• The korean journal of orthodontics
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• v.52 no.4
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• pp.268-277
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• 2022

Objective: Poor experience with Invisalign treatment affects patient compliance and, thus, treatment outcome. Knowing the potential discomfort level in advance can help orthodontists better prepare the patient to overcome the difficult stage. This study aimed to construct artificial neural networks (ANNs) to predict patient experience in the early stages of Invisalign treatment. Methods: In total, 196 patients were enrolled. Data collection included questionnaires on pain, anxiety, and quality of life (QoL). A four-layer fully connected multilayer perception with three backpropagations was constructed to predict patient experience of the treatment. The input data comprised 17 clinical features. The partial derivative method was used to calculate the relative contributions of each input in the ANNs. Results: The predictive success rates for pain, anxiety, and QoL were 87.7%, 93.4%, and 92.4%, respectively. ANNs for predicting pain, anxiety, and QoL yielded areas under the curve of 0.963, 0.992, and 0.982, respectively. The number of teeth with lingual attachments was the most important factor affecting the outcome of negative experience, followed by the number of lingual buttons and upper incisors with attachments. Conclusions: The constructed ANNs in this preliminary study show good accuracy in predicting patient experience (i.e., pain, anxiety, and QoL) of Invisalign treatment. Artificial intelligence system developed for predicting patient comfort has potential for clinical application to enhance patient compliance.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6227-6232
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• 2012

Interleukin-4 receptor (IL-4R) gene single nucleotide polymorphisms (SNPs) are implicated in cancer development. However, results from the published reports have remained inconclusive. The objective of this study was to conduct a meta-analysis investigating the association between polymorphisms in IL-4R gene and cancer risk. Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) were searched for case-control studies published up to October 30, 2012 that investigated IL-4R polymorphisms and cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of any associations. Three IL-4R polymorphisms (Q576R, rs1801275; I75V, rs1805010; S503P, rs1805015) in 21 case-control studies were analyzed. Our meta-analysis indicated that these three polymorphisms are not associated with cancer risk when all studies were pooled together. In the subgroup analysis by tumor site, the results showed that Q576R G allele carriers were associated with a significantly decreased cervical cancer risk (recessive model: OR = 0.77, 95%CI = 0.60-0.98; homozygote comparison: OR = 0.76, 95%CI = 0.58-0.98). I75V G allele carriers were associated with a decreased risk of renal cancer (dominant model = 0.71, 95%CI = 0.57-0.89, heterozygote comparison: OR = 0.69, 95%CI = 0.55-0.87). When stratified by ethnicity, Q576R G allele carriers were associated with a decreased cancer risk in Caucasians (dominant model: OR = 0.90, 95%CI = 0.83-0.98; heterozygote comparison: OR = 0.89, 95%CI = 0.82-0.98). I75V G allele carriers were associated with a decreased cancer risk in Asians (heterozygote comparison: OR = 0.76, 95%CI = 0.62-0.94). S503P C allele carriers were also associated with a decreased cancer risk in Asians (CC VS TT: OR = 0.29, 95%CI = 0.08-0.99). Our results suggest that Q576R, I75V and S503P may be associated with a decreased cancer risk for certain types of cancers and in some specific ethnic groups. Future case-control studies with large sample size are needed to evaluate these associations in detail.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.43 no.2
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• pp.115-119
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• 2017

Maxillofacial images must be examined to find pathologies not identified during clinical examination. Unicystic ameloblastoma (UA) extending to the mandibular body and ramus was neglected on initial panoramic radiographic examination. After orthodontic therapy, a huge lesion was observed clinically and through imaging exams. After the conservative surgery, no recurrence was observed during five years of follow-up. This case emphasized the need for careful evaluation of patient images focusing on the oral diagnosis before any dental treatment planning, including orthodontic therapy.

• Imaging Science in Dentistry
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• v.53 no.2
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• pp.127-135
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• 2023

Purpose: This study assessed the intensity of artifacts produced by 2 metal posts, 2 cements, and different exposure parameters using 2 cone-beam computed tomography (CBCT) units. Materials and Methods: The sample was composed of 20 single-rooted premolars, divided into 4 groups: Ni-Cr/zinc phosphate, Ni-Cr/resin cement, Ag-Pd/zinc phosphate, and Ag-Pd/resin cement. Samples were scanned before and after post insertion and cementation using a CS9000 3D scanner with 4 exposure parameters (85/90 kV and 6.3/10 mA) and an i-CAT scanner with 120 kV and 5 mA. The presence of artifacts was assessed subjectively by 2 observers and objectively by a trained observer using ImageJ software. The Mann-Whitney, Wilcoxon, weighted kappa, and chi-square tests were used to assess data at a 95% confidence level(α<0.05). Results: In the subjective analyses, AgPd presented more hypodense and hyperdense lines than NiCr (P<0.05), and more hypodense halos were found using i-CAT (P<0.05) than using CS9000 3D. More hypodense halos, hypodense lines, and hyperdense lines were observed at 10 mA than at 6.3 mA (P<0.05). More hypodense halos were observed at 85 kV than at 90 kV (P<0.05). CS9000 3D presented more hypodense and hyperdense lines than i-CAT (P<0.05). In the objective analyses, AgPd presented higher percentages of hyperdense and hypodense artifacts than NiCr (P<0.05). Zinc phosphate cement presented higher hyperdense artifact percentages on CS9000 3D scans(P<0.05). CS9000 3D presented higher artifact percentages than i-CAT(P<0.05). Conclusion: High-atomic-number alloys, higher tube current, and lower tube voltage may increase the artifacts present in CBCT images.

• Journal of Oral Medicine and Pain
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• v.18 no.2
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• pp.71-79
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• 1993

Many types of occlusal splints are used for treatment of craniomandibular disorders. Most widely used splint among them is flat-type centric relation splint. Insertion of splint into the mouth may cause increasing of vertical dimension, masticatory muscle realignment and rearrangement of maxillo-mandibular relationship, so as a result of splint treatment, occlusal relation may vary whether you like it or not. From this point of view, occlusal state of patient shold be frequently monitored to prevent undesired or harmful effect during occlusal splint therapy. The purpose of this study was to investigate the effect of occlusal splint, especially centric relation splint, on the occlusal contact state after 3 months treatment. 32 patients with craniomandibular disorders who had unilateral symptoms participated in this study. To observe and record occlusal contact state, the author used T-Scan system (Tekscan Co. U.S.A.) at both pretreatment and posttreatment. The recorded date were analyzed with regard to contact number, contact force and contact time, change of anterior tooth contact and coincidence of first contact point with affected side were observed, too. Aan last, the subjects were divided into 2 groups and compared, according to average value of VAS index, with respect to joint pain, sound and limitation of movement, respectively. The collected date were statistically processed with SPSS and the result as follows : 1. Total occlusal contact number and force were not changed by occlusal splint therapy but total occlusal contact time decreased slightly. 2. There was a tendency of increasing number of subjects with anterior tooth contact after treatment and change of first contact point side were observed in as many as 40.6% of subjects. 3. There were no difference between higher and lower group of VAS index, and between pretreatment and posttreatment in each group, either.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4621-4625
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• 2013

The purpose of this study was to construct a protein-protein interaction (PPI) network related to oral squamous cell carcinoma (OSCC). Each protein was ranked and those most associated with OSCC were mined within the network. First, OSCC-related genes were retrieved from the Online Mendelian Inheritance in Man (OMIM) database. Then they were mapped to their protein identifiers and a seed set of proteins was built. The seed proteins were expanded using the nearest neighbor expansion method to construct a PPI network through the Online Predicated Human Interaction Database (OPHID). The network was verified to be statistically significant, the score of each protein was evaluated by algorithm, then the OSCC-related proteins were ranked. 38 OSCC related seed proteins were expanded to 750 protein pairs. A protein-protein interaction nerwork was then constructed and the 30 top-ranked proteins listed. The four highest-scoring seed proteins were SMAD4, CTNNB1, HRAS, NOTCH1, and four non-seed proteins P53, EP300, SMAD3, SRC were mined using the nearest neighbor expansion method. The methods shown here may facilitate the discovery of important OSCC proteins and guide medical researchers in further pertinent studies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.8
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• pp.303-311
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• 2018

This study was conducted to investigate the effects of oral health awareness and oral health behavior on cardiocerebrovascular prevention behavior in a cardiocerebrovascular diseases risk group and provide basic data for a nursing intervention program for the group. Data were collected from 131 people in the risk group of cardiocerebrovascular diseases living in J Province in February and March of 2018. The obtained data were analyzed using descriptive statistics, t-tests, Pearson's correlation, and stepwise multiple regression analysis. The results revealed that preventive acts were positively correlated with subjective oral health state (r=0.261, p=0.003), importance of oral health (r=0.250, p=0.004), and practice of oral health (r=0.303, p<0.001). Moreover, acts to prevent cardiocerebrovascular disease were influenced by oral health (${\beta}=0.29$, p<0.001), age (${\beta}=0.27$, p=0.001), and subjective oral health state (${\beta}=0.24$, p=0.003). Specifically, scores of preventive acts for cardiocerebrovascular diseases increased with higher degree of oral health behavior, older age, and better subjective oral health state. These variables had an explanatory power of 19.3%. The results of this study imply a need to prepare measures to enhance the oral health level of the risk group of cardiocerebrovascular diseases and conduct ongoing follow-up studies of the perception, attitude, and behavior of individuals toward oral health, as well as the state of oral health.

• Journal of Korean society of Dental Hygiene
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• v.9 no.1
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• pp.1-14
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• 2009

The purpose of this study was to examine the oral health care aware-ness of pregnant women and their actual oral health care in an effort to provide information on how to assist pregnant women to have the right knowledge on oral health and improve their oral health care. The subjects in this study were pregnant women who used obstetrics and gynecology hospitals or participated in pregnancy/child-rearing programs in the region of P. After a self-administered survey was conducted in July and August 2008, the following findings were given: 1. As for the best case of oral health care, the largest number(77.2%) of the pregnant women investigated brushed all the teeth, gums and tongue when they did toothbrushing. The smallest number of the women(6.8%) spent three minutes or more brushing their teeth. 2. As to dental treatment experience during pregnancy by age, 27.0 percent of the age 26-30 group had ever received dental treatment during pregnancy, which was higher than the rates of the other age groups with the same experience. 3. Regarding the necessity of oral health education geared toward pregnant women, 94.1 percent of the age 26-30 group and 96.3 percent of the group of age 31 and up felt the need for that, which were significantly higher than 72.7 percent of the age 20-25 group who agreed to the necessity of that education. 4. As to connections between oral health status and oral health care, the women who were in good oral health got 6.60 on oral health care. They scored significantly higher than those who were in a moderate state of oral health and who were in bad oral health, as the latter two groups respectively got 5. There was a significant correlation between oral health state and oral health care and between oral health knowledge and oral health care. The better oral health status led to better oral health knowledge, and the better oral health knowledge was followed by better oral health care. 6. As for factors affecting oral health care, oral health knowledge had the largest impact on that, followed by age, oral health status, experience of receiving oral health education for pregnant woman, dental treatment experience during pregnancy, monthly income and stress caused by oral diseases. Given the findings of the study, oral health education should be provided in light of the special physical and mental state of pregnant women. They should be encouraged to receive possible dental treatment during pregnancy if necessary, and they should learn about how to cope with a dental disease in case of develop it.

• Journal of Korean Academy of Nursing
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• v.40 no.4
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• pp.473-481
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• 2010

Purpose: This study was done to examine the effects of oral care with essential oil in improving the oral health status of hospice patients with terminal cancer. Methods: The participants were 43 patients with terminal cancer admitted to K hospital in G city, Korea. Twenty-two patients were assigned to the experimental group and 21 to the control group. Participants in the experimental group received special mouth care with essential oil (application of essential oil mixture consisting of geranium, lavender, tea tree, and peppermint). The control group received special mouth care with 0.9% saline. The special mouth care was performed twice daily for one week in both groups. The scores for subjective oral comfortness, objective oral state, and numbers of colonizing Candida albicans were measured before and after the treatment. Results: The score for subjective oral comfortness and objective oral state were significantly higher in the experimental group compared to the control group. The numbers of colonizing Candida albicans significantly decreased in the experimental group compared to the control group. Conclusion: Oral care with essential oil could be an effective oral health nursing intervention for hospice patients with terminal cancer.

• Journal of Korean society of Dental Hygiene
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• v.7 no.4
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• pp.441-453
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• 2007

This study was conducted among 831 industrial workers in Gumi City in Gyung-Sang-Buk Do for the purpose of acquiring knowledge to improve quality of life though industrial workers' oral health promotion. Oral examination and questionnaire surveying were used to evaluate workers' oral health state and subjective health state and analyze their effect on quality of life. At the same time, the scales used in measuring the subjects' health state and quality of life-OHIP and WHOQOL-BREF-were validated for their constituent concepts and their relations were analyzed through structural modeling. The analysis results can be summarized as follows; The constituent concepts of OHIP and QOL factor structural models were validated since they were all in the range of appropriateness, as shown in the result of analysis using Indices of Fit-GFI, CFL, TLI and RMSEA. The result of analysis of constituent concepts to identitify the relations between OHIP and QOL confirmed that OHIP influences QOL.