• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.2
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• pp.65-85
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• 2023

The use of TBM (Tunnel boring machine) has increased worldwide due to its performance together with the benefit of being safely and environmentally friendly compared to conventional tunneling. In particular, EPB (Earth Pressure Balanced) TBM is widely used because it can be applied to various grounds compared to Open TBM. Also EPB TBM has a simple mechanical structure and advantages in cost, requires less ground area than Slurry TBM. EPB TBM has advantages in soft ground, and more importantly, can extend its applicability by use of appropriate soil conditioning, which improves mechanical and hydrological properties of excavated soil and increases the excavation performance of EPB TBM. Various studies suggested the proper mixing ratio and injection ratio, but almost they are limited to laboratory test under atmospheric pressure such as slump test. Actual field conditions may differ depending on the ground and mechanical condition. In this study, first the amount of used soil conditioning used in the field with various grounds from hard rock to soft ground was estimated through laboratory tests and compared with the estimate in design stage. And also it was compared with the amount used during actual excavation. In addition, experience of soil conditioning for the problems of cutter head clogging and groundwater inrush that occurred during excavation is discussed. Finally, lesson learned for the use of soil conditioning in difficult ground condition such as mixed ground are reviewed.

• Journal of Korean Neurosurgical Society
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• v.66 no.5
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• pp.511-524
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• 2023

Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte colony stimulating factor (G-CSF) treatment. In addition, the effects of G-CSF on brain functions were examined by magnetic resonance (MR) imaging and histopathologically. Methods : This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at the beginning of the study and continued for 15 days after whole-brain radiotherapy (WBRT). WBRT was given on day 7 of the start of the study. At the end of 15 days, the behavioral tests, including the three-chamber sociability test, open field test, and passive avoidance learning test, were done. After the behavioral test, the animals performed the MR spectroscopy procedure. At the end of the study, cervical dislocation was applied to all animals. Results : G-CSF treatment positively affected the results of the three-chamber sociability test, open-space test and passive avoidance learning test, cornu Ammonis (CA) 1, CA3, and Purkinje neuron counts, and the brain levels of brain-derived neurotrophic factor and postsynaptic density protein-95. However, G-CSF treatment reduced the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde, tumor necrosis factor-alpha, nuclear factor kappa-B, and lactate. In addition, on MR spectroscopy, G-CSF had a reversible effect on brain lactate levels. Conclusion : In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.183-192
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• 2018

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear circuit. The present study measured several anxiety-related behavioral responses to examine the effects of berberine (BER) on symptoms of anxiety in rats after single prolonged stress (SPS) exposure, and to determine if BER reversed the dopamine (DA) dysfunction. Rats received BER (10, 20, or 30 mg/kg, intraperitoneally, once daily) for 14 days after SPS exposure. BER administration significantly increased the time spent in the open arms and reduced grooming behavior during the elevated plus maze test, and increased the time spent in the central zone and the number of central zone crossings in the open field test. BER restored neurochemical abnormalities and the SPS-induced decrease in DA tissue levels in the hippocampus and striatum. The increased DA concentration during BER treatment may partly be attributed to mRNA expression of tyrosine hydroxylase and the DA transporter in the hippocampus, while BER exerted no significant effects on vesicular monoamine transporter mRNA expression in the hippocampus of rats with PTSD. These results suggest that BER had anxiolytic-like effects on behavioral and biochemical measures associated with anxiety. These findings support a role for reduced anxiety altered DAergic transmission and reduced anxiety in rats with PTSD. Thus, BER may be a useful agent to treat or alleviate psychiatric disorders like those observed in patients with PTSD.

• Journal of the Korean GEO-environmental Society
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• v.10 no.2
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• pp.61-68
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• 2009

This paper presents the numerical investigation for the hydraulic behavior of a fractured rock mass with a hydromechanical interaction which may be considered during the in-situ hydraulic injection test. These experiments consist in a series of flow meter injection tests for fractures existing along an open hole section installed in a borehole, and experimental results are applied for testing a numerical model developed to the analysis and prediction of such hydromechanical interactions. Field experimental results show that conductive fractures form a dynamic and interdependent network, that individual fractures cannot be adequately modeled as independent systems, that new fluid intaking zones generate when pore pressure exceeds the minimum principal stress magnitude in that borehole, and that pore pressures much larger than this minimum stress can be further supported by the circulated fractures. In this study, these characteristics are investigated numerically how to influence the morphology of the natural fracture network in a rock mass by using a discrete fracture ntework model.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.5
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• pp.525-538
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• 2018

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several anxiety-related behavioral responses to examine the effects of TMP on symptoms of anxiety in rats after single prolonged stress (SPS) exposure by reversing the serotonin (5-HT) and hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Rats were given TMP (10, 20, or 40 mg/kg, i.p.) for 14 days after SPS exposure. Administration of TMP significantly reduced grooming behavior, increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. TMP administration significantly reduced the freezing response to contextual fear conditioning and significantly restored the neurochemical abnormalities and the SPS-induced decrease in 5-HT tissue levels in the prefrontal cortex and hippocampus. The increased 5-HT concentration during TMP treatment might be partially attribute to the tryptophan and 5-hydroxyindoleacetic acid mRNA level expression in the hippocampus of rats with PTSD. These findings support a role for reducing the altered serotonergic transmission in rats with PTSD. TMP simultaneously attenuated the HPA axis dysfunction. Therefore, TMP may be useful for developing an agent for treating psychiatric disorders, such those observed in patients with PTSD.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.4
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• pp.357-366
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• 2016

Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of PTSD induced by a single prolonged stress (SPS) procedure. The effects of IBU on inflammation and BDNF modulation in the hippocampus and the mechanisms underlying for anxiolytic action of IBU were also investigated. Male Sprague-Dawley rats were given IBU (20 or 40 mg/kg, i.p., once daily) for 14 days. Daily IBU (40 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index in the EPM test, and increased the time spent in the center of an open field after SPS. IBU administration significantly decreased the expression of pro-inflammatory mediators, such as tumor necrosis $factor-{\alpha}$, $interleukin-1{\beta}$, and BDNF, in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. These findings suggest that IBU exerts a therapeutic effect on PTSD that might be at least partially mediated by alleviation of anxiety symptoms due to its anti-inflammatory activity and BDNF expression in the rat brain.

• Journal of the Society of Naval Architects of Korea
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• v.58 no.1
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• pp.1-9
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• 2021

In the present study, the model-scale Propeller Open Water (POW) tests for the propeller of 176K bulk carrier and 8600TEU container ship were conducted through Computational Fluid Dynamics (CFD) simulation. In order to solve the incompressible viscous flow field, the Reynolds-averaged Navier-Stokes (RaNS) equations were employed as the governing equations. The γ-Reθ(gamma-Re-theta) transition model combined with the SST k-ωturbulence model was introduced to describe the laminar-turbulence transition considering the low Reynolds number of model-scale. Firstly, the flow simulation developing over a flat plate was performed to verify the transition modeling, in which the wall shear stresses were compared with experiments and other numerical results. Then, to investigate the effect of the model, the CFD simulation for the POW test was performed and the simulated propeller performance was validated through comparison with the experiment conducted at Korea Research Institute of Ships & Ocean Engineering (KRISO).

• Journal of the Korean Society for information Management
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• v.35 no.1
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• pp.157-182
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• 2018

As data management and processing techniques have been developed rapidly in the era of big data, nowadays a lot of business companies and researchers have been interested in long tail data which were ignored in the past. This study proposes methods for generating and controlling a network of technical terms based on text mining technique to enhance data utilization in the distribution of long tail theory. Especially, an edit distance technique of text mining has given us efficient methods to automatically create an interlinking network of technical terms in the scholarly field. We have also used linked open data system to gather experimental data to improve data utilization and proposed effective methods to use data of LOD systems and algorithm to recognize patterns of terms. Finally, the performance evaluation test of the network of technical terms has shown that the proposed methods were useful to enhance the rate of data utilization.

• Journal of Korean Ophthalmic Optics Society
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• v.12 no.3
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• pp.65-70
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• 2007

This research aims at knowing educational objectives and understanding the whole departmental processes of two-year education programs of junior colleges in the field of ophthalmic optics. Our analyses can be categorized by on liberal art courses, compulsory subjects and optional subjects. The educational purpose of all the seven colleges was training the professional worker, meets well the educational requirements of two year college. All seven colleges' curriculum is open to the national licence examination subjects, but more academic credits are demended in eye examination of refraction, test of ocular function, professional sense of cultural subjects field, leadership in organization and course of marketing related subjects, and stronger relation with clinical examination are also required.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.6
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• pp.1179-1186
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• 2012

For better understanding of carbon cycle dynamics of an agro-ecosystem, an accurate assessment of seasonal and daily $CO_2$ flux is essential to understand the relationship between various environmental factors and crop productivity. We developed the automatic sliding canopy chamber (ASCC) system that measured continuous net ecosystem productivity (NEP) over whole growing season under the natural meteorological rhythm. The ASCC was composed of two main parts which were sliding part for measuring NEP, and automatic opening and closing chamber (AOCC) for measuring soil respiration (SR) on the soil surface. The ASCC was developed by using open flow method for measuring soil $CO_2$ efflux. The disturbance of natural meteorological condition was minimized by opening the base frames. In the field test with barley (Hordeum vulgare L.), NEP was calculated at $140mg\;CO_2\;m^{-2}h^{-1}$ on a clear day using continuous data and eliminated the possibility of overestimate about 16% using one hour data during the day time. Unlike other small scale chamber system, installation on cropping-field made it possible to take any modifications which might be caused by natural environmental condition.