• 전산구조공학
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• 제9권3호
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• pp.179-186
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• 1996

본 연구에서는 구조체의 위상학적 최적화를 위한 비선형 formulation(NLP)가 개발, 검토되었다. 이 NLP는 multiple-loading하에서 임의의 오브젝티브 함수, 응력, 변위 제약조건들을 쉽게 다룰 수가 있다. 또한 이 NLP는 해석과 최적화 디자인을 동시에 실시함으로써 요소 사이즈가 영으로 접근함에 따른 강성 매트릭스의 singularity를 피할 수 있다. 즉, 평형 방정식을 등제약조건으로 치환함으로써 강성 매트릭스 그 자체나 그의 역매트릭스를 구할 필요도 없어진다. 이 NLP는 multiple-loading conditon하에서 테스트되었으며, 이를 통해 이 NLP가 다양한 제약조건하에서 강력하게 작용함이 입증되었다.

• Archives of Pharmacal Research
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• 제27권7호
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• pp.797-805
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• 2004

LPD vectors are non-viral vehicles for gene delivery comprised of polycation-condensed plasmid DNA and liposomes. Here, we described a novel anionic LPD formulation containing protamine-DNA complexes and pH sensitive liposomes composed of DOPE and cholesteryl hemisuccinate (Chems). Central composite design (CCD) was employed to optimize stable LPD formulation with small particle size. A three factor, five-level CCD design was used for the optimization procedure, with the weight ratio of protamine/DNA ($X_1$), the weight ratio of Chems/DNA ($X_2$) and the molar ratio of Chems/DOPE in the anionic liposomes ($X_3$) as the independent variables. LPD size ($Y_1$) and LPD protection efficiency against nuclease ($Y_2$) were response variables. Zeta potential determination was utilized to define the experimental design region. Based on experimental design, responses for the 15 formulations were obtained. Mathematical equations and response surface plots were used to relate the dependent and independent variables. The mathematical model predicted optimized $X_1-X_3$ levels that achieve the desired particle size and the protection efficiency against nuclease. According to these levels, an optimized LPD formulation was prepared, resulting in a particle size of 185.3 nm and protection efficiency of 80.22％.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1993년도 춘계공동학술대회 발표논문 및 초록집; 계명대학교, 대구; 30 Apr.-1 May 1993
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• pp.109-118
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• 1993

This paper describes the management of knowledge base and optimization models using knowledge-assisted optimization model formulation system UNIK-OPT (UNIfied Knowledge-OPTimization). We will illustrate UNIK-OPT with the case of production scheduling in refinery.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2005년도 춘계 학술대회논문집
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• pp.187-190
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• 2005

In this study, the reliablility based design optimization is peformed for an aircraft wing. The flexiblility of the wing was assumed by considering the interaction modeled by static aeroelasticity between aerodynamic forces and the structure. For a multidisciplinary design optimization the results of aerodynamic analysis and structural analysis were included in the optimization formulation. The First Order Reliability Method(FORM) was employed to consider the uncertainty of the designed points.

• 농약과학회지
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• 제14권2호
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• pp.138-147
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• 2010

소나무재선충에 대한 살선충 활성을 나타내는 Micromonospora sp. AW050027 균주를 최적의 배지에서 배양한 미생물배양액을 제제하여 포트 및 포장에서 살선충 효과를 확인하였다. 최적화된 배지조성은 리터당 glycerol 10 g, soybean meal 10 g, NaCl 1 g, $CaCO_3$ 2 g, $K_2HPO_4$ 0.125 g 이었으며, 활성균주를 배양하여 농축한 후 액상 및 분말 미생물제제를 제조하였다. 제제에는 소나무재선충 공생미생물에 대하여 가장 효과적으로 항균활성을 나타내는 kanamycin을 첨가하여 사용하였다. 포트시험, 예비포장 시험 및 본포장 시험을 통하여 소나무재선충 방제효과를 확인한 결과, 액상제제를 수간수사하여 처리한 경우 1회처리시 고사율 53%, 5회 분할처리시 28%로 분할처리가 1회처리보다 2배 가량 효과적이었고, 배양농축액을 분할처리한 경우에서는 대조구의 고사율 100%에 대하여 고사율 10% 이내로 가장 낮게 나타났다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2002년도 봄 학술발표회 논문집
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• pp.123-130
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• 2002

A general formulation for shape design sensitivity analysis over three dimensional beam structure is developed based on a variational formulation of the beam in linear elasticity. Sensitivity formula is derived based on variational equations in cartesian coordinates using the material derivative concept and adjoint variable method for the displacement and Von-Mises stress functionals. Shape variation is considered for the beam shape in general 3-dimensional direction as well as for the orientation angle of the beam cross section. In the sensitivity expression, the end points evaluation at each beam segment is added to the integral formula, which are summed over the entire structure. The sensitivity formula can be evaluated with generality and ease even by employing piecewise linear design velocity field despite the bending model is fourth order differential equation. For the numerical implementation, commercial software ANSYS is used as analysis tool for the primal and adjoint analysis. Once the design variable set is defined using ANSYS language, shape and orientation variation vector at each node is generated by making finite difference to the shape with respect to each design parameter, and is used for the computation of sensitivity formula. Several numerical examples are taken to show the advantage of the method, in which the accuracy of the sensitivity is evaluated. The results are found excellent even by employing a simple linear function for the design velocity evaluation. Shape optimization is carried out for the geometric design of an archgrid and tilted bridge, which is to minimize maximum stress over the structure while maintaining constant weight. In conclusion, the proposed formulation is a useful and easy tool in finding optimum shape in a variety of the spatial frame structures.

• 전자공학회논문지SC
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• 제48권5호
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• pp.52-58
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• 2011

유도탄의 유도제어시스템은 오토파일롯, 유도법칙 및 호밍필터 등의 다양한 제어시스템으로 구성된다. 기존에는 이러한 유도제어시스템을 설계하기 위해 이러한 각 단계의 제어기를 개별적으로 최적화하는 방식이 널리 활용되었다. 하지만 이러한 방식의 경우 각 단계의 최적화시 시간과 비용이 많이 필요함은 물론, 전체시스템의 관점에서의 최적화라 볼 수 없다. 본 논문에서는 최적화 툴을 이용한 유도제어시스템 설계를 위해 각 제어시스템 설계 시 필요한 성능지수 및 구속조건을 정식화하고, 이를 통합적으로 최적화하는 기법을 제안한다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1995년도 Proceedings of the Korea Automation Control Conference, 10th (KACC); Seoul, Korea; 23-25 Oct. 1995
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• pp.315-318
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• 1995

The optimum design problem of a coat-hanger die is solved by the inverse formulation. The flow in the die is analyzed using three-dimensional model. The new model for the manifold geometry is developed for the inverse formulation. The inverse problem for the optimum die geometry is formed as the optimization problem whose objective function is the linear combination of the square sum of pressure gradient deviation at die exit and the penalty function relating to the measure of non-smoothness of solution. From the several iterative solutions of the optimization problem, the optimum solution can be obtained automatically while producing the uniform flow rate distribution at die exit.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2000년도 가을 학술발표회논문집
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• pp.238-245
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• 2000

A general formulation for shape design sensitivity analysis over a plane arch structure is developed based on a variational formulation of curved beam in linear elasticity. Sensitivity formula is derived using the material derivative concept and adjoint variable method for the stress defined at a local segment. Obtained sensitivity expression, which can be computed by simple algebraic manipulation of the solution variables, is well suited for numerical implementation since it does not involve numerical differentiation. Due to the complete description for the shape and its variation of the arch, the formulation can manage more complex design problems with ease and gives better optimum design than before. Several examples are taken to show the advantage of the method, in which the accuracy of the sensitivity is evaluated. Shape optimization is also conducted with two design problems to illustrate the excellent applicability.

• Journal of Communications and Networks
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• 제9권4호
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• pp.419-427
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• 2007

In wavelength-division-multiplexing(WDM) networks a link failure may cause the failure of several high-bit-rate optical channels, thereby leading to large data loss. Recently, various protection and restoration mechanisms have been proposed to efficiently deal with this problem in mesh networks. Among them, dedicated path protection(DPP) is a promising candidate because of its ultra-fast restoration time and robustness. In this work we investigate the issue of planning and optimization of WDM networks with DPP. Integer linear programming(ILP), in particular, is one of the most common exact method to solve the design optimization problem for protected WDM networks. Traditional ILP formalizations to solve this problem rely on the classical flow or route formulation approaches, but both these approaches suffer from a excessively high computational burden. In this paper, we present a variable-aggregation method that has the ability of significantly reducing the complexity of the traditional flow formulation. We compare also the computational burden of flow formulation with variable aggregation both with the classical flow and route formulations. The comparison is carried out by applying the three alternative methods to the optimization of two case-study networks.