• 한국약용작물학회:학술대회논문집
• /
• 2012.05a
• /
• pp.281-282
• /
• 2012

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.390.2-390.2
• /
• 2002

The fruits of cardamon (family Zingiberaceae) are used in traditional medicine for the treatment of several ailments. such as stomach disorders, liver abscess, and infection of the throat, and as a common spice as well, Amomum tsao-ko Crevost et Lemarie. a Zingiberaceous plant called "초과" in korea, is an oriental folk medicinal herb for the treatment of stomach illness. The present paper reports the isolation of the constituents of the fruits of this plant and their antifungal activity. (omitted)

• Proceedings of the PSK Conference
• /
• 2003.04a
• /
• pp.212.1-212.1
• /
• 2003

2-Hydroxycinnamaldehyde is an active compound isolated from the Stem Bark of Cinnamomum cassia, a traditional oriental medicinal herb, which has been shown to inhibit tumor cell proliferation. In this study, we investigated the effects of 2-hydroxycinnamaldehyde on the cytotoxicity. induction of apoptosis and the putative pathways of its actions in human promyelocytic leukemia cells (HL-60). (omitted)

• The Korea Journal of Herbology
• /
• v.35 no.6
• /
• pp.1-9
• /
• 2020

Objective : For the purpose of developing Boraginaceae plants recorded in Korean Herbology in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods : Books and research papers about Herbology which published at Korea and other countries were examined. Results : A list was made about Boraginaceae plant which were cultivated or grew naturally in Korea, after investigated the data on domestic and foreign Boraginaceae plants. Boraginaceae(grew in Korea) were divided into 14 classes with 24 species. Out of those, 6 classes with 9 species were found serviceable which indicates 37.5% of all. Out of all 24 species of Boraginaceae family, Trigonotis genus were found 5 species, which were shown the most. Among 3 genus of Lithospermum species, medicinal plants were all one species each. Out of all serviceable parts in Boraginaceae, Herb·Radix·Fructus parts took first place as 3 species. There are 2 species toxic, the survey said. 3 Classifying medicinal plants among the Borginaceae plants by part, whole herbs, roots, and fruits are found to be 3 separate species each. When it comes to the nature of taste, 5 kinds of taste without action and seven kinds of bitter taste are the most common. For channel tropism, liver channel has the largest number of 5 types. Conclusion : There were totaled to 14 genera and 24 species in Boraginaceae in Korea and among them medicinal plants are 6 genera, 9 species, some 37.5% in total.

• The Korea Journal of Herbology
• /
• v.31 no.1
• /
• pp.33-40
• /
• 2016

Objectives : Liver is one of the largest organs in the human, and has a function of detoxification and energy sensing to prevent severe disease. Paeoniae radix has been used to treat a variety of liver diseases such as hepatitis and chronic hepatic failure. Although P. radix has been used as an medicinal herb for a long time, the effects of P. radix on severe oxidative stress and its action mechanism on the liver was not clearly verified.Methods : This study investigated the protective effects of P. radix extract (PRE), and the underlying mechanism of its action in the liver. tert-butyl hydroperoxide (t-BHP) and carbon tetrachlroride (CCl₄) were used to induce oxidative stress in the HepG2 hepatocyte cell line and Sprague-Dawley rats, respectively.Results : t-BHP significantly induced cell death and ROS production in HepG2 cell, as indicated by MTT and FACS analysis. However, pretreatment of PRE inhibited a decrease in cell viability and H₂O₂ production in the HepG2 cells. PRE also blocked the ability of t-BHP to damage in mitochondrial membrane transition. More importantly, PRE induced Nrf2 activation and antioxidant Phase II enzyme, which may have a role in the effects of PRE. In mice, PRE inhibited the liver damage induced by CCl₄.Conclusions : PRE inhibited oxidative stress and hepatic damages as mediated with Nrf2 activation. This study unveil, in part, the effect and mechanism of old medicinal herb, P. radix.

• Integrative Medicine Research
• /
• v.3 no.2
• /
• pp.67-73
• /
• 2014

Background: The transcription factor signal transducer and activator of transcription 3 (Stat3)is constitutively activated in many human cancers. It promotes tumor cell proliferation,inhibits apoptosis, induces angiogenesis and metastasis, and suppresses antitumor hostimmune responses. Therefore, Stat3 has emerged as a promising molecular target for cancertherapies. In this study, we evaluated the Stat3-suppressive activity of 38 herbal medicinestraditionally used in Korea.Methods: Medicinal herb extracts in 70% ethanol were screened for their ability to suppressStat3 in the A549 human lung cancer cell line. A Stat3-responsive reporter assay system wasused to detect intracellular Stat3 activity in extract-treated cells, and Western blot analyseswere performed to measure the expression profiles of Stat3-regulated proteins.Results: Fifty percent of the 38 extracts possessed at least mild Stat3-suppressive activities(i.e., activity less than 75% of the vehicle control). Ethanol extracts of Bupleurum falcatumL., Taraxacum officinale Weber, Solanum nigrum L., Ulmus macrocarpa Hance, Euonymus alatusSieb., Artemisia capillaris Thunb., and Saururus chinensis (Lour.) Baill inhibited up to 75% of thevehicle control Stat3 activity level. A549 cells treated with these extracts also had reducedBcl-xL, Survivin, c-Myc, and Mcl-1 expression.Conclusion: Many medicinal herbs traditionally used in Korea contain Stat3 activity-suppressing substances. Because of the therapeutic impact of Stat3 inhibition, these resultscould be useful when developing novel cancer therapeutics from medicinal herbs.

• Journal of Oriental Neuropsychiatry
• /
• v.31 no.1
• /
• pp.49-61
• /
• 2020

Objectives: The objective of this study is to analyze clinical reports of treatment of menopausal depression in traditional Chinese medicine (TCM). Methods: This study included randomized controlled trials (RCT) in treating menopausal depression. Literature studies of Chinese National Knowledge Infrastructure Database(CNKI) were performed. Clinical reports on menopausal depression treatment were searched using the following key words in the CNKI: 'menopausal depression' and 'postmenopausal depression'. Results and Conclusions: A total of 24 RCT articles on menopausal depression were selected. The most widely used diagnostic tool for menopausal depression was CCMD-3. Effective rate and HAMD were the most commonly used assessment tools. Bosinhaeultang-gagam (Bushenjieyu-tang jiajian) and Gami-gammaegdaejotang(Jiawei ganmaidazao-tang) were used much more than other prescriptions, while Bupleuri Radix was the most used single medicine herb. Additionally, the Chinese medicine treatment group showed less adverse reactions than the control group. As a result, we could know frequently used herbal prescription and single medicinal herbs and this can be helpful in developing more advanced studies in future.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2023.04a
• /
• pp.49-49
• /
• 2023

본 실험은 콤부차의 발효시 에너지원으로 첨가되는 당(sucrose) 대신 꾸지뽕(Cudrania tricuspidata Bureau; silkworm thorn) 과일 발효액을 첨가하여 꾸지뽕-콤부차의 기능성을 구명하고자 하였다. 대조구인 콤부차는 끓여서 식힌 물 900mL에 홍차 2.4g을 넣어 한시간 동안 추출한 후 초기당도가 10°Bx가 되도록 sucrose를 첨가하였고, 처리구는 sucrose대신 꾸지뽕 과일 무게 대 sucrose의 비율을 1 대 0.9의 비율로 조제하여 발효시킨 꾸지뽕 발효액(당도 50°Bx)을 10°Bx가 되도록 희석하여 첨가하였다. 여기에 발효균인 SCOBY를 첨가한 후 실온에 3주간 보관하면서 1주일 간격으로 시료를 채취하여 총폴리페놀성 화합물 및 카테킨류 함량, 항산화 활성 및 인체 정상 폐세포주인 MRC-5와 폐암세포주인 A549의 세포 증식에 미치는 영향을 구명하였다. 발효 3주 동안 채취한 꾸지뽕-콤부차를 MRC-5 세포에 처리하였을 때 발효 2주까지는 꾸지뽕-콤부차가 대조구에 비해 약 10~30% 세포 증식효과를 보였고 발표 3주째에는 유사한 증식효과를 보였다. 폐암세포주 A549에 처리시에는 발효 2주째 대조구에 비해 낮은 증식율을 보였으나 그 차이는 크지 않았다. 이 결과는 꾸지뽕-콤부차가 인체 폐세포 증식을 촉진하나 폐암세포의 증식을 크게 억제하지는 않음을 의미한다. 총폴리페놀성화합물 함량은 대조구의 경우 발효기간이 경과함에 따라 증가하는 반면 꾸지뽕-콤부차는 조제직후 대조구에 비해 유의적으로 높은 함량을 보이다 서서히 감소하였는데 발효 2주째 대조구와 유사한 수준에 도달하였으며 3주째에는 대조구에 비해 낮은 함량을 보였다. 카테킨류(Epigallocatechin, Epigallocatechin gallate, 그리고 Epicatechin gallate, epicatechin)는 총 페놀성화합물과는 반대의 경향을 보였는데, 발표 2주까지는 꾸지뽕-콤부차의 함량이 유의적으로 높았다가 발표 3주째 크게 낮아졌다. 활성산소 제거능은 발효 2주째까지는 대조구에 비해 낮았으나 3주째 유의적으로 높아져 꾸지뽕-콤부차의 항산화활성은 카테킨류 함량에 비례함을 알 수 있었다. 기능성분 함량과 MRC-5 증식에 관한 상관분석시 총풀리페놀함량이 세포증식에 정의 상관관계를 나타내었다.

• Food Science of Animal Resources
• /
• v.27 no.1
• /
• pp.87-94
• /
• 2007

This study was carried out to know the effect of the oriental medicinal plants byproduct containing vitamin E and 0.1% antibiotics (T1) and the oriental medicinal plants byproduct containing vitamin E and the replacing antibiotics by 0.03% herb extracts (T2) and 0.1% aminolevulinic acid (T3) on production performance of finishing hog and its meat qualities. There were no significant differences in the daily weight gain, feed intake, and feed conversion rate values between all treatment groups. However, the T2 group tends to have a higher daily weight gain (g/day) than the other groups (p>0.05). The T2 group showed lower total-cholesterol and LDL-cholesterol contents (114.71 and 68.09 mg/dl, respectively) than the control in the blood serum (p<0.001), and all the treated groups of oriental medicinal plants byproduct and vitamin E increased HDL-cholesterol and decreased LDL-cholesterol contents in the blood serum. Content of vitamin E in muscles from the group T1, T2 and T3 (2.11, 2.21 and 2.18 mg $kg^{-1}$, respectively) showed higher levels than those of control. The presence of antibiotics (chlortetracycline) in hog loin meat were detected (0.08 ppm) in control sample. However, there was no antibiotic in other treated hog loin meats (T1, T2 and T3, respectively). The thiobarbituric acid reactive substances and volatile basic nitrogen values of the groups T2 (0.06 mg MA $kg^{-1}$ and 11.21 mg%, respectively) and T3 (0.05 mg MA $kg^{-1}$ and 8.23 mg%, respectively) were significantly (p<0.05) lower than that of control in loin meat. However, there was no significant difference between treated samples (T1, T2 and T3, respectively) and control in cooking loss and drip loss.

• Journal of Ginseng Research
• /
• v.23 no.1 s.53
• /
• pp.21-37
• /
• 1999

For the purpose of wide application of Korea Ginseng Radix (KGR) as a tonic and medicinal drug, bibliographical study on Ginseng Radix (GR) was done about its herbal and pharmacological effects known so far. Herbal effect of GR was studied in 28 classical books including Shennongbencaojing(신농본초경), the oldest herbal book in oriental medicine and also its pharmacological effects was compared with its herbal effect. In bibliographical study 38 kinds of efficacies of GR were referred in those books, for example, in fields of gastrointestinal tract, heart, psychology, body fluid, hormone and respiratory tract in order from statistical analysis. GR was chiefly used for supplementing Qi, vital energy in oriental medicine. However, experimental study on respiratory diseases was not reported except lung cancer yet, while GR was used for the treatment of asthma mostly mixed with other herb in oriental medicine. So far research with GR was performed chiefly for isolation of constituents as saponins and evaluation of its efficacy experimentally by KGTR (Korea Ginseng Tobacco Research Institute). From the above studies, to make KGR used widely than before, I suggest study with KGR should be done according to oriental principles such as Qi and tasters and combination theory between herbs excepting typical analytical research with saponins.