• International Journal of CAD/CAM
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• v.6 no.1
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• pp.51-58
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• 2006

In rapid prototyping, the optimal part orientation during fabrication is critical as it can improve part accuracy, minimize the requirement for supports and reduce the production time. Through investigating the geometric issues of STL model and process planning of RPM, This paper establishes optimizing model based on the considerations of staircase effect, support area and production time. The general satisfactory degree function is constructed employing the multi-objective optimization theory based on the general satisfactory degree principle. The best part-building orientation is obtained by solving the function employing generic algorithm. Experiment shows that the methods can effective resolve the part-building orientation in RP.

• Journal of Microbiology and Biotechnology
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• v.6 no.5
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• pp.347-351
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• 1996

Flavonoid production by suspended cells of Scutellaria baicalensis Georgi was studied and the medium was optimized for cell growth and baicalin production. In SH medium the flavonoid production was not closely associated with the cell growth. A modified SH medium, FPM, was therefore designed for enhanced baicalin production. In FPM, both cell growth and baicalin production were increased by 1.5 times and 1.67 times than in the original SH medium, respectively. The increases could be attributed to the increased metabolic activities involved in the flavonoid biosynthesis as represented by enhanced activities of phenylalanine ammonia-lyase.

• Industrial Engineering and Management Systems
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• v.6 no.2
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• pp.106-118
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• 2007

This paper present a new optimization model to generate aggregate production planning by considering electric cost. The new Time Of Switching (TOS) electric type is introduced by switching over Time Of Day (TOD) and Time Of Use (TOU) electric types to minimize the electric cost. The fuzzy demand and Dynamic inventory tracking with multiple plant capacity are modeled to cover the uncertain demand of customer. The constraint for minimum hour limitation of plant running per one start up event is introduced to minimize plants idle time. Furthermore; the Optimal Weight Moving Average Factor for customer demand forecasting is introduced by monthly factors to reduce forecasting error. Application is illustrated for multiple cement mill plants. The mathematical model was formulated in spreadsheet format. Then the spreadsheet-solver technique was used as a tool to solve the model. A simulation running on part of the system in a test for six months shows the optimal solution could save 60% of the actual cost.

• Nuclear Engineering and Technology
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• v.53 no.10
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• pp.3460-3463
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• 2021

Present computing power and enhanced technology is progressing at a dramatic rate. These systems can unravel complex issues, assess and control processes, learn, and-in many cases-fully automate production. There is no doubt that technological advancement is improving many aspects of life, changing the landscape of virtually all industries and enhancing production beyond what was thought possible. However, the human is still a part of these systems. Consequently, as the advancement of systems transpires, the role of humans within those systems will unavoidably continue to adapt as well. Due to the human tendency for error, this technological advancement should compel a persistent emphasis on human error reduction as part of maximizing system efficiency and safety-especially in the context of the nuclear industry. Within this context, as new systems are designed and the role of the human is transformed, human error should be targeted for a significant decrease relative to predecessor systems and an equivalent increase in system stability and safety. This article contends that optimizing the roles of humans and machines in the design and implementation of new types of automation in nuclear facility systems should involve human error reduction without ignoring the essential importance of human interaction within those systems.

• Journal of Microbiology and Biotechnology
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• v.7 no.5
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• pp.345-351
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• 1997

An aqueous/organic two-phase reaction system was applied to the production of catechol using immobilized resting cells of Pseudomonas putida CY 400. Water/ethyl ether system was used because of high partition coefficient of catechol and thus to reduce the product inhibition and degradation. Among the tested immobilization carriers, polyacrylamide gel gave the highest catechol productivity. The immobilization seemed to protect the cells against solvent toxicity. From the simulation of reaction conditions based on two-phase models, it was found that there was an optimum acetate concentration at fixed benzoate and cell concentrations for the catechol productivity. A lower phase volume ratio (lower fraction of organic phase) gave a higher productivity. However, the substrate conversion was low at low phase volume ratio.

• Microbiology and Biotechnology Letters
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• v.22 no.4
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• pp.401-406
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• 1994

The medium compositions of Alcaligenes eutrophus were optimized for increasing PHB productivity. It is very important to optimize the concentrations of inorganic salts and trace eleme- nts as well as carbon and nitrogen sources to maximize cell growth rate and productivity. The fed-batch culture of Alcaligenes eutrophus by dual feeding of ammonia water and glucose under optimized initial medium concentrations was carried out. Glucose was fed manually according to glucose consumption rate and ammonia water by pH-stat. The final cell concentrations and PHB content in 30 hours were 122 g/l and 65% of dry cell weight(yielding 79 g of PHB/l), respectively and 2.64 g/l/hr of PHB production rate was obtained.

• Microbiology and Biotechnology Letters
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• v.17 no.6
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• pp.619-623
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• 1989

The effects of temperature on yeast growth and ethanol production were investigated in batch cultures. The maximum specific growth rate of yeast was obtained at 36$^{\circ}C$ and the maximum specific production rate of ethanol was obtained at 33$^{\circ}C$. A mathematical model was employed to describe the temperature effects in ethanol fermentation and the parameters in the model were expressed as a function of temperature. Optimum temperature control strategy, from the simulation result, consists of starting the fermentation at high temperature and lowering the temperature as the fermentation proceeds.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.463-468
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• 2002

Recently, a multi-facility, multi-product and multi-period industrial problem has been widely investigated in Supply Chain Management(SCM). One of the key issues in the current SCM research area involves reducing both production and distribution costs. We have developed an optimization model to tackle the above problems under the restricted conditions such as transportation time and a zero inventory. The model can be used to deride an appropriate factory and assign an optimal output the factory yields. This paper deals with the main idea of the proposed methodology in depth.

• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1178-1185
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• 2022

Steroids are a class of compounds with cyclopentane polyhydrophenanthrene as the parent nucleus, and they usually have unique biological and pharmacological activities. Most of the biosynthesis of steroids is completed by a series of enzymatic reactions starting from cholesterol. Synthetic biology can be used to synthesize cholesterol in engineered microorganisms, but the production of cholesterol is too low to further produce other high-value steroids from cholesterol as the raw material and precursor. In this work, combinational strategies were established to increase the production of cholesterol in engineered Saccharomyces cerevisiae RH6829. The basic medium for high cholesterol production was selected by screening 8 kinds of culture media. Single-factor optimization of the carbon and nitrogen sources of the culture medium, and the addition of calcium ions, zinc ions and citric acid, further increased the cholesterol production to 192.53 mg/l. In the 5-L bioreactor, through the establishment of strategies for glucose and citric acid feeding and dissolved oxygen regulation, the cholesterol production was further increased to 339.87 mg/l, which was 734% higher than that in the original medium. This is the highest titer of cholesterol produced by microorganisms currently reported. The fermentation program has also been conducted in a 50-L bioreactor to prove its stability and feasibility.

• Journal of the Korean Operations Research and Management Science Society
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• v.22 no.2
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• pp.125-137
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• 1997

We are concerned with the packing policy determines the optimal packing of products with variable sizes to minimize the penalty costs for idle space and product spliting. Optimal packing problem is closely related to the optimal packet/record sizing problem in that randomly generated data stream with variable bytes are divided into a unit of packet/record for transmitting or storing. Assuming the product size and the production period are independently determined by renewal process, we can approximate the renewal process and formulate the optimization problem that minimize the expected packing cost for a production period. The problem is divided into two cases according to whether a product is allowed to split or not. Computational results for various distributions will be given to verify the approximation procedure and the resulting optimization problem.