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http://dx.doi.org/10.7314/APJCP.2012.13.12.6227

Associations Between Three Polymorphisms in the Interleukin-4 Receptor Gene and Risk of Cancer: a Meta-analysis  

Wang, Jia-Yi (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Zhou, Yu-Qiao (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Li, Xiao-Xu (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Jin, Xin (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Wang, Li-Li (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Lei, Lei (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Zhou, Yu (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Lu, Jiang (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Zeng, Xin (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Dan, Hong-Xia (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Liao, Ga (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Chen, Qian-Ming (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.12, 2012 , pp. 6227-6232 More about this Journal
Abstract
Interleukin-4 receptor (IL-4R) gene single nucleotide polymorphisms (SNPs) are implicated in cancer development. However, results from the published reports have remained inconclusive. The objective of this study was to conduct a meta-analysis investigating the association between polymorphisms in IL-4R gene and cancer risk. Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) were searched for case-control studies published up to October 30, 2012 that investigated IL-4R polymorphisms and cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of any associations. Three IL-4R polymorphisms (Q576R, rs1801275; I75V, rs1805010; S503P, rs1805015) in 21 case-control studies were analyzed. Our meta-analysis indicated that these three polymorphisms are not associated with cancer risk when all studies were pooled together. In the subgroup analysis by tumor site, the results showed that Q576R G allele carriers were associated with a significantly decreased cervical cancer risk (recessive model: OR = 0.77, 95%CI = 0.60-0.98; homozygote comparison: OR = 0.76, 95%CI = 0.58-0.98). I75V G allele carriers were associated with a decreased risk of renal cancer (dominant model = 0.71, 95%CI = 0.57-0.89, heterozygote comparison: OR = 0.69, 95%CI = 0.55-0.87). When stratified by ethnicity, Q576R G allele carriers were associated with a decreased cancer risk in Caucasians (dominant model: OR = 0.90, 95%CI = 0.83-0.98; heterozygote comparison: OR = 0.89, 95%CI = 0.82-0.98). I75V G allele carriers were associated with a decreased cancer risk in Asians (heterozygote comparison: OR = 0.76, 95%CI = 0.62-0.94). S503P C allele carriers were also associated with a decreased cancer risk in Asians (CC VS TT: OR = 0.29, 95%CI = 0.08-0.99). Our results suggest that Q576R, I75V and S503P may be associated with a decreased cancer risk for certain types of cancers and in some specific ethnic groups. Future case-control studies with large sample size are needed to evaluate these associations in detail.
Keywords
Cancer; interleukin-4 receptor; polymorphisms; meta-analysis;
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