• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3405-3409
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• 2016

Malignant pleural mesothelioma (MPM), an aggressive malignant tumor of mesothelial origin associated with asbestos exposure, shows a limited response to conventional chemotherapy and radiotherapy. Therefore, the overall survival of MPM patients remains very poor. Progress in the development of therapeutic strategies for MPM has been limited. We recently reported that the calpain inhibitor, calpeptin exerted inhibitory effects on pulmonary fibrosis by inhibiting the proliferation of lung fibroblasts. In the present study, we examined the preventive effects of calpeptin on the cell growth of MPM, the origin of which is mesenchymal cells, similar to lung fibroblasts. Calpeptin inhibited the proliferation of MPM cells, but not mesothelial cells. It also prevented 1) the expression of angiopoietin (Ang)-1 and Tie-2 mRNA in MPM cells, but not mesothelial cells and 2) the Ang-1-induced proliferation of MPM cells through an NF-kB dependent pathway, which may be the mechanism underlying the preventive effects of calpeptin on the growth of MPM cells. These results suggest potential clinical use of calpeptin for the treatment of MPM.

• 통상정보연구
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• 제18권1호
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• pp.179-208
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• 2016

본 연구는 시장의 후발주자가 선발우위를 극복하기 위한 전략적 수단으로 사용할 수 있는 요소브랜딩전략의 효과를 살펴보고자 한다. 구체적으로 브랜드성분의 원산지정보와 요소브랜딩제품의 제시된 가격수준이 소비자 평가에 미치는 영향에 관해서 연구하고자 한다. 본 연구는 실험연구로 진행되었으며, 총 400명의 피험자를 대상으로 2개의 실험을 실시하였다. 연구결과, 연구1에서는 요소브랜드의 시장지위 및 원산지정보는 소비자의 요소브랜딩 제품 평가에 유의한 영향을 미치는 것으로 나타났다. 연구2에서는 시장진입순서와 요소브랜드의 원산지정보가 소비자의 요소브랜딩 제품에 대한 평가에 미치는 영향은 제시되는 제품의 가격수준에 의해 조절되는 것으로 나타났다. 본 연구의 내용은 후발브랜드의 선발우위 극복을 위한 전략적 방안을 제안하고, 후발기업의 브랜드 운용전략에 대한 시사점도 제시하고 있다.

• 국제지역연구
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• 제13권2호
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• pp.475-504
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• 2009

본 연구는 한국의 소비자들과 수입명품과의 실증관계를 분석하는 것으로 소비자가 구매하려고 하는 수입명품에 대한 원산지 이미지, 브랜드 이미지, 객관적인 제품 특성, 주관적인 소비자 특성 등의 속성(Product Attributes)이 소비자 제품구매의도와 제품선호도에 왜, 어떻게, 얼마나 영향을 실증적으로 미치는가를 계량적으로 분석하는 데에 있다고 할 수 있다. 이를 위한 세부적인 연구방향 다음과 같다. 첫째, 원산지 이미지와 브랜드 이미지가 수입명품의 선호도에 미치는 각각의 영향을 파악한다. 둘째, 소비자가 수입명품을 선택할 때, 구매리스크가 다른 제품특성이 소비자의 제품선호도에 영향을 미치는 원산지효과의 차이를 분석한다. 셋째, 제품선호도에 영향을 미치는 원산지 이미지와 브랜드 이미지의 중요도를 상호 비교함으로써 제품특성이 다른 제품 간의 차이를 규명한다. 넷째, 한국소비자의 구매태도를 분석하여 상호 비교함으로써 연구결과의 보편성을 조사하고 입증하는데 초점을 맞춘다. 분석에 사용된 실증분석방법은 구조방정식모델링이며 통계프로그램으로 Lisrel 7.0을 활용하였다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.101-102
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• 2001

Antimutagens, including diverse compounds of botanical origin, offer some promise of reducing the risk posed by exposure to mutagens. Caution is warranted, however, as there may sometimes be a delicate balance between antimutagenic effects and potentiating effects of the same compounds. We studied effects of the antimutagens spermidine (SPD) and cysteamine (CSM) on the genetic activity of the radiomimetic cancer chemotherapy drug bleomycin (BLM).(omitted)

• 천문학회보
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• 제40권1호
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• pp.47.2-47.2
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• 2015

At local, galaxy properties are well known to be clearly different in different environments. However, it is still an open question how this environment-dependent trend has been shaped. In this presentation, we will show the results of our investigation about the evolution of star-formation properties of galaxies over a wide redshift range, from z~2 to z~0.5, focusing its dependence on their stellar mass and environment. In the UKIDSS/UDS region, we estimated photometric redshifts and stellar population properties, such as stellar masses and star-formation rates, using the deep optical and near-infrared data available in this field. Then, we identified galaxy cluster candidates at z~0.5-2. Through the analysis and comparison of star-formation (SF) properties of galaxies in clusters and in field, we found interesting results regarding the evolution of SF properties of galaxies: (1) regardless of redshifts, stellar mass is a key parameter controlling quenching of star formation in galaxies; (2) At z<1, environmental effects become important at quenching star formation regardless of stellar mass of galaxies; and (3) However, the result of the environmental quenching is prominent only for low mass galaxies (M* < $10^{10}M_{\odot}$) since the star formation in most of high mass galaxies are already quenched at z > 1.

• 한국생활과학회지
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• 제22권4호
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• pp.559-574
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• 2013

The purpose of this study was to develop the couple relationship improvement program for college students and to examine the effects of the program based on the family of origin and attachment. Does based on Bowen's theory of differentiation of self, adult attachment, group counseling for this and establishes program goals according to systematic group counseling program development model and composed program. In order to attain like this research objective, six male and female couples attending colleges were divided into the participating group and comparison group; the students were from H University in Daejeon, Korea, and they had the experience of participating in the comprehensive group program. The changes shown by the couples were studied, and the cases were analyzed by examining the minutes and reports, which supplemented the quantitative analysis of the effectiveness of the group counseling program. The analysis of the effectiveness of the program showed the following. The case showed that goals of the individuals and couples, enhancing the understanding of self and partners by understanding the self-differentiation and adult attachment while having a positive impact on understanding, acceptance, disclosure of self partner and couple relationship based on the social support of the cognitive emotion regulation strategies.

• Asian-Australasian Journal of Animal Sciences
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• 제26권11호
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• pp.1536-1544
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• 2013

A least squares regression interval mapping model was derived to detect quantitative trait loci (QTL) with a unique mode of genomic imprinting, polar overdominance (POD), under a breed cross design model in outbred mammals. Tests to differentiate POD QTL from Mendelian, paternal or maternal expression QTL were also developed. To evaluate the power of the POD models and to determine the ability to differentiate POD from non-POD QTL, phenotypic data, marker data and a biallelic QTL were simulated on 512 F2 offspring. When tests for Mendelian versus parent-of-origin expression were performed, most POD QTL were classified as partially imprinted QTL. The application of the series of POD tests showed that more than 90% and 80% of medium and small POD QTL were declared as POD type. However, when breed-origin alleles were segregating in the grand parental breeds, the proportion of declared POD QTL decreased, which was more pronounced in a mating design with a small number of parents ($F_0$ and $F_1$). Non-POD QTL, i.e. with Mendelian or parent-of-origin expression (complete imprinting) inheritance, were well classified (>90%) as non-POD QTL, except for QTL with small effects and paternal or maternal expression in the design with a small number of parents, for which spurious POD QTL were declared.

• Journal of Dairy Science and Biotechnology
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• 제27권1호
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• pp.53-57
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• 2009

Lactic acid bacteria (LAB) Play an important role in the human diet and are used in the production of edible fermented products such as kimchi and yoghurt. LAB are regarded as safe food additives used to enhance the nutritive value of foods. Plant-origin lactic acid bacteria (PLAB) cultured in vegetal media are now widely used in food industries. PLAB have been found to activate intestinal immunity, modulate the balance of the intestinal bacterial from, and enhance intestinal function. They are known for their strong resistance to acid; this enables them to persist for a longer duration in the human intestine. PLAB can also survive in the intestinal environment under conditions of poor nutrition. They have stronger vitality as compared to LAB of animal origin. Due to the unique characteristics of PLAB, they are being widely used in Japan for processing foods such as yoghurt and beverages. Recently, PLAB has also been used as the culture for processing yoghurt in Korea. We expect further research on the functional effects of PLAB.

• 사상체질의학회지
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• 제22권4호
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• pp.124-129
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• 2010

1. Objectives The purpose of this case is to report the effects of Sibimijihwang-tang(十二味地黃湯) which is based on Sasang constitutional Medicine for Yin-Deficit Diurnal-Heat Symptomatology(陰虛午熱證) in Soyangin. 2. Methods We treated a Soyangin patients that had Fever Unknow Origin. We prescribed Sibimijihwang-tang(十二味地黃湯) for her physical symptoms. The improvement of her diseases was evaluated by her fever and other physical symptoms. 3. Results After the Sasang constitutional medication of Sibimijihwang-tang(十二味地黃湯) was given, the patient's fever and physical symptoms were improved. 4. Conclusions This case study show an efficient result of using Sibimijihwang-tang(十二味地黃湯) in the Yin-Deficit Diurnal-Heat Symptomatology(陰虛午熱證) of Soyangin.

• 한국지반환경공학회 논문집
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• 제2권3호
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• pp.57-69
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• 2001

샌드파일 공법은 연약지반 개량을 위해 널리 사용되는 방법중의 하나이다. 샌드파일 설치에 의해 얻고자 하는 주된 목적은 압밀촉진에 있으나 이와 더불어 복합지반효과를 지니게 된다. 본 연구에서는 상대적으로 면적 치환비가 작은 연직배수재로서 적용된 샌드파일 설치지반에서의 복합지반효과를 파악하고자 하였다. 이를 위하여 원지반과 샌드파일의 지내력 확인을 위한 평판재하시험을 실시하였으며, 성토체와 지반과의 상호거동을 확인하기 위하여 토압계를 설치하여 계측관리를 실시하였다. 분석결과 면적치환비가 작은 샌드파일 설치지반에서 복합지반을 고려한 지지력은 원지반의 지지력과 비교하여 매우 작은 증가효과를 보였다. 그러나 원지반과 비교한 샌드파일 설치위치에서의 지지력 증가는 약 60% 로 나타났다. 이와 같이 샌드파일의 강성증대에 의한 파일설치 위치에서의 지지력 증대는 재하하중 작용에 의한 압밀진행 과정중 압밀특성 변화의 요인으로 작용하게 될 것이다. 따라서 샌드파일 강성증대에 따른 복합지반효과는 샌드파일 설치지반에서 압밀침하량이 감소하는 요인으로 평가될 수 있는 것으로 판단된다.