mu}M$ forskolin), 8-Br-cyclic AMP ($300{\mu}M$) or 8-Br-cyclic GMP ($300{\mu}M$). These results suggest that human skin fibroblasts (CR-1474) have typical $BK_{Ca}$ channel and this channel could be modulated by c-AMP and c-GMP. The electrophysiological characteristics of fibroblasts might be used as the diagnostic clues for Alzheimer disease.

• 대한의용생체공학회:의공학회지
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• 제30권4호
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• pp.347-354
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• 2009

For the reliable transmission of meaningful visual information using prosthetic electrical stimulation, it is required to develop an effective stimulation strategy for the generation of electrical pulse trains based on input visual information. The characteristics of neuronal activities of retinal ganglion cells (RGCs) evoked by electrical stimulation should be understood for this purpose. In this study, for the development of an optimal stimulation strategy for visual prosthesis, we analyzed the neuronal responses of RGCs in rd1 mouse, photoreceptor-degenerated retina of animal model of retinal diseases (retinitis pigmentosa). Based on the in-vitro model of epiretinal prosthesis which consists of planar multielectrode array (MEA) and retinal patch, we recorded and analyzed multiunit RGC activities evoked by amplitude-modulated electrical pulse trains. Two modes of responses were observed. Short-latency responses occurring at 3 ms after the stimulation were estimated to be from direct stimulation of RGCs. Long-latency responses were also observed mainly at 2 - 100 ms after stimulation and showed rhythmic firing with same frequency as the oscillatory background field potential. The long-latency responses could be modulated by pulse amplitude and duration. From the results, we expect that optimal stimulation conditions such as pulse amplitude and pulse duration can be determined for the successful transmission of visual information by electrical stimulation.

• Wind and Structures
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• 제5권2_3_4호
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• pp.291-300
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• 2002

An efficient large eddy simulation algorithm is used to compute surface pressure distributions on an eleven story (target) building on the NIST campus. Local meteorology, neighboring buildings, topography and large vegetation (trees) all play an important part in determining the flows and therefore the pressures experienced by the target. The wind profile imposed at the upstream surface of the computational domain follows a power law with an exponent representing a suburban terrain. This profile accounts for the flow retardation due to friction from the surface of the earth, but does not include fluctuations that would naturally occur in this flow. The effect of neighboring buildings on the time dependent surface pressures experienced by the target is examined. Comparison of the pressure fluctuations on the single target building alone with those on the target building in situ show that, owing to vortices shed by the upstream buildings, fluctuations are larger when such buildings are present. Even when buildings are lateral to or behind the target, the pressure disturbances generate significantly different flows around this building. A simple grid-free mathematical model of a tree is presented in which the trunk and the branches are each represented by a collection of spherical particles strung together like beads on a string. The drag from the tree, determined as the sum of the drags of the component particles, produces an oscillatory, spreading wake of slower fluid, suggesting that the behavior of trees as wind breakers can be modeled usefully.

• 한국미생물·생명공학회지
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• 제20권4호
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• pp.417-421
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• 1992

Sucrose에 의한 재조합 Saccharomyces cerevisiae의 invertase 생성 양성을 이단계 배양을 통하여 관찰하였다. 포도당 배지에서 SUC2 유전자의 발현이 억제된 상태에서 발현배지의 sucrose 농도가 2$g/\ell$일 경우 invertase 최대 비역가는 10 units로 5$g/\ell$보다 40% 향상된 값을 보여주었다. 발현배지에서의 당의 농도변화와 invertase 발현은 서로 대응관계가 있음을 발견하였다. 초기에는 SUC2 유전자가 발현되어 invertase가 생성 분비되어서 배지중 sucrose를 포도당과 과당으로 분해하였다. 분해된 포도당의 농도가 2$g/\ell$ 이상이 되면 invertase 생성은 다시 억제되었다. 동시에 미생물에 생육에 의해 포도당 농도가 2$g/\ell$이하로 감소되면서 다시 invertase 생성이 유도되었다. 이러한 현사은 5$g/\ell$의 sucrose 배지에서 더욱 현저하게 관찰 할 수 있었다. 발현배지의 온도를 $35^{\circ}C$증가시켰을 경우 invertase 생성은 $30^{\circ}C$보다 약 1.7배만큼 증가하였다.

• 조명전기설비학회논문지
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• 제25권3호
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• pp.24-32
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• 2011

[ $SF_6$ ]gas, which has an excellent dielectric strength and interruption performance, is used in various applications such as gas insulated switchgear (GIS) in substations. However, since $SF_6$ has a high global warming potential (GWP), it is necessary to find an eco-friendly alternative insulation gas. In order to examine the possibility of using alternative insulation gases for $SF_6$ in power distribution system equipment, the dielectric strength and physical phenomena of dry air in a quasi-uniform electric field are investigated experimentally in this paper. As a result, the breakdown voltages for positive polarity are higher than those for negative polarity under impulse voltage applications. The negative 50[%] flashover voltage, $V_{50}$ of dry air under conditions above 0.4[MPa] gas pressure, is higher than 150[kV], that is the basic impulse insulation level of distribution equipment. The $V_{50}$ increases linearly with increasing the gas pressure, regardless of the waveform and polarity of the applied impulse voltages. The voltage-time curves are dependent on the rise time of the impulse voltage and gas pressure. Furthermore, streamer discharge was observed through light emission images by an ICCD camera under impulse voltage applications.

• 암석학회지
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• 제23권2호
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• pp.139-144
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• 2014

저어콘 음극선발광영상의 입체적 연구를 위해, 단계적 연마를 사용한 연쇄단층촬영과 영상 후처리작업으로 저어콘 내부 누대구조의 3차원 복원을 최초로 시도하였다. 연구에 사용된 시료는 경상분지 북동부 영덕화강암체에서 분리한 고생대말 시기의 저어콘으로 평면 음극선발광영상에서는 전형적인 진동누대구조가 관찰된다. 시료의 연쇄단층촬영을 위해 에폭시마운트 제작 후 $3{\mu}m$과 $1{\mu}m$ 연마액을 이용한 연마와 후방산란전자영상과 음극선발광영상 촬영을 시료가 소진될 때까지 반복하였다. 단계별 두께의 차이는 약 $3{\mu}m$이며, 약 80여개의 저어콘 중 7개를 선정하여 같은 면적 영상파일로 저장한 후 영상편집 소프트웨어인 Image J와 Volume Viewer를 이용하여 3차원 내부구조를 복원하여, 저어콘의 진동누대 및 덧성장구조를 입체적으로 재현하는데 성공하였다. 3차원적 내부구조 영상은 2차원적으로 관찰하는 단면영상의 내부구조와 달리 특정방향에 따른 단면관찰이 가능하고 다양한 변화양상을 재현할 수 있다. 이 방법은 고분해능 이차이온질량분석기 연대결과가 복잡하게 나오는 저어콘이나 미세구조 파악이 필요한 다른 지질시료의 입체적인 성장 및 재결정작용의 내부 구조연구에 응용될 수 있다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1983-1989
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• 2005

Industrial robots are powerful, extremely accurate multi-jointed systems, but they are heavy and highly rigid because of their mechanical structure and motorization. Therefore, sharing the robot working space with its environment is problematic. A novel pneumatic artificial muscle actuator (PAM actuator) has been regarded during the recent decades as an interesting alternative to hydraulic and electric actuators. Its main advantages are high strength and high power/weight ratio, low cost, compactness, ease of maintenance, cleanliness, readily available and cheap power source, inherent safety and mobility assistance to humans performing tasks. The PAM is undoubtedly the most promising artificial muscle for the actuation of new types of industrial robots such as Rubber Actuator and PAM manipulators. However, some limitations still exist, such as the air compressibility and the lack of damping ability of the actuator bring the dynamic delay of the pressure response and cause the oscillatory motion. In addition, the nonlinearities in the PAM manipulator still limit the controllability. Therefore, it is not easy to realize motion with high accuracy and high speed and with respect to various external inertia loads in order to realize a human-friendly therapy robot To overcome these problems a novel controller, which harmonizes a phase plane switching control method with conventional PID controller and the adaptabilities of neural network, is newly proposed. In order to realize satisfactory control performance a variable damper - Magneto-Rheological Brake (MRB) is equipped to the joint of the manipulator. Superb mixture of conventional PID controller and a phase plane switching control using neural network brings us a novel controller. This proposed controller is appropriate for a kind of plants with nonlinearity uncertainties and disturbances. The experiments were carried out in practical PAM manipulator and the effectiveness of the proposed control algorithm was demonstrated through experiments, which had proved that the stability of the manipulator can be improved greatly in a high gain control by using MRB with phase plane switching control using neural network and without regard for the changes of external inertia loads.