• Environmental and Resource Economics Review
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• v.12 no.1
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• pp.75-90
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• 2003

In this paper we have shown that a Pigouvian tax is an adequate resolution of congestion externality to attain Pareto optimality using utility maximization. For this objective, taking an open access freeway as an example, we not only derived both marginal private benefit and marginal social benefit, but also assessed the divergence between marginal private benefit and marginal social benefit. As a result, we identified that the amount of a Pigouvian tax should be the same amount as the external time cost, which is the value of the marginal time cost to Individual a incurred by Individual b through freeway congestion. This Pigouvian tax coincides with the profit or wealth maximizing toll suggested by literature on the basis of profit maximization. In addition, because an open access freeway is accounted as common property resource, we proved that average social congestion cost is essentially equal to marginal private congestion cost in our model. Finally, we showed that the optimal value of trip derived in our model is the same as that generated on profit maximization approach.

• IMMUNE NETWORK
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• v.12 no.3
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• pp.89-95
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• 2012

Immune cells express toll-like receptors (TLRs) and respond to molecular patterns of various pathogens. CpG motif in bacterial DNA activates innate and acquired immune systems through binding to TLR9 of immune cells. Several studies reported that CpG can directly regulate B cell activation, differentiation, and Ig production. However, the role of CpG in B cell growth and Ig production is not fully understood. In this study, we analyzed the effect of CpG on the kinetics of mouse B cell viability, proliferation, and Igs production. Overall, CpG enhanced mouse B cell growth and production of Igs in a dose-dependent manner. Unlike LPS, 100 nM CpG (high dose) did not support TGF-${\beta}1$-induced IgA and IgG2b production. Moreover, 100 nM CpG treatment abrogated either LPS-induced IgM or LPS/TGF-${\beta}1$-induced IgA and IgG2b production, although B cell growth was enhanced by CpG under the same culture conditions. We subsequently found that 10 nM CpG (low dose) is sufficient for B cell growth. Again, 10 nM CpG did not support TGF-${\beta}1$-induced IgA production but, interestingly enough, supported RA-induced IgA production. Further, 10 nM CpG, unlike 100 nM, neither abrogated the LPS/TGF-${\beta}1$- nor the LPS/RA-induced IgA production. Taken together, these results suggest that dose of CpG is critical in B cell growth and Igs production and the optimal dose of CpG cooperates with LPS in B cell activation and differentiation toward Igs production.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.1 no.1
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• pp.52-57
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• 2002

A simulation tool for an optimal ATIS design and drivers' dynamic route choice behavior analysis is developed, which is applicable to urban networks. Due to the difficulty to make drivers feel the time pressure according to traffic conditions, current SP questionnaire survey type surveys have a limitation to capture correct driver reactions to real-time traffic Information provision. The simulator Is a web-based upgraded version, named WATiSim (Web-based ATIS Simulator), to quickly perform a wide population survey with a minimal cost using INTERNET Furthermore, the time pressure issue is lessened by its interface and simulation modules. After WATiSim mimicked a VMS based ATIS in a partial network of Seoul Metropolitan, reactions of drivers to various traffic conditions were surveyed through INTERNET and analyzed using a logit model. Drivers under the ATIS environment clearly understood the provided traffic information, and their reactions were closely related to traffic conditions, scheduled delay, trip purposes as well as toll charge if any.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.1
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• pp.117-124
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• 2010

Different to other social infrastructures, bridge elements or bridges can be damaged or collapsed and this may cause death toll and severe social and economical damage, bridges should be managed to maintain a safety level. Diverse strengthening methods is developed to improve a deteriorated bridge performance up to original design level. But rational decision-making process and methodologies to select a optimum strengthening method are absence yet in Korea. This paper therefore derived items and proposed methodologies for quantity estimate considering uncertainty to select a optimum strengthening method among conceptually designed alternatives. And also, to demonstrate the applicability and verification of the proposed approach, it was applied to select the optimum strengthening method for the deteriorated T-shape concrete girder bridge. The model and the procedure can greatly contribute to the uncertainty-oriented alternative selection.

• Journal of Korean Society of Transportation
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• v.19 no.5
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• pp.49-59
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• 2001

In the transportation planning process, origin and destination(O-D) trip matrix is one of the most important elements. There have been developments and applications of the methodology to adjust old matrices using link traffic counts. Commonly, the accuracy of an adjusted O-D matrix depends very much on the reliability of the input data such as the numbers and locations of traffic counting points in the road network. In the real application of the methodology, decisions on the numbers and locations of traffic counting points are one of the difficult problems, because usually as networks become bigger, the numbers of traffic counting points are required more. Therefore, this paper investigates these issues as an experiment using a nationwide network in Korea. We have compared and contrasted the set of link flows assigned by the old and the adjusted O-D matrices with the set of observed link flows. It has been analyzed by increasing the number of the traffic counting points on the experimental road network. As a result of these analyses, we can see an optimal set of the number of counting links through statistical analysis, which are approximately ten percentages of the total link numbers. In addition, the results show that the discrepancies between the old and the adjusted matrices in terms of the trip length frequency distributions and the assigned and the counted link flows are minimized using the optimal set of the counted links.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.7
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• pp.1156-1166
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• 2020

Objective: The aim of this study was to evaluate the effects of compound organic acid calcium (COAC) on growth performance, hepatic antioxidant status and intestinal barrier of male broilers under high ambient temperature (32.7℃). Methods: Nine hundred healthy one-d-old Cobb-500 male broiler chicks were randomly assigned into three groups with six replicates of 50 birds each. A basal diet supplemented with 0% (control), 0.4% and 0.8% COAC, respectively were fed to birds for 6 weeks. All treatments were under high ambient indoor temperature of 32.7℃, and had a constant calcium and available phosphorus ratio. Results: The results showed that, compared with control, the average daily gain of broilers in 0.4% and 0.8% was significantly increased and the ratio of feed to gain in in 0.4% and 0.8% was significantly decreased at 1 to 21, 22 to 42 and 1 to 42 days of age (p<0.05). Compared with control, 0.8% COAC slightly decreased (p = 0.093) the content of malondialdehyde in liver at 42 days of age while 0.4% COAC significantly decreased (p<0.05) the activity of alkaline phosphatase. Furthermore, 0.4% COAC significantly enhanced the intestinal barrier function via increasing jejunal and ileal ocln transcription, promoting jejunal mucin 2 transcription at 42 days of age (p<0.05), and decreasing jejunal toll-like receptor 2 (TLR-2) and ileal TLR-15, inducible nitric oxide synthase compared with control group (p<0.05). Whereas, no significant differences on the transcription of interleukin-1β in jejunum and ileum were observed among three treatments (p>0.05). Overall, heat stress caused by high natural environment temperature may induce the damage to hepatic antioxidation and intestinal barrier. Conclusion: Dietary inclusion of COAC can improve the tolerance of broilers to thermal environment through the modification of antioxidative parameters in liver and the mRNA expression of genes in intestinal barrier, resulting in an optimal inclusion level of 0.4%.