• International Journal of Oral Biology
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• 제43권4호
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• pp.193-200
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• 2018

The purpose of this study is to determine if natural extracts could be used as an additive in oral health food made with Weissella cibaria CMU (oraCMU). Natural extracts of green tea, mulberry leaf, licorice, and propolis, which are reported to have antimicrobial activities, were selected and used in this study. The minimum inhibitory concentrations (MIC) of extracts on periodontal pathogens such as Fusobacterium nucleatum and Porphyromonas gingivalis and their synergy effects with oraCMU by the fractional inhibitory concentrations methods were measured. From the results obtained, all the extracts showed no effect on the growth of oraCMU. Green tea extract showed the best antibacterial activity with MIC of 1.8 mg/ml against both F. nucleatum and P. gingivalis. In addition, green tea extract had a synergistic effect with oraCMU against F. nucleatum. Therefore, these results suggested that green tea extract is available as an additive in oral health food made with oraCMU.

• 한국융합학회논문지
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• 제7권4호
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• pp.209-215
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• 2016

본 연구는 중년층을 대상으로 구강건강신념과 구강병 예방행동에 관한 융합적 관계를 분석하였다. U시 일부 중년층 280명을 최종 분석 대상으로 하였다. 회귀분석의 결과로 볼 때 구강건강신념 중 구강병 예방행동의도, 구강병 예방행동에 가장 큰 영향을 미치는 요인은 구강건강은 가치 있는 것이라고 느끼는 중요성이었다. 구강병 예방행동의도를 매개로 직간접적 영향을 알아본 결과, 중요성, 유익성 변인이 구강병 예방행동에 미치는 영향은 부분매개효과를 가지는 것으로 나타났고, 자기 효능감은 완전매개효과를 가지는 것으로 나타났다. 본 연구 결과, 이미 구강병에 이환되어 심각성과 장애를 느끼고 있는 중장년층의 구강예방행동을 수행할 수 있도록 하기 위해서는 구강 건강이 전신질환만큼 중요하다는 중요성과 구강건강이 전신건강에 유익하다는 것을 계몽할 수 있는 중재프로그램 개발이 필요 하겠다.

• 한국치위생학회지
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• 제22권5호
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• pp.417-424
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• 2022

Objectives: This study aimed to find a way to solve oral health inequality in old age by understanding the effect of the socioeconomic level of the elderly on oral health. Methods: We used data from the 7th Korea National Health and Nutrition Examination Survey. A chi-square test was performed to investigate differences in oral health according to socioeconomic status and demographic and oral health-related factors. Socioeconomic status and oral health inequality were analyzed using multiple logistic regression. Results: The average number of teeth in the elderly was 17.20, which is insufficient for the minimum number of teeth required for mastication. In the analysis of the correlation between socioeconomic status and oral health inequality, education level, income level, and home ownership were factors influencing the oral health of the elderly; education level was found to have the strongest effect. Conclusions: Oral health inequality according to socioeconomic status was confirmed, and it is necessary to measure the level of oral health inequality with active efforts at the government level to resolve the gap in oral health by social class.

• 한국치위생학회지
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• 제11권4호
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• pp.595-602
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• 2011

Objectives : This study purpose were the effect of toothbrushing for decreasing halitosis for gingivitis and periodontitis patients. Methods : The university staffs were examined oral condition and analysised a change of oral health state score after using 3 types of toothbrushing. Results : The results were as followed : OHI-S shows that the decreasing effect takes place in the M. bass method and Tooth pick method, but shows no differences by each method. GI for Self test method shows decreasing effect after 2nd week during education while the M. bass method and Tooth pick method shows after 1st week during education. The M. bass method shows much greater effect of halitosis amongst 3 kind of method. PI for Self test method and Tooth pick method show decreasing effect. Decreasing effect during education shows until 2nd week by 3 kind of method, but it shows no differences after 3rd week. VSC(ppb) for M. bass method and Tooth pick method show decreasing effect. Decreasing effect during education shows after 3rd week by 3 kind of method, but it shows no differences until 2nd week. PHP for Self test method, M. bass method and Tooth pick method show decreasing effect after 2nd week during education. But, there is no differences of decreasing effect by among 3 kind of method. Conclusions : This study reports that it is necessary to carry outt further studies on the improvement of oral health management of adults based on the development of oral health education.

• International Journal of Oral Biology
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• 제38권4호
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• pp.149-154
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• 2013

In general, oleanolic acid (OA) and ursolic acid (UA) have antimicrobial effect against Gram-positive bacteria but not Gram-negative bacteria whereas sophoraflavanone G has antimicrobial activity against both bacterial types. However, the antimicrobial effects of OA, UA, and sophoraflavanone G against periodontopathogens have not been studied to any great extent. The aim of this study was to investigate antimicrobial effect of OA, UA, and sophoraflavanone G against 15 strains (5 species) of oral Gram-negative bacteria, which are the major causative bacteria of periodontal disease. The antimicrobial activity was evaluated by minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determinations. OA and UA showed antimicrobial effects against all of the Porphyromonas gingivalis strains tested and also Prevotella intermedia ATCC $25611^T$. Interestingly, P. intermedia ATCC 49046 showed greater resistance to OA and UA than P. intermedia ATCC $25611^T$. In contrast, sophoraflavanone G had antimicrobial activity against all strains, with MIC and MBC values below $32{\mu}g/ml$, except Aggregatibacter actinomycetemcomitans. These results indicate that sophoraflavanone G may have potential for use in future oral hygiene products such as dentifrices and gargling solution to prevent periodontitis.

• 한국치위생학회지
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• 제14권1호
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• pp.17-24
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• 2014

Objectives : The purpose of this study was to investigate cognition on oral health education and dental caries preventive effect in kindergartens and child care facilities. Methods : A self-reported questionnaire was completed by 260 teachers in kindergartens and nursery facility in Daejeon from January to February, 2013. Except incomplete answers, 248 questionnaires were analyzed by using the statistical package SPSS WIN 18.0. Results : High intention to participate in oral health education was shown in the teachers who experienced the oral health education. Dental caries preventive effect included correct tooth brushing, fluoride dentifrice, fluoride mouth rinse, and use of xylitol. The teachers agreed that the fluoride mouth rinses would help good oral health in the children. Conclusions : Teachers in kindergartens and nursery facility are the most important persons in childhood oral health care. So it is necessary to provide the continuing standardized education for the teachers systematically.

• 한국치위생학회지
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• 제22권4호
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• pp.297-305
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• 2022

Objectives: The purpose of this study is to investigate the effect of depression and stress on subjective oral-related symptoms in adolescen. Methods: This study was based on the 17th Korea Youth Risk Behavior Survey(KYRBS, 2021). A total of 54,848 individuals who responded to items regarding to depression, stress, and subjective oral symptoms were analyzed. Logistic regression analysis was performed to examine subjective oral-related symptoms according to depression and stress, and the analysis results were presented as OR (odds ratio) and 95% CI (confidence interval). Results: Among the subjective oral-related symptoms, 'aching and throbbing teeth' was 1.41 times (95% CI: 1.34-1.49) higher in the group with depression, and 1.40 times (95% CI: 1.31-1.51) was significantly higher in the group with stress. In the case of 'gum pain or bleeding', the symptoms were significantly higher in the group with depression and stress by 1.36 times (95% CI: 1.27-1.45), respectively. Conclusions: As a result of this study, it was found that depression and stress in Korean adolescents had an effect on subjective oral symptoms. Study results suggest that depression and stress in Korean adolescents has an effect on their subjective oral-related symptoms

• International Journal of Oral Biology
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• 제36권1호
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• pp.7-11
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• 2011

Ursolic acid is a triterpenoid compound present in many plants. This study examined the antimicrobial activity of ursolic acid against mutans streptococci (MS) isolated from the Korean population. The antimicrobial activity was evaluated by the minimum inhibitory concentration (MIC) and time kill curves of MS. The cytotoxicity of ursolic acid against KB cells was tested using an MTT assay. The $MIC_{90}$ values of ursolic acid for Streptococcus mutans and Streptococcus sobrinus isolated from the Korean population were $2 {\mu}g$/ml and $4 {\mu}g$/ml, respectively. Ursolic acid had a bactericidal effect on S. mutans ATCC $25175^T$ and S. sobrinus ATCC $33478^T$ at > $2 \;{\times}\; MIC (4 {\mu}g$/ml) and $4 \;{\times}\; MIC (8 {\mu}g$/ml), respectively. Ursolic acid had no cytotoxic effect on KB cells at concentrations at which it exerted antimicrobial effects. The results suggest that ursolic acid can be used in the development of oral hygiene products for the prevention of dental caries.

• 융합정보논문지
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• 제11권11호
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• pp.229-238
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• 2021

본 연구 목적은 교직원들의 신체 건강이 구강건강에 미치는 영향을 살펴보고, 이들 간의 관계에서 스트레스의 매개 효과를 살펴보고자 한다. 연구 방법은 2021년 6월 15일부터 6월 30일까지 서울지역 일부 대학교 교직원을 대상으로 설문조사를 실시하였다. 연구 도구로는 일반적인 특성, 신체 증상, 구강 증상, 인지된 스트레스를 조사하였다. 연구 분석 방법은 신체 증상, 스트레스, 구강 증상 간의 상관성을 알아보기 위한 피어슨 상관분석을 실시하였고, 매개효과 검증을 위한 회귀분석을 시행하였다. 연구 결과 신체 증상, 스트레스와 구강 증상 모두 양의 상관성을 나타냈다. 또한 신체증상이 구강 증상에 영향을 미치는 것으로 나타났으며, 신체 증상이 구강 증상에 미치는 관계에 대한 스트레스는 부분 매개 효과를 나타냈다. 신체 증상이 구강 증상에 직접적인 영향을 미치며, 스트레스는 구강증상에 직·간접적인 영향을 미치는 것으로 나타났다. 결론적으로 교직원들의 업무 스트레스를 줄이기 위한 제도적 방안이 필요하며, 구강건강 증진을 위한 정기적인 구강보건교육이 확대되길 기대한다.

• Journal of Periodontal and Implant Science
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• 제48권5호
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• pp.284-294
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• 2018

Purpose: Epithelial barrier dysfunction is involved in the pathophysiology of periodontitis and oral lichen planus. Estrogens have been shown to enhance the physical barrier function of intestinal and esophageal epithelia, and we aimed to investigate the effect of estradiol (E2) on the regulation of physical barrier and tight junction (TJ) proteins in human oral epithelial cell monolayers. Methods: HOK-16B cell monolayers cultured on transwells were treated with E2, an estrogen receptor (ER) antagonist (ICI 182,780), tumor necrosis factor alpha ($TNF{\alpha}$), or dexamethasone (Dexa), and the transepithelial electrical resistance (TER) was then measured. Cell proliferation was measured by the cell counting kit (CCK)-8 assay. The levels of TJ proteins and nuclear translocation of nuclear factor $(NF)-{\kappa}B$ were examined by confocal microscopy. Results: E2 treatment increased the TER and the levels of junctional adhesion molecule (JAM)-A and zonula occludens (ZO)-1 in a dose-dependent manner, without affecting cell proliferation during barrier formation. Treatment of the tight-junctioned cell monolayers with $TNF{\alpha}$ induced decreases in the TER and the levels of ZO-1 and nuclear translocation of $NF-{\kappa}B$. These $TNF{\alpha}-induced$ changes were inhibited by E2, and this effect was completely reversed by co-treatment with ICI 182,780. Furthermore, E2 and Dexa presented an additive effect on the epithelial barrier function. Conclusions: E2 reinforces the physical barrier of oral epithelial cells through the nuclear ER-dependent upregulation of TJ proteins. The protective effect of E2 on the $TNF{\alpha}-induced$ impairment of the epithelial barrier and its additive effect with Dexa suggest its potential use to treat oral inflammatory diseases involving epithelial barrier dysfunction.