• Journal of Oriental Neuropsychiatry
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• v.11 no.1
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• pp.75-81
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• 2000

A clinical analysis was carried out for 37 patients who was treated for functional headache with HWANGRYUNHAEDOKTANG(黃連解毒湯) herb-acupuncture in Seoul Red-Cross Oriental Hospital. The results were as follows; 1. The effect of HWANGRYUNHAEDOKTANG(黃連解毒湯) herb-acupuncture for functional headache was turned out to be better effective the young and middle age than the old. 2. Man was better effective than woman 3. There were effective at tention headache and migraine. 4. There were effective within 6 monthes from onset. 5. There were availability in according with increasing treatment. Through the clinical consequences of therapy mentioned above, we came to confirm regular therapeutic effects for functional headache and hereafter, it is considered that a clinical comparative study on oriental cure and herb-acupuncture therapy for headache has to be more progressed than now.

• Journal of Korean Medicine for Obesity Research
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• v.6 no.2
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• pp.43-49
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• 2006

Objective : This study was conducted to offer basic materials for the clinical study of Chi acupuncture (carboxytherapy). Methods : Recent clinical studies were reviewed for carboxytherapy (carbon dioxide therapy) and the ancient and present texts were reviewed for Chi acupuncture. Results and Conclusions : Chi acupuncture is oriental medical therapeutic treatment using carboxytherapy. Chi acupuncture refers to the transcutaneous administration of CO2 gas for therapeutical purposes relating to obesity, cellulites, local circulation and skin irregularity. Recent studies have demonstrated the effects of this therapy on adipose tissue by showing vasomotor effects, increasing local circulation and inducing a partial increase in tcPO2. Chi acupuncture influences the microcirculation and likely has a positive effect upon the physiological oxidative lipolytic process.

• Advances in Traditional Medicine
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• v.5 no.4
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• pp.272-282
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• 2005

Piper betle Linn. (PB), which belongs to the family Piperaceae, is used traditionally in many Asian countries for treatment of a variety of aliments. It has also been used in Ayurveda and Unani systems of medicine. PB leaves are also used as a masticatory in the form of quid. The basic preparation of PB leaves for chewing purposes (PB quid) is known as Paan in India. It is recommended in ancient scripture of Ayurveda and is closely associated with Indian culture. PB is reported to have several therapeutic potentials as well as to produce some untoward effects. The review deals with phytoconstituents present, therapeutic potentials and untoward effects of PB.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.43-52
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• 2005

Objectives : This study is an investigation the clinical development of oriental neuropsychiatry through the practical application of respiration techniques in oriental medicine and Buddhism. Methods : Oriental medicine and Buddhism both make much use of respiration techniques. According to a comparative study on these; A group for the clinical application of oriental medical respiration methods, and A study both the differences and common features of oriental medical and Buddhist respiration techniques, to deliver therapeutic and preventive medical assistance to patients. Results and Conclusion : 1. Oriental medical respiration techniques have as their object the prevention and treatment of disease through smooth circulation of Gi(氣) and Hyeol(血) according to the concentration of the mind on acupuncture points. 2. Buddhist respiration techniques make use of planned psychological rest and ascetic practical expedience according to the close observation of the five senses(五感) of the real world through exhalation(呼) and inhalation(吸) based on Buddhist philosophy. 3. Although the pursuit of oriental medicine and Buddhism can be different, I think a need to develop new respiration techniques can lead to psychological balance and medical treatment through compounding both sets of knowledge.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.13-24
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• 2005

Background and Objectives : Acupuncture as a therapeutic intervention is widely used for the treatment of many functional disorders such as substance abuse and mental dysfunction. Clinical trials are currently underway to determine the effectiveness of acupuncture in the treatment of drug addiction. Yet, there are still many unanswered questions about the basic mechanism of acupuncture. Studies have shown that both the psychomotor stimulant effects and rewarding properties of addictive drugs, including morphine, are sensitized by repeated drug administration and raised the possibility that both of these effects may be linked to the same or closely overlapping the mesolimbic dopamine systems. Neiguan (PC6) point on the pericardium channel which is associated with the brain and its mental function, has been used to treat mental, psychosomatic disorders and gastroenterological disorders. The present study was designed to investigate the effect of acupuncture on repeated morphine-induced changes in extracellular dopamine levels using in vivo microdialysis and to measure the effect of acupuncture on Fos-like immunoreactivity. Methods : Male Sprague-Dawley rats were treated twice a day for three days with increasing doses of morphine (10, 20 and 40 mg/kg, s.c.) or with saline. After 15 days of withdrawal, rats were challenged with morphine hydrochloride (5 mg/kg, s.c.). Acupuncture was applied at bilateral Neiguan (PC6) points for 1 min after the morphine challenge. Results showed that acupuncture at the specific acupoint PC6, but not at control points (tail and HE8) significantly decreased Fos-like immunoreactivity induced by a systemic morphine challenge or a single s.c. morphine injection in the morphine-repeated animals. Results and Conclusions : These results suggest that reduction in sensitization may be one mechanism whereby acupuncture alleviates morphine craving in addicts. Moreover, in a more general sense these results suggest that acupuncture can be used as a therapeutic intervention for correcting reversible malfunction of the body by direction of brain pathway and thus acupuncture can contribute to the biochemical balance in the central nervous system by regulating neurotransmitters.

• The Journal of Korean Medicine
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• v.25 no.4
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• pp.188-199
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• 2004

Transglutaminase 2 (TGase 2) is an enzyme that is widely used in many biological systems for generic tissue stabilization purposes or immediate defenses for wounds. Many reports have showed that TGase 2 is aberrantly activated in tissues and cells and contributes to a variety of diseases, including neurodegenerative diseases and autoimmune diseases. In most cases, the TGase 2 appears to be a factor in the formation of inappropriate proteinaceous aggregates that may be cytotoxic. However, in other cases such as celiac disease, arthritis, lupus, amyotrophic lateral sclerosis, TGase 2 is involved in the generation of autoantibodies. This suggests the possibility that the inappropriate expression and/or presentation of TGase 2 to T cells might contribute to these diseases in genetically predisposed individuals. Others and we have found that TGase 2 expression is also increased in the inflammation process. We also demonstrated reverse of inflammation by TGase inhibition. Furthermore we discovered the genuine role of TGase 2 in immune cell activation. Increase of TGase activity induces or exacerbates inflammation via NF-κB activation without I-κBα kinase signalings. This review will examine a possibility of TGase inhibitors as therapeutic agents in a variety of inflammatory diseases.

• Journal of Pharmacopuncture
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• v.7 no.2
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• pp.97-105
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• 2004

Objectives : The purpose of this study is to compare the improvement rate in managering patients who had lumbago and pain in loin & feet by herbal-acupunture therapy with conservative treatment. Methods : 40patients who invited from March. 2003 to May. 2004 with lumbago and pain in loin & feet inve, were divided into two classes. A class was managed with conservative treatment(acupuncture, herb med, negative therapy, bed rest and physical therapy) and herbal-acupuncture therapy, the other class was managed with conservative treatment only. Two classes were distributed by sex and age, therapeutic periods, radiolographic results and therapeutic results that checked with VAS(visual analog scale) and ODI(Oswestry disability index). Results : According to VAS and OBI results, A class was managed with conservative treatment and herbal-acupuncture therapy shows the improvement in controling the pain of lumbago etc. comparing with the other class.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.2
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• pp.177-188
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• 2001

Background : Atopic Dermatitis is thought to be a common and chronic relapsing inflammatory skin disease that probably results from allergic reaction. Because it make some serious problems in children, it is needed to treat and at least subside symptoms. Objective : The aim of this study was to evaluate the efficacy of GamiYeoldahansotang(加味熱多寒少湯) for treating Atopic Dermatitis and survey the general characteristics in children with Atopic Dermatitis. Method : Atopic Dermatitis with typical clinical symptoms were included in this study. Forty two patients were treated with hot water extract of GamiYeoldahansotang(加味熱多寒少湯) for four weeks. Clinical evaluation were made by Jacob T scoring system before and after treatment. Total Serum IgE, Eosinophil count were also conducted. Results : Reduction in body surface area was not observed. But significant reductions of severity scores before and after adminstration of GamiYeoldahansotang(加味熱多寒少湯) were observed in all of three groups: mind, moderate, severe. specially severe intensity group was very statistically significant.(p<0.05) Conclusion : We speculate that GamiYeoldahansotang(加味熱多寒少湯) has some therapeutic effects in mitigating the symptoms of Atopic Dermatitis.

• Journal of Acupuncture Research
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• v.19 no.5
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• pp.176-188
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• 2002

Objective : Sono-acupoint (SA) therapy is a new therapeutic technique that combined with acupuncture points, herbal medicine and ultrasound therapy. This study was carried out to investigate the analgesic and anti-inflammatory effects of sono-acupoint therapy. Methods : We performed the tail-flick test with normal rats to examine the tail-flick latency (TFL), and the Freund's adjuvant-induced arthritis rat model to examine the edema, skin temperature and serum concentration of c-reactive protein and rheumatoid factor (RF). Herbal SA (HSA) treatment was performed at bilateral Zusanli (ST36) with the hanbang-gel made of several selected herbal drugs in Sprague-Dawley rats (male, $250{\pm}30g$). General SA (GSA) treatment was performed at bilateral Zusanli (ST36) with the gel used in ultrasound therapy. In arthritis rat model, Freund's adjuvant (50mg/ml) was injected in dorsal part of right foot, and these treatments were performed after 15 days. Results : TFL was lengthened after SA treatments. Skin temperature and RF concentration that were the evidence of arthritis in rats were decreased by HSA treatment (P < 0.05). Conclusion : These results indicate that HSA has the analgesic and anti-inflammatory effects in rats, and further developments will produce the advance of this new therapeutic skill.

• Journal of Haehwa Medicine
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• v.14 no.2
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• pp.55-70
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• 2005

In oriental medicine, Gamibangpungtongsungsan (KBTS) has been used as a therapeutic agent for the treatments of acute stage of cerebrovascular diseases and hypertension. In the present study, underlying mechanism on KBTS effects was investigated using spontaneously hypertensive rats (SHR) by determining related parameters such as blood pressure, heart-beat rates, and hormones and plasma constituents. The major finding are summarized as follows. 1. KBTS treatment at concentrations lower than $125\;{\mu}g/m{\ell}$ did not show any cytotoxicity on cultured human fibroblast cells. 2. KBTS treatment in SHR significantly decreased blood pressure and heart-beat rate compared with untreated control. 3. KBTS treatment in SHR decreased aldosterone levels in the blood compared with untreated control, but the difference was not statistically significant. 4. KBTS treatment in SHR significantly decreased dopamine, norepinephrine and epinephrine levels in the blood compared with untreated control. 5. KBTS treatment in SHR decreased plasma ion concentrations such as Na+, K+, Ca2+, Cl- compared with untreated control; decreases in Na+ and Cl- were statistically significant. 6. KBTS treatment in SHR significantly decreased TNF-$\alpha$, IL-6, and IL-10 levels in the blood compared with untreated control. Thus, the present data show evidence on anti-hypertension activity of KBTS in an experimental animal system, which can provide further insights into the development of anti-hypertension therapeutic agents.