Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.101-102
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- 2001
A COMPLEX PATTERN OF ANTIMUTAGENIC AND POTENTIATING INFLUENCES OF SPERMIDINE AND CYSTEAMINE ON THE GENOTOXICITY OF BLEOMYCIN IN YEAST AND LYMPHOCYTES
- Hoffmann, George R. (Department of Biology, Holy Cross College) ;
- Fitzpatrick, Jennifer L. (Department of Biology, Holy Cross Colleg) ;
- Soron, Gabrielle J. (Department of Biology, Holy Cross College) ;
- Willett, Christine J. (Department of Biology, Holy Cross College)
- Published : 2001.10.01
Abstract
Antimutagens, including diverse compounds of botanical origin, offer some promise of reducing the risk posed by exposure to mutagens. Caution is warranted, however, as there may sometimes be a delicate balance between antimutagenic effects and potentiating effects of the same compounds. We studied effects of the antimutagens spermidine (SPD) and cysteamine (CSM) on the genetic activity of the radiomimetic cancer chemotherapy drug bleomycin (BLM).(omitted)
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